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Rate of brain aging and APOE ε4 are synergistic risk factors for Alzheimer's disease.

Glorioso CA, Pfenning AR, Lee SS, Bennett DA, Sibille EL, Kellis M, Guarente LP.

Life Sci Alliance. 2019 May 27;2(3). pii: e201900303. doi: 10.26508/lsa.201900303. Print 2019 Jun.


NAD+ supplementation rejuvenates aged gut adult stem cells.

Igarashi M, Miura M, Williams E, Jaksch F, Kadowaki T, Yamauchi T, Guarente L.

Aging Cell. 2019 Jun;18(3):e12935. doi: 10.1111/acel.12935. Epub 2019 Mar 27.


Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging.

Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA.

Cell. 2019 Feb 7;176(4):944-945. doi: 10.1016/j.cell.2019.01.026. No abstract available.


Efficacy and tolerability of EH301 for amyotrophic lateral sclerosis: a randomized, double-blind, placebo-controlled human pilot study.

de la Rubia JE, Drehmer E, Platero JL, Benlloch M, Caplliure-Llopis J, Villaron-Casales C, de Bernardo N, AlarcÓn J, Fuente C, Carrera S, Sancho D, GarcÍa-Pardo P, Pascual R, JuÁrez M, Cuerda-Ballester M, Forner A, Sancho-Castillo S, Barrios C, Obrador E, Marchio P, Salvador R, Holmes HE, Dellinger RW, Guarente L, Estrela JM.

Amyotroph Lateral Scler Frontotemporal Degener. 2019 Feb;20(1-2):115-122. doi: 10.1080/21678421.2018.1536152. Epub 2019 Jan 22.


SIRT1 deacetylase in aging-induced neuromuscular degeneration and amyotrophic lateral sclerosis.

Herskovits AZ, Hunter TA, Maxwell N, Pereira K, Whittaker CA, Valdez G, Guarente LP.

Aging Cell. 2018 Dec;17(6):e12839. doi: 10.1111/acel.12839. Epub 2018 Oct 8.


Erratum: Author Correction: Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study.

Dellinger RW, Santos SR, Morris M, Evans M, Alminana D, Guarente L, Marcotulli E.

NPJ Aging Mech Dis. 2018 Aug 20;4:8. doi: 10.1038/s41514-018-0027-1. eCollection 2018.


Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging.

Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA.

Cell. 2018 Mar 22;173(1):74-89.e20. doi: 10.1016/j.cell.2018.02.008. Erratum in: Cell. 2019 Feb 7;176(4):944-945.


DEP domain-containing mTOR-interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease.

Chen H, Shen F, Sherban A, Nocon A, Li Y, Wang H, Xu MJ, Rui X, Han J, Jiang B, Lee D, Li N, Keyhani-Nejad F, Fan JG, Liu F, Kamat A, Musi N, Guarente L, Pacher P, Gao B, Zang M.

Hepatology. 2018 Aug;68(2):496-514. doi: 10.1002/hep.29849. Epub 2018 May 21.


Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice.

Hayashi H, Cherpokova D, Martinod K, Witsch T, Wong SL, Gallant M, Cifuni SM, Guarente LP, Wagner DD.

PLoS One. 2017 Dec 13;12(12):e0188341. doi: 10.1371/journal.pone.0188341. eCollection 2017.


Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study.

Dellinger RW, Santos SR, Morris M, Evans M, Alminana D, Guarente L, Marcotulli E.

NPJ Aging Mech Dis. 2017 Nov 24;3:17. doi: 10.1038/s41514-017-0016-9. eCollection 2017. Erratum in: NPJ Aging Mech Dis. 2018 Aug 20;4:8.


SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis.

Zainabadi K, Liu CJ, Caldwell ALM, Guarente L.

PLoS One. 2017 Sep 22;12(9):e0185236. doi: 10.1371/journal.pone.0185236. eCollection 2017.


It takes two to tango: NAD+ and sirtuins in aging/longevity control.

Imai SI, Guarente L.

NPJ Aging Mech Dis. 2016 Aug 18;2:16017. doi: 10.1038/npjamd.2016.17. eCollection 2016. Review.


Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota.

Wellman AS, Metukuri MR, Kazgan N, Xu X, Xu Q, Ren NSX, Czopik A, Shanahan MT, Kang A, Chen W, Azcarate-Peril MA, Gulati AS, Fargo DC, Guarente L, Li X.

Gastroenterology. 2017 Sep;153(3):772-786. doi: 10.1053/j.gastro.2017.05.022. Epub 2017 May 26.


SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2.

Zainabadi K, Liu CJ, Guarente L.

PLoS One. 2017 May 25;12(5):e0178520. doi: 10.1371/journal.pone.0178520. eCollection 2017.


The brain, sirtuins, and ageing.

Satoh A, Imai SI, Guarente L.

Nat Rev Neurosci. 2017 May 18;18(6):362-374. doi: 10.1038/nrn.2017.42. Review.


Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c-SIRT2 axis.

Cha Y, Han MJ, Cha HJ, Zoldan J, Burkart A, Jung JH, Jang Y, Kim CH, Jeong HC, Kim BG, Langer R, Kahn CR, Guarente L, Kim KS.

Nat Cell Biol. 2017 May;19(5):445-456. doi: 10.1038/ncb3517. Epub 2017 Apr 24.


Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment.

Ondracek CR, Frappier V, Ringel AE, Wolberger C, Guarente L.

Cell Rep. 2017 Mar 7;18(10):2310-2319. doi: 10.1016/j.celrep.2017.02.031.


Sirtuin 1 Promotes Deacetylation of Oct4 and Maintenance of Naive Pluripotency.

Williams EO, Taylor AK, Bell EL, Lim R, Kim DM, Guarente L.

Cell Rep. 2016 Oct 11;17(3):809-820. doi: 10.1016/j.celrep.2016.09.046.


Overcoming ATM Deficiency by Activating the NAD+/SIRT1 Axis.

Guarente L.

Cell Metab. 2016 Oct 11;24(4):526-528. doi: 10.1016/j.cmet.2016.09.019.


The unexpected role of mTORC1 in intestinal stem cells during calorie restriction.

Igarashi M, Guarente L.

Cell Cycle. 2017 Jan 2;16(1):1-2. doi: 10.1080/15384101.2016.1221210. Epub 2016 Aug 11. No abstract available.


Aging and Rejuvenation: Insights from Rusty Gage, Leonard Guarente, and Amy Wagers.

Gage FH, Guarente LP, Wagers AJ.

Trends Mol Med. 2016 Aug;22(8):633-634. doi: 10.1016/j.molmed.2016.06.011. Epub 2016 Jul 5. No abstract available.


mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction.

Igarashi M, Guarente L.

Cell. 2016 Jul 14;166(2):436-450. doi: 10.1016/j.cell.2016.05.044. Epub 2016 Jun 23.


CELL METABOLISM. The resurgence of NAD⁺.

Guarente L.

Science. 2016 Jun 17;352(6292):1396-7. doi: 10.1126/science.aag1718. No abstract available.


Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway.

Cunha-Santos J, Duarte-Neves J, Carmona V, Guarente L, Pereira de Almeida L, Cavadas C.

Nat Commun. 2016 May 11;7:11445. doi: 10.1038/ncomms11445.


Correction: Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells.

Bordone L, Motta MC, Picard F, Robinson A, Jhala US, Apfeld J, McDonagh T, Lemieux M, McBurney M, Szilvasi A, Easlon EJ, Lin SJ, Guarente L.

PLoS Biol. 2015 Dec 29;13(12):e1002346. doi: 10.1371/journal.pbio.1002346. eCollection 2015 Dec. No abstract available.


The multifaceted functions of sirtuins in cancer.

Chalkiadaki A, Guarente L.

Nat Rev Cancer. 2015 Oct;15(10):608-24. doi: 10.1038/nrc3985. Epub 2015 Sep 18. Review.


Linking DNA damage, NAD(+)/SIRT1, and aging.

Guarente L.

Cell Metab. 2014 Nov 4;20(5):706-707. doi: 10.1016/j.cmet.2014.10.015. Epub 2014 Nov 4.


Aging research-where do we stand and where are we going?

Guarente L.

Cell. 2014 Sep 25;159(1):15-19. doi: 10.1016/j.cell.2014.08.041.


SirT1 is required in the male germ cell for differentiation and fecundity in mice.

Bell EL, Nagamori I, Williams EO, Del Rosario AM, Bryson BD, Watson N, White FM, Sassone-Corsi P, Guarente L.

Development. 2014 Sep;141(18):3495-504. doi: 10.1242/dev.110627. Epub 2014 Aug 19.


Muscle-specific SIRT1 gain-of-function increases slow-twitch fibers and ameliorates pathophysiology in a mouse model of duchenne muscular dystrophy.

Chalkiadaki A, Igarashi M, Nasamu AS, Knezevic J, Guarente L.

PLoS Genet. 2014 Jul 17;10(7):e1004490. doi: 10.1371/journal.pgen.1004490. eCollection 2014 Jul.


SnapShot: sirtuins, NAD, and aging.

Nakagawa T, Guarente L.

Cell Metab. 2014 Jul 1;20(1):192-192.e1. doi: 10.1016/j.cmet.2014.06.001.


NAD+ and sirtuins in aging and disease.

Imai S, Guarente L.

Trends Cell Biol. 2014 Aug;24(8):464-71. doi: 10.1016/j.tcb.2014.04.002. Epub 2014 Apr 29. Review.


SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism.

Yao H, Sundar IK, Ahmad T, Lerner C, Gerloff J, Friedman AE, Phipps RP, Sime PJ, McBurney MW, Guarente L, Rahman I.

