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Items: 1 to 50 of 53

1.

Inhibiting the copper efflux system in microbes as a novel approach for developing antibiotics.

Meir A, Lepechkin-Zilbermintz V, Kahremany S, Schwerdtfeger F, Gevorkyan-Airapetov L, Munder A, Viskind O, Gruzman A, Ruthstein S.

PLoS One. 2019 Dec 30;14(12):e0227070. doi: 10.1371/journal.pone.0227070. eCollection 2019.

2.

The lipophilic 4-phenylbutyric acid derivative prevents aggregation and retention of misfolded proteins.

Azoulay-Ginsburg S, Trobiani L, Setini A, Favaloro FL, Giorda E, Jacobs A, Hauschner H, Levy L, Cestra G, De Jaco A, Gruzman A.

Chemistry. 2019 Nov 27. doi: 10.1002/chem.201904292. [Epub ahead of print]

PMID:
31773792
3.

Novel inhibitors of leukocyte transendothelial migration.

Getter T, Margalit R, Kahremany S, Levy L, Blum E, Khazanov N, Keshet-Levy NY, Tamir TY, Ben Major M, Lahav R, Zilber S, Senderowitz H, Bradfield P, Imhof BA, Alpert E, Gruzman A.

Bioorg Chem. 2019 Nov;92:103250. doi: 10.1016/j.bioorg.2019.103250. Epub 2019 Sep 9.

PMID:
31580982
4.

Nrf2 Activation by SK-119 Attenuates Oxidative Stress, UVB, and LPS-Induced Damage.

Kahremany S, Babaev I, Gvirtz R, Ogen-Stern N, Azoulay-Ginsburg S, Senderowitz H, Cohen G, Gruzman A.

Skin Pharmacol Physiol. 2019;32(4):173-181. doi: 10.1159/000499432. Epub 2019 May 10.

PMID:
31079103
5.

Neuroligin-2-derived peptide-covered polyamidoamine-based (PAMAM) dendrimers enhance pancreatic β-cells' proliferation and functions.

Munder A, Moskovitz Y, Meir A, Kahremany S, Levy L, Kolitz-Domb M, Cohen G, Shtriker E, Viskind O, Lellouche JP, Senderowitz H, Chessler SD, Korshin EE, Ruthstein S, Gruzman A.

Medchemcomm. 2018 Dec 13;10(2):280-293. doi: 10.1039/c8md00419f. eCollection 2019 Feb 1.

6.

Structurally Simple, Readily Available Peptidomimetic 1-Benzyl-5-methyl-4-( n-octylamino)pyrimidin-2(1 H)-one Exhibited Efficient Cardioprotection in a Myocardial Ischemia (MI) Mouse Model.

Trifonov L, Nudelman V, Zhenin M, Matsree E, Afri M, Schmerling B, Cohen G, Jozwiak K, Weitman M, Korshin E, Senderowitz H, Shainberg A, Hochhauser E, Gruzman A.

J Med Chem. 2018 Dec 27;61(24):11309-11326. doi: 10.1021/acs.jmedchem.8b01471. Epub 2018 Dec 11.

PMID:
30507195
7.

An Expedient Synthesis of CMF-019: (S)-5-Methyl-3-{1-(pentan-3-yl)-2- (thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamido}hexanoic Acid, a Potent Apelin Receptor (APJ) Agonist.

Trifonov L, Afri M, Palczewski K, Korshin EE, Gruzman A.

Med Chem. 2018;14(7):688-694. doi: 10.2174/1573406414666180412154952.

PMID:
29651942
8.

A Novel Phenylchromane Derivative Increases the Rate of Glucose Uptake in L6 Myotubes and Augments Insulin Secretion from Pancreatic Beta-Cells by Activating AMPK.

Rozentul N, Avrahami Y, Shubely M, Levy L, Munder A, Cohen G, Cerasi E, Sasson S, Gruzman A.

Pharm Res. 2017 Dec;34(12):2873-2890. doi: 10.1007/s11095-017-2271-7. Epub 2017 Oct 5.

PMID:
28983714
9.

Supportive data on the regulation of GLUT4 activity by 3-O-methyl-D-glucose.

Shamni O, Cohen G, Gruzman A, Zaid H, Klip A, Cerasi E, Sasson S.

Data Brief. 2017 Jul 28;14:329-336. doi: 10.1016/j.dib.2017.07.069. eCollection 2017 Oct.

10.

Regulation of GLUT4 activity in myotubes by 3-O-methyl-d-glucose.

Shamni O, Cohen G, Gruzman A, Zaid H, Klip A, Cerasi E, Sasson S.

