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First report of black-heart disease in Kumamoto oyster Crassostrea sikamea spat caused by Polydora lingshuiensis in China.

Ye LT, Wu L, Wang JY, Li QZ, Guan JL, Luo B.

Dis Aquat Organ. 2019 Mar 28;133(3):247-252. doi: 10.3354/dao03352.


Nuclear Focal Adhesion Kinase Controls Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia Through GATA4-Mediated Cyclin D1 Transcription.

Jeong K, Kim JH, Murphy JM, Park H, Kim SJ, Rodriguez YAR, Kong H, Choi C, Guan JL, Taylor JM, Lincoln TM, Gerthoffer WT, Kim JS, Ahn EE, Schlaepfer DD, Lim SS.

Circ Res. 2019 Jul 5;125(2):152-166. doi: 10.1161/CIRCRESAHA.118.314344. Epub 2019 May 17.


Demography of vascular Behcet's disease with different gender and age: an investigation with 166 Chinese patients.

Chen Y, Cai JF, Lin CH, Guan JL.

Orphanet J Rare Dis. 2019 Apr 29;14(1):88. doi: 10.1186/s13023-019-1061-1.


Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally.

Huang H, Weng H, Zhou K, Wu T, Zhao BS, Sun M, Chen Z, Deng X, Xiao G, Auer F, Klemm L, Wu H, Zuo Z, Qin X, Dong Y, Zhou Y, Qin H, Tao S, Du J, Liu J, Lu Z, Yin H, Mesquita A, Yuan CL, Hu YC, Sun W, Su R, Dong L, Shen C, Li C, Qing Y, Jiang X, Wu X, Sun M, Guan JL, Qu L, Wei M, Müschen M, Huang G, He C, Yang J, Chen J.

Nature. 2019 Mar;567(7748):414-419. doi: 10.1038/s41586-019-1016-7. Epub 2019 Mar 13.


Incidence and risk factors for anemia among newly-diagnosed intestinal Behcet's disease patients.

Ye JF, Chen Y, Cai JF, Shen Y, Zou J, Guan JL.

J Natl Med Assoc. 2019 Feb 22. pii: S0027-9684(18)30319-5. doi: 10.1016/j.jnma.2019.01.010. [Epub ahead of print]


Differentiation between intestinal Behçet’s disease and Crohn’sdisease based on endoscopy

Ye JF, Guan JL.

Turk J Med Sci. 2019 Feb 11;49(1):42-49. doi: 10.3906/sag-1807-67.


The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy.

Ho WY, Tai YK, Chang JC, Liang J, Tyan SH, Chen S, Guan JL, Zhou H, Shen HM, Koo E, Ling SC.

Autophagy. 2019 May;15(5):827-842. doi: 10.1080/15548627.2019.1569441. Epub 2019 Jan 28.


miR-200c/141 Regulates Breast Cancer Stem Cell Heterogeneity via Targeting HIPK1/β-Catenin Axis.

Liu B, Du R, Zhou L, Xu J, Chen S, Chen J, Yang X, Liu DX, Shao ZM, Zhang L, Yu Z, Xie N, Guan JL, Liu S.

Theranostics. 2018 Nov 10;8(21):5801-5813. doi: 10.7150/thno.29380. eCollection 2018.


Super-Resolution Tracking of Mitochondrial Dynamics with An Iridium(III) Luminophore.

Chen Q, Jin C, Shao X, Guan R, Tian Z, Wang C, Liu F, Ling P, Guan JL, Ji L, Wang F, Chao H, Diao J.

Small. 2018 Oct;14(41):e1802166. doi: 10.1002/smll.201802166. Epub 2018 Sep 14.


Effect of Mechanical Stress in Combination with Verapamil on Levels of Aggrecan and ADAMTS-5 mRNAs and Proteins in Human Osteoarthritic Chondrocyte/Agarose Constructs.

Luo D, Shen Y, Lyu JQ, Fan YQ, Huang DH, Lin WL, Shen HM, Xu HJ, Guan JL.

Chin Med J (Engl). 2018 Sep 20;131(18):2229-2231. doi: 10.4103/0366-6999.240800. No abstract available.


Serum uric acid could be served as an independent marker for increased risk and severity of ascending aortic dilatation in Behçet's disease patients.

