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GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis.
Wang Q, Bin C, Xue Q, Gao Q, Huang A, Wang K, Tang N. Wang Q, et al. Cell Death Dis. 2021 Apr 30;12(5):426. doi: 10.1038/s41419-021-03718-4. Cell Death Dis. 2021. PMID: 33931597 Free PMC article.
This study aimed to investigate the role and underlying molecular mechanisms of GSTZ1 in sorafenib-induced ferroptosis in HCC. GSTZ1 was significantly downregulated in sorafenib-resistant hepatoma cells. ...In vivo, the combination of sorafenib and RSL3 had a synerg …
This study aimed to investigate the role and underlying molecular mechanisms of GSTZ1 in sorafenib-induced ferroptosis in HCC. GST …
Clinical physiology and pharmacology of GSTZ1/MAAI.
Stacpoole PW. Stacpoole PW. Biochem Pharmacol. 2023 Nov;217:115818. doi: 10.1016/j.bcp.2023.115818. Epub 2023 Sep 22. Biochem Pharmacol. 2023. PMID: 37742772 Review.
GSTZ1 is most abundant in rodent and human liver, with its concentration several fold higher in cytoplasm than in mitochondria. ...Haplotype variations in GSTZ1 influence the rate of DCA metabolism, enabling a genotyping strategy to allow potentially safe, precision …
GSTZ1 is most abundant in rodent and human liver, with its concentration several fold higher in cytoplasm than in mitochondria. ...Ha …
GSTZ1-1 downregulates Wnt/beta-catenin signalling in hepatocellular carcinoma cells.
Lei C, Wang Q, Tang N, Wang K. Lei C, et al. FEBS Open Bio. 2020 Jan;10(1):6-17. doi: 10.1002/2211-5463.12769. Epub 2019 Dec 10. FEBS Open Bio. 2020. PMID: 31782257 Free PMC article.
Here, we further explored the function of GSTZ1-1 in HCC through transcriptome analysis by RNA sequencing. ...These results provide a comprehensive overview of the transcriptome in GSTZ1-1-overexpressing Huh7 cells and indicate that GSTZ1-1 may play a tumour …
Here, we further explored the function of GSTZ1-1 in HCC through transcriptome analysis by RNA sequencing. ...These results provide a …
GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway.
Li J, Wang Q, Yang Y, Lei C, Yang F, Liang L, Chen C, Xia J, Wang K, Tang N. Li J, et al. J Exp Clin Cancer Res. 2019 Oct 30;38(1):438. doi: 10.1186/s13046-019-1459-6. J Exp Clin Cancer Res. 2019. PMID: 31666108 Free PMC article.
METHODS: We first analyzed GSTZ1 expression levels in paired human HCC and adjacent normal tissue specimens and the prognostic effect of GSTZ1 on HCC patients. ...RESULTS: GSTZ1 was downregulated in HCC, thus indicating a poor prognosis. ...
METHODS: We first analyzed GSTZ1 expression levels in paired human HCC and adjacent normal tissue specimens and the prognostic effect …
GSTZ1-1 Deficiency Activates NRF2/IGF1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone.
Yang F, Li J, Deng H, Wang Y, Lei C, Wang Q, Xiang J, Liang L, Xia J, Pan X, Li X, Long Q, Chang L, Xu P, Huang A, Wang K, Tang N. Yang F, et al. EMBO J. 2019 Aug 1;38(15):e101964. doi: 10.15252/embj.2019101964. Epub 2019 Jun 28. EMBO J. 2019. PMID: 31267557 Free PMC article.
Mechanistically, GSTZ1-1 deficiency led to succinylacetone accumulation, alkylation modification of KEAP1, and NRF2 activation, thus promoting IGF1R transcription by recruiting SP1 to its promoter. Moreover, inhibition of IGF1R or NRF2 significantly inhibited tumor-promoti …
Mechanistically, GSTZ1-1 deficiency led to succinylacetone accumulation, alkylation modification of KEAP1, and NRF2 activation, thus …
Glutathione transferase zeta: discovery, polymorphic variants, catalysis, inactivation, and properties of Gstz1-/- mice.