Am J Physiol Lung Cell Mol Physiol. 2014 May 1;306(9):L816-28. doi: 10.1152/ajplung.00323.2013. Epub 2014 Mar 14.


SIRT1 in neurodevelopment and brain senescence.

Herskovits AZ, Guarente L.

Neuron. 2014 Feb 5;81(3):471-83. doi: 10.1016/j.neuron.2014.01.028. Review.


The many faces of sirtuins: Sirtuins and the Warburg effect.

Guarente L.

Nat Med. 2014 Jan;20(1):24-5. doi: 10.1038/nm.3438. No abstract available.


SIRT1 and other sirtuins in metabolism.

Chang HC, Guarente L.

Trends Endocrinol Metab. 2014 Mar;25(3):138-45. doi: 10.1016/j.tem.2013.12.001. Epub 2013 Dec 30. Review.


Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection.

Crotty Alexander LE, Marsh BJ, Timmer AM, Lin AE, Zainabadi K, Czopik A, Guarente L, Nizet V.

PLoS One. 2013 Dec 26;8(12):e84481. doi: 10.1371/journal.pone.0084481. eCollection 2013.


Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21.

Li Y, Wong K, Giles A, Jiang J, Lee JW, Adams AC, Kharitonenkov A, Yang Q, Gao B, Guarente L, Zang M.

Gastroenterology. 2014 Feb;146(2):539-49.e7. doi: 10.1053/j.gastro.2013.10.059. Epub 2013 Nov 1.


Small-molecule allosteric activators of sirtuins.

Sinclair DA, Guarente L.

Annu Rev Pharmacol Toxicol. 2014;54:363-80. doi: 10.1146/annurev-pharmtox-010611-134657. Epub 2013 Oct 16. Review.


Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes.

Hasegawa K, Wakino S, Simic P, Sakamaki Y, Minakuchi H, Fujimura K, Hosoya K, Komatsu M, Kaneko Y, Kanda T, Kubota E, Tokuyama H, Hayashi K, Guarente L, Itoh H.

Nat Med. 2013 Nov;19(11):1496-504. doi: 10.1038/nm.3363. Epub 2013 Oct 20.


Calorie restriction and sirtuins revisited.

Guarente L.

Genes Dev. 2013 Oct 1;27(19):2072-85. doi: 10.1101/gad.227439.113. Review.


SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD.

Yao H, Hwang JW, Sundar IK, Friedman AE, McBurney MW, Guarente L, Gu W, Kinnula VL, Rahman I.

Am J Physiol Lung Cell Mol Physiol. 2013 Nov 1;305(9):L615-24. doi: 10.1152/ajplung.00249.2012. Epub 2013 Sep 13.


Introduction: sirtuins in aging and diseases.

Guarente L.

Methods Mol Biol. 2013;1077:3-10. doi: 10.1007/978-1-62703-637-5_1.


Sirtuins and ageing--new findings.

Guarente L.

EMBO Rep. 2013 Sep;14(9):750. doi: 10.1038/embor.2013.121. Epub 2013 Aug 9. No abstract available.


Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells.

Fendt SM, Bell EL, Keibler MA, Olenchock BA, Mayers JR, Wasylenko TM, Vokes NI, Guarente L, Vander Heiden MG, Stephanopoulos G.

Nat Commun. 2013;4:2236. doi: 10.1038/ncomms3236.


The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling.

Mouchiroud L, Houtkooper RH, Moullan N, Katsyuba E, Ryu D, Cantó C, Mottis A, Jo YS, Viswanathan M, Schoonjans K, Guarente L, Auwerx J.

Cell. 2013 Jul 18;154(2):430-41. doi: 10.1016/j.cell.2013.06.016.


SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging.

Chang HC, Guarente L.

Cell. 2013 Jun 20;153(7):1448-60. doi: 10.1016/j.cell.2013.05.027.


Sirtuin deacetylases in neurodegenerative diseases of aging.

Herskovits AZ, Guarente L.

Cell Res. 2013 Jun;23(6):746-58. doi: 10.1038/cr.2013.70. Epub 2013 May 21. Review.


Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism.

Fendt SM, Bell EL, Keibler MA, Davidson SM, Wirth GJ, Fiske B, Mayers JR, Schwab M, Bellinger G, Csibi A, Patnaik A, Blouin MJ, Cantley LC, Guarente L, Blenis J, Pollak MN, Olumi AF, Vander Heiden MG, Stephanopoulos G.

Cancer Res. 2013 Jul 15;73(14):4429-38. doi: 10.1158/0008-5472.CAN-13-0080. Epub 2013 May 17.


SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis.

Simic P, Williams EO, Bell EL, Gong JJ, Bonkowski M, Guarente L.

Cell Rep. 2013 Apr 25;3(4):1175-86. doi: 10.1016/j.celrep.2013.03.019. Epub 2013 Apr 11.

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