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Items: 46


Cellular Control of Brain Capillary Blood Flow: In Vivo Imaging Veritas.

Grutzendler J, Nedergaard M.

Trends Neurosci. 2019 Aug;42(8):528-536. doi: 10.1016/j.tins.2019.05.009. Epub 2019 Jun 26. Review.


Uncovering the biology of myelin with optical imaging of the live brain.

Hill RA, Grutzendler J.

Glia. 2019 Nov;67(11):2008-2019. doi: 10.1002/glia.23635. Epub 2019 Apr 29. Review.


Publisher Correction: Flexible Learning-Free Segmentation and Reconstruction of Neural Volumes.

Shahbazi A, Kinnison J, Vescovi R, Du M, Hill R, Joesch M, Takeno M, Zeng H, da Costa NM, Grutzendler J, Kasthuri N, Scheirer WJ.

Sci Rep. 2018 Nov 29;8(1):17585. doi: 10.1038/s41598-018-36220-7.


Flexible Learning-Free Segmentation and Reconstruction of Neural Volumes.

Shahbazi A, Kinnison J, Vescovi R, Du M, Hill R, Joesch M, Takeno M, Zeng H, da Costa NM, Grutzendler J, Kasthuri N, Scheirer WJ.

Sci Rep. 2018 Sep 24;8(1):14247. doi: 10.1038/s41598-018-32628-3. Erratum in: Sci Rep. 2018 Nov 29;8(1):17585.


Lifelong cortical myelin plasticity and age-related degeneration in the live mammalian brain.

Hill RA, Li AM, Grutzendler J.

Nat Neurosci. 2018 May;21(5):683-695. doi: 10.1038/s41593-018-0120-6. Epub 2018 Mar 19.


Activation of pial and dural macrophages and dendritic cells by cortical spreading depression.

Schain AJ, Melo-Carrillo A, Borsook D, Grutzendler J, Strassman AM, Burstein R.

Ann Neurol. 2018 Mar;83(3):508-521. doi: 10.1002/ana.25169. Epub 2018 Mar 13.


Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging.

Condello C, Yuan P, Grutzendler J.

Biol Psychiatry. 2018 Feb 15;83(4):377-387. doi: 10.1016/j.biopsych.2017.10.007. Epub 2017 Oct 14. Review.


Oxalate-curcumin-based probe for micro- and macroimaging of reactive oxygen species in Alzheimer's disease.

Yang J, Zhang X, Yuan P, Yang J, Xu Y, Grutzendler J, Shao Y, Moore A, Ran C.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12384-12389. doi: 10.1073/pnas.1706248114. Epub 2017 Nov 6.


Targeted two-photon chemical apoptotic ablation of defined cell types in vivo.

Hill RA, Damisah EC, Chen F, Kwan AC, Grutzendler J.

Nat Commun. 2017 Jun 16;8:15837. doi: 10.1038/ncomms15837.


A fluoro-Nissl dye identifies pericytes as distinct vascular mural cells during in vivo brain imaging.

Damisah EC, Hill RA, Tong L, Murray KN, Grutzendler J.

Nat Neurosci. 2017 Jul;20(7):1023-1032. doi: 10.1038/nn.4564. Epub 2017 May 15.


TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.

Yuan P, Condello C, Keene CD, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J.

Neuron. 2016 Oct 5;92(1):252-264. doi: 10.1016/j.neuron.2016.09.016. No abstract available.


TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.

Yuan P, Condello C, Keene CD, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J.

Neuron. 2016 May 18;90(4):724-39. doi: 10.1016/j.neuron.2016.05.003.


TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques.

Wang Y, Ulland TK, Ulrich JD, Song W, Tzaferis JA, Hole JT, Yuan P, Mahan TE, Shi Y, Gilfillan S, Cella M, Grutzendler J, DeMattos RB, Cirrito JR, Holtzman DM, Colonna M.

J Exp Med. 2016 May 2;213(5):667-75. doi: 10.1084/jem.20151948. Epub 2016 Apr 18.


Increased Nanoparticle Delivery to Brain Tumors by Autocatalytic Priming for Improved Treatment and Imaging.