Biochim Biophys Acta Biomembr. 2017 Oct;1859(10):1900-1910. doi: 10.1016/j.bbamem.2017.06.013. Epub 2017 Jun 23.

11.

Mimicking Neuroligin-2 Functions in β-Cells by Functionalized Nanoparticles as a Novel Approach for Antidiabetic Therapy.

Munder A, Israel LL, Kahremany S, Ben-Shabat-Binyamini R, Zhang C, Kolitz-Domb M, Viskind O, Levine A, Senderowitz H, Chessler S, Lellouche JP, Gruzman A.

ACS Appl Mater Interfaces. 2017 Jan 18;9(2):1189-1206. doi: 10.1021/acsami.6b10568. Epub 2017 Jan 3.

12.

Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction.

Ben-Hail D, Begas-Shvartz R, Shalev M, Shteinfer-Kuzmine A, Gruzman A, Reina S, De Pinto V, Shoshan-Barmatz V.

J Biol Chem. 2016 Nov 25;291(48):24986-25003. Epub 2016 Oct 13.

13.

Design and synthesis of novel protein kinase R (PKR) inhibitors.

Weintraub S, Yarnitzky T, Kahremany S, Barrera I, Viskind O, Rosenblum K, Niv MY, Gruzman A.

Mol Divers. 2016 Nov;20(4):805-819. Epub 2016 Aug 1.

PMID:
27480630
14.

A versatile water-soluble chelating and radical scavenging platform.

Eckshtain-Levi M, Lavi R, Yufit DS, Daniel B, Green O, Fleker O, Richman M, Rahimipour S, Gruzman A, Benisvy L.

Chem Commun (Camb). 2016 Feb 7;52(11):2350-3. doi: 10.1039/c5cc08198j.

PMID:
26731129
15.

SOD mimetic activity and antiproliferative properties of a novel tetra nuclear copper (II) complex.

Weintraub S, Moskovitz Y, Fleker O, Levy AR, Meir A, Ruthstein S, Benisvy L, Gruzman A.

J Biol Inorg Chem. 2015 Dec;20(8):1287-98. doi: 10.1007/s00775-015-1307-x. Epub 2015 Nov 7.

PMID:
26547749
16.

A DJ-1 Based Peptide Attenuates Dopaminergic Degeneration in Mice Models of Parkinson's Disease via Enhancing Nrf2.

Lev N, Barhum Y, Ben-Zur T, Aharony I, Trifonov L, Regev N, Melamed E, Gruzman A, Offen D.

PLoS One. 2015 May 29;10(5):e0127549. doi: 10.1371/journal.pone.0127549. eCollection 2015.

17.

A chemical chaperone-based drug candidate is effective in a mouse model of amyotrophic lateral sclerosis (ALS).

Getter T, Zaks I, Barhum Y, Ben-Zur T, Böselt S, Gregoire S, Viskind O, Shani T, Gottlieb H, Green O, Shubely M, Senderowitz H, Israelson A, Kwon I, Petri S, Offen D, Gruzman A.

ChemMedChem. 2015 May;10(5):850-61. doi: 10.1002/cmdc.201500045. Epub 2015 Mar 13.

PMID:
25772747
18.

Antiproliferative Effect of Novel Aminoacridine-based Compounds.

Munder A, Moskovitz Y, Redko B, Levy AR, Ruthstein S, Gellerman G, Gruzman A.

Med Chem. 2015;11(4):373-82.

PMID:
25524547
19.

Activation of PPARδ: from computer modelling to biological effects.

Kahremany S, Livne A, Gruzman A, Senderowitz H, Sasson S.

Br J Pharmacol. 2015 Feb;172(3):754-70. doi: 10.1111/bph.12950. Epub 2014 Dec 15. Review.

20.

Activators of AMPK: not just for type II diabetes.

Zaks I, Getter T, Gruzman A.

Future Med Chem. 2014 Jul;6(11):1325-53. doi: 10.4155/fmc.14.74. Review.

PMID:
25163002
21.

Benzothiazole derivatives augment glucose uptake in skeletal muscle cells and stimulate insulin secretion from pancreatic β-cells via AMPK activation.

Pasternak L, Meltzer-Mats E, Babai-Shani G, Cohen G, Viskind O, Eckel J, Cerasi E, Sasson S, Gruzman A.

Chem Commun (Camb). 2014 Oct 4;50(76):11222-5. doi: 10.1039/c4cc03310h.

PMID:
25116279
22.

Multifunctional cyclic D,L-α-peptide architectures stimulate non-insulin dependent glucose uptake in skeletal muscle cells and protect them against oxidative stress.

