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Repurposing Azithromycin and Rifampicin Against Gram-Negative Pathogens by Combination With Peptidomimetics.

Baker KR, Jana B, Hansen AM, Nielsen HM, Franzyk H, Guardabassi L.

Front Cell Infect Microbiol. 2019 Jul 2;9:236. doi: 10.3389/fcimb.2019.00236. eCollection 2019.


High Prevalence of USA300 Among Clinical Isolates of Methicillin-Resistant Staphylococcus aureus on St. Kitts and Nevis, West Indies.

Guardabassi L, Moodley A, Williams A, Stegger M, Damborg P, Halliday-Simmonds I, Butaye P.

Front Microbiol. 2019 Jun 5;10:1123. doi: 10.3389/fmicb.2019.01123. eCollection 2019.


Publisher Correction: Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections.

Greco I, Emborg AP, Jana B, Molchanova N, Oddo A, Damborg P, Guardabassi L, Hansen PR.

Sci Rep. 2019 Jun 4;9(1):8361. doi: 10.1038/s41598-019-44436-4.


EUCAST disc diffusion criteria for the detection of mecA-Mediated β-lactam resistance in Staphylococcus pseudintermedius: oxacillin versus cefoxitin.

Skov R, Varga A, Matuschek E, Åhman J, Bemis D, Bengtsson B, Sunde M, Humphries R, Westblade L, Guardabassi L, Kahlmeter G.

Clin Microbiol Infect. 2019 May 17. pii: S1198-743X(19)30215-0. doi: 10.1016/j.cmi.2019.05.002. [Epub ahead of print]


International Society for Companion Animal Infectious Diseases (ISCAID) guidelines for the diagnosis and management of bacterial urinary tract infections in dogs and cats.

Weese JS, Blondeau J, Boothe D, Guardabassi LG, Gumley N, Papich M, Jessen LR, Lappin M, Rankin S, Westropp JL, Sykes J.

Vet J. 2019 May;247:8-25. doi: 10.1016/j.tvjl.2019.02.008. Epub 2019 Feb 26.


Structure⁻Activity Study, Characterization, and Mechanism of Action of an Antimicrobial Peptoid D2 and Its d- and l-Peptide Analogues.

Greco I, Hansen JE, Jana B, Molchanova N, Oddo A, Thulstrup PW, Damborg P, Guardabassi L, Hansen PR.

Molecules. 2019 Mar 21;24(6). pii: E1121. doi: 10.3390/molecules24061121.


Fate of CMY-2-Encoding Plasmids Introduced into the Human Fecal Microbiota by Exogenous Escherichia coli.

Anjum M, Madsen JS, Nesme J, Jana B, Wiese M, Jasinskytė D, Nielsen DS, Sørensen SJ, Dalsgaard A, Moodley A, Bortolaia V, Guardabassi L.

Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e02528-18. doi: 10.1128/AAC.02528-18. Print 2019 May.


Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections.

Greco I, Emborg AP, Jana B, Molchanova N, Oddo A, Damborg P, Guardabassi L, Hansen PR.

Sci Rep. 2019 Mar 6;9(1):3679. doi: 10.1038/s41598-019-39042-3. Erratum in: Sci Rep. 2019 Jun 4;9(1):8361.


Isolation and characterization of bacteriophages active against methicillin-resistant Staphylococcus pseudintermedius.

Moodley A, Kot W, Nälgård S, Jakociune D, Neve H, Hansen LH, Guardabassi L, Vogensen FK.

Res Vet Sci. 2019 Feb;122:81-85. doi: 10.1016/j.rvsc.2018.11.008. Epub 2018 Nov 12.


Repurposing azithromycin and rifampicin against Gram-negative pathogens by combination with peptide potentiators.

Baker KR, Jana B, Hansen AM, Vissing KJ, Nielsen HM, Franzyk H, Guardabassi L.

Int J Antimicrob Agents. 2019 Jun;53(6):868-872. doi: 10.1016/j.ijantimicag.2018.10.025. Epub 2018 Nov 14.


