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Items: 48

1.

KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2.

Spiombi E, Angrisani A, Fonte S, De Feudis G, Fabretti F, Cucchi D, Izzo M, Infante P, Miele E, Po A, Di Magno L, Magliozzi R, Guardavaccaro D, Maroder M, Canettieri G, Giannini G, Ferretti E, Gulino A, Di Marcotullio L, Moretti M, De Smaele E.

Oncogenesis. 2019 Nov 4;8(11):64. doi: 10.1038/s41389-019-0175-6.

2.

Cyclin F-dependent degradation of E2F7 is critical for DNA repair and G2-phase progression.

Yuan R, Liu Q, Segeren HA, Yuniati L, Guardavaccaro D, Lebbink RJ, Westendorp B, de Bruin A.

EMBO J. 2019 Oct 15;38(20):e101430. doi: 10.15252/embj.2018101430. Epub 2019 Sep 2.

3.

ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP.

Bufalieri F, Infante P, Bernardi F, Caimano M, Romania P, Moretti M, Lospinoso Severini L, Talbot J, Melaiu O, Tanori M, Di Magno L, Bellavia D, Capalbo C, Puget S, De Smaele E, Canettieri G, Guardavaccaro D, Busino L, Peschiaroli A, Pazzaglia S, Giannini G, Melino G, Locatelli F, Gulino A, Ayrault O, Fruci D, Di Marcotullio L.

Nat Commun. 2019 Jul 24;10(1):3304. doi: 10.1038/s41467-019-11093-0.

4.

β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression.

Mavrommati I, Faedda R, Galasso G, Li J, Burdova K, Fischer R, Kessler BM, Carrero ZI, Guardavaccaro D, Pagano M, D'Angiolella V.

Cell Rep. 2018 Sep 25;24(13):3404-3412. doi: 10.1016/j.celrep.2018.08.076.

5.

Inheritance of the Golgi Apparatus and Cytokinesis Are Controlled by Degradation of GBF1.

Magliozzi R, Carrero ZI, Low TY, Yuniati L, Valdes-Quezada C, Kruiswijk F, van Wijk K, Heck AJR, Jackson CL, Guardavaccaro D.

Cell Rep. 2018 Jun 12;23(11):3381-3391.e4. doi: 10.1016/j.celrep.2018.05.031.

6.

Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis.

Infante P, Faedda R, Bernardi F, Bufalieri F, Lospinoso Severini L, Alfonsi R, Mazzà D, Siler M, Coni S, Po A, Petroni M, Ferretti E, Mori M, De Smaele E, Canettieri G, Capalbo C, Maroder M, Screpanti I, Kool M, Pfister SM, Guardavaccaro D, Gulino A, Di Marcotullio L.

Nat Commun. 2018 Mar 7;9(1):976. doi: 10.1038/s41467-018-03339-0.

7.

Two paths to let the replisome go.

D'Angiolella V, Guardavaccaro D.

Cell Death Differ. 2017 Jul;24(7):1140-1141. doi: 10.1038/cdd.2017.75. Epub 2017 May 19. No abstract available.

8.

Datasets from an interaction proteomics screen for substrates of the SCF(βTrCP) ubiquitin ligase.

Magliozzi R, Peng M, Mohammed S, Guardavaccaro D, Heck AJ, Low TY.

Data Brief. 2015 Jun 10;4:229-34. doi: 10.1016/j.dib.2015.05.003. eCollection 2015 Sep.

9.

Nodal signaling range is regulated by proprotein convertase-mediated maturation.

Tessadori F, Noël ES, Rens EG, Magliozzi R, Evers-van Gogh IJ, Guardavaccaro D, Merks RM, Bakkers J.

Dev Cell. 2015 Mar 9;32(5):631-9. doi: 10.1016/j.devcel.2014.12.014. Epub 2015 Feb 12.

10.

A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.

Low TY, Peng M, Magliozzi R, Mohammed S, Guardavaccaro D, Heck AJ.