Shapira R, Rudnick S, Daniel B, Viskind O, Aisha V, Richman M, Ayasolla KR, Perelman A, Chill JH, Gruzman A, Rahimipour S.

J Med Chem. 2013 Sep 12;56(17):6709-18. doi: 10.1021/jm4005225. Epub 2013 Aug 28.

PMID:
23984871
23.

Riluzole increases the rate of glucose transport in L6 myotubes and NSC-34 motor neuron-like cells via AMPK pathway activation.

Daniel B, Green O, Viskind O, Gruzman A.

Amyotroph Lateral Scler Frontotemporal Degener. 2013 Sep;14(5-6):434-43. doi: 10.3109/21678421.2013.808226. Epub 2013 Jul 8.

PMID:
23834207
24.

Synthesis and mechanism of hypoglycemic activity of benzothiazole derivatives.

Meltzer-Mats E, Babai-Shani G, Pasternak L, Uritsky N, Getter T, Viskind O, Eckel J, Cerasi E, Senderowitz H, Sasson S, Gruzman A.

J Med Chem. 2013 Jul 11;56(13):5335-50. doi: 10.1021/jm4001488. Epub 2013 Jun 26.

PMID:
23750537
25.

Antihyperglycaemic activity of 2,4:3,5-dibenzylidene-D-xylose-diethyl dithioacetal in diabetic mice.

Gruzman A, Elgart A, Viskind O, Billauer H, Dotan S, Cohen G, Mishani E, Hoffman A, Cerasi E, Sasson S.

J Cell Mol Med. 2012 Mar;16(3):594-604. doi: 10.1111/j.1582-4934.2011.01340.x.

26.

Carbonic anhydrase I is recognized by an SOD1 antibody upon biotinylation of human spinal cord extracts.

Liu J, Akhavan A, Lu M, Gruzman A, Lingappa VR, An J, Bowser R.

Int J Mol Sci. 2010 Oct 20;11(10):4051-62. doi: 10.3390/ijms11104051.

27.

The natural protective mechanism against hyperglycemia in vascular endothelial cells: roles of the lipid peroxidation product 4-hydroxydodecadienal and peroxisome proliferator-activated receptor delta.

Riahi Y, Sin-Malia Y, Cohen G, Alpert E, Gruzman A, Eckel J, Staels B, Guichardant M, Sasson S.

Diabetes. 2010 Apr;59(4):808-18. doi: 10.2337/db09-1207. Epub 2010 Jan 27.

28.

Adenosine Monophosphate-Activated Protein Kinase (AMPK) as a New Target for Antidiabetic Drugs: A Review on Metabolic, Pharmacological and Chemical Considerations.

Gruzman A, Babai G, Sasson S.

Rev Diabet Stud. 2009 Spring;6(1):13-36. doi: 10.1900/RDS.2009.6.13. Epub 2009 May 10.

29.

Novel D-xylose derivatives stimulate muscle glucose uptake by activating AMP-activated protein kinase alpha.

Gruzman A, Shamni O, Ben Yakir M, Sandovski D, Elgart A, Alpert E, Cohen G, Hoffman A, Katzhendler Y, Cerasi E, Sasson S.

J Med Chem. 2008 Dec 25;51(24):8096-108. doi: 10.1021/jm8008713.

PMID:
19049348
30.

The roles of hyperglycaemia and oxidative stress in the rise and collapse of the natural protective mechanism against vascular endothelial cell dysfunction in diabetes.

Cohen G, Riahi Y, Alpert E, Gruzman A, Sasson S.

Arch Physiol Biochem. 2007 Oct-Dec;113(4-5):259-67. Review.

PMID:
18158647
31.

Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis.

Gruzman A, Wood WL, Alpert E, Prasad MD, Miller RG, Rothstein JD, Bowser R, Hamilton R, Wood TD, Cleveland DW, Lingappa VR, Liu J.

Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12524-9. Epub 2007 Jul 16.

32.

Selective cyclooxygenase-2 inhibitors stimulate glucose transport in L6 myotubes in a protein kinase Cdelta-dependent manner.

Alpert E, Gruzman A, Tennenbaum T, Sasson S.

Biochem Pharmacol. 2007 Feb 1;73(3):368-77. Epub 2006 Oct 13.

PMID:
17098211
33.

Cyclooxygenase-2 (PTGS2) inhibitors augment the rate of hexose transport in L6 myotubes in an insulin- and AMPKalpha-independent manner.

Alpert E, Gruzman A, Lardi-Studler B, Cohen G, Reich R, Sasson S.

Diabetologia. 2006 Mar;49(3):562-70. Epub 2006 Jan 31.

PMID:
16447059
34.

Delayed autoregulation of glucose transport in vascular endothelial cells.

Alpert E, Gruzman A, Riahi Y, Blejter R, Aharoni P, Weisinger G, Eckel J, Kaiser N, Sasson S.

Diabetologia. 2005 Apr;48(4):752-5. Epub 2005 Mar 1.

PMID:
15739115
35.

4-Hydroxy tempol-induced impairment of mitochondrial function and augmentation of glucose transport in vascular endothelial and smooth muscle cells.

Alpert E, Altman H, Totary H, Gruzman A, Barnea D, Barash V, Sasson S.

Biochem Pharmacol. 2004 May 15;67(10):1985-95.

PMID:
15130774
36.

Synthesis and characterization of new and potent alpha-lipoic acid derivatives.

Gruzman A, Hidmi A, Katzhendler J, Haj-Yehie A, Sasson S.

Bioorg Med Chem. 2004 Mar 1;12(5):1183-90.

PMID:
14980629
37.

Amelioration of TNBS-induced colon inflammation in rats by phospholipase A2 inhibitor.

Krimsky M, Yedgar S, Aptekar L, Schwob O, Goshen G, Gruzman A, Sasson S, Ligumsky M.

Am J Physiol Gastrointest Liver Physiol. 2003 Sep;285(3):G586-92. Epub 2003 Apr 30.

38.

Pardaxin stimulation of phospholipases A2 and their involvement in exocytosis in PC-12 cells.

Bloch-Shilderman E, Abu-Raya S, Trembovler V, Boschwitz H, Gruzman A, Linial M, Lazarovici P.

J Pharmacol Exp Ther. 2002 Jun;301(3):953-62.

PMID:
12023524
39.
40.

Eicosanoids participate in the regulation of cardiac glucose transport by contribution to a rearrangement of actin cytoskeletal elements.

Dransfeld O, Rakatzi I, Sasson S, Gruzman A, Schmitt M, Häussinger D, Eckel J.

Biochem J. 2001 Oct 1;359(Pt 1):47-54.

41.

[The effect of cerebrolysin intravenous injections in resistant forms of night enuresis in children].

Gruzman AV, Levina IN.

Zh Nevrol Psikhiatr Im S S Korsakova. 1998;98(11):46. Russian. No abstract available.

PMID:
9845942
42.

[The treatment of nocturnal enuresis in children].

Gruzman AV.

Zh Nevrol Psikhiatr Im S S Korsakova. 1997;97(8):26-8. Russian.

PMID:
9343478
43.

Residual pneumoperitoneum: a cause of postoperative pain after laparoscopic cholecystectomy.

Fredman B, Jedeikin R, Olsfanger D, Flor P, Gruzman A.

Anesth Analg. 1994 Jul;79(1):152-4.

PMID:
8010427
44.

[Carbohydrate metabolism in the brain in comatose states. Mechanisms of gluconeogenesis].

Gruzman AB, Khapiĭ KhKh.

Anesteziol Reanimatol. 1991 May-Jun;(3):17-21. Russian.

PMID:
1897787
45.

[The adult respiratory distress syndrome in eclampsia and eclamptic coma. The diagnostic problems].

Gruzman AB, Ashikhmina IG, Nefedova VO, Davydov VV.

Akush Ginekol (Mosk). 1991 Feb;(2):28-32. Russian. No abstract available.

PMID:
1862848
46.

[Carbohydrate metabolism in the brain in comatose states].

Khapiĭ KhKh, Gruzman AB.

Anesteziol Reanimatol. 1990 Nov-Dec;(6):27-9. Russian.

PMID:
2075925
47.

[Organization of intensive therapy of eclampsia and eclamptic coma].

Gruzman AB, Manevich LE, Rychkov EV.

Akush Ginekol (Mosk). 1990 Jul;(7):18-21. Russian.

PMID:
2240441
48.

[X-ray image of the lungs in patients subjected to auxiliary artificial respiration after thoracic surgery].

Veretennikova VP, Vorob'ev VM, Shapiro AI, Gruzman AB.

Vestn Rentgenol Radiol. 1975 Jan-Feb;(1):50-4. Russian. No abstract available.

PMID:
1198903
49.

[Use of artificial ventilation of the lungs in the internal disease clinic].

Smetnev AS, Iurevich VM, Korziuk LS, Iunusov IuM, Gruzman AB.

Ter Arkh. 1975;47(3):130-5. Russian. No abstract available.

PMID:
1065019
50.

Special devices for supportive artificial pulmonary ventilation.

Gruzman AB, Yurevich VM.

Biomed Eng (NY). 1974 Mar;7(3):166-8. No abstract available.

PMID:
4593695

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