Transcriptome analysis of extended-spectrum β-lactamase-producing Escherichia coli and methicillin-resistant Staphylococcus aureus exposed to cefotaxime.

Brochmann PR, Hesketh A, Jana B, Brodersen GH, Guardabassi L.

Sci Rep. 2018 Oct 30;8(1):16076. doi: 10.1038/s41598-018-34191-3.


A culture-independent method for studying transfer of IncI1 plasmids from wild-type Escherichia coli in complex microbial communities.

Anjum M, Madsen JS, Espinosa-Gongora C, Jana B, Wiese M, Nielsen DS, Sørensen SJ, Moodley A, Bortolaia V, Guardabassi L.

J Microbiol Methods. 2018 Sep;152:18-26. doi: 10.1016/j.mimet.2018.07.009. Epub 2018 Jul 18.


DNA Damage Repair and Drug Efflux as Potential Targets for Reversing Low or Intermediate Ciprofloxacin Resistance in E. coli K-12.

Klitgaard RN, Jana B, Guardabassi L, Nielsen KL, Løbner-Olesen A.

Front Microbiol. 2018 Jul 2;9:1438. doi: 10.3389/fmicb.2018.01438. eCollection 2018.


Optimization of Antimicrobial Treatment to Minimize Resistance Selection.

Guardabassi L, Apley M, Olsen JE, Toutain PL, Weese S.

Microbiol Spectr. 2018 May;6(3). doi: 10.1128/microbiolspec.ARBA-0018-2017. Review.


Diversity of Staphylococcus pseudintermedius in carriage sites and skin lesions of dogs with superficial bacterial folliculitis: potential implications for diagnostic testing and therapy.

Larsen RF, Boysen L, Jessen LR, Guardabassi L, Damborg P.

Vet Dermatol. 2018 May 21. doi: 10.1111/vde.12549. [Epub ahead of print]


Corrigendum to 'Panton-Valentine Leucocidin (PVL) Staphylococcus aureus a position statement from the International Society of Chemotherapy' [International Journal of Antimicrobial Agents 51/1 (2018) 16-25].

Saeed K, Gould I, Esposito S, Ahmad-Saeed N, Ahmed SS, Alp E, Bal AM, Bassetti M, Bonnet E, Chan M, Coombs G, Dancer SJ, David MZ, De Simone G, Dryden M, Guardabassi L, Hanitsch LG, Hijazi K, Kruger R, Lee A, Leistner R, Pagliano P, Righi E, Schneider-Burrus S, Skov RL, Tattevin P, VanWamel W, Vos MC, Voss A; International Society of Chemotherapy.

Int J Antimicrob Agents. 2018 Jul;52(1):125. doi: 10.1016/j.ijantimicag.2018.03.005. Epub 2018 Mar 21. No abstract available.


High diversity of genes and plasmids encoding resistance to third-generation cephalosporins and quinolones in clinical Escherichia coli from commercial poultry flocks in Italy.

Niero G, Bortolaia V, Vanni M, Intorre L, Guardabassi L, Piccirillo A.

Vet Microbiol. 2018 Mar;216:93-98. doi: 10.1016/j.vetmic.2018.02.012. Epub 2018 Feb 9.


The role of 'filth flies' in the spread of antimicrobial resistance.

Onwugamba FC, Fitzgerald JR, Rochon K, Guardabassi L, Alabi A, Kühne S, Grobusch MP, Schaumburg F.

Travel Med Infect Dis. 2018 Mar - Apr;22:8-17. doi: 10.1016/j.tmaid.2018.02.007. Epub 2018 Mar 1. Review.


Effects of Diagnostic Work-Up on Medical Decision-Making for Canine Urinary Tract Infection: An Observational Study in Danish Small Animal Practices.

Sørensen TM, Bjørnvad CR, Cordoba G, Damborg P, Guardabassi L, Siersma V, Bjerrum L, Jessen LR.

J Vet Intern Med. 2018 Mar;32(2):743-751. doi: 10.1111/jvim.15048. Epub 2018 Feb 22.


