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Items: 1 to 50 of 356

1.

Volume adaptation controls stem cell mechanotransduction.

Major LG, Holle AW, Young JL, Hepburn MS, Jeong K, Chin IL, Sanderson RW, Jeong JH, Aman ZM, Kennedy BF, Hwang Y, Han DW, Park HW, Guan KL, Spatz JP, Choi YS.

ACS Appl Mater Interfaces. 2019 Nov 12. doi: 10.1021/acsami.9b19770. [Epub ahead of print]

PMID:
31714734
2.

Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb.

Shi H, Chapman NM, Wen J, Guy C, Long L, Dhungana Y, Rankin S, Pelletier S, Vogel P, Wang H, Peng J, Guan KL, Chi H.

Immunity. 2019 Oct 17. pii: S1074-7613(19)30418-2. doi: 10.1016/j.immuni.2019.10.001. [Epub ahead of print]

PMID:
31668641
3.

The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis.

Wang TX, Liang JY, Zhang C, Xiong Y, Guan KL, Yuan HX.

Cell Death Dis. 2019 Oct 7;10(10):755. doi: 10.1038/s41419-019-1984-4.

4.

YAP and TAZ regulate cell volume.

Perez-Gonzalez NA, Rochman ND, Yao K, Tao J, Le MT, Flanary S, Sablich L, Toler B, Crentsil E, Takaesu F, Lambrus B, Huang J, Fu V, Chengappa P, Jones TM, Holland AJ, An S, Wirtz D, Petrie RJ, Guan KL, Sun SX.

J Cell Biol. 2019 Oct 7;218(10):3472-3488. doi: 10.1083/jcb.201902067. Epub 2019 Sep 3.

PMID:
31481532
5.

Hippo kinase loss contributes to del(20q) hematologic malignancies through chronic innate immune activation.

Stoner SA, Yan M, Liu KTH, Arimoto KI, Shima T, Wang HY, Johnson DT, Bejar R, Jamieson C, Guan KL, Zhang DE.

Blood. 2019 Nov 14;134(20):1730-1744. doi: 10.1182/blood.2019000170.

PMID:
31434702
6.

ELP3 Acetyltransferase is phosphorylated and regulated by the oncogenic anaplastic lymphoma kinase (ALK).

Li MT, Liang JY, Sun YP, Jin J, Xiong Y, Guan KL, Yuan HX.

Biochem J. 2019 Aug 15;476(15):2239-2254. doi: 10.1042/BCJ20190106.

PMID:
31341009
7.

GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor.

Jewell JL, Fu V, Hong AW, Yu FX, Meng D, Melick CH, Wang H, Lam WM, Yuan HX, Taylor SS, Guan KL.

Elife. 2019 May 21;8. pii: e43038. doi: 10.7554/eLife.43038.

8.

Withdrawal: Transformation potential of Ras isoforms correlates with activation of phosphatidylinositol 3-kinase but not ERK.

Li W, Zhu T, Guan KL.

J Biol Chem. 2019 May 17;294(20):8310. doi: 10.1074/jbc.W119.009032. No abstract available.

9.

A special issue to mark the 90th Anniversary of College of Life Sciences, Zhejiang University.

Peng JR, Guan KL, Hong DY, Lin XH, Yang HM, Zhu YX.

J Zhejiang Univ Sci B. 2019 May;20(5):371-372. doi: 10.1631/jzus.B1910002.

10.
11.

Correction: The N-terminal phosphodegron targets TAZ/WWTR1 protein for SCFβ-TrCP-dependent degradation in response to phosphatidylinositol 3-kinase inhibition.

Huang W, Lv X, Liu C, Zha Z, Zhang H, Jiang Y, Xiong Y, Lei QY, Guan KL.

J Biol Chem. 2019 Apr 12;294(15):5809. doi: 10.1074/jbc.AAC119.008437. No abstract available.

12.

Correction: TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition.

Zhang H, Liu CY, Zha ZY, Zhao B, Yao J, Zhao S, Xiong Y, Lei QY, Guan KL.

J Biol Chem. 2019 Apr 12;294(15):5808. doi: 10.1074/jbc.AAC119.008436. No abstract available.

13.

Correction: The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3.

Li Y, Inoki K, Vacratsis P, Guan KL.

J Biol Chem. 2019 Apr 12;294(15):5807. doi: 10.1074/jbc.AAC119.008435. No abstract available.

14.

Corrigendum: Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome.

Corradetti MN, Inoki K, Bardeesy N, DePinho RA, Guan KL.

Genes Dev. 2019 Apr 1;33(7-8):477. doi: 10.1101/gad.324970.119. No abstract available.