Cai J, Zhang Y, Zou J, Shen Y, Luo D, Bao H, Chen Y, Ye J, Guan JL.

J Clin Lab Anal. 2019 Jan;33(1):e22637. doi: 10.1002/jcla.22637. Epub 2018 Aug 12.


Improved efficacy of mitochondrial disrupting agents upon inhibition of autophagy in a mouse model of BRCA1-deficient breast cancer.

Yeo SK, Paul R, Haas M, Wang C, Guan JL.

Autophagy. 2018;14(7):1214-1225. doi: 10.1080/15548627.2018.1460010. Epub 2018 Jul 20.


Tsc1 Regulates the Balance Between Osteoblast and Adipocyte Differentiation Through Autophagy/Notch1/β-Catenin Cascade.

Choi HK, Yuan H, Fang F, Wei X, Liu L, Li Q, Guan JL, Liu F.

J Bone Miner Res. 2018 Nov;33(11):2021-2034. doi: 10.1002/jbmr.3530. Epub 2018 Jul 19.


Author Correction: Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation.

Huang H, Weng H, Sun W, Qin X, Shi H, Wu H, Zhao BS, Mesquita A, Liu C, Yuan CL, Hu YC, Hüttelmaier S, Skibbe JR, Su R, Deng X, Dong L, Sun M, Li C, Nachtergaele S, Wang Y, Hu C, Ferchen K, Greis KD, Jiang X, Wei M, Qu L, Guan JL, He C, Yang J, Chen J.

Nat Cell Biol. 2018 Sep;20(9):1098. doi: 10.1038/s41556-018-0102-7.


[Effects of nitrogen and sulfur combined application on nutritional components and active components of Isatis indigotica at seedling stage].

Miao YJ, Guan JL, Zeng JL, Xu J, Tang XQ.

Zhongguo Zhong Yao Za Zhi. 2018 Apr;43(8):1571-1578. doi: 10.19540/j.cnki.cjcmm.20180201.006. Chinese.


Effectiveness and safety of Glycyrrhizae Decoction for Purging Stomach-Fire in Behcet disease patients: Study protocol for a randomized controlled and double-blinding trail.

Chen Y, Luo D, Cai JF, Lin CH, Shen Y, Zou J, Guan JL.

Medicine (Baltimore). 2018 Mar;97(13):e0265. doi: 10.1097/MD.0000000000010265.


Molecular mechanisms of Streptococcus pneumoniae-targeted autophagy via pneumolysin, Golgi-resident Rab41, and Nedd4-1-mediated K63-linked ubiquitination.

Ogawa M, Matsuda R, Takada N, Tomokiyo M, Yamamoto S, Shizukusihi S, Yamaji T, Yoshikawa Y, Yoshida M, Tanida I, Koike M, Murai M, Morita H, Takeyama H, Ryo A, Guan JL, Yamamoto M, Inoue JI, Yanagawa T, Fukuda M, Kawabe H, Ohnishi M.

Cell Microbiol. 2018 Aug;20(8):e12846. doi: 10.1111/cmi.12846. Epub 2018 Apr 22.


AMPK Inhibits ULK1-Dependent Autophagosome Formation and Lysosomal Acidification via Distinct Mechanisms.

Nwadike C, Williamson LE, Gallagher LE, Guan JL, Chan EYW.

Mol Cell Biol. 2018 Apr 30;38(10). pii: e00023-18. doi: 10.1128/MCB.00023-18. Print 2018 May 15.


Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation.

Huang H, Weng H, Sun W, Qin X, Shi H, Wu H, Zhao BS, Mesquita A, Liu C, Yuan CL, Hu YC, Hüttelmaier S, Skibbe JR, Su R, Deng X, Dong L, Sun M, Li C, Nachtergaele S, Wang Y, Hu C, Ferchen K, Greis KD, Jiang X, Wei M, Qu L, Guan JL, He C, Yang J, Chen J.

Nat Cell Biol. 2018 Mar;20(3):285-295. doi: 10.1038/s41556-018-0045-z. Epub 2018 Feb 23. Erratum in: Nat Cell Biol. 2018 Sep;20(9):1098.


Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase.