Han L, Kong DK, Zheng MQ, Murikinati S, Ma C, Yuan P, Li L, Tian D, Cai Q, Ye C, Holden D, Park JH, Gao X, Thomas JL, Grutzendler J, Carson RE, Huang Y, Piepmeier JM, Zhou J.

ACS Nano. 2016 Apr 26;10(4):4209-18. doi: 10.1021/acsnano.5b07573. Epub 2016 Mar 16.


Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium.

Akassoglou K, Agalliu D, Chang CJ, Davalos D, Grutzendler J, Hillman EM, Khakh BS, Kleinfeld D, McGavern DB, Nelson SJ, Zlokovic BV.

Front Neurosci. 2016 Feb 22;10:46. doi: 10.3389/fnins.2016.00046. eCollection 2016.


Attenuation of β-Amyloid Deposition and Neurotoxicity by Chemogenetic Modulation of Neural Activity.

Yuan P, Grutzendler J.

J Neurosci. 2016 Jan 13;36(2):632-41. doi: 10.1523/JNEUROSCI.2531-15.2016.


Absolute two-photon excitation spectra of red and far-red fluorescent probes.

Velasco MG, Allgeyer ES, Yuan P, Grutzendler J, Bewersdorf J.

Opt Lett. 2015 Nov 1;40(21):4915-8. doi: 10.1364/OL.40.004915.


Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer's disease amyloid plaques.

Gowrishankar S, Yuan P, Wu Y, Schrag M, Paradise S, Grutzendler J, De Camilli P, Ferguson SM.

Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):E3699-708. doi: 10.1073/pnas.1510329112. Epub 2015 Jun 29.


Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes.

Hill RA, Tong L, Yuan P, Murikinati S, Gupta S, Grutzendler J.

Neuron. 2015 Jul 1;87(1):95-110. doi: 10.1016/j.neuron.2015.06.001. Epub 2015 Jun 25.


Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuli.

Housley WJ, Fernandez SD, Vera K, Murikinati SR, Grutzendler J, Cuerdon N, Glick L, De Jager PL, Mitrovic M, Cotsapas C, Hafler DA.

Sci Transl Med. 2015 Jun 10;7(291):291ra93. doi: 10.1126/scitranslmed.aaa9223.


Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques.

Condello C, Yuan P, Schain A, Grutzendler J.

Nat Commun. 2015 Jan 29;6:6176. doi: 10.1038/ncomms7176.


In vivo imaging of oligodendrocytes with sulforhodamine 101.

Hill RA, Grutzendler J.

Nat Methods. 2014 Nov;11(11):1081-2. doi: 10.1038/nmeth.3140. No abstract available.


Modulation of oligodendrocyte generation during a critical temporal window after NG2 cell division.

Hill RA, Patel KD, Goncalves CM, Grutzendler J, Nishiyama A.

Nat Neurosci. 2014 Nov;17(11):1518-27. doi: 10.1038/nn.3815. Epub 2014 Sep 28.


A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease.

Zhang X, Tian Y, Yuan P, Li Y, Yaseen MA, Grutzendler J, Moore A, Ran C.

Chem Commun (Camb). 2014 Oct 9;50(78):11550-3. doi: 10.1039/c4cc03731f.


Label-free in vivo imaging of myelinated axons in health and disease with spectral confocal reflectance microscopy.

Schain AJ, Hill RA, Grutzendler J.

Nat Med. 2014 Apr;20(4):443-9. doi: 10.1038/nm.3495. Epub 2014 Mar 30.


Angiophagy prevents early embolus washout but recanalizes microvessels through embolus extravasation.

Grutzendler J, Murikinati S, Hiner B, Ji L, Lam CK, Yoo T, Gupta S, Hafler BP, Adelman RA, Yuan P, Rodriguez G.

Sci Transl Med. 2014 Mar 5;6(226):226ra31. doi: 10.1126/scitranslmed.3006585.


Perturbed neural activity disrupts cerebral angiogenesis during a postnatal critical period.

Whiteus C, Freitas C, Grutzendler J.

Nature. 2014 Jan 16;505(7483):407-11. doi: 10.1038/nature12821. Epub 2013 Dec 4.


Angiophagy: mechanism of microvascular recanalization independent of the fibrinolytic system.

Grutzendler J.

Stroke. 2013 Jun;44(6 Suppl 1):S84-6. doi: 10.1161/STROKEAHA.112.678730. Review. No abstract available.


