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Items: 1 to 50 of 60

1.

The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability.

Huang Y, Mouttet B, Warnatz HJ, Risch T, Rietmann F, Frommelt F, Ngo QA, Dobay MP, Marovca B, Jenni S, Tsai YC, Matzk S, Amstislavskiy V, Schrappe M, Stanulla M, Gstaiger M, Bornhauser B, Yaspo ML, Bourquin JP.

Cancer Cell. 2019 Nov 1. pii: S1535-6108(19)30478-7. doi: 10.1016/j.ccell.2019.10.004. [Epub ahead of print]

PMID:
31735627
2.

Elucidating essential kinases of endothelin signalling by logic modelling of phosphoproteomics data.

Schäfer A, Gjerga E, Welford RW, Renz I, Lehembre F, Groenen PM, Saez-Rodriguez J, Aebersold R, Gstaiger M.

Mol Syst Biol. 2019 Aug;15(8):e8828. doi: 10.15252/msb.20198828.

3.

Quantitative Interactomics in Primary T Cells Provides a Rationale for Concomitant PD-1 and BTLA Coinhibitor Blockade in Cancer Immunotherapy.

Celis-Gutierrez J, Blattmann P, Zhai Y, Jarmuzynski N, Ruminski K, Grégoire C, Ounoughene Y, Fiore F, Aebersold R, Roncagalli R, Gstaiger M, Malissen B.

Cell Rep. 2019 Jun 11;27(11):3315-3330.e7. doi: 10.1016/j.celrep.2019.05.041.

4.

BRAF inhibition sensitizes melanoma cells to α-amanitin via decreased RNA polymerase II assembly.

Frischknecht L, Britschgi C, Galliker P, Christinat Y, Vichalkovski A, Gstaiger M, Kovacs WJ, Krek W.

Sci Rep. 2019 May 23;9(1):7779. doi: 10.1038/s41598-019-44112-7.

5.

ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail.

Bertran MT, Mouilleron S, Zhou Y, Bajaj R, Uliana F, Kumar GS, van Drogen A, Lee R, Banerjee JJ, Hauri S, O'Reilly N, Gstaiger M, Page R, Peti W, Tapon N.

Nat Commun. 2019 Feb 15;10(1):771. doi: 10.1038/s41467-019-08686-0.

6.

Complex-centric proteome profiling by SEC-SWATH-MS.

Heusel M, Bludau I, Rosenberger G, Hafen R, Frank M, Banaei-Esfahani A, van Drogen A, Collins BC, Gstaiger M, Aebersold R.

Mol Syst Biol. 2019 Jan 14;15(1):e8438. doi: 10.15252/msb.20188438.

7.

AP-SWATH Reveals Direct Involvement of VCP/p97 in Integrated Stress Response Signaling Through Facilitating CReP/PPP1R15B Degradation.

Hülsmann J, Kravic B, Weith M, Gstaiger M, Aebersold R, Collins BC, Meyer H.

Mol Cell Proteomics. 2018 Jul;17(7):1295-1307. doi: 10.1074/mcp.RA117.000471. Epub 2018 Mar 29.

8.

Meru couples planar cell polarity with apical-basal polarity during asymmetric cell division.

Banerjee JJ, Aerne BL, Holder MV, Hauri S, Gstaiger M, Tapon N.

Elife. 2017 Jun 30;6. pii: e25014. doi: 10.7554/eLife.25014.

9.

Precise Temporal Profiling of Signaling Complexes in Primary Cells Using SWATH Mass Spectrometry.

Caron E, Roncagalli R, Hase T, Wolski WE, Choi M, Menoita MG, Durand S, García-Blesa A, Fierro-Monti I, Sajic T, Heusel M, Weiss T, Malissen M, Schlapbach R, Collins BC, Ghosh S, Kitano H, Aebersold R, Malissen B, Gstaiger M.

Cell Rep. 2017 Mar 28;18(13):3219-3226. doi: 10.1016/j.celrep.2017.03.019.

10.

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.

Yadav L, Tamene F, Göös H, van Drogen A, Katainen R, Aebersold R, Gstaiger M, Varjosalo M.

Cell Syst. 2017 Apr 26;4(4):430-444.e5. doi: 10.1016/j.cels.2017.02.011. Epub 2017 Mar 18.

11.

Contribution of Mass Spectrometry-Based Proteomics to the Understanding of TNF-α Signaling.

Ciuffa R, Caron E, Leitner A, Uliana F, Gstaiger M, Aebersold R.

J Proteome Res. 2017 Jan 6;16(1):14-33. doi: 10.1021/acs.jproteome.6b00728. Epub 2016 Oct 20. Review.

PMID:
27762135
12.

