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Items: 1 to 50 of 215

1.

Genetics, Biochemistry, and "Simple" Organisms Converge to Unlock Secrets in Histone Biology: The 2018 Albert Lasker Basic Medical Research Award.

Grunstein M, Allis CD.

JAMA. 2018 Sep 25;320(12):1233-1234. doi: 10.1001/jama.2018.12437. No abstract available.

PMID:
30208392
2.

Constitutively active signaling by the G protein βγ-subunit mediates intrinsically increased phosphodiesterase-4 activity in human asthmatic airway smooth muscle cells.

Hu A, Diener BL, Josephson MB, Grunstein MM.

PLoS One. 2015 Mar 5;10(3):e0118712. doi: 10.1371/journal.pone.0118712. eCollection 2015.

3.

Max Birnstiel 1933-2014: Gene pioneer.

Grunstein M, Bird A.

Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):302-3. doi: 10.1073/pnas.1423755112. Epub 2015 Jan 2. No abstract available.

4.

Smooth muscle hypercontractility in airway hyperresponsiveness: innate, acquired, or nonexistent?

Bossé Y, Rousseau E, Amrani Y, Grunstein MM.

J Allergy (Cairo). 2013;2013:938046. doi: 10.1155/2013/938046. Epub 2013 Jun 17. No abstract available.

5.

Epigenetics in Saccharomyces cerevisiae.

Grunstein M, Gasser SM.

Cold Spring Harb Perspect Biol. 2013 Jul 1;5(7). pii: a017491. doi: 10.1101/cshperspect.a017491. Review.

6.

Acetylated histone H3K56 interacts with Oct4 to promote mouse embryonic stem cell pluripotency.

Tan Y, Xue Y, Song C, Grunstein M.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11493-8. doi: 10.1073/pnas.1309914110. Epub 2013 Jun 24.

7.

Pro-asthmatic cytokines regulate unliganded and ligand-dependent glucocorticoid receptor signaling in airway smooth muscle.

Hu A, Josephson MB, Diener BL, Nino G, Xu S, Paranjape C, Orange JS, Grunstein MM.

PLoS One. 2013 Apr 4;8(4):e60452. doi: 10.1371/journal.pone.0060452. Print 2013.

8.

Mechanism for epigenetic variegation of gene expression at yeast telomeric heterochromatin.

Kitada T, Kuryan BG, Tran NN, Song C, Xue Y, Carey M, Grunstein M.

Genes Dev. 2012 Nov 1;26(21):2443-55. doi: 10.1101/gad.201095.112.

9.

IL-13-induced changes in endogenous glucocorticoid metabolism in the lung regulate the proasthmatic response.

Josephson MB, Jiao J, Xu S, Hu A, Paranjape C, Grunstein JS, Grumbach Y, Nino G, Kreiger PA, McDonough J, Grunstein MM.

Am J Physiol Lung Cell Mol Physiol. 2012 Sep;303(5):L382-90. doi: 10.1152/ajplung.00125.2012. Epub 2012 Jul 6.

10.

Histone H3 lysine 56 methylation regulates DNA replication through its interaction with PCNA.

Yu Y, Song C, Zhang Q, DiMaggio PA, Garcia BA, York A, Carey MF, Grunstein M.

Mol Cell. 2012 Apr 13;46(1):7-17. doi: 10.1016/j.molcel.2012.01.019. Epub 2012 Mar 1.

11.

G Protein βγ-subunit signaling mediates airway hyperresponsiveness and inflammation in allergic asthma.

Nino G, Hu A, Grunstein JS, McDonough J, Kreiger PA, Josephson MB, Choi JK, Grunstein MM.

PLoS One. 2012;7(2):e32078. doi: 10.1371/journal.pone.0032078. Epub 2012 Feb 22.

12.

The Rpd3 core complex is a chromatin stabilization module.

Chen XF, Kuryan B, Kitada T, Tran N, Li JY, Kurdistani S, Grunstein M, Li B, Carey M.

Curr Biol. 2012 Jan 10;22(1):56-63. doi: 10.1016/j.cub.2011.11.042. Epub 2011 Dec 15.

13.

Topoisomerase II binds nucleosome-free DNA and acts redundantly with topoisomerase I to enhance recruitment of RNA Pol II in budding yeast.

Sperling AS, Jeong KS, Kitada T, Grunstein M.

Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12693-8. doi: 10.1073/pnas.1106834108. Epub 2011 Jul 19.

