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Targeting dihydrofolate reductase: Design, synthesis and biological evaluation of novel 6-substituted pyrrolo[2,3-d]pyrimidines as nonclassical antifolates and as potential antitumor agents.

Gao T, Zhang C, Shi X, Guo R, Zhang K, Gu J, Li L, Li S, Zheng Q, Cui M, Cui M, Gao X, Liu Y, Wang L.

Eur J Med Chem. 2019 Jun 6;178:329-340. doi: 10.1016/j.ejmech.2019.06.013. [Epub ahead of print]


Atomically dispersed Fe3+ sites catalyze efficient CO2 electroreduction to CO.

Gu J, Hsu CS, Bai L, Chen HM, Hu X.

Science. 2019 Jun 14;364(6445):1091-1094. doi: 10.1126/science.aaw7515.


Cryo-EM structure of the mammalian ATP synthase tetramer bound with inhibitory protein IF1.

Gu J, Zhang L, Zong S, Guo R, Liu T, Yi J, Wang P, Zhuo W, Yang M.

Science. 2019 Jun 14;364(6445):1068-1075. doi: 10.1126/science.aaw4852.


IgG Galactosylation status combined with MYOM2-rs2294066 precisely predicts anti-TNF response in ankylosing spondylitis.

Liu J, Zhu Q, Han J, Zhang H, Li Y, Ma Y, He D, Gu J, Zhou X, Reveille JD, Jin L, Zou H, Ren S, Wang J.

Mol Med. 2019 Jun 13;25(1):25. doi: 10.1186/s10020-019-0093-2.


Data on MECOM rearrangement-driven chromosomal aberrations in myeloid malignancies.

Tang Z, Tang G, Hu S, Patel KP, Cameron Yin C, Wang W, Lin P, Toruner GA, Ok CY, Gu J, Lu X, Khoury JD, Jeffrey Medeiros L.

Data Brief. 2019 May 23;24:104025. doi: 10.1016/j.dib.2019.104025. eCollection 2019 Jun.


Three Capsular Polysaccharide Synthesis-Related Glucosyltransferases, GT-1, GT-2 and WcaJ, Are Associated With Virulence and Phage Sensitivity of Klebsiella pneumoniae.

Cai R, Wang G, Le S, Wu M, Cheng M, Guo Z, Ji Y, Xi H, Zhao C, Wang X, Xue Y, Wang Z, Zhang H, Fu Y, Sun C, Feng X, Lei L, Yang Y, Ur Rahman S, Liu X, Han W, Gu J.

Front Microbiol. 2019 May 28;10:1189. doi: 10.3389/fmicb.2019.01189. eCollection 2019.


Combined ultrasound and nerve stimulator-guided deep nerve block may decrease the rate of local anesthetics systemic toxicity: a randomized clinical trial.

Zhang XH, Li YJ, He WQ, Yang CY, Gu JT, Lu KZ, Yi B.

BMC Anesthesiol. 2019 Jun 12;19(1):103. doi: 10.1186/s12871-019-0750-6.


Cross-modal representations in early visual and auditory cortices revealed by multi-voxel pattern analysis.

Gu J, Liu B, Li X, Wang P, Wang B.

Brain Imaging Behav. 2019 Jun 10. doi: 10.1007/s11682-019-00135-2. [Epub ahead of print]


Ginsenoside compound K ameliorates imiquimod-induced psoriasis-like dermatitis through inhibiting REG3A/RegIIIγ expression in keratinocytes.

Fan H, Wang Y, Zhang X, Chen J, Zhou Q, Yu Z, Chen Y, Chen Z, Gu J, Shi Y.

Biochem Biophys Res Commun. 2019 Jun 7. pii: S0006-291X(19)31118-0. doi: 10.1016/j.bbrc.2019.06.007. [Epub ahead of print]


Serum Ngb (Neuroglobin) Is Associated With Brain Metabolism and Functional Outcome of Aneurysmal Subarachnoid Hemorrhage.