15.

mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism.

Tang H, Inoki K, Brooks SV, Okazawa H, Lee M, Wang J, Kim M, Kennedy CL, Macpherson PCD, Ji X, Van Roekel S, Fraga DA, Wang K, Zhu J, Wang Y, Sharp ZD, Miller RA, Rando TA, Goldman D, Guan KL, Shrager JB.

Aging Cell. 2019 Jun;18(3):e12943. doi: 10.1111/acel.12943. Epub 2019 Mar 29.

16.

BRCA1/BARD1-dependent ubiquitination of NF2 regulates Hippo-YAP1 signaling.

Verma S, Yeddula N, Soda Y, Zhu Q, Pao G, Moresco J, Diedrich JK, Hong A, Plouffe S, Moroishi T, Guan KL, Verma IM.

Proc Natl Acad Sci U S A. 2019 Apr 9;116(15):7363-7370. doi: 10.1073/pnas.1822155116. Epub 2019 Mar 27.

17.

Retraction: FAK and Src kinases are required for netrin-induced tyrosine phosphorylation of UNC5 (doi: 10.1242/jcs.02697).

Li W, Aurandt J, Jürgensen C, Rao Y, Guan KL.

J Cell Sci. 2019 Feb 19;132(5). pii: jcs230342. doi: 10.1242/jcs.230342. No abstract available.

18.

SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress.

Zhang M, Wu J, Sun R, Tao X, Wang X, Kang Q, Wang H, Zhang L, Liu P, Zhang J, Xia Y, Zhao Y, Yang Y, Xiong Y, Guan KL, Zou Y, Ye D.

PLoS One. 2019 Feb 13;14(2):e0211796. doi: 10.1371/journal.pone.0211796. eCollection 2019.

19.

mTOR as a central hub of nutrient signalling and cell growth.

Kim J, Guan KL.

Nat Cell Biol. 2019 Jan;21(1):63-71. doi: 10.1038/s41556-018-0205-1. Epub 2019 Jan 2. Review.

PMID:
30602761
20.

Rapid diagnosis of IDH1-mutated gliomas by 2-HG detection with gas chromatography mass spectrometry.

Xu H, Xia YK, Li CJ, Zhang JY, Liu Y, Yi W, Qin ZY, Chen L, Shi ZF, Quan K, Yang ZX, Guan KL, Xiong Y, Ng HK, Ye D, Hua W, Mao Y.

Lab Invest. 2019 Apr;99(4):588-598. doi: 10.1038/s41374-018-0163-z. Epub 2018 Dec 20.

PMID:
30573870
21.

The Hippo Pathway: Biology and Pathophysiology.

Ma S, Meng Z, Chen R, Guan KL.

Annu Rev Biochem. 2019 Jun 20;88:577-604. doi: 10.1146/annurev-biochem-013118-111829. Epub 2019 Dec 19.

PMID:
30566373
22.

Determining the Phosphorylation Status of Hippo Components YAP and TAZ Using Phos-tag.

Chen R, Plouffe SW, Guan KL.

Methods Mol Biol. 2019;1893:281-287. doi: 10.1007/978-1-4939-8910-2_21.

PMID:
30565141
23.

Cell type-dependent function of LATS1/2 in cancer cell growth.

Pan WW, Moroishi T, Koo JH, Guan KL.

Oncogene. 2019 Apr;38(14):2595-2610. doi: 10.1038/s41388-018-0610-8. Epub 2018 Dec 10.

24.

OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ.

Zhang Z, Du J, Wang S, Shao L, Jin K, Li F, Wei B, Ding W, Fu P, van Dam H, Wang A, Jin J, Ding C, Yang B, Zheng M, Feng XH, Guan KL, Zhang L.

Mol Cell. 2019 Jan 3;73(1):7-21.e7. doi: 10.1016/j.molcel.2018.10.030. Epub 2018 Nov 21.

PMID:
30472188
25.

Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Cells.

Badur MG, Muthusamy T, Parker SJ, Ma S, McBrayer SK, Cordes T, Magana JH, Guan KL, Metallo CM.

Cell Rep. 2018 Nov 6;25(6):1680. doi: 10.1016/j.celrep.2018.10.099. No abstract available.

26.

SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.

Chen LL, Lin HP, Zhou WJ, He CX, Zhang ZY, Cheng ZL, Song JB, Liu P, Chen XY, Xia YK, Chen XF, Sun RQ, Zhang JY, Sun YP, Song L, Liu BJ, Du RK, Ding C, Lan F, Huang SL, Zhou F, Liu S, Xiong Y, Ye D, Guan KL.

