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Items: 19


Rate of brain aging and APOE ε4 are synergistic risk factors for Alzheimer's disease.

Glorioso CA, Pfenning AR, Lee SS, Bennett DA, Sibille EL, Kellis M, Guarente LP.

Life Sci Alliance. 2019 May 27;2(3). pii: e201900303. doi: 10.26508/lsa.201900303. Print 2019 Jun.


SIRT1 deacetylase in aging-induced neuromuscular degeneration and amyotrophic lateral sclerosis.

Herskovits AZ, Hunter TA, Maxwell N, Pereira K, Whittaker CA, Valdez G, Guarente LP.

Aging Cell. 2018 Dec;17(6):e12839. doi: 10.1111/acel.12839. Epub 2018 Oct 8.


Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice.

Hayashi H, Cherpokova D, Martinod K, Witsch T, Wong SL, Gallant M, Cifuni SM, Guarente LP, Wagner DD.

PLoS One. 2017 Dec 13;12(12):e0188341. doi: 10.1371/journal.pone.0188341. eCollection 2017.


Aging and Rejuvenation: Insights from Rusty Gage, Leonard Guarente, and Amy Wagers.

Gage FH, Guarente LP, Wagers AJ.

Trends Mol Med. 2016 Aug;22(8):633-634. doi: 10.1016/j.molmed.2016.06.011. Epub 2016 Jul 5. No abstract available.


Dietary restriction: standing up for sirtuins.

Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, Helfand SL, Imai S, Itoh H, Kadowaki T, Koya D, Leeuwenburgh C, McBurney M, Nabeshima Y, Neri C, Oberdoerffer P, Pestell RG, Rogina B, Sadoshima J, Sartorelli V, Serrano M, Sinclair DA, Steegborn C, Tatar M, Tissenbaum HA, Tong Q, Tsubota K, Vaquero A, Verdin E.

Science. 2010 Aug 27;329(5995):1012-3; author reply 1013-4. doi: 10.1126/science.329.5995.1012. No abstract available.


Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction.

Cohen DE, Supinski AM, Bonkowski MS, Donmez G, Guarente LP.

Genes Dev. 2009 Dec 15;23(24):2812-7. doi: 10.1101/gad.1839209. Erratum in: Genes Dev. 2010 Mar 1;24(5):516.


The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control.

Nakahata Y, Kaluzova M, Grimaldi B, Sahar S, Hirayama J, Chen D, Guarente LP, Sassone-Corsi P.

Cell. 2008 Jul 25;134(2):329-40. doi: 10.1016/j.cell.2008.07.002.


The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.

Firestein R, Blander G, Michan S, Oberdoerffer P, Ogino S, Campbell J, Bhimavarapu A, Luikenhuis S, de Cabo R, Fuchs C, Hahn WC, Guarente LP, Sinclair DA.

PLoS One. 2008 Apr 16;3(4):e2020. doi: 10.1371/journal.pone.0002020.


Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.

Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV Jr, Weissman S, Verdin E, Schwer B.

Mol Cell Biol. 2007 Dec;27(24):8807-14. Epub 2007 Oct 8.


Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction.

Haigis MC, Guarente LP.

Genes Dev. 2006 Nov 1;20(21):2913-21. Review.


Changes of telomere length cause reciprocal changes in the lifespan of mother cells in Saccharomyces cerevisiae.

Austriaco NR Jr, Guarente LP.

Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9768-72.


Mitochondrial and nonmitochondrial citrate synthases in Saccharomyces cerevisiae are encoded by distinct homologous genes.

Rosenkrantz M, Alam T, Kim KS, Clark BJ, Srere PA, Guarente LP.

Mol Cell Biol. 1986 Dec;6(12):4509-15.


Regulation of the yeast CYC1 gene.

Guarente LP.

Basic Life Sci. 1986;40:513-8. No abstract available.


Conferral of transposable properties to a chromosomal gene in Escherichia coli.

Guarente LP, Isberg RR, Syvanen M, Silhavy TJ.

J Mol Biol. 1980 Aug 15;141(3):235-48. No abstract available.


Deletions of distal sequence after termination of transcription at the end of the tryptophan operon in E. coli.

Wu AM, Chapman AB, Platt T, Guarente LP, Beckwith J.

Cell. 1980 Apr;19(4):829-36. No abstract available.


A mutation distal to the messenger RNA endpoint reduces transcription termination in the tryptophan operon in Escherichia coli.

Guarente LP, Beckwth J, Wu AM, Platt T.

J Mol Biol. 1979 Sep 5;133(1):189-97. No abstract available.


Transcription termination at the end of the tryptophan operon of Escherichia coli.

Guarente LP, Mitchell DH, Beckwith J.

J Mol Biol. 1977 May 25;112(3):423-36. No abstract available.


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