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Items: 21

1.

Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease.

Pera M, Larrea D, Guardia-Laguarta C, Montesinos J, Velasco KR, Agrawal RR, Xu Y, Chan RB, Di Paolo G, Mehler MF, Perumal GS, Macaluso FP, Freyberg ZZ, Acin-Perez R, Enriquez JA, Schon EA, Area-Gomez E.

EMBO J. 2017 Nov 15;36(22):3356-3371. doi: 10.15252/embj.201796797. Epub 2017 Oct 10.

2.

The Ubiquitination of PINK1 Is Restricted to Its Mature 52-kDa Form.

Liu Y, Guardia-Laguarta C, Yin J, Erdjument-Bromage H, Martin B, James M, Jiang X, Przedborski S.

Cell Rep. 2017 Jul 5;20(1):30-39. doi: 10.1016/j.celrep.2017.06.022.

3.

ApoE4 upregulates the activity of mitochondria-associated ER membranes.

Tambini MD, Pera M, Kanter E, Yang H, Guardia-Laguarta C, Holtzman D, Sulzer D, Area-Gomez E, Schon EA.

EMBO Rep. 2016 Jan;17(1):27-36. doi: 10.15252/embr.201540614. Epub 2015 Nov 12.

4.

A new role for α-synuclein in Parkinson's disease: Alteration of ER-mitochondrial communication.

Guardia-Laguarta C, Area-Gomez E, Schon EA, Przedborski S.

Mov Disord. 2015 Jul;30(8):1026-33. doi: 10.1002/mds.26239. Epub 2015 May 7. Review.

PMID:
25952565
5.

Novel subcellular localization for α-synuclein: possible functional consequences.

Guardia-Laguarta C, Area-Gomez E, Schon EA, Przedborski S.

Front Neuroanat. 2015 Feb 23;9:17. doi: 10.3389/fnana.2015.00017. eCollection 2015. Review.

6.

Prognostic value of plasma β-amyloid levels in patients with acute intracerebral hemorrhage.

Martí-Fàbregas J, Delgado-Mederos R, Marín R, de la Ossa NP, Alonso de Leciñana M, Rodríguez-Yáñez M, Sanahuja J, Purroy F, De Arce AM, Carrera D, Dinia L, Guardia-Laguarta C, Lleó A.

Stroke. 2014 Feb;45(2):413-7. doi: 10.1161/STROKEAHA.113.002838. Epub 2014 Jan 2.

PMID:
24385273
7.

α-Synuclein is localized to mitochondria-associated ER membranes.

Guardia-Laguarta C, Area-Gomez E, Rüb C, Liu Y, Magrané J, Becker D, Voos W, Schon EA, Przedborski S.

J Neurosci. 2014 Jan 1;34(1):249-59. doi: 10.1523/JNEUROSCI.2507-13.2014.

8.

Autosomal-dominant Alzheimer's disease mutations at the same codon of amyloid precursor protein differentially alter Aβ production.

Suárez-Calvet M, Belbin O, Pera M, Badiola N, Magrané J, Guardia-Laguarta C, Muñoz L, Colom-Cadena M, Clarimón J, Lleó A.

J Neurochem. 2014 Jan;128(2):330-9. doi: 10.1111/jnc.12466. Epub 2013 Oct 24.

9.

Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease.

Pera M, Alcolea D, Sánchez-Valle R, Guardia-Laguarta C, Colom-Cadena M, Badiola N, Suárez-Calvet M, Lladó A, Barrera-Ocampo AA, Sepulveda-Falla D, Blesa R, Molinuevo JL, Clarimón J, Ferrer I, Gelpi E, Lleó A.

Acta Neuropathol. 2013 Feb;125(2):201-13. doi: 10.1007/s00401-012-1062-9. Epub 2012 Dec 6.

10.

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease.

Area-Gomez E, Del Carmen Lara Castillo M, Tambini MD, Guardia-Laguarta C, de Groof AJ, Madra M, Ikenouchi J, Umeda M, Bird TD, Sturley SL, Schon EA.

EMBO J. 2012 Nov 5;31(21):4106-23. doi: 10.1038/emboj.2012.202. Epub 2012 Aug 14.

11.

Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease.

Cooper O, Seo H, Andrabi S, Guardia-Laguarta C, Graziotto J, Sundberg M, McLean JR, Carrillo-Reid L, Xie Z, Osborn T, Hargus G, Deleidi M, Lawson T, Bogetofte H, Perez-Torres E, Clark L, Moskowitz C, Mazzulli J, Chen L, Volpicelli-Daley L, Romero N, Jiang H, Uitti RJ, Huang Z, Opala G, Scarffe LA, Dawson VL, Klein C, Feng J, Ross OA, Trojanowski JQ, Lee VM, Marder K, Surmeier DJ, Wszolek ZK, Przedborski S, Krainc D, Dawson TM, Isacson O.