Ding CY, Kang DZ, Wang ZL, Lin YX, Jiang CZ, Yu LH, Wang DL, Lin ZY, Gu JJ.

Stroke. 2019 Jun 11:STROKEAHA119025733. doi: 10.1161/STROKEAHA.119.025733. [Epub ahead of print]


Functional properties of mechanoreceptors in mouse whisker hair follicles determined by the pressure-clamped single-fiber recording technique.

Sonekatsu M, Gu JG.

Neurosci Lett. 2019 Jun 7;707:134321. doi: 10.1016/j.neulet.2019.134321. [Epub ahead of print]


Ultrahigh-throughput absolute quantitative analysis of linezolid in human plasma by direct analysis in real time mass spectrometry without chromatographic separation and its application to a pharmacokinetic study.

Yin L, Feng Y, Tong J, Guo Z, Zhang Y, Zhang Q, Sun Y, Fawcett JP, Gu J.

Anal Bioanal Chem. 2019 Jun 10. doi: 10.1007/s00216-019-01891-2. [Epub ahead of print]


Porcine circovirus type 2 promotes Actinobacillus pleuropneumoniae survival during coinfection of porcine alveolar macrophages by inhibiting ROS production.

Qi W, Zhu R, Bao C, Xiao J, Liu B, Sun M, Feng X, Gu J, Li Y, Lei L.

Vet Microbiol. 2019 Jun;233:93-101. doi: 10.1016/j.vetmic.2019.04.028. Epub 2019 Apr 26.


Methanogenic degradation of long n-alkanes requires fumarate-dependent activation.

Ji JH, Liu YF, Zhou L, Mbadinga SM, Pan P, Chen J, Liu JF, Yang SZ, Sand W, Gu JD, Mu BZ.

Appl Environ Microbiol. 2019 Jun 7. pii: AEM.00985-19. doi: 10.1128/AEM.00985-19. [Epub ahead of print]


Role of 4‑aminobutyrate aminotransferase (ABAT) and the lncRNA co‑expression network in the development of myelodysplastic syndrome.

Chen Y, Zhao G, Li N, Luo Z, Wang X, Gu J.

Oncol Rep. 2019 May 29. doi: 10.3892/or.2019.7175. [Epub ahead of print]


Anaerobic hydrocarbon degradation in candidate phylum 'Atribacteria' (JS1) inferred from genomics.

Liu YF, Qi ZZ, Shou LB, Liu JF, Yang SZ, Gu JD, Mu BZ.

ISME J. 2019 Jun 6. doi: 10.1038/s41396-019-0448-2. [Epub ahead of print]


Multiplex profiling of peritoneal metastases from gastric adenocarcinoma identified novel targets and molecular subtypes that predict treatment response.

Wang R, Song S, Harada K, Ghazanfari Amlashi F, Badgwell B, Pizzi MP, Xu Y, Zhao W, Dong X, Jin J, Wang Y, Scott A, Ma L, Huo L, Vicente D, Blum Murphy M, Shanbhag N, Tatlonghari G, Thomas I, Rogers J, Kobayashi M, Vykoukal J, Estrella JS, Roy-Chowdhuri S, Han G, Zhang S, Mao X, Song X, Zhang J, Gu J, Johnson RL, Calin GA, Peng G, Lee JS, Hanash SM, Futreal A, Wang Z, Wang L, Ajani JA.

Gut. 2019 Jun 6. pii: gutjnl-2018-318070. doi: 10.1136/gutjnl-2018-318070. [Epub ahead of print]


Antimicrobials and anti-epileptics are the leading causes of idiosyncratic drug induced liver injury in american children.

DiPaola F, Molleston JP, Gu J, Cirulli ET, Chalasani N, Barnhart H, Kleiner DE, Hoofnagle JH, Fontana RJ; US Drug Induced Liver Injury Network.

J Pediatr Gastroenterol Nutr. 2019 May 6. doi: 10.1097/MPG.0000000000002383. [Epub ahead of print]


Acute Rodent Tolerability, Toxicity, and Radiation Dosimetry Estimates of the S1P1-Specific Radioligand [11C]CS1P1.