A High-Density Map for Navigating the Human Polycomb Complexome.

Hauri S, Comoglio F, Seimiya M, Gerstung M, Glatter T, Hansen K, Aebersold R, Paro R, Gstaiger M, Beisel C.

Cell Rep. 2016 Oct 4;17(2):583-595. doi: 10.1016/j.celrep.2016.08.096.

13.

The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles.

Orme MH, Liccardi G, Moderau N, Feltham R, Wicky-John S, Tenev T, Aram L, Wilson R, Bianchi K, Morris O, Monteiro Domingues C, Robertson D, Tare M, Wepf A, Williams D, Bergmann A, Gstaiger M, Arama E, Ribeiro PS, Meier P.

Nat Commun. 2016 Mar 10;7:10972. doi: 10.1038/ncomms10972.

14.

An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client.

Bigenzahn JW, Fauster A, Rebsamen M, Kandasamy RK, Scorzoni S, Vladimer GI, Müller AC, Gstaiger M, Zuber J, Bennett KL, Superti-Furga G.

Mol Cell Proteomics. 2016 Mar;15(3):1139-50. doi: 10.1074/mcp.O115.055350 .

15.

Assessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation.

Marcon E, Jain H, Bhattacharya A, Guo H, Phanse S, Pu S, Byram G, Collins BC, Dowdell E, Fenner M, Guo X, Hutchinson A, Kennedy JJ, Krastins B, Larsen B, Lin ZY, Lopez MF, Loppnau P, Miersch S, Nguyen T, Olsen JB, Paduch M, Ravichandran M, Seitova A, Vadali G, Vogelsang MS, Whiteaker JR, Zhong G, Zhong N, Zhao L, Aebersold R, Arrowsmith CH, Emili A, Frappier L, Gingras AC, Gstaiger M, Paulovich AG, Koide S, Kossiakoff AA, Sidhu SS, Wodak SJ, Gräslund S, Greenblatt JF, Edwards AM.

Nat Methods. 2015 Aug;12(8):725-31. doi: 10.1038/nmeth.3472. Epub 2015 Jun 29.

PMID:
26121405
16.

Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub.

Roncagalli R, Hauri S, Fiore F, Liang Y, Chen Z, Sansoni A, Kanduri K, Joly R, Malzac A, Lähdesmäki H, Lahesmaa R, Yamasaki S, Saito T, Malissen M, Aebersold R, Gstaiger M, Malissen B.

Nat Immunol. 2014 Apr;15(4):384-392. doi: 10.1038/ni.2843. Epub 2014 Mar 2.

17.

Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1.

Hauri S, Wepf A, van Drogen A, Varjosalo M, Tapon N, Aebersold R, Gstaiger M.

Mol Syst Biol. 2013 Dec 22;9:713. doi: 10.1002/msb.201304750. Print 2013.

18.

Quantifying protein interaction dynamics by SWATH mass spectrometry: application to the 14-3-3 system.

Collins BC, Gillet LC, Rosenberger G, Röst HL, Vichalkovski A, Gstaiger M, Aebersold R.

Nat Methods. 2013 Dec;10(12):1246-53. doi: 10.1038/nmeth.2703. Epub 2013 Oct 27.

PMID:
24162925
19.

The CRAPome: a contaminant repository for affinity purification-mass spectrometry data.

Mellacheruvu D, Wright Z, Couzens AL, Lambert JP, St-Denis NA, Li T, Miteva YV, Hauri S, Sardiu ME, Low TY, Halim VA, Bagshaw RD, Hubner NC, Al-Hakim A, Bouchard A, Faubert D, Fermin D, Dunham WH, Goudreault M, Lin ZY, Badillo BG, Pawson T, Durocher D, Coulombe B, Aebersold R, Superti-Furga G, Colinge J, Heck AJ, Choi H, Gstaiger M, Mohammed S, Cristea IM, Bennett KL, Washburn MP, Raught B, Ewing RM, Gingras AC, Nesvizhskii AI.

Nat Methods. 2013 Aug;10(8):730-6. doi: 10.1038/nmeth.2557. Epub 2013 Jul 7.

20.

EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion.

Sugiyama N, Gucciardo E, Tatti O, Varjosalo M, Hyytiäinen M, Gstaiger M, Lehti K.

J Cell Biol. 2013 Apr 29;201(3):467-84. doi: 10.1083/jcb.201205176.

21.

The protein interaction landscape of the human CMGC kinase group.

Varjosalo M, Keskitalo S, Van Drogen A, Nurkkala H, Vichalkovski A, Aebersold R, Gstaiger M.

Cell Rep. 2013 Apr 25;3(4):1306-20. doi: 10.1016/j.celrep.2013.03.027. Epub 2013 Apr 18.