Sci Signal. 2014 Dec 16;7(356):rs8. doi: 10.1126/scisignal.2005882.

PMID:
25515538
11.

USP17- and SCFβTrCP--regulated degradation of DEC1 controls the DNA damage response.

Kim J, D'Annibale S, Magliozzi R, Low TY, Jansen P, Shaltiel IA, Mohammed S, Heck AJ, Medema RH, Guardavaccaro D.

Mol Cell Biol. 2014 Nov 15;34(22):4177-85. doi: 10.1128/MCB.00530-14. Epub 2014 Sep 8.

12.

Degradation of Tiam1 by casein kinase 1 and the SCFβTrCP ubiquitin ligase controls the duration of mTOR-S6K signaling.

Magliozzi R, Kim J, Low TY, Heck AJ, Guardavaccaro D.

J Biol Chem. 2014 Oct 3;289(40):27400-9. doi: 10.1074/jbc.M114.575571. Epub 2014 Aug 14.

13.

Proteasome-dependent degradation of transcription factor activating enhancer-binding protein 4 (TFAP4) controls mitotic division.

D'Annibale S, Kim J, Magliozzi R, Low TY, Mohammed S, Heck AJ, Guardavaccaro D.

J Biol Chem. 2014 Mar 14;289(11):7730-7. doi: 10.1074/jbc.M114.549535. Epub 2014 Feb 5.

14.

Control of epithelial cell migration and invasion by the IKKβ- and CK1α-mediated degradation of RAPGEF2.

Magliozzi R, Low TY, Weijts BG, Cheng T, Spanjaard E, Mohammed S, van Veen A, Ovaa H, de Rooij J, Zwartkruis FJ, Bos JL, de Bruin A, Heck AJ, Guardavaccaro D.

Dev Cell. 2013 Dec 9;27(5):574-85. doi: 10.1016/j.devcel.2013.10.023. Epub 2013 Nov 27.

15.

Human papillomavirus (HPV) upregulates the cellular deubiquitinase UCHL1 to suppress the keratinocyte's innate immune response.

Karim R, Tummers B, Meyers C, Biryukov JL, Alam S, Backendorf C, Jha V, Offringa R, van Ommen GJ, Melief CJ, Guardavaccaro D, Boer JM, van der Burg SH.

PLoS Pathog. 2013;9(5):e1003384. doi: 10.1371/journal.ppat.1003384. Epub 2013 May 23.

16.

Unraveling the ubiquitin-regulated signaling networks by mass spectrometry-based proteomics.

Low TY, Magliozzi R, Guardavaccaro D, Heck AJ.

Proteomics. 2013 Feb;13(3-4):526-37. doi: 10.1002/pmic.201200244. Epub 2012 Nov 26. Review.

PMID:
23019148
17.

Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress.

Kruiswijk F, Yuniati L, Magliozzi R, Low TY, Lim R, Bolder R, Mohammed S, Proud CG, Heck AJ, Pagano M, Guardavaccaro D.

Sci Signal. 2012 Jun 5;5(227):ra40. doi: 10.1126/scisignal.2002718.

18.

APC/C (Cdh1) controls the proteasome-mediated degradation of E2F3 during cell cycle exit.

Ping Z, Lim R, Bashir T, Pagano M, Guardavaccaro D.

Cell Cycle. 2012 May 15;11(10):1999-2005. doi: 10.4161/cc.20402. Epub 2012 May 15.

19.

asb11 is a regulator of embryonic and adult regenerative myogenesis.

Tee JM, Sartori da Silva MA, Rygiel AM, Muncan V, Bink R, van den Brink GR, van Tijn P, Zivkovic D, Kodach LL, Guardavaccaro D, Diks SH, Peppelenbosch MP.

Stem Cells Dev. 2012 Nov 20;21(17):3091-103. doi: 10.1089/scd.2012.0123. Epub 2012 Jun 7.

20.

Wnt/β-catenin and MAPK signaling: allies and enemies in different battlefields.