Liu H, Laforest R, Gu J, Luo Z, Jones LA, Gropler RJ, Benzinger TLS, Tu Z.

Mol Imaging Biol. 2019 Jun 4. doi: 10.1007/s11307-019-01380-z. [Epub ahead of print]


Negative regulation of miR-1275 by H3K27me3 is critical for glial induction of glioblastoma cells.

Mai J, Gu J, Liu Y, Liu X, Sai K, Chen Z, Lu W, Yang X, Wang J, Guo C, Sun S, Xing F, Sheng L, Lu B, Zhu Z, Sun H, Xue D, Lin Y, Cai J, Tan Y, Li C, Yin W, Cao L, Ou-Yang Y, Qiu P, Su X, Yan G, Liang J, Zhu W.

Mol Oncol. 2019 Jun 4. doi: 10.1002/1878-0261.12525. [Epub ahead of print]


Using Mobile Apps for Health Management: A New Health Care Mode in China.

Lv Q, Jiang Y, Qi J, Zhang Y, Zhang X, Fang L, Tu L, Yang M, Liao Z, Zhao M, Guo X, Qiu M, Gu J, Lin Z.

JMIR Mhealth Uhealth. 2019 Jun 3;7(6):e10299. doi: 10.2196/10299.


l-arginine alleviates doxorubicin-induced endothelium-dependent dysfunction by promoting nitric oxide generation and inhibiting apoptosis.

Li X, Gu J, Zhang Y, Feng S, Huang X, Jiang Y, Xia Y, Liu Y, Yang X.

Toxicology. 2019 May 31;423:105-111. doi: 10.1016/j.tox.2019.05.016. [Epub ahead of print]


MgrB affects the acid stress response of Escherichia coli by modulating the expression of iraM.

Xu J, Li T, Gao Y, Deng J, Gu J.

FEMS Microbiol Lett. 2019 Jun 3. pii: fnz123. doi: 10.1093/femsle/fnz123. [Epub ahead of print]


Geometrically invariant watermarking for medical images based on digital holography and three-level DWT-SVD.

Chen W, Gu J, Li Q, Tang X, Chen D.

Appl Opt. 2019 May 20;58(15):4185-4191. doi: 10.1364/AO.58.004185.


Simultaneous removal of nitrogen oxides and sulfur dioxide using ultrasonically atomized hydrogen peroxide.

Wei J, Gu J, Guo J, Li W, Wang C, Zhang J.

Environ Sci Pollut Res Int. 2019 Jun 1. doi: 10.1007/s11356-019-05531-1. [Epub ahead of print]


Direct microbial transformation of carbon dioxide to value-added chemicals: A comprehensive analysis and application potentials.

Irfan M, Bai Y, Zhou L, Kazmi M, Yuan S, Maurice Mbadinga S, Yang SZ, Liu JF, Sand W, Gu JD, Mu BZ.

Bioresour Technol. 2019 Apr 30:121401. doi: 10.1016/j.biortech.2019.121401. [Epub ahead of print] Review.


Effects of transitional health management on adherence and prognosis in elderly patients with acute myocardial infarction in percutaneous coronary intervention: A cluster randomized controlled trial.

Wu Q, Zhang D, Zhao Q, Liu L, He Z, Chen Y, Huang H, Hou Y, Yang X, Gu J.

PLoS One. 2019 May 31;14(5):e0217535. doi: 10.1371/journal.pone.0217535. eCollection 2019.


A hydrogenated black TiO2 coating with excellent effects for photothermal therapy of bone tumor and bone regeneration.

Zhang W, Gu J, Li K, Zhao J, Ma H, Wu C, Zhang C, Xie Y, Yang F, Zheng X.

Mater Sci Eng C Mater Biol Appl. 2019 Sep;102:458-470. doi: 10.1016/j.msec.2019.04.025. Epub 2019 Apr 10.


Differences in Dry Sliding Wear Behavior between Al-12Si-CuNiMg Alloy and Its Composite Reinforced with Al2O3 Fibers.