Response to "A concern with the clinical consensus guidelines on meticillin-resistant staphylococci," a letter in Veterinary Dermatology 2018; 29: 174.

Loeffler A, Morris DO, Davis MF, Guardabassi L, Weese S.

Vet Dermatol. 2018 Apr;29(2):175. doi: 10.1111/vde.12523. Epub 2018 Jan 24. No abstract available.


Panton-Valentine leukocidin-positive Staphylococcus aureus: a position statement from the International Society of Chemotherapy.

Saeed K, Gould I, Esposito S, Ahmad-Saeed N, Ahmed SS, Alp E, Bal AM, Bassetti M, Bonnet E, Chan M, Coombs G, Dancer SJ, David MZ, De Simone G, Dryden M, Guardabassi L, Hanitsch LG, Hijazi K, Krüger R, Lee A, Leistner R, Pagliano P, Righi E, Schneider-Burrus S, Skov RL, Tattevin P, Van Wamel W, Vos MC, Voss A; International Society of Chemotherapy.

Int J Antimicrob Agents. 2018 Jan;51(1):16-25. doi: 10.1016/j.ijantimicag.2017.11.002. Epub 2017 Nov 22. Review. No abstract available. Erratum in: Int J Antimicrob Agents. 2018 Mar 20;:.


Frequency, antimicrobial susceptibility and clonal distribution of methicillin-resistant Staphylococcus pseudintermedius in canine clinical samples submitted to a veterinary diagnostic laboratory in Italy: A 3-year retrospective investigation.

Ventrella G, Moodley A, Grandolfo E, Parisi A, Corrente M, Buonavoglia D, Guardabassi L.

Vet Microbiol. 2017 Nov;211:103-106. doi: 10.1016/j.vetmic.2017.09.015. Epub 2017 Oct 12.


Genome and Plasmid Sequences of Escherichia coli KV7, an Extended-Spectrum β-Lactamase Isolate Derived from Feces of a Healthy Pig.

Bateman MD, de Vries SPW, Gupta S, Guardabassi L, Cavaco LM, Grant AJ, Holmes MA.

Genome Announc. 2017 Sep 21;5(38). pii: e00595-17. doi: 10.1128/genomeA.00595-17.


Antimicrobial resistance in clinical Escherichia coli isolates from poultry and livestock, China.

Yassin AK, Gong J, Kelly P, Lu G, Guardabassi L, Wei L, Han X, Qiu H, Price S, Cheng D, Wang C.

PLoS One. 2017 Sep 21;12(9):e0185326. doi: 10.1371/journal.pone.0185326. eCollection 2017.


Comparison of the fecal bacterial microbiota of healthy and diarrheic foals at two and four weeks of life.

Schoster A, Staempfli HR, Guardabassi LG, Jalali M, Weese JS.

BMC Vet Res. 2017 May 30;13(1):144. doi: 10.1186/s12917-017-1064-x.


Horses in Denmark Are a Reservoir of Diverse Clones of Methicillin-Resistant and -Susceptible Staphylococcus aureus.

Islam MZ, Espinosa-Gongora C, Damborg P, Sieber RN, Munk R, Husted L, Moodley A, Skov R, Larsen J, Guardabassi L.

Front Microbiol. 2017 Apr 3;8:543. doi: 10.3389/fmicb.2017.00543. eCollection 2017.


Evidence for the evolutionary steps leading to mecA-mediated β-lactam resistance in staphylococci.

Rolo J, Worning P, Boye Nielsen J, Sobral R, Bowden R, Bouchami O, Damborg P, Guardabassi L, Perreten V, Westh H, Tomasz A, de Lencastre H, Miragaia M.

PLoS Genet. 2017 Apr 10;13(4):e1006674. doi: 10.1371/journal.pgen.1006674. eCollection 2017 Apr.


Evolutionary Origin of the Staphylococcal Cassette Chromosome mec (SCCmec).