Board PG, Anders MW. Board PG, et al. Drug Metab Rev. 2011 May;43(2):215-25. doi: 10.3109/03602532.2010.549132. Epub 2011 Feb 8. Drug Metab Rev. 2011. PMID: 21303221 Review.
A sequence that was found was expressed and termed GSTZ1-1. In common with other GSTs, GSTZ1-1 showed some peroxidase activity, but lacked activity with most known GST substrates. ...DCA was shown to be a k(cat) inactivator of human, rat, and mouse GSTZ1-1; h …
A sequence that was found was expressed and termed GSTZ1-1. In common with other GSTs, GSTZ1-1 showed some peroxidase activity …
GSTZ1 genotypes correlate with dichloroacetate pharmacokinetics and chronic side effects in multiple myeloma patients in a pilot phase 2 clinical trial.
Tian DD, Bennett SK, Coupland LA, Forwood K, Lwin Y, Pooryousef N, Tea I, Truong TT, Neeman T, Crispin P, D'Rozario J, Blackburn AC. Tian DD, et al. Pharmacol Res Perspect. 2019 Oct 8;7(6):e00526. doi: 10.1002/prp2.526. eCollection 2019 Dec. Pharmacol Res Perspect. 2019. PMID: 31624634 Free PMC article. Clinical Trial.
GSTZ1 is also irreversibly inactivated by DCA. In the first clinical trial of DCA in a hematological malignancy, DiCAM (DiChloroAcetate in Myeloma), we have examined the relationship between DCA concentrations, GSTZ1 genotype, side effects, and patient response. ... …
GSTZ1 is also irreversibly inactivated by DCA. In the first clinical trial of DCA in a hematological malignancy, DiCAM (DiChloroAceta …
Signaling metabolite succinylacetone activates HIF-1alpha and promotes angiogenesis in GSTZ1-deficient hepatocellular carcinoma.
Luo H, Wang Q, Yang F, Liu R, Gao Q, Cheng B, Lin X, Huang L, Chen C, Xiang J, Wang K, Qin B, Tang N. Luo H, et al. JCI Insight. 2023 Oct 31;8(23):e164968. doi: 10.1172/jci.insight.164968. JCI Insight. 2023. PMID: 37906252 Free PMC article.
Here, we reported that deficiency of the enzyme in phenylalanine/tyrosine catabolism, glutathione S-transferase zeta 1 (GSTZ1), led to accumulation of succinylacetone, which was structurally similar to alpha-ketoglutarate. ...Moreover, we explored the therapeutic potential …
Here, we reported that deficiency of the enzyme in phenylalanine/tyrosine catabolism, glutathione S-transferase zeta 1 (GSTZ1), led t …
GSTZ1 expression and chloride concentrations modulate sensitivity of cancer cells to dichloroacetate.
Jahn SC, Solayman MH, Lorenzo RJ, Langaee T, Stacpoole PW, James MO. Jahn SC, et al. Biochim Biophys Acta. 2016 Jun;1860(6):1202-10. doi: 10.1016/j.bbagen.2016.01.024. Epub 2016 Feb 2. Biochim Biophys Acta. 2016. PMID: 26850694 Free PMC article.
The cellular concentration of chloride, an ion that influences the stability of GSTZ1 in the presence of DCA, was also found to be abnormal in tumors, with consistently higher concentrations in hepatocellular carcinoma than in surrounding non-tumor tissue. Finally, results …
The cellular concentration of chloride, an ion that influences the stability of GSTZ1 in the presence of DCA, was also found to be ab …
Age-Related Changes in miRNA Expression Influence GSTZ1 and Other Drug Metabolizing Enzymes.
Jahn SC, Gay LA, Weaver CJ, Renne R, Langaee TY, Stacpoole PW, James MO. Jahn SC, et al. Drug Metab Dispos. 2020 Jul;48(7):563-569. doi: 10.1124/dmd.120.090639. Epub 2020 May 1. Drug Metab Dispos. 2020. PMID: 32357971 Free PMC article.
However, the mechanism regulating this change of expression is still unknown, and previous studies showed that GSTZ1 mRNA levels did not correlate with GSTZ1 protein expression. ...Using cell culture, we confirmed that miR-376c-3p could downregulate GSTZ1 pro …
However, the mechanism regulating this change of expression is still unknown, and previous studies showed that GSTZ1 mRNA levels did …
146 results