Zhang Q, Gu J, Wei S, Qi M.

Materials (Basel). 2019 May 29;12(11). pii: E1749. doi: 10.3390/ma12111749.


Effects of inoculation with lignocellulose-degrading microorganisms on antibiotic resistance genes and the bacterial community during co-composting of swine manure with spent mushroom substrate.

Hu T, Wang X, Zhen L, Gu J, Zhang K, Wang Q, Ma J, Peng H.

Environ Pollut. 2019 May 17;252(Pt A):110-118. doi: 10.1016/j.envpol.2019.05.078. [Epub ahead of print]


Establishment of CSUASOi001-A, a non-integrated induced pluripotent stem cell line from urine-derived cells of a Chinese patient carrying RS1 gene mutation.

Yan X, Guo Y, Chen J, Cui Z, Gu J, Wang Y, Mao S, Ding C, Chen J, Tang S.

Stem Cell Res. 2019 May 17;38:101466. doi: 10.1016/j.scr.2019.101466. [Epub ahead of print]


Quantitative decision making for a groundwater monitoring and subsurface contamination early warning network.

Li H, Gu J, Hanif A, Dhanasekar A, Carlson K.

Sci Total Environ. 2019 May 10;683:498-507. doi: 10.1016/j.scitotenv.2019.05.121. [Epub ahead of print]


Efficacy and safety of loxoprofen hydrogel patch versus loxoprofen tablet in patients with ankylosing spondylitis: A 4-week randomized, open-label study.

Fan M, Cao S, Tu L, Wei Q, Yuan R, Li X, Gu J.

Biomed Rep. 2019 Jun;10(6):331-336. doi: 10.3892/br.2019.1209. Epub 2019 May 2.


Surgical complications after different therapeutic approaches for locally advanced rectal cancer.

Zhan TC, Zhang DK, Gu J, Li M.

World J Gastrointest Oncol. 2019 May 15;11(5):393-403. doi: 10.4251/wjgo.v11.i5.393.


Loss of Vision Dominance at the Preresponse Level in Tinnitus Patients: Preliminary Behavioral Evidence.

Li Z, Gu R, Qi M, Cen J, Zhang S, Gu J, Zeng X, Chen Q.

Front Neurosci. 2019 May 14;13:482. doi: 10.3389/fnins.2019.00482. eCollection 2019.


MicroRNA-198 inhibits proliferation and induces apoptosis by directly suppressing FGFR1 in gastric cancer.

Gu J, Li X, Li H, Jin Z, Jin J.

Biosci Rep. 2019 Jun 10;39(6). pii: BSR20181258. doi: 10.1042/BSR20181258. Print 2019 Jun 28.


Downregulation of α7 nicotinic acetylcholine receptors in peripheral blood monocytes is associated with enhanced inflammation in preeclampsia.

Xu H, Shi Q, Mo Y, Wu L, Gu J, Xu Y.

BMC Pregnancy Childbirth. 2019 May 28;19(1):188. doi: 10.1186/s12884-019-2340-5.


Transcriptional Profiling of Daily Patterns of mRNA Expression in the C57BL/6J Mouse Cornea.

Jiao X, Wu M, Lu D, Gu J, Li Z.

Curr Eye Res. 2019 May 28. doi: 10.1080/02713683.2019.1625408. [Epub ahead of print]


Whole-genome resequencing-based QTL-seq identified AhTc1 gene encoding a R2R3-MYB transcription factor controlling peanut purple testa colour.

Zhao Y, Ma J, Li M, Deng L, Li G, Xia H, Zhao S, Hou L, Li P, Ma C, Yuan M, Ren L, Gu J, Guo B, Zhao C, Wang X.

Plant Biotechnol J. 2019 May 26. doi: 10.1111/pbi.13175. [Epub ahead of print]


Metagenomic and metatranscriptomic analyses reveal activity and hosts of antibiotic resistance genes in activated sludge.

Liu Z, Klümper U, Liu Y, Yang Y, Wei Q, Lin JG, Gu JD, Li M.