Thiagarajan PS, Sinyuk M, Turaga SM, Mulkearns-Hubert EE, Hale JS, Rao V, Demelash A, Saygin C, China A, Alban TJ, Hitomi M, Torre-Healy LA, Alvarado AG, Jarrar A, Wiechert A, Adorno-Cruz V, Fox PL, Calhoun BC, Guan JL, Liu H, Reizes O, Lathia JD.

Nat Commun. 2018 Feb 8;9(1):578. doi: 10.1038/s41467-018-02938-1.


Nuclear FAK and its kinase activity regulate VEGFR2 transcription in angiogenesis of adult mice.

Sun S, Wu HJ, Guan JL.

Sci Rep. 2018 Feb 7;8(1):2550. doi: 10.1038/s41598-018-20930-z.


Infliximab associated with life-threatening lung infection in a patient with Behcet disease with intestinal and hematopoietic system involvement: A case report.

Chen Y, Shen Y, Ma HF, Cai JF, Hua YQ, Zou J, Guan JL.

Medicine (Baltimore). 2017 Dec;96(50):e9202. doi: 10.1097/MD.0000000000009202.


Metformin Might Inhibit Virus through Increasing Insulin Sensitivity.

Chen Y, Gu F, Guan JL.

Chin Med J (Engl). 2018 Feb 5;131(3):376-377. doi: 10.4103/0366-6999.223856. No abstract available.


Strong convergence theorem for split monotone variational inclusion with constraints of variational inequalities and fixed point problems.

Guan JL, Ceng LC, Hu B.

J Inequal Appl. 2018;2018(1):311. doi: 10.1186/s13660-018-1905-6. Epub 2018 Nov 15.


Is Warfarin Indicated in Behcet's Syndrome Associated with Thrombosis? Reflections on Treatment and Death of a Patient.

Chen Y, Guan JL.

Chin Med J (Engl). 2018 Jan 5;131(1):105-106. doi: 10.4103/0366-6999.221282. No abstract available.


Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity.

Xia H, Wang W, Crespo J, Kryczek I, Li W, Wei S, Bian Z, Maj T, He M, Liu RJ, He Y, Rattan R, Munkarah A, Guan JL, Zou W.

Sci Immunol. 2017 Nov 17;2(17). pii: eaan4631. doi: 10.1126/sciimmunol.aan4631.


Breast Cancer: Multiple Subtypes within a Tumor?

Yeo SK, Guan JL.

Trends Cancer. 2017 Nov;3(11):753-760. doi: 10.1016/j.trecan.2017.09.001. Epub 2017 Oct 24. Review.


The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway.

Wang B, Iyengar R, Li-Harms X, Joo JH, Wright C, Lavado A, Horner L, Yang M, Guan JL, Frase S, Green DR, Cao X, Kundu M.

Autophagy. 2018;14(5):796-811. doi: 10.1080/15548627.2017.1386820. Epub 2017 Dec 24.


Surgical Intervention for Behcet's Disease with Aorta Aneurysm and Pseudoaneurysm: Opposite Outcomes in Two Cases.

Chen Y, Cui JS, Cai JF, Zou J, Guan JL.

Chin Med J (Engl). 2017 Oct 20;130(20):2503-2505. doi: 10.4103/0366-6999.216414. No abstract available.


HGFL-mediated RON signaling supports breast cancer stem cell phenotypes via activation of non-canonical β-catenin signaling.

Ruiz-Torres SJ, Benight NM, Karns RA, Lower EE, Guan JL, Waltz SE.

Oncotarget. 2017 Jul 22;8(35):58918-58933. doi: 10.18632/oncotarget.19441. eCollection 2017 Aug 29.


Male germline recombination of a conditional allele by the widely used Dermo1-cre (Twist2-cre) transgene.

He Y, Sun X, Wang L, Mishina Y, Guan JL, Liu F.

Genesis. 2017 Sep;55(9). doi: 10.1002/dvg.23048. Epub 2017 Aug 14.


Autophagy gene FIP200 in neural progenitors non-cell autonomously controls differentiation by regulating microglia.

Wang C, Yeo S, Haas MA, Guan JL.

J Cell Biol. 2017 Aug 7;216(8):2581-2596. doi: 10.1083/jcb.201609093. Epub 2017 Jun 20.


LC3-association with the parasitophorous vacuole membrane of Plasmodium berghei liver stages follows a noncanonical autophagy pathway.