14.

γH2A is a component of yeast heterochromatin required for telomere elongation.

Kitada T, Schleker T, Sperling AS, Xie W, Gasser SM, Grunstein M.

Cell Cycle. 2011 Jan 15;10(2):293-300. Epub 2011 Jan 15.

15.

Genome-wide mapping of histone modifications and mass spectrometry reveal H4 acetylation bias and H3K36 methylation at gene promoters in fission yeast.

Sinha I, Buchanan L, Rönnerblad M, Bonilla C, Durand-Dubief M, Shevchenko A, Grunstein M, Stewart AF, Ekwall K.

Epigenomics. 2010 Jun;2(3):377-93. doi: 10.2217/epi.10.18.

PMID:
22121899
16.

Mechanism of glucocorticoid protection of airway smooth muscle from proasthmatic effects of long-acting beta2-adrenoceptor agonist exposure.

Nino G, Hu A, Grunstein JS, Grunstein MM.

J Allergy Clin Immunol. 2010 May;125(5):1020-7. doi: 10.1016/j.jaci.2010.02.007. Epub 2010 Apr 14.

17.

Current concepts on the use of glucocorticosteroids and beta-2-adrenoreceptor agonists to treat childhood asthma.

Nino G, Grunstein MM.

Curr Opin Pediatr. 2010 Jun;22(3):290-5. doi: 10.1097/MOP.0b013e328337cb0c. Review.

18.

Variants of DENND1B associated with asthma in children.

Sleiman PM, Flory J, Imielinski M, Bradfield JP, Annaiah K, Willis-Owen SA, Wang K, Rafaels NM, Michel S, Bonnelykke K, Zhang H, Kim CE, Frackelton EC, Glessner JT, Hou C, Otieno FG, Santa E, Thomas K, Smith RM, Glaberson WR, Garris M, Chiavacci RM, Beaty TH, Ruczinski I, Orange JS, Allen J, Spergel JM, Grundmeier R, Mathias RA, Christie JD, von Mutius E, Cookson WO, Kabesch M, Moffatt MF, Grunstein MM, Barnes KC, Devoto M, Magnusson M, Li H, Grant SF, Bisgaard H, Hakonarson H.

N Engl J Med. 2010 Jan 7;362(1):36-44. doi: 10.1056/NEJMoa0901867. Epub 2009 Dec 23. Erratum in: N Engl J Med. 2010 Sep 2;363(10):994. N Engl J Med. 2012 Feb 16;366(7):672. Orange, Jordan M [corrected to Orange, Jordan S].

19.

Mechanism regulating proasthmatic effects of prolonged homologous beta2-adrenergic receptor desensitization in airway smooth muscle.

Nino G, Hu A, Grunstein JS, Grunstein MM.

Am J Physiol Lung Cell Mol Physiol. 2009 Oct;297(4):L746-57. doi: 10.1152/ajplung.00079.2009. Epub 2009 Aug 7.

20.

Histone H3 N-terminus regulates higher order structure of yeast heterochromatin.

Sperling AS, Grunstein M.

Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13153-9. doi: 10.1073/pnas.0906866106. Epub 2009 Aug 3.

21.

17q12-21 variants interact with smoke exposure as a risk factor for pediatric asthma but are equally associated with early-onset versus late-onset asthma in North Americans of European ancestry.

Flory JH, Sleiman PM, Christie JD, Annaiah K, Bradfield J, Kim CE, Glessner J, Imielinski M, Li H, Frackelton EC, Cuiping H, Otieno G, Thomas K, Smith R, Glaberson W, Garris M, Chiavacci R, Allen J, Spergel J, Grundmeier R, Grunstein M, Magnusson M, Grant SF, Bønnelykke K, Bisgaard H, Hakonarson H.

J Allergy Clin Immunol. 2009 Sep;124(3):605-7. doi: 10.1016/j.jaci.2009.05.047. Epub 2009 Aug 5. No abstract available.

PMID:
19660801
22.

Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures.

Chin MH, Mason MJ, Xie W, Volinia S, Singer M, Peterson C, Ambartsumyan G, Aimiuwu O, Richter L, Zhang J, Khvorostov I, Ott V, Grunstein M, Lavon N, Benvenisty N, Croce CM, Clark AT, Baxter T, Pyle AD, Teitell MA, Pelegrini M, Plath K, Lowry WE.

Cell Stem Cell. 2009 Jul 2;5(1):111-23. