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What's new in management and clearing of airway secretions in ICU patients? It is time to focus on cough augmentation.

Terzi N, Guerin C, Gonçalves MR.

Intensive Care Med. 2018 Dec 5. doi: 10.1007/s00134-018-5484-2. [Epub ahead of print] No abstract available.


Treprostinil treatment decreases circulating platelet microvesicles and their procoagulant activity in pediatric pulmonary hypertension.

Bacha NC, Levy M, Guerin CL, Le Bonniec B, Harroche A, Szezepanski I, Renard JM, Gaussem P, Israel-Biet D, Boulanger CM, Smadja DM.

Pediatr Pulmonol. 2018 Nov 28. doi: 10.1002/ppul.24190. [Epub ahead of print]


Purification of Leukemia-Derived Exosomes to Study Microenvironment Modulation.

Wierz M, Pierson S, Gargiulo E, Guerin C, Moussay E, Paggetti J.

Methods Mol Biol. 2019;1884:231-245. doi: 10.1007/978-1-4939-8885-3_16.


Effects of patient positioning on respiratory mechanics in mechanically ventilated ICU patients.

Mezidi M, Guérin C.

Ann Transl Med. 2018 Oct;6(19):384. doi: 10.21037/atm.2018.05.50. Review.


Physiological Effect of Prone Position in Children with Severe Bronchiolitis: A Randomized Cross-Over Study (BRONCHIO-DV).

Baudin F, Emeriaud G, Essouri S, Beck J, Portefaix A, Javouhey E, Guerin C.

J Pediatr. 2018 Nov 14. pii: S0022-3476(18)31401-X. doi: 10.1016/j.jpeds.2018.09.066. [Epub ahead of print]


NIFT-P: Are they indolent tumors? Results of a multi-institutional study.

Chereau N, Greilsamer T, Mirallié E, Sadowski SM, Pusztaszeri M, Triponez F, Baud G, Pattou F, Christou N, Mathonnet M, Brunaud L, Santucci N, Goudet P, Guérin C, Sebag F, Donatini G, Kraimps JL, Tissier F, Lussey C, Leenhardt L, Menegaux F.

Surgery. 2018 Nov 9. pii: S0039-6060(18)30624-X. doi: 10.1016/j.surg.2018.04.089. [Epub ahead of print]


Disagreement Between Clinicians and Score in Decision-Making Capacity of Critically Ill Patients.

Bertrand PM, Pereira B, Adda M, Timsit JF, Wolff M, Hilbert G, Gruson D, Garrouste-Orgeas M, Argaud L, Constantin JM, Chabanne R, Quenot JP, Bohe J, Guerin C, Papazian L, Jonquet O, Klouche K, Delahaye A, Riu B, Zieleskiewicz L, Darmon M, Azoulay E, Souweine B, Lautrette A.

Crit Care Med. 2018 Nov 9. doi: 10.1097/CCM.0000000000003550. [Epub ahead of print]


Neonicotinoid exposure disrupts bumblebee nest behavior, social networks, and thermoregulation.

Crall JD, Switzer CM, Oppenheimer RL, Ford Versypt AN, Dey B, Brown A, Eyster M, Guérin C, Pierce NE, Combes SA, de Bivort BL.

Science. 2018 Nov 9;362(6415):683-686. doi: 10.1126/science.aat1598.


Mechanical Insufflation-Exsufflation: Room for Improvement.

Burle JF, Vincent B, Lachal R, Louis B, Guérin C.

Respir Care. 2018 Oct;63(10):1318-1319. doi: 10.4187/respcare.06542. No abstract available.


A key function for microtubule-associated-protein 6 in activity-dependent stabilisation of actin filaments in dendritic spines.

Peris L, Bisbal M, Martinez-Hernandez J, Saoudi Y, Jonckheere J, Rolland M, Sebastien M, Brocard J, Denarier E, Bosc C, Guerin C, Gory-Fauré S, Deloulme JC, Lanté F, Arnal I, Buisson A, Goldberg Y, Blanchoin L, Delphin C, Andrieux A.

Nat Commun. 2018 Sep 17;9(1):3775. doi: 10.1038/s41467-018-05869-z.


Clinical features and outcome of patients with acute respiratory failure revealing anti-synthetase or anti-MDA-5 dermato-pulmonary syndrome: a French multicenter retrospective study.

Vuillard C, Pineton de Chambrun M, de Prost N, Guérin C, Schmidt M, Dargent A, Quenot JP, Préau S, Ledoux G, Neuville M, Voiriot G, Fartoukh M, Coudroy R, Dumas G, Maury E, Terzi N, Tandjaoui-Lambiotte Y, Schneider F, Grall M, Guérot E, Larcher R, Ricome S, Le Mao R, Colin G, Guitton C, Zafrani L, Morawiec E, Dubert M, Pajot O, Mentec H, Plantefève G, Contou D.

Ann Intensive Care. 2018 Sep 11;8(1):87. doi: 10.1186/s13613-018-0433-3.


Effects of positive end-expiratory pressure strategy in supine and prone position on lung and chest wall mechanics in acute respiratory distress syndrome.

Mezidi M, Parrilla FJ, Yonis H, Riad Z, Böhm SH, Waldmann AD, Richard JC, Lissonde F, Tapponnier R, Baboi L, Mancebo J, Guérin C.

Ann Intensive Care. 2018 Sep 10;8(1):86. doi: 10.1186/s13613-018-0434-2.


Pressure support ventilation + sigh in acute hypoxemic respiratory failure patients: study protocol for a pilot randomized controlled trial, the PROTECTION trial.

Mauri T, Foti G, Fornari C, Constantin JM, Guerin C, Pelosi P, Ranieri M, Conti S, Tubiolo D, Rondelli E, Lovisari F, Fossali T, Spadaro S, Grieco DL, Navalesi P, Calamai I, Becher T, Roca O, Wang YM, Knafelj R, Cortegiani A, Mancebo J, Brochard L, Pesenti A; Protection Study Group.

Trials. 2018 Aug 29;19(1):460. doi: 10.1186/s13063-018-2828-8.


Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer-Mediated Cytotoxicity.

Al Absi A, Wurzer H, Guerin C, Hoffmann C, Moreau F, Mao X, Brown-Clay J, Petrolli R, Casellas CP, Dieterle M, Thiery JP, Chouaib S, Berchem G, Janji B, Thomas C.

Cancer Res. 2018 Oct 1;78(19):5631-5643. doi: 10.1158/0008-5472.CAN-18-0441. Epub 2018 Aug 13.


Effects of long-term dietary administration of estrogen receptor-beta agonist diarylpropionitrile on ovariectomized female ICR (CD-1) mice.

Said SA, Isedowo R, Guerin C, Nar NN, Lillie L, Bukovac S, Simone JJ, Green MR, McCormick CM, Stuart JA.

Geroscience. 2018 Aug;40(4):393-403. doi: 10.1007/s11357-018-0038-7. Epub 2018 Aug 11.


Prone positioning acute respiratory distress syndrome patients.

Guérin C.

J Thorac Dis. 2018 Jun;10(Suppl 17):S2092-S2094. doi: 10.21037/jtd.2018.05.109. No abstract available.


Value of 123I/99mTc-sestamibi parathyroid scintigraphy with subtraction SPECT/CT in primary hyperparathyroidism for directing minimally invasive parathyroidectomy.

Asseeva P, Paladino NC, Guerin C, Castinetti F, Vaillant-Lombard J, Abdullah AE, Farman-Ara B, Loundou A, Sebag F, Taïeb D.

Am J Surg. 2018 Jun 30. pii: S0002-9610(18)30687-1. doi: 10.1016/j.amjsurg.2018.06.027. [Epub ahead of print]


Accuracy of Delivery and Effects on Absolute Humidity of Low Tidal Volume by ICU Ventilators.

Moro B, Baboi L, Yonis H, Subtil F, Louis B, Guérin C.

Respir Care. 2018 Oct;63(10):1253-1263. doi: 10.4187/respcare.06132. Epub 2018 Jun 26.


Coexpression network and phenotypic analysis identify metabolic pathways associated with the effect of warming on grain yield components in wheat.

Girousse C, Roche J, Guerin C, Le Gouis J, Balzegue S, Mouzeyar S, Bouzidi MF.

PLoS One. 2018 Jun 25;13(6):e0199434. doi: 10.1371/journal.pone.0199434. eCollection 2018.


Colonic Mucosal Proteome Signature Reveals Reduced Energy Metabolism and Protein Synthesis but Activated Autophagy during Anorexia-Induced Malnutrition in Mice.

Nobis S, Achamrah N, Goichon A, L'Huillier C, Morin A, Guérin C, Chan P, do Rego JL, do Rego JC, Vaudry D, Déchelotte P, Belmonte L, Coëffier M.

Proteomics. 2018 Aug;18(15):e1700395. doi: 10.1002/pmic.201700395. Epub 2018 Jul 15.


Characterization of adrenocortical tumors by 18F-FDG PET/CT: Does steroid hormone hypersecretion status modify the uptake pattern?

Paladino NC, Guérin C, Lowery A, Attard A, Essamet W, Slotema E, Morange I, Castinetti F, Brue T, Loundou A, Taïeb D, Sebag F.

Surg Oncol. 2018 Jun;27(2):231-235. doi: 10.1016/j.suronc.2018.04.003. Epub 2018 Apr 23.


Reliability of Tidal Volume in Average Volume Assured Pressure Support Mode.

Stagnara A, Baboi L, Nesme P, Subtil F, Louis B, Guérin C.

Respir Care. 2018 Sep;63(9):1139-1146. doi: 10.4187/respcare.05917. Epub 2018 Jun 19.


Diagnostic yield and therapeutic impact of open lung biopsy in the critically ill patient.

Philipponnet C, Cassagnes L, Pereira B, Kemeny JL, Devouassoux-Shisheboran M, Lautrette A, Guerin C, Souweine B.

PLoS One. 2018 May 25;13(5):e0196795. doi: 10.1371/journal.pone.0196795. eCollection 2018.


Bacillus cereus, a serious cause of nosocomial infections: Epidemiologic and genetic survey.

Glasset B, Herbin S, Granier SA, Cavalié L, Lafeuille E, Guérin C, Ruimy R, Casagrande-Magne F, Levast M, Chautemps N, Decousser JW, Belotti L, Pelloux I, Robert J, Brisabois A, Ramarao N.

PLoS One. 2018 May 23;13(5):e0194346. doi: 10.1371/journal.pone.0194346. eCollection 2018.


Alterations of proteome, mitochondrial dynamic and autophagy in the hypothalamus during activity-based anorexia.

Nobis S, Goichon A, Achamrah N, Guérin C, Azhar S, Chan P, Morin A, Bôle-Feysot C, do Rego JC, Vaudry D, Déchelotte P, Belmonte L, Coëffier M.

Sci Rep. 2018 May 8;8(1):7233. doi: 10.1038/s41598-018-25548-9.


Dietary n-3 PUFA May Attenuate Experimental Colitis.

Charpentier C, Chan R, Salameh E, Mbodji K, Ueno A, Coëffier M, Guérin C, Ghosh S, Savoye G, Marion-Letellier R.

Mediators Inflamm. 2018 Feb 15;2018:8430614. doi: 10.1155/2018/8430614. eCollection 2018.


Estimation of Extra Length of Stay Attributable to Hospital-Acquired Infections in Adult ICUs Using a Time-Dependent Multistate Model.

Ohannessian R, Gustin MP, Bénet T, Gerbier-Colomban S, Girard R, Argaud L, Rimmelé T, Guerin C, Bohé J, Piriou V, Vanhems P.

Crit Care Med. 2018 Jul;46(7):1093-1098. doi: 10.1097/CCM.0000000000003131.


Acute respiratory distress syndrome-a worldwide economic perspective.

Chebib N, Kreitmann L, Guérin C.

J Thorac Dis. 2018 Feb;10(2):570-575. doi: 10.21037/jtd.2018.01.72. No abstract available.


Intra-Cardiac Release of Extracellular Vesicles Shapes Inflammation Following Myocardial Infarction.

Loyer X, Zlatanova I, Devue C, Yin M, Howangyin KY, Klaihmon P, Guerin CL, Kheloufi M, Vilar J, Zannis K, Fleischmann BK, Hwang DW, Park J, Lee H, Menasché P, Silvestre JS, Boulanger CM.

Circ Res. 2018 Jun 22;123(1):100-106. doi: 10.1161/CIRCRESAHA.117.311326. Epub 2018 Mar 28.


School-Age Hearing Screening Based on Speech-in-Noise Perception Using the Digit Triplet Test.

Denys S, Hofmann M, Luts H, Guérin C, Keymeulen A, Van Hoeck K, van Wieringen A, Hoppenbrouwers K, Wouters J.

Ear Hear. 2018 Nov/Dec;39(6):1104-1115. doi: 10.1097/AUD.0000000000000563.


18F-FDOPA PET/CT Imaging of MAX-Related Pheochromocytoma.

Taïeb D, Jha A, Guerin C, Pang Y, Adams KT, Chen CC, Romanet P, Roche P, Essamet W, Ling A, Quezado MM, Castinetti F, Sebag F, Pacak K.

J Clin Endocrinol Metab. 2018 Apr 1;103(4):1574-1582. doi: 10.1210/jc.2017-02324.


The Emerging Workforce of International University Student Workers: Injury Experience in an Australian University.

Thamrin Y, Pisaniello D, Guerin C, Rothmore P.

Int J Environ Res Public Health. 2018 Mar 6;15(3). pii: E456. doi: 10.3390/ijerph15030456.


Genomic Diversity and Evolution of the Fish Pathogen Flavobacterium psychrophilum.

Duchaud E, Rochat T, Habib C, Barbier P, Loux V, Guérin C, Dalsgaard I, Madsen L, Nilsen H, Sundell K, Wiklund T, Strepparava N, Wahli T, Caburlotto G, Manfrin A, Wiens GD, Fujiwara-Nagata E, Avendaño-Herrera R, Bernardet JF, Nicolas P.

Front Microbiol. 2018 Feb 7;9:138. doi: 10.3389/fmicb.2018.00138. eCollection 2018.


Expiratory Flow Limitation Assessment in Patients with Acute Respiratory Distress Syndrome. A Reappraisal.

Yonis H, Mortaza S, Baboi L, Mercat A, Guérin C.

Am J Respir Crit Care Med. 2018 Jul 1;198(1):131-134. doi: 10.1164/rccm.201711-2326LE. No abstract available.


Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia.

Wierz M, Pierson S, Guyonnet L, Viry E, Lequeux A, Oudin A, Niclou SP, Ollert M, Berchem G, Janji B, Guérin C, Paggetti J, Moussay E.

Blood. 2018 Apr 5;131(14):1617-1621. doi: 10.1182/blood-2017-06-792267. Epub 2018 Feb 13. No abstract available.


Effect of parathyroidectomy on quality of life and non-specific symptoms in normocalcaemic primary hyperparathyroidism.

Bannani S, Christou N, Guérin C, Hamy A, Sebag F, Mathonnet M, Guillot P, Caillard C, Blanchard C, Mirallié E.

Br J Surg. 2018 Feb;105(3):223-229. doi: 10.1002/bjs.10739.


Prevalence of prone position use and complications among ventilated ARDS patients.

Taito S, Sarada K, Guérin C.

Intensive Care Med. 2018 Mar;44(3):397-398. doi: 10.1007/s00134-018-5065-4. Epub 2018 Jan 27. No abstract available.


Adjunct and rescue therapies for refractory hypoxemia: prone position, inhaled nitric oxide, high frequency oscillation, extra corporeal life support.

Ferguson ND, Guérin C.

Intensive Care Med. 2018 Sep;44(9):1528-1531. doi: 10.1007/s00134-017-5040-5. Epub 2018 Jan 18. No abstract available.


Selective EGF-Receptor Inhibition in CD4+ T Cells Induces Anergy and Limits Atherosclerosis.

Zeboudj L, Maître M, Guyonnet L, Laurans L, Joffre J, Lemarie J, Bourcier S, Nour-Eldine W, Guérin C, Friard J, Wakkach A, Fabre E, Tedgui A, Mallat Z, Tharaux PL, Ait-Oufella H.

J Am Coll Cardiol. 2018 Jan 16;71(2):160-172. doi: 10.1016/j.jacc.2017.10.084.


PamR, a new MarR-like regulator affecting prophages and metabolic genes expression in Bacillus subtilis.

De San Eustaquio-Campillo A, Cornilleau C, Guérin C, Carballido-López R, Chastanet A.

PLoS One. 2017 Dec 14;12(12):e0189694. doi: 10.1371/journal.pone.0189694. eCollection 2017.


Short-Term Effects of the Prone Positioning Maneuver on Lung and Chest Wall Mechanics in Patients with Acute Respiratory Distress Syndrome.

Riad Z, Mezidi M, Subtil F, Louis B, Guérin C.

Am J Respir Crit Care Med. 2018 May 15;197(10):1355-1358. doi: 10.1164/rccm.201709-1853LE. No abstract available.


A prospective international observational prevalence study on prone positioning of ARDS patients: the APRONET (ARDS Prone Position Network) study.

Guérin C, Beuret P, Constantin JM, Bellani G, Garcia-Olivares P, Roca O, Meertens JH, Maia PA, Becher T, Peterson J, Larsson A, Gurjar M, Hajjej Z, Kovari F, Assiri AH, Mainas E, Hasan MS, Morocho-Tutillo DR, Baboi L, Chrétien JM, François G, Ayzac L, Chen L, Brochard L, Mercat A; investigators of the APRONET Study Group, the REVA Network, the Réseau recherche de la Société Française d’Anesthésie-Réanimation (SFAR-recherche) and the ESICM Trials Group.

Intensive Care Med. 2018 Jan;44(1):22-37. doi: 10.1007/s00134-017-4996-5. Epub 2017 Dec 7.


Change in cardiac output during Trendelenburg maneuver is a reliable predictor of fluid responsiveness in patients with acute respiratory distress syndrome in the prone position under protective ventilation.

Yonis H, Bitker L, Aublanc M, Perinel Ragey S, Riad Z, Lissonde F, Louf-Durier A, Debord S, Gobert F, Tapponnier R, Guérin C, Richard JC.

Crit Care. 2017 Dec 5;21(1):295. doi: 10.1186/s13054-017-1881-0.


A systematic review of interventions and performance measures for antifungal stewardship programmes.

Bienvenu AL, Argaud L, Aubrun F, Fellahi JL, Guerin C, Javouhey E, Piriou V, Rimmele T, Chidiac C, Leboucher G.

J Antimicrob Chemother. 2018 Feb 1;73(2):297-305. doi: 10.1093/jac/dkx388.


Enteral versus parenteral early nutrition in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group study (NUTRIREA-2).

Reignier J, Boisramé-Helms J, Brisard L, Lascarrou JB, Ait Hssain A, Anguel N, Argaud L, Asehnoune K, Asfar P, Bellec F, Botoc V, Bretagnol A, Bui HN, Canet E, Da Silva D, Darmon M, Das V, Devaquet J, Djibre M, Ganster F, Garrouste-Orgeas M, Gaudry S, Gontier O, Guérin C, Guidet B, Guitton C, Herbrecht JE, Lacherade JC, Letocart P, Martino F, Maxime V, Mercier E, Mira JP, Nseir S, Piton G, Quenot JP, Richecoeur J, Rigaud JP, Robert R, Rolin N, Schwebel C, Sirodot M, Tinturier F, Thévenin D, Giraudeau B, Le Gouge A; NUTRIREA-2 Trial Investigators; Clinical Research in Intensive Care and Sepsis (CRICS) group.

Lancet. 2018 Jan 13;391(10116):133-143. doi: 10.1016/S0140-6736(17)32146-3. Epub 2017 Nov 8.


Endothelial Microparticles are Associated to Pathogenesis of Idiopathic Pulmonary Fibrosis.

Bacha NC, Blandinieres A, Rossi E, Gendron N, Nevo N, Lecourt S, Guerin CL, Renard JM, Gaussem P, Angles-Cano E, Boulanger CM, Israel-Biet D, Smadja DM.

Stem Cell Rev. 2018 Apr;14(2):223-235. doi: 10.1007/s12015-017-9778-5.


Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner.

Mgrditchian T, Arakelian T, Paggetti J, Noman MZ, Viry E, Moussay E, Van Moer K, Kreis S, Guerin C, Buart S, Robert C, Borg C, Vielh P, Chouaib S, Berchem G, Janji B.

Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9271-E9279. doi: 10.1073/pnas.1703921114. Epub 2017 Oct 16.


Egfl7 Represses the Vasculogenic Potential of Human Endothelial Progenitor Cells.

d'Audigier C, Susen S, Blandinieres A, Mattot V, Saubamea B, Rossi E, Nevo N, Lecourt S, Guerin CL, Dizier B, Gendron N, Caetano B, Gaussem P, Soncin F, Smadja DM.

Stem Cell Rev. 2018 Feb;14(1):82-91. doi: 10.1007/s12015-017-9775-8.


Network heterogeneity regulates steering in actin-based motility.

Boujemaa-Paterski R, Suarez C, Klar T, Zhu J, Guérin C, Mogilner A, Théry M, Blanchoin L.

Nat Commun. 2017 Sep 21;8(1):655. doi: 10.1038/s41467-017-00455-1.


Quantitative 18F-DOPA PET/CT in pheochromocytoma: the relationship between tumor secretion and its biochemical phenotype.

Amodru V, Guerin C, Delcourt S, Romanet P, Loundou A, Viana B, Brue T, Castinetti F, Sebag F, Pacak K, Taïeb D.

Eur J Nucl Med Mol Imaging. 2018 Feb;45(2):278-282. doi: 10.1007/s00259-017-3833-y. Epub 2017 Sep 16.


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