Guardavaccaro D, Clevers H.

Sci Signal. 2012 Apr 10;5(219):pe15. doi: 10.1126/scisignal.2002921.

PMID:
22494969
21.

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.

de Lau W, Barker N, Low TY, Koo BK, Li VS, Teunissen H, Kujala P, Haegebarth A, Peters PJ, van de Wetering M, Stange DE, van Es JE, Guardavaccaro D, Schasfoort RB, Mohri Y, Nishimori K, Mohammed S, Heck AJ, Clevers H.

Nature. 2011 Jul 4;476(7360):293-7. doi: 10.1038/nature10337.

PMID:
21727895
22.

Essential role for the d-Asb11 cul5 Box domain for proper notch signaling and neural cell fate decisions in vivo.

Sartori da Silva MA, Tee JM, Paridaen J, Brouwers A, Runtuwene V, Zivkovic D, Diks SH, Guardavaccaro D, Peppelenbosch MP.

PLoS One. 2010 Nov 19;5(11):e14023. doi: 10.1371/journal.pone.0014023.

23.

betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis.

Dehan E, Bassermann F, Guardavaccaro D, Vasiliver-Shamis G, Cohen M, Lowes KN, Dustin M, Huang DC, Taunton J, Pagano M.

Mol Cell. 2009 Jan 16;33(1):109-16. doi: 10.1016/j.molcel.2008.12.020.

24.

KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state.

Frescas D, Guardavaccaro D, Kuchay SM, Kato H, Poleshko A, Basrur V, Elenitoba-Johnson KS, Katz RA, Pagano M.

Cell Cycle. 2008 Nov 15;7(22):3539-47. Epub 2008 Nov 24.

25.

The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint.

Bassermann F, Frescas D, Guardavaccaro D, Busino L, Peschiaroli A, Pagano M.

Cell. 2008 Jul 25;134(2):256-67. doi: 10.1016/j.cell.2008.05.043.

26.

The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein.

Zhao X, Heng JI, Guardavaccaro D, Jiang R, Pagano M, Guillemot F, Iavarone A, Lasorella A.

Nat Cell Biol. 2008 Jun;10(6):643-53. doi: 10.1038/ncb1727. Epub 2008 May 18.

27.

Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division.

Michaelson D, Abidi W, Guardavaccaro D, Zhou M, Ahearn I, Pagano M, Philips MR.

J Cell Biol. 2008 May 5;181(3):485-96. doi: 10.1083/jcb.200801047. Epub 2008 Apr 28.

28.

Control of chromosome stability by the beta-TrCP-REST-Mad2 axis.

Guardavaccaro D, Frescas D, Dorrello NV, Peschiaroli A, Multani AS, Cardozo T, Lasorella A, Iavarone A, Chang S, Hernando E, Pagano M.

Nature. 2008 Mar 20;452(7185):365-9. doi: 10.1038/nature06641.

29.

JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes.

Frescas D, Guardavaccaro D, Bassermann F, Koyama-Nasu R, Pagano M.

Nature. 2007 Nov 8;450(7167):309-13.

PMID:
17994099
30.

APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase.

Amador V, Ge S, Santamaría PG, Guardavaccaro D, Pagano M.

Mol Cell. 2007 Aug 3;27(3):462-73.

31.

DRE-1: an evolutionarily conserved F box protein that regulates C. elegans developmental age.

Fielenbach N, Guardavaccaro D, Neubert K, Chan T, Li D, Feng Q, Hutter H, Pagano M, Antebi A.

Dev Cell. 2007 Mar;12(3):443-55.

32.

S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth.

Dorrello NV, Peschiaroli A, Guardavaccaro D, Colburn NH, Sherman NE, Pagano M.

Science. 2006 Oct 20;314(5798):467-71.

33.

SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response.

Peschiaroli A, Dorrello NV, Guardavaccaro D, Venere M, Halazonetis T, Sherman NE, Pagano M.

Mol Cell. 2006 Aug 4;23(3):319-29.