Rolo J, Worning P, Nielsen JB, Bowden R, Bouchami O, Damborg P, Guardabassi L, Perreten V, Tomasz A, Westh H, de Lencastre H, Miragaia M.

Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e02302-16. doi: 10.1128/AAC.02302-16. Print 2017 Jun.


The secondary resistome of multidrug-resistant Klebsiella pneumoniae.

Jana B, Cain AK, Doerrler WT, Boinett CJ, Fookes MC, Parkhill J, Guardabassi L.

Sci Rep. 2017 Feb 15;7:42483. doi: 10.1038/srep42483.


Antimicrobial use Guidelines for Treatment of Respiratory Tract Disease in Dogs and Cats: Antimicrobial Guidelines Working Group of the International Society for Companion Animal Infectious Diseases.

Lappin MR, Blondeau J, Boothe D, Breitschwerdt EB, Guardabassi L, Lloyd DH, Papich MG, Rankin SC, Sykes JE, Turnidge J, Weese JS.

J Vet Intern Med. 2017 Mar;31(2):279-294. doi: 10.1111/jvim.14627. Epub 2017 Feb 10.


Diagnostic microbiology in veterinary dermatology: present and future.

Guardabassi L, Damborg P, Stamm I, Kopp PA, Broens EM, Toutain PL; ESCMID Study Group for Veterinary Microbiology.

Vet Dermatol. 2017 Feb;28(1):146-e30. doi: 10.1111/vde.12414. Review.


Expanding the Repertoire of Carbapenem-Hydrolyzing Metallo-ß-Lactamases by Functional Metagenomic Analysis of Soil Microbiota.

Gudeta DD, Bortolaia V, Pollini S, Docquier JD, Rossolini GM, Amos GC, Wellington EM, Guardabassi L.

Front Microbiol. 2016 Dec 26;7:1985. doi: 10.3389/fmicb.2016.01985. eCollection 2016.


Macromolecule Biosynthesis Assay and Fluorescence Spectroscopy Methods to Explore Antimicrobial Peptide Mode(s) of Action.

Jana B, Baker KR, Guardabassi L.

Methods Mol Biol. 2017;1548:181-190. doi: 10.1007/978-1-4939-6737-7_12.


Cephem Potentiation by Inactivation of Nonessential Genes Involved in Cell Wall Biogenesis of β-Lactamase-Producing Escherichia coli.

Baker KR, Sigurðardóttir HH, Jana B, Guardabassi L.

Antimicrob Agents Chemother. 2017 Feb 23;61(3). pii: e01773-16. doi: 10.1128/AAC.01773-16. Print 2017 Mar.


Antimicrobial resistance: a global threat with remarkable geographical differences.

Guardabassi L.

N Z Vet J. 2017 Mar;65(2):57-59. doi: 10.1080/00480169.2017.1270645. Epub 2017 Jan 2. No abstract available.


Evaluation of Veterinary-Specific Interpretive Criteria for Susceptibility Testing of Streptococcus equi Subspecies with Trimethoprim-Sulfamethoxazole and Trimethoprim-Sulfadiazine.

Sadaka C, Kanellos T, Guardabassi L, Boucher J, Watts JL.

J Clin Microbiol. 2016 Dec 28;55(1):326-330. doi: 10.1128/JCM.01610-16. Print 2017 Jan.


Evaluation of different sampling methods and criteria for diagnosing canine urinary tract infection by quantitative bacterial culture.

Sørensen TM, Jensen AB, Damborg P, Bjørnvad CR, Guardabassi L, Jessen LR.

Vet J. 2016 Oct;216:168-73. doi: 10.1016/j.tvjl.2016.08.007. Epub 2016 Aug 17.


European multicenter study on antimicrobial resistance in bacteria isolated from companion animal urinary tract infections.

Marques C, Gama LT, Belas A, Bergström K, Beurlet S, Briend-Marchal A, Broens EM, Costa M, Criel D, Damborg P, van Dijk MA, van Dongen AM, Dorsch R, Espada CM, Gerber B, Kritsepi-Konstantinou M, Loncaric I, Mion D, Misic D, Movilla R, Overesch G, Perreten V, Roura X, Steenbergen J, Timofte D, Wolf G, Zanoni RG, Schmitt S, Guardabassi L, Pomba C.