In vivo imaging of cerebral microvascular plasticity from birth to death.

Harb R, Whiteus C, Freitas C, Grutzendler J.

J Cereb Blood Flow Metab. 2013 Jan;33(1):146-56. doi: 10.1038/jcbfm.2012.152. Epub 2012 Oct 24.


Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition.

Condello C, Schain A, Grutzendler J.

Sci Rep. 2011;1:19. doi: 10.1038/srep00019. Epub 2011 Jun 21.


Transcranial two-photon imaging of the living mouse brain.

Grutzendler J, Yang G, Pan F, Parkhurst CN, Gan WB.

Cold Spring Harb Protoc. 2011 Sep 1;2011(9). pii: pdb.prot065474. doi: 10.1101/pdb.prot065474.


CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-β phagocytosis.

Liu Z, Condello C, Schain A, Harb R, Grutzendler J.

J Neurosci. 2010 Dec 15;30(50):17091-101. doi: 10.1523/JNEUROSCI.4403-10.2010.


Embolus extravasation is an alternative mechanism for cerebral microvascular recanalization.

Lam CK, Yoo T, Hiner B, Liu Z, Grutzendler J.

Nature. 2010 May 27;465(7297):478-82. doi: 10.1038/nature09001.


Ballistic delivery of dyes for structural and functional studies of the nervous system.

Gan WB, Grutzendler J, Wong RO, Lichtman JW.

Cold Spring Harb Protoc. 2009 Apr;2009(4):pdb.prot5202. doi: 10.1101/pdb.prot5202.


Thinned-skull cranial window technique for long-term imaging of the cortex in live mice.

Yang G, Pan F, Parkhurst CN, Grutzendler J, Gan WB.

Nat Protoc. 2010 Feb;5(2):201-8. doi: 10.1038/nprot.2009.222. Epub 2010 Jan 14.


Various dendritic abnormalities are associated with fibrillar amyloid deposits in Alzheimer's disease.

Grutzendler J, Helmin K, Tsai J, Gan WB.

Ann N Y Acad Sci. 2007 Feb;1097:30-9.


Long-term two-photon transcranial imaging of synaptic structures in the living brain.

Grutzendler J, Gan WB.

CSH Protoc. 2007 Jul 1;2007:pdb.prot4766. doi: 10.1101/pdb.prot4766.


Two-photon imaging of synaptic plasticity and pathology in the living mouse brain.

Grutzendler J, Gan WB.

NeuroRx. 2006 Oct;3(4):489-96. Review.


ATP mediates rapid microglial response to local brain injury in vivo.

Davalos D, Grutzendler J, Yang G, Kim JV, Zuo Y, Jung S, Littman DR, Dustin ML, Gan WB.

Nat Neurosci. 2005 Jun;8(6):752-8. Epub 2005 May 15.


Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches.

Tsai J, Grutzendler J, Duff K, Gan WB.

Nat Neurosci. 2004 Nov;7(11):1181-3. Epub 2004 Oct 10.


Age-associated synapse elimination in mouse parasympathetic ganglia.

Coggan JS, Grutzendler J, Bishop DL, Cook MR, Gan W, Heym J, Lichtman JW.

J Neurobiol. 2004 Aug;60(2):214-26.


Rapid labeling of neuronal populations by ballistic delivery of fluorescent dyes.

Grutzendler J, Tsai J, Gan WB.

Methods. 2003 May;30(1):79-85.


Long-term dendritic spine stability in the adult cortex.

Grutzendler J, Kasthuri N, Gan WB.

Nature. 2002 Dec 19-26;420(6917):812-6.


Cholinesterase inhibitors for Alzheimer's disease.

Grutzendler J, Morris JC.

Drugs. 2001;61(1):41-52. Review.


Two modes of radial migration in early development of the cerebral cortex.

Nadarajah B, Brunstrom JE, Grutzendler J, Wong RO, Pearlman AL.

Nat Neurosci. 2001 Feb;4(2):143-50.


Multicolor "DiOlistic" labeling of the nervous system using lipophilic dye combinations.

Gan WB, Grutzendler J, Wong WT, Wong RO, Lichtman JW.

Neuron. 2000 Aug;27(2):219-25.

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