22.

Genotype-phenotype relationships in light of a modular protein interaction landscape.

Gstaiger M, Aebersold R.

Mol Biosyst. 2013 Jun;9(6):1064-7. doi: 10.1039/c3mb25583b. Epub 2013 Mar 26.

PMID:
23529396
23.

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.

Varjosalo M, Sacco R, Stukalov A, van Drogen A, Planyavsky M, Hauri S, Aebersold R, Bennett KL, Colinge J, Gstaiger M, Superti-Furga G.

Nat Methods. 2013 Apr;10(4):307-14. doi: 10.1038/nmeth.2400. Epub 2013 Mar 3.

PMID:
23455922
24.

Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition.

Berti M, Ray Chaudhuri A, Thangavel S, Gomathinayagam S, Kenig S, Vujanovic M, Odreman F, Glatter T, Graziano S, Mendoza-Maldonado R, Marino F, Lucic B, Biasin V, Gstaiger M, Aebersold R, Sidorova JM, Monnat RJ Jr, Lopes M, Vindigni A.

Nat Struct Mol Biol. 2013 Mar;20(3):347-54. doi: 10.1038/nsmb.2501. Epub 2013 Feb 10.

25.

A method to resolve the composition of heterogeneous affinity-purified protein complexes assembled around a common protein by chemical cross-linking, gel electrophoresis and mass spectrometry.

Rudashevskaya EL, Sacco R, Kratochwill K, Huber ML, Gstaiger M, Superti-Furga G, Bennett KL.

Nat Protoc. 2013 Jan;8(1):75-97. doi: 10.1038/nprot.2012.133. Epub 2012 Dec 13.

PMID:
23237831
26.

Regulation of PTEN activity by p38δ-PKD1 signaling in neutrophils confers inflammatory responses in the lung.

Ittner A, Block H, Reichel CA, Varjosalo M, Gehart H, Sumara G, Gstaiger M, Krombach F, Zarbock A, Ricci R.

J Exp Med. 2012 Nov 19;209(12):2229-46. doi: 10.1084/jem.20120677. Epub 2012 Nov 5.

27.

Bacterial effector binds host cell adenylyl cyclase to potentiate Gαs-dependent cAMP production.

Pulliainen AT, Pieles K, Brand CS, Hauert B, Böhm A, Quebatte M, Wepf A, Gstaiger M, Aebersold R, Dessauer CW, Dehio C.

Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9581-6. doi: 10.1073/pnas.1117651109. Epub 2012 May 25.

28.

SAINT-MS1: protein-protein interaction scoring using label-free intensity data in affinity purification-mass spectrometry experiments.

Choi H, Glatter T, Gstaiger M, Nesvizhskii AI.

J Proteome Res. 2012 Apr 6;11(4):2619-24. doi: 10.1021/pr201185r. Epub 2012 Mar 2.

29.

Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome.

Glatter T, Schittenhelm RB, Rinner O, Roguska K, Wepf A, Jünger MA, Köhler K, Jevtov I, Choi H, Schmidt A, Nesvizhskii AI, Stocker H, Hafen E, Aebersold R, Gstaiger M.

Mol Syst Biol. 2011 Nov 8;7:547. doi: 10.1038/msb.2011.79.

30.

Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations.

Ritz D, Vuk M, Kirchner P, Bug M, Schütz S, Hayer A, Bremer S, Lusk C, Baloh RH, Lee H, Glatter T, Gstaiger M, Aebersold R, Weihl CC, Meyer H.

Nat Cell Biol. 2011 Aug 7;13(9):1116-23. doi: 10.1038/ncb2301.

31.

The oxygen sensor PHD3 limits glycolysis under hypoxia via direct binding to pyruvate kinase.

Chen N, Rinner O, Czernik D, Nytko KJ, Zheng D, Stiehl DP, Zamboni N, Gstaiger M, Frei C.

Cell Res. 2011 Jun;21(6):983-6. doi: 10.1038/cr.2011.66. Epub 2011 Apr 12. No abstract available.

32.

Tandem affinity purification combined with inducible shRNA expression as a tool to study the maturation of macromolecular assemblies.

Wyler E, Zimmermann M, Widmann B, Gstaiger M, Pfannstiel J, Kutay U, Zemp I.

RNA. 2011 Jan;17(1):189-200. doi: 10.1261/rna.2325911. Epub 2010 Nov 19.

33.

Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling.

Ribeiro PS, Josué F, Wepf A, Wehr MC, Rinner O, Kelly G, Tapon N, Gstaiger M.

Mol Cell. 2010 Aug 27;39(4):521-34. doi: 10.1016/j.molcel.2010.08.002.

34.

The dASPP-dRASSF8 complex regulates cell-cell adhesion during Drosophila retinal morphogenesis.