Sci Transl Med. 2012 Jul 4;4(141):141ra90. doi: 10.1126/scitranslmed.3003985.

12.

A deeper look at mitochondrial dynamics in Parkinson’s disease.

Guardia-Laguarta C.

Mov Disord. 2012 Mar;27(3):343. No abstract available.

PMID:
22512003
13.

Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease.

Guix FX, Wahle T, Vennekens K, Snellinx A, Chávez-Gutiérrez L, Ill-Raga G, Ramos-Fernandez E, Guardia-Laguarta C, Lleó A, Arimon M, Berezovska O, Muñoz FJ, Dotti CG, De Strooper B.

EMBO Mol Med. 2012 Jul;4(7):660-73. doi: 10.1002/emmm.201200243. Epub 2012 May 2.

14.

Tau enhances α-synuclein aggregation and toxicity in cellular models of synucleinopathy.

Badiola N, de Oliveira RM, Herrera F, Guardia-Laguarta C, Gonçalves SA, Pera M, Suárez-Calvet M, Clarimon J, Outeiro TF, Lleó A.

PLoS One. 2011;6(10):e26609. doi: 10.1371/journal.pone.0026609. Epub 2011 Oct 24.

15.

beta-Amyloid disrupts activity-dependent gene transcription required for memory through the CREB coactivator CRTC1.

España J, Valero J, Miñano-Molina AJ, Masgrau R, Martín E, Guardia-Laguarta C, Lleó A, Giménez-Llort L, Rodríguez-Alvarez J, Saura CA.

J Neurosci. 2010 Jul 14;30(28):9402-10. doi: 10.1523/JNEUROSCI.2154-10.2010.

16.

Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease.

Coma M, Serenó L, Da Rocha-Souto B, Scotton TC, España J, Sánchez MB, Rodríguez M, Agulló J, Guardia-Laguarta C, Garcia-Alloza M, Borrelli LA, Clarimón J, Lleó A, Bacskai BJ, Saura CA, Hyman BT, Gómez-Isla T.

Neurobiol Dis. 2010 Jun;38(3):482-91. doi: 10.1016/j.nbd.2010.01.019. Epub 2010 Feb 10.

17.

gamma-Secretase as a therapeutic target in Alzheimer's disease.

Guardia-Laguarta C, Pera M, Lleó A.

Curr Drug Targets. 2010 Apr;11(4):506-17. Review.

PMID:
20015011
18.

Clinical, neuropathologic, and biochemical profile of the amyloid precursor protein I716F mutation.

Guardia-Laguarta C, Pera M, Clarimón J, Molinuevo JL, Sánchez-Valle R, Lladó A, Coma M, Gómez-Isla T, Blesa R, Ferrer I, Lleó A.

J Neuropathol Exp Neurol. 2010 Jan;69(1):53-9. doi: 10.1097/NEN.0b013e3181c6b84d.

PMID:
20010303
19.

A novel GSK-3beta inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo.

Serenó L, Coma M, Rodríguez M, Sánchez-Ferrer P, Sánchez MB, Gich I, Agulló JM, Pérez M, Avila J, Guardia-Laguarta C, Clarimón J, Lleó A, Gómez-Isla T.

Neurobiol Dis. 2009 Sep;35(3):359-67. doi: 10.1016/j.nbd.2009.05.025. Epub 2009 Jun 10.

PMID:
19523516
20.

Mild cholesterol depletion reduces amyloid-beta production by impairing APP trafficking to the cell surface.

Guardia-Laguarta C, Coma M, Pera M, Clarimón J, Sereno L, Agulló JM, Molina-Porcel L, Gallardo E, Deng A, Berezovska O, Hyman BT, Blesa R, Gómez-Isla T, Lleó A.

J Neurochem. 2009 Jul;110(1):220-30. doi: 10.1111/j.1471-4159.2009.06126.x. Epub 2009 Apr 27.

21.

Early-onset familial lewy body dementia with extensive tauopathy: a clinical, genetic, and neuropathological study.

Clarimón J, Molina-Porcel L, Gómez-Isla T, Blesa R, Guardia-Laguarta C, González-Neira A, Estorch M, Ma Grau J, Barraquer L, Roig C, Ferrer I, Lleó A.

J Neuropathol Exp Neurol. 2009 Jan;68(1):73-82. doi: 10.1097/NEN.0b013e3181927577.

PMID:
19104444

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