Wacker R, Eickel N, Schmuckli-Maurer J, Annoura T, Niklaus L, Khan SM, Guan JL, Heussler VT.

Cell Microbiol. 2017 Oct;19(10). doi: 10.1111/cmi.12754. Epub 2017 Jun 19.


Gastric syphilis.

Cai J, Ji D, Guan JL.

IDCases. 2017 Apr 26;8:87-88. doi: 10.1016/j.idcr.2017.03.008. eCollection 2017.


Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine.

Chen X, Clark J, Wunderlich M, Fan C, Davis A, Chen S, Guan JL, Mulloy JC, Kumar A, Zheng Y.

Autophagy. 2017 May 4;13(5):955-966. doi: 10.1080/15548627.2017.1287652. Epub 2017 Feb 15.


Long-Term Outcomes and Predictors of Sustained Response in Patients with Intestinal Behcet's Disease Treated with Infliximab.

Zou J, Ji DN, Cai JF, Guan JL, Bao ZJ.

Dig Dis Sci. 2017 Feb;62(2):441-447. doi: 10.1007/s10620-016-4395-8. Epub 2017 Jan 2.


[Progression of Behcet's disease with brain involvement: a case report].

Chen Y, Lu F, Guan JL.

Nan Fang Yi Ke Da Xue Xue Bao. 2016 Dec 20;36(12):1737-1739. Chinese.


MMTV-cre;Ccn6 knockout mice develop tumors recapitulating human metaplastic breast carcinomas.

Martin EE, Huang W, Anwar T, Arellano-Garcia C, Burman B, Guan JL, Gonzalez ME, Kleer CG.

Oncogene. 2017 Apr 20;36(16):2275-2285. doi: 10.1038/onc.2016.381. Epub 2016 Nov 7.


FAK Promotes Osteoblast Progenitor Cell Proliferation and Differentiation by Enhancing Wnt Signaling.

Sun C, Yuan H, Wang L, Wei X, Williams L, Krebsbach PH, Guan JL, Liu F.

J Bone Miner Res. 2016 Dec;31(12):2227-2238. doi: 10.1002/jbmr.2908. Epub 2016 Oct 24.


Hierarchical heterogeneity in mammary tumors and its regulation by autophagy.

Yeo SK, Guan JL.

Autophagy. 2016 Oct 2;12(10):1960-1961. Epub 2016 Sep 13.


Impaired autophagy in macrophages promotes inflammatory eye disease.

Santeford A, Wiley LA, Park S, Bamba S, Nakamura R, Gdoura A, Ferguson TA, Rao PK, Guan JL, Saitoh T, Akira S, Xavier R, Virgin HW 4th, Apte RS.

Autophagy. 2016 Oct 2;12(10):1876-1885. Epub 2016 Jul 27.


Autophagy Differentially Regulates Distinct Breast Cancer Stem-like Cells in Murine Models via EGFR/Stat3 and Tgfβ/Smad Signaling.

Yeo SK, Wen J, Chen S, Guan JL.

Cancer Res. 2016 Jun 1;76(11):3397-410. doi: 10.1158/0008-5472.CAN-15-2946. Epub 2016 Apr 13.


Modeling lymphangiosarcoma in mice.

Sun S, Guan JL.

Cell Cycle. 2016 Jul 17;15(14):1801-2. doi: 10.1080/15384101.2016.1176414. Epub 2016 Apr 22. No abstract available.


Neuronal Wiskott-Aldrich syndrome protein regulates TGF-β1-mediated lung vascular permeability.

Wagener BM, Hu M, Zheng A, Zhao X, Che P, Brandon A, Anjum N, Snapper S, Creighton J, Guan JL, Han Q, Cai GQ, Han X, Pittet JF, Ding Q.

FASEB J. 2016 Jul;30(7):2557-69. doi: 10.1096/fj.201600102R. Epub 2016 Mar 29.


Distinct roles of autophagy-dependent and -independent functions of FIP200 revealed by generation and analysis of a mutant knock-in mouse model.

Chen S, Wang C, Yeo S, Liang CC, Okamoto T, Sun S, Wen J, Guan JL.

Genes Dev. 2016 Apr 1;30(7):856-69. doi: 10.1101/gad.276428.115. Epub 2016 Mar 24.

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