Environ Int. 2019 Aug;129:208-220. doi: 10.1016/j.envint.2019.05.036. Epub 2019 May 23.


Effects of rhamnolipid and Tween-80 on cellulase activities and metabolic functions of the bacterial community during chicken manure composting.

Yin Y, Gu J, Wang X, Zhang Y, Zheng W, Chen R, Wang X.

Bioresour Technol. 2019 May 18;288:121507. doi: 10.1016/j.biortech.2019.121507. [Epub ahead of print]


VCF-Server: A web-based visualization tool for high-throughput variant data mining and management.

Jiang J, Gu J, Zhao T, Lu H.

Mol Genet Genomic Med. 2019 May 24:e641. doi: 10.1002/mgg3.641. [Epub ahead of print]


Anthracycline dose optimisation in patients with diffuse large B-cell lymphoma: a multicentre, phase 3, randomised, controlled trial.

Xu PP, Fu D, Li JY, Hu JD, Wang X, Zhou JF, Yu H, Zhao X, Huang YH, Jiang L, Liu F, Su LP, Chen ZW, Zeng QS, Chen JP, Fang MY, Ma J, Liu T, Song YP, Yu K, Li Y, Qiu LG, Chen XQ, Gu J, Yan JS, Hou M, Huang HY, Wang L, Cheng S, Shen Y, Xiong H, Chen SJ, Zhao WL.

Lancet Haematol. 2019 Jun;6(6):e328-e337. doi: 10.1016/S2352-3026(19)30051-1.


Assessment of tumor mutation burden calculation from gene panel sequencing data.

Xu Z, Dai J, Wang D, Lu H, Dai H, Ye H, Gu J, Chen S, Huang B.

Onco Targets Ther. 2019 May 6;12:3401-3409. doi: 10.2147/OTT.S196638. eCollection 2019.


AICD: an integrated anti-inflammatory compounds database for drug discovery.

Wang K, Xiao J, Liu X, Jiang Z, Zhan Y, Yin T, He L, Zhang F, Xing S, Chen B, Li Y, Zhang F, Kuang Z, Du B, Gu J.

Sci Rep. 2019 May 23;9(1):7737. doi: 10.1038/s41598-019-44227-x.


Metabolomic modulations of HepG2 cells exposed to bisphenol analogues.

Yue S, Yu J, Kong Y, Chen H, Mao M, Ji C, Shao S, Zhu J, Gu J, Zhao M.

Environ Int. 2019 Aug;129:59-67. doi: 10.1016/j.envint.2019.05.008. Epub 2019 May 20.


Development of large-scale mosquito densovirus production by in vivo methods.

Sun Y, Dong Y, Li J, Lai Z, Hao Y, Liu P, Chen X, Gu J.

Parasit Vectors. 2019 May 22;12(1):255. doi: 10.1186/s13071-019-3509-5.


Prophylactic and therapeutic protection of human IgG purified from sera containing anti-exotoxin A titers against pneumonia caused by Pseudomonas aeruginosa.

Zhang J, Wan C, Yu B, Gao C, Zhao L, Cheng X, Yang F, Gu H, Zou Q, Gu J, Wang X.

Hum Vaccin Immunother. 2019 May 22. doi: 10.1080/21645515.2019.1619404. [Epub ahead of print]


A novel mutation associated with Type III Bartter syndrome: A report of five cases.

Li Y, Wu C, Gu J, Li D, Yang Y.

Mol Med Rep. 2019 Jul;20(1):65-72. doi: 10.3892/mmr.2019.10255. Epub 2019 May 16.


In situ synthesis of BiOCl nanosheets on three-dimensional hierarchical structures for efficient photocatalysis under visible light.

Yan X, Zhao H, Li T, Zhang W, Liu Q, Yuan Y, Huang L, Yao L, Yao J, Su H, Su Y, Gu J, Zhang D.

Nanoscale. 2019 May 30;11(21):10203-10208. doi: 10.1039/c9nr02304f.


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