Cell Rep. 2018 Nov 6;25(6):1485-1500.e4. doi: 10.1016/j.celrep.2018.10.028.

27.

Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Sells.

Badur MG, Muthusamy T, Parker SJ, Ma S, McBrayer SK, Cordes T, Magana JH, Guan KL, Metallo CM.

Cell Rep. 2018 Oct 23;25(4):1018-1026.e4. doi: 10.1016/j.celrep.2018.09.074. Erratum in: Cell Rep. 2018 Nov 6;25(6):1680.

28.

Regulation of the Hippo Pathway by Phosphatidic Acid-Mediated Lipid-Protein Interaction.

Han H, Qi R, Zhou JJ, Ta AP, Yang B, Nakaoka HJ, Seo G, Guan KL, Luo R, Wang W.

Mol Cell. 2018 Oct 18;72(2):328-340.e8. doi: 10.1016/j.molcel.2018.08.038. Epub 2018 Oct 4.

29.

RAP2 mediates mechanoresponses of the Hippo pathway.

Meng Z, Qiu Y, Lin KC, Kumar A, Placone JK, Fang C, Wang KC, Lu S, Pan M, Hong AW, Moroishi T, Luo M, Plouffe SW, Diao Y, Ye Z, Park HW, Wang X, Yu FX, Chien S, Wang CY, Ren B, Engler AJ, Guan KL.

Nature. 2018 Aug;560(7720):655-660. doi: 10.1038/s41586-018-0444-0. Epub 2018 Aug 22.

30.

Interplay between YAP/TAZ and Metabolism.

Koo JH, Guan KL.

Cell Metab. 2018 Aug 7;28(2):196-206. doi: 10.1016/j.cmet.2018.07.010. Review.

31.

Author Correction: Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation.

Lin KC, Moroishi T, Meng Z, Jeong HS, Plouffe SW, Sekido Y, Han J, Park HW, Guan KL.

Nat Cell Biol. 2018 Sep;20(9):1098. doi: 10.1038/s41556-018-0101-8.

PMID:
30018319
32.

Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma.

Akgül S, Li Y, Zheng S, Kool M, Treisman DM, Li C, Wang Y, Gröbner S, Ikenoue T, Shen Y, Camelo-Piragua S, Tomasek G, Stark S, Guduguntla V, Gusella JF, Guan KL, Pfister SM, Verhaak RGW, Zhu Y.

Cell Rep. 2018 Jul 10;24(2):463-478.e5. doi: 10.1016/j.celrep.2018.06.050.

33.

Assembly and activation of the Hippo signalome by FAT1 tumor suppressor.

Martin D, Degese MS, Vitale-Cross L, Iglesias-Bartolome R, Valera JLC, Wang Z, Feng X, Yeerna H, Vadmal V, Moroishi T, Thorne RF, Zaida M, Siegele B, Cheong SC, Molinolo AA, Samuels Y, Tamayo P, Guan KL, Lippman SM, Lyons JG, Gutkind JS.

Nat Commun. 2018 Jul 9;9(1):2372. doi: 10.1038/s41467-018-04590-1.

34.

Polycystic kidney disease: a Hippo connection.

Ma S, Guan KL.

Genes Dev. 2018 Jun 1;32(11-12):737-739. doi: 10.1101/gad.316570.118. Review.

35.

YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity.

Yu OM, Benitez JA, Plouffe SW, Ryback D, Klein A, Smith J, Greenbaum J, Delatte B, Rao A, Guan KL, Furnari FB, Chaim OM, Miyamoto S, Brown JH.

Oncogene. 2018 Oct;37(41):5492-5507. doi: 10.1038/s41388-018-0301-5. Epub 2018 Jun 11.

36.

The Hippo pathway effector proteins YAP and TAZ have both distinct and overlapping functions in the cell.

Plouffe SW, Lin KC, Moore JL 3rd, Tan FE, Ma S, Ye Z, Qiu Y, Ren B, Guan KL.

J Biol Chem. 2018 Jul 13;293(28):11230-11240. doi: 10.1074/jbc.RA118.002715. Epub 2018 May 25.

37.

A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis.

Azad T, Janse van Rensburg HJ, Lightbody ED, Neveu B, Champagne A, Ghaffari A, Kay VR, Hao Y, Shen H, Yeung B, Croy BA, Guan KL, Pouliot F, Zhang J, Nicol CJB, Yang X.

Nat Commun. 2018 Mar 13;9(1):1061. doi: 10.1038/s41467-018-03278-w.

38.

SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer.

