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Items: 16

1.

Human ether-à-go-go-related potassium channel: exploring SAR to improve drug design.

Cavalluzzi MM, Imbrici P, Gualdani R, Stefanachi A, Mangiatordi GF, Lentini G, Nicolotti O.

Drug Discov Today. 2019 Nov 19. pii: S1359-6446(19)30426-X. doi: 10.1016/j.drudis.2019.11.005. [Epub ahead of print] Review.

PMID:
31756511
2.

Superparamagnetic iron oxide nanoparticles (SPIONs) modulate hERG ion channel activity.

Gualdani R, Guerrini A, Fantechi E, Tadini-Buoninsegni F, Moncelli MR, Sangregorio C.

Nanotoxicology. 2019 Nov;13(9):1197-1209. doi: 10.1080/17435390.2019.1650969. Epub 2019 Aug 22.

PMID:
31437063
3.

Store-Operated Calcium Entry Contributes to Cisplatin-Induced Cell Death in Non-Small Cell Lung Carcinoma.

Gualdani R, de Clippele M, Ratbi I, Gailly P, Tajeddine N.

Cancers (Basel). 2019 Mar 26;11(3). pii: E430. doi: 10.3390/cancers11030430.

4.

Activation of TRPC1 Channel by Metabotropic Glutamate Receptor mGluR5 Modulates Synaptic Plasticity and Spatial Working Memory.

Lepannetier S, Gualdani R, Tempesta S, Schakman O, Seghers F, Kreis A, Yerna X, Slimi A, de Clippele M, Tajeddine N, Voets T, Bon RS, Beech DJ, Tissir F, Gailly P.

Front Cell Neurosci. 2018 Sep 14;12:318. doi: 10.3389/fncel.2018.00318. eCollection 2018.

5.

Drug Interactions With the Ca2+-ATPase From Sarco(Endo)Plasmic Reticulum (SERCA).

Tadini-Buoninsegni F, Smeazzetto S, Gualdani R, Moncelli MR.

Front Mol Biosci. 2018 Apr 11;5:36. doi: 10.3389/fmolb.2018.00036. eCollection 2018. Review.

6.

Molecular Insights into hERG Potassium Channel Blockade by Lubeluzole.

Gualdani R, Cavalluzzi MM, Tadini-Buoninsegni F, Convertino M, Gailly P, Stary-Weinzinger A, Lentini G.

Cell Physiol Biochem. 2018;45(6):2233-2245. doi: 10.1159/000488169. Epub 2018 Mar 10.

7.

Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX).

Fragai M, Comito G, Di Cesare Mannelli L, Gualdani R, Calderone V, Louka A, Richichi B, Francesconi O, Angeli A, Nocentini A, Gratteri P, Chiarugi P, Ghelardini C, Tadini-Buoninsegni F, Supuran CT, Nativi C.

J Med Chem. 2017 Nov 9;60(21):9003-9011. doi: 10.1021/acs.jmedchem.7b01237. Epub 2017 Oct 27.

PMID:
29048889
8.

Discovery of a new mexiletine-derived agonist of the hERG K+ channel.

Gualdani R, Cavalluzzi MM, Tadini-Buoninsegni F, Lentini G.

Biophys Chem. 2017 Oct;229:62-67. doi: 10.1016/j.bpc.2017.06.005. Epub 2017 Jun 19.

PMID:
28673509
9.

The Chemistry and Pharmacology of Citrus Limonoids.

Gualdani R, Cavalluzzi MM, Lentini G, Habtemariam S.

Molecules. 2016 Nov 13;21(11). pii: E1530. Review.

10.

Recent Trends in the Discovery of Small Molecule Blockers of Sodium Channels.

Gualdani R, Cavalluzzi MM, Lentini G.

Curr Med Chem. 2016;23(22):2289-332. Review.

PMID:
27183981
11.

Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine.

Gualdani R, Tadini-Buoninsegni F, Roselli M, Defrenza I, Contino M, Colabufo NA, Lentini G.

Pharmacol Res Perspect. 2015 Oct;3(5):e00160. doi: 10.1002/prp2.160. Epub 2015 Jul 31.

12.

Lipoic-based TRPA1/TRPV1 antagonist to treat orofacial pain.

Gualdani R, Ceruti S, Magni G, Merli D, Di Cesare Mannelli L, Francesconi O, Richichi B, la Marca G, Ghelardini C, Moncelli MR, Nativi C.

ACS Chem Neurosci. 2015 Mar 18;6(3):380-5. doi: 10.1021/cn500248u. Epub 2015 Jan 6.

PMID:
25546551
13.

Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel.

Materazzi S, Benemei S, Fusi C, Gualdani R, De Siena G, Vastani N, Andersson DA, Trevisan G, Moncelli MR, Wei X, Dussor G, Pollastro F, Patacchini R, Appendino G, Geppetti P, Nassini R.

Pain. 2013 Dec;154(12):2750-8. doi: 10.1016/j.pain.2013.08.002. Epub 2013 Aug 8.

14.

A TRPA1 antagonist reverts oxaliplatin-induced neuropathic pain.

Nativi C, Gualdani R, Dragoni E, Di Cesare Mannelli L, Sostegni S, Norcini M, Gabrielli G, la Marca G, Richichi B, Francesconi O, Moncelli MR, Ghelardini C, Roelens S.

Sci Rep. 2013;3:2005. doi: 10.1038/srep02005.

15.

Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents.

Gemma S, Camodeca C, Brindisi M, Brogi S, Kukreja G, Kunjir S, Gabellieri E, Lucantoni L, Habluetzel A, Taramelli D, Basilico N, Gualdani R, Tadini-Buoninsegni F, Bartolommei G, Moncelli MR, Martin RE, Summers RL, Lamponi S, Savini L, Fiorini I, Valoti M, Novellino E, Campiani G, Butini S.

J Med Chem. 2012 Dec 13;55(23):10387-404. doi: 10.1021/jm300831b. Epub 2012 Nov 21.

PMID:
23145816
16.

Simultaneous intracellular chloride and pH measurements using a GFP-based sensor.

Arosio D, Ricci F, Marchetti L, Gualdani R, Albertazzi L, Beltram F.

Nat Methods. 2010 Jul;7(7):516-8. doi: 10.1038/nmeth.1471. Epub 2010 Jun 27.

PMID:
20581829

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