Langton PF, Colombani J, Chan EH, Wepf A, Gstaiger M, Tapon N.

Curr Biol. 2009 Dec 15;19(23):1969-78. doi: 10.1016/j.cub.2009.10.027.

35.

Applying mass spectrometry-based proteomics to genetics, genomics and network biology.

Gstaiger M, Aebersold R.

Nat Rev Genet. 2009 Sep;10(9):617-27. doi: 10.1038/nrg2633. Review.

PMID:
19687803
36.

Comparative profiling identifies C13orf3 as a component of the Ska complex required for mammalian cell division.

Theis M, Slabicki M, Junqueira M, Paszkowski-Rogacz M, Sontheimer J, Kittler R, Heninger AK, Glatter T, Kruusmaa K, Poser I, Hyman AA, Pisabarro MT, Gstaiger M, Aebersold R, Shevchenko A, Buchholz F.

EMBO J. 2009 May 20;28(10):1453-65. doi: 10.1038/emboj.2009.114. Epub 2009 Apr 23.

37.

NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase.

Habjan M, Pichlmair A, Elliott RM, Overby AK, Glatter T, Gstaiger M, Superti-Furga G, Unger H, Weber F.

J Virol. 2009 May;83(9):4365-75. doi: 10.1128/JVI.02148-08. Epub 2009 Feb 11.

38.

Quantitative interaction proteomics using mass spectrometry.

Wepf A, Glatter T, Schmidt A, Aebersold R, Gstaiger M.

Nat Methods. 2009 Mar;6(3):203-5. doi: 10.1038/nmeth.1302. Epub 2009 Feb 8.

PMID:
19198594
39.

An integrated workflow for charting the human interaction proteome: insights into the PP2A system.

Glatter T, Wepf A, Aebersold R, Gstaiger M.

Mol Syst Biol. 2009;5:237. doi: 10.1038/msb.2008.75. Epub 2009 Jan 20.

40.

PIMS modulates immune tolerance by negatively regulating Drosophila innate immune signaling.

Lhocine N, Ribeiro PS, Buchon N, Wepf A, Wilson R, Tenev T, Lemaitre B, Gstaiger M, Meier P, Leulier F.

Cell Host Microbe. 2008 Aug 14;4(2):147-58. doi: 10.1016/j.chom.2008.07.004.

41.

Quantitative proteomic analysis of protein complexes: concurrent identification of interactors and their state of phosphorylation.

Pflieger D, Jünger MA, Müller M, Rinner O, Lee H, Gehrig PM, Gstaiger M, Aebersold R.

Mol Cell Proteomics. 2008 Feb;7(2):326-46. Epub 2007 Oct 23.

42.

S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling.

Djouder N, Metzler SC, Schmidt A, Wirbelauer C, Gstaiger M, Aebersold R, Hess D, Krek W.

Mol Cell. 2007 Oct 12;28(1):28-40.

43.

Analysis of protein complexes using mass spectrometry.

Gingras AC, Gstaiger M, Raught B, Aebersold R.

Nat Rev Mol Cell Biol. 2007 Aug;8(8):645-54. Review.

PMID:
17593931
44.

An integrated mass spectrometric and computational framework for the analysis of protein interaction networks.

Rinner O, Mueller LN, Hubálek M, Müller M, Gstaiger M, Aebersold R.

Nat Biotechnol. 2007 Mar;25(3):345-52. Epub 2007 Feb 25.

PMID:
17322870
45.

The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase II.

Yart A, Gstaiger M, Wirbelauer C, Pecnik M, Anastasiou D, Hess D, Krek W.

Mol Cell Biol. 2005 Jun;25(12):5052-60.

46.

Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI.

Gstaiger M, Luke B, Hess D, Oakeley EJ, Wirbelauer C, Blondel M, Vigneron M, Peter M, Krek W.

Science. 2003 Nov 14;302(5648):1208-12.

47.

Open reading frame UL26 of human cytomegalovirus encodes a novel tegument protein that contains a strong transcriptional activation domain.

Stamminger T, Gstaiger M, Weinzierl K, Lorz K, Winkler M, Schaffner W.

J Virol. 2002 May;76(10):4836-47.

48.

Skp2 is oncogenic and overexpressed in human cancers.

Gstaiger M, Jordan R, Lim M, Catzavelos C, Mestan J, Slingerland J, Krek W.

Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5043-8. Epub 2001 Apr 17.

49.
50.

Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E.

Dealy MJ, Nguyen KV, Lo J, Gstaiger M, Krek W, Elson D, Arbeit J, Kipreos ET, Johnson RS.

Nat Genet. 1999 Oct;23(2):245-8.

PMID:
10508527

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