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Items: 22

1.

SYK inhibition blocks proliferation and migration of glioma cells and modifies the tumor microenvironment.

Moncayo G, Grzmil M, Smirnova T, Zmarz P, Huber RM, Hynx D, Kohler H, Wang Y, Hotz HR, Hynes NE, Keller G, Frank S, Merlo A, Hemmings BA.

Neuro Oncol. 2018 Apr 9;20(5):621-631. doi: 10.1093/neuonc/noy008.

2.

Inhibition of MNK pathways enhances cancer cell response to chemotherapy with temozolomide and targeted radionuclide therapy.

Grzmil M, Seebacher J, Hess D, Behe M, Schibli R, Moncayo G, Frank S, Hemmings BA.

Cell Signal. 2016 Sep;28(9):1412-21. doi: 10.1016/j.cellsig.2016.06.005. Epub 2016 Jun 8.

PMID:
27289018
3.

The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility.

Tang F, Gill J, Ficht X, Barthlott T, Cornils H, Schmitz-Rohmer D, Hynx D, Zhou D, Zhang L, Xue G, Grzmil M, Yang Z, Hergovich A, Hollaender GA, Stein JV, Hemmings BA, Matthias P.

Sci Signal. 2015 Oct 6;8(397):ra100. doi: 10.1126/scisignal.aab2425.

PMID:
26443704
4.

MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas.

Grzmil M, Huber RM, Hess D, Frank S, Hynx D, Moncayo G, Klein D, Merlo A, Hemmings BA.

J Clin Invest. 2014 Feb;124(2):742-54. doi: 10.1172/JCI70198. Epub 2014 Jan 9.

5.

Overcoming resistance to rapalogs in gliomas by combinatory therapies.

Grzmil M, Hemmings BA.

Biochim Biophys Acta. 2013 Jul;1834(7):1371-80. doi: 10.1016/j.bbapap.2013.01.041. Epub 2013 Feb 8. Review.

PMID:
23395884
6.

Translation regulation as a therapeutic target in cancer.

Grzmil M, Hemmings BA.

Cancer Res. 2012 Aug 15;72(16):3891-900. doi: 10.1158/0008-5472.CAN-12-0026. Epub 2012 Jul 31. Review.

7.

Constitutive Notch2 signaling in neural stem cells promotes tumorigenic features and astroglial lineage entry.

Tchorz JS, Tome M, Cloëtta D, Sivasankaran B, Grzmil M, Huber RM, Rutz-Schatzmann F, Kirchhoff F, Schaeren-Wiemers N, Gassmann M, Hemmings BA, Merlo A, Bettler B.

Cell Death Dis. 2012 Jun 21;3:e325. doi: 10.1038/cddis.2012.65.

8.

Mer receptor tyrosine kinase promotes invasion and survival in glioblastoma multiforme.

Wang Y, Moncayo G, Morin P Jr, Xue G, Grzmil M, Lino MM, Clément-Schatlo V, Frank S, Merlo A, Hemmings BA.

Oncogene. 2013 Feb 14;32(7):872-82. doi: 10.1038/onc.2012.104. Epub 2012 Apr 2.

PMID:
22469987
9.

MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-β signaling pathway in human glioblastoma.

Grzmil M, Morin P Jr, Lino MM, Merlo A, Frank S, Wang Y, Moncayo G, Hemmings BA.

Cancer Res. 2011 Mar 15;71(6):2392-402. doi: 10.1158/0008-5472.CAN-10-3112. Epub 2011 Mar 14.

10.

An oncogenic role of eIF3e/INT6 in human breast cancer.

Grzmil M, Rzymski T, Milani M, Harris AL, Capper RG, Saunders NJ, Salhan A, Ragoussis J, Norbury CJ.

Oncogene. 2010 Jul 15;29(28):4080-9. doi: 10.1038/onc.2010.152. Epub 2010 May 10.

PMID:
20453879
11.

Deregulated signalling networks in human brain tumours.

Grzmil M, Hemmings BA.

Biochim Biophys Acta. 2010 Mar;1804(3):476-83. doi: 10.1016/j.bbapap.2009.10.018. Epub 2009 Oct 29. Review.

PMID:
19879382
12.

Leupaxin, a novel coactivator of the androgen receptor, is expressed in prostate cancer and plays a role in adhesion and invasion of prostate carcinoma cells.

Kaulfuss S, Grzmil M, Hemmerlein B, Thelen P, Schweyer S, Neesen J, Bubendorf L, Glass AG, Jarry H, Auber B, Burfeind P.

Mol Endocrinol. 2008 Jul;22(7):1606-21. doi: 10.1210/me.2006-0546. Epub 2008 May 1.

13.

The INT6 cancer gene and MEK signaling pathways converge during zebrafish development.

Grzmil M, Whiting D, Maule J, Anastasaki C, Amatruda JF, Kelsh RN, Norbury CJ, Patton EE.

PLoS One. 2007 Sep 26;2(9):e959.

14.

Expression and functional analysis of Bax inhibitor-1 in human breast cancer cells.

Grzmil M, Kaulfuss S, Thelen P, Hemmerlein B, Schweyer S, Obenauer S, Kang TW, Burfeind P.

J Pathol. 2006 Feb;208(3):340-9.

PMID:
16353131
15.

Inhibition of telomerase activity and secretion of prostate specific antigen by silibinin in prostate cancer cells.

Thelen P, Wuttke W, Jarry H, Grzmil M, Ringert RH.

J Urol. 2004 May;171(5):1934-8.

PMID:
15076315
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A new type of congenital disorders of glycosylation (CDG-Ii) provides new insights into the early steps of dolichol-linked oligosaccharide biosynthesis.

Thiel C, Schwarz M, Peng J, Grzmil M, Hasilik M, Braulke T, Kohlschütter A, von Figura K, Lehle L, Körner C.

J Biol Chem. 2003 Jun 20;278(25):22498-505. Epub 2003 Apr 8.

21.

Identification of the human ortholog of the t-complex-encoded protein TCTE3 and evaluation as a candidate gene for primary ciliary dyskinesia.

Neesen J, Drenckhahn JD, Tiede S, Burfeind P, Grzmil M, Konietzko J, Dixkens C, Kreutzberger J, Laccone F, Omran H.

Cytogenet Genome Res. 2002;98(1):38-44.

PMID:
12584439
22.

Identification and characterization of murine Brunol4, a new member of the elav/bruno family.

Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Gläser B, Grzmil M, Burfeind P, Laccone F.

Cytogenet Genome Res. 2002;97(3-4):254-60.

PMID:
12438720

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