34.

Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth.

Lasorella A, Stegmüller J, Guardavaccaro D, Liu G, Carro MS, Rothschild G, de la Torre-Ubieta L, Pagano M, Bonni A, Iavarone A.

Nature. 2006 Jul 27;442(7101):471-4. Epub 2006 Jun 28.

PMID:
16810178
35.

Skp2 contains a novel cyclin A binding domain that directly protects cyclin A from inhibition by p27Kip1.

Ji P, Goldin L, Ren H, Sun D, Guardavaccaro D, Pagano M, Zhu L.

J Biol Chem. 2006 Aug 18;281(33):24058-69. Epub 2006 Jun 14.

36.

Stabilizers and destabilizers controlling cell cycle oscillators.

Guardavaccaro D, Pagano M.

Mol Cell. 2006 Apr 7;22(1):1-4. Review.

37.

Role of F-box protein betaTrcp1 in mammary gland development and tumorigenesis.

Kudo Y, Guardavaccaro D, Santamaria PG, Koyama-Nasu R, Latres E, Bronson R, Yamasaki L, Pagano M.

Mol Cell Biol. 2004 Sep;24(18):8184-94.

38.

Oncogenic aberrations of cullin-dependent ubiquitin ligases.

Guardavaccaro D, Pagano M.

Oncogene. 2004 Mar 15;23(11):2037-49. Review.

PMID:
15021891
39.

Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase.

Bashir T, Dorrello NV, Amador V, Guardavaccaro D, Pagano M.

Nature. 2004 Mar 11;428(6979):190-3.

40.

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage.

Busino L, Donzelli M, Chiesa M, Guardavaccaro D, Ganoth D, Dorrello NV, Hershko A, Pagano M, Draetta GF.

Nature. 2003 Nov 6;426(6962):87-91.

PMID:
14603323
41.

Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo.

Guardavaccaro D, Kudo Y, Boulaire J, Barchi M, Busino L, Donzelli M, Margottin-Goguet F, Jackson PK, Yamasaki L, Pagano M.

Dev Cell. 2003 Jun;4(6):799-812.

42.

PC3 potentiates NGF-induced differentiation and protects neurons from apoptosis.

Corrente G, Guardavaccaro D, Tirone F.

Neuroreport. 2002 Mar 25;13(4):417-22.

PMID:
11930152
43.

Arrest of G(1)-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcription.

Guardavaccaro D, Corrente G, Covone F, Micheli L, D'Agnano I, Starace G, Caruso M, Tirone F.

Mol Cell Biol. 2000 Mar;20(5):1797-815.

44.

Identification of a family of human F-box proteins.

Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M.

Curr Biol. 1999 Oct 21;9(20):1177-9.

45.

Cloning of the human interferon-related developmental regulator (IFRD1) gene coding for the PC4 protein, a member of a novel family of developmentally regulated genes.

Buanne P, Incerti B, Guardavaccaro D, Avvantaggiato V, Simeone A, Tirone F.

Genomics. 1998 Jul 15;51(2):233-42.

PMID:
9722946
46.

Overexpression of the nerve growth factor-inducible PC3 immediate early gene is associated with growth inhibition.

Montagnoli A, Guardavaccaro D, Starace G, Tirone F.

Cell Growth Differ. 1996 Oct;7(10):1327-36.

47.

Inhibition of differentiation in myoblasts deprived of the interferon-related protein PC4.

Guardavaccaro D, Ciotti MT, Schäfer BW, Montagnoli A, Tirone F.

Cell Growth Differ. 1995 Feb;6(2):159-69.

48.

Nerve growth factor regulates the subcellular localization of the nerve growth factor-inducible protein PC4 in PC12 cells.

Guardavaccaro D, Montagnoli A, Ciotti MT, Gatti A, Lotti L, Di Lazzaro C, Torrisi MR, Tirone F.

J Neurosci Res. 1994 Apr 1;37(5):660-74.

PMID:
8028043

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