Chen XF, Tian MX, Sun RQ, Zhang ML, Zhou LS, Jin L, Chen LL, Zhou WJ, Duan KL, Chen YJ, Gao C, Cheng ZL, Wang F, Zhang JY, Sun YP, Yu HX, Zhao YZ, Yang Y, Liu WR, Shi YH, Xiong Y, Guan KL, Ye D.

EMBO Rep. 2018 May;19(5). pii: e45124. doi: 10.15252/embr.201745124. Epub 2018 Feb 28.

39.

Metabolism, Activity, and Targeting of D- and L-2-Hydroxyglutarates.

Ye D, Guan KL, Xiong Y.

Trends Cancer. 2018 Feb;4(2):151-165. doi: 10.1016/j.trecan.2017.12.005. Epub 2018 Jan 5. Review.

40.

Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis.

Li FL, Liu JP, Bao RX, Yan G, Feng X, Xu YP, Sun YP, Yan W, Ling ZQ, Xiong Y, Guan KL, Yuan HX.

Nat Commun. 2018 Feb 6;9(1):508. doi: 10.1038/s41467-018-02950-5.

41.

Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma.

Liu MX, Jin L, Sun SJ, Liu P, Feng X, Cheng ZL, Liu WR, Guan KL, Shi YH, Yuan HX, Xiong Y.

Oncogene. 2018 Mar;37(12):1637-1653. doi: 10.1038/s41388-017-0070-6. Epub 2018 Jan 16.

42.

The Hippo pathway in organ development, homeostasis, and regeneration.

Fu V, Plouffe SW, Guan KL.

Curr Opin Cell Biol. 2017 Dec;49:99-107. doi: 10.1016/j.ceb.2017.12.012. Epub 2018 Jan 6. Review.

43.

Colonic epithelium rejuvenation through YAP/TAZ.

Chen R, Guan KL.

EMBO J. 2018 Jan 17;37(2):164-166. doi: 10.15252/embj.201798618. Epub 2017 Dec 27. No abstract available.

44.

Glut3 Addiction Is a Druggable Vulnerability for a Molecularly Defined Subpopulation of Glioblastoma.

Cosset É, Ilmjärv S, Dutoit V, Elliott K, von Schalscha T, Camargo MF, Reiss A, Moroishi T, Seguin L, Gomez G, Moo JS, Preynat-Seauve O, Krause KH, Chneiweiss H, Sarkaria JN, Guan KL, Dietrich PY, Weis SM, Mischel PS, Cheresh DA.

Cancer Cell. 2017 Dec 11;32(6):856-868.e5. doi: 10.1016/j.ccell.2017.10.016. Epub 2017 Nov 30.

45.

Non-radioactive LATS in vitro Kinase Assay.

Hong AW, Guan KL.

Bio Protoc. 2017 Jul 20;7(14). pii: e2391. doi: 10.21769/BioProtoc.2391.

46.

CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis.

Lin R, Mo Y, Zha H, Qu Z, Xie P, Zhu ZJ, Xu Y, Xiong Y, Guan KL.

Mol Cell. 2017 Oct 5;68(1):198-209.e6. doi: 10.1016/j.molcel.2017.09.008.

47.

Regulation of the Hippo Pathway Transcription Factor TEAD.

Lin KC, Park HW, Guan KL.

Trends Biochem Sci. 2017 Nov;42(11):862-872. doi: 10.1016/j.tibs.2017.09.003. Epub 2017 Sep 27. Review.

48.

SIRT7 deacetylates DDB1 and suppresses the activity of the CRL4 E3 ligase complexes.

Mo Y, Lin R, Liu P, Tan M, Xiong Y, Guan KL, Yuan HX.

FEBS J. 2017 Nov;284(21):3619-3636. doi: 10.1111/febs.14259. Epub 2017 Oct 10.

49.

Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation.

Lin KC, Moroishi T, Meng Z, Jeong HS, Plouffe SW, Sekido Y, Han J, Park HW, Guan KL.

Nat Cell Biol. 2017 Jul 28;19(8):996-1002. doi: 10.1038/ncb3581. Erratum in: Nat Cell Biol. 2018 Sep;20(9):1098.

50.

mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT.

Gu Y, Albuquerque CP, Braas D, Zhang W, Villa GR, Bi J, Ikegami S, Masui K, Gini B, Yang H, Gahman TC, Shiau AK, Cloughesy TF, Christofk HR, Zhou H, Guan KL, Mischel PS.

Mol Cell. 2017 Jul 6;67(1):128-138.e7. doi: 10.1016/j.molcel.2017.05.030. Epub 2017 Jun 22.

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