BMC Vet Res. 2016 Sep 22;12(1):213.


Differential Analysis of the Nasal Microbiome of Pig Carriers or Non-Carriers of Staphylococcus aureus.

Espinosa-Gongora C, Larsen N, Schønning K, Fredholm M, Guardabassi L.

PLoS One. 2016 Aug 10;11(8):e0160331. doi: 10.1371/journal.pone.0160331. eCollection 2016.


A High-Throughput Approach To Identify Compounds That Impair Envelope Integrity in Escherichia coli.

Baker KR, Jana B, Franzyk H, Guardabassi L.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):5995-6002. doi: 10.1128/AAC.00537-16. Print 2016 Oct.


High genotypic diversity among methicillin-resistant Staphylococcus pseudintermedius isolated from canine infections in Denmark.

Damborg P, Moodley A, Aalbæk B, Ventrella G, Dos Santos TP, Guardabassi L.

BMC Vet Res. 2016 Jun 29;12(1):131. doi: 10.1186/s12917-016-0756-y.


Antimicrobial synergy between carprofen and doxycycline against methicillin-resistant Staphylococcus pseudintermedius ST71.

Brochmann RP, Helmfrid A, Jana B, Magnowska Z, Guardabassi L.

BMC Vet Res. 2016 Jun 24;12(1):126. doi: 10.1186/s12917-016-0751-3.


Adaptive responses to cefotaxime treatment in ESBL-producing Escherichia coli and the possible use of significantly regulated pathways as novel secondary targets.

Møller TS, Rau MH, Bonde CS, Sommer MO, Guardabassi L, Olsen JE.

J Antimicrob Chemother. 2016 Sep;71(9):2449-59. doi: 10.1093/jac/dkw198. Epub 2016 Jun 5.


Host-Specific Patterns of Genetic Diversity among IncI1-Iγ and IncK Plasmids Encoding CMY-2 β-Lactamase in Escherichia coli Isolates from Humans, Poultry Meat, Poultry, and Dogs in Denmark.

Hansen KH, Bortolaia V, Nielsen CA, Nielsen JB, Schønning K, Agersø Y, Guardabassi L.

Appl Environ Microbiol. 2016 Jul 15;82(15):4705-14. doi: 10.1128/AEM.00495-16. Print 2016 Aug 1.


Erratum for Gudeta et al., The Soil Microbiota Harbors a Diversity of Carbapenem-Hydrolyzing β-Lactamases of Potential Clinical Relevance.

Gudeta DD, Bortolaia V, Amos G, Wellington EM, Brandt KK, Poirel L, Nielsen JB, Westh H, Guardabassi L.

Antimicrob Agents Chemother. 2016 Mar 25;60(4):2599. doi: 10.1128/AAC.00375-16. Print 2016 Apr. No abstract available.


Relation between tetR and tetA expression in tetracycline resistant Escherichia coli.

Møller TS, Overgaard M, Nielsen SS, Bortolaia V, Sommer MO, Guardabassi L, Olsen JE.

BMC Microbiol. 2016 Mar 12;16:39. doi: 10.1186/s12866-016-0649-z.


spa typing and antimicrobial resistance of Staphylococcus aureus from healthy humans, pigs and dogs in Tanzania.

Katakweba AS, Muhairwa AP, Espinosa-Gongora C, Guardabassi L, Mtambo MM, Olsen JE.

J Infect Dev Ctries. 2016 Feb 28;10(2):143-8. doi: 10.3855/jidc.6790.


Prevalence of carriage and characterisation of methicillin-resistant Staphylococcus aureus in slaughter pigs and personnel exposed to pork carcasses.

Boost MV, O'Donoghue M, Guardabassi L.

Hong Kong Med J. 2015 Dec;21 Suppl 7:S36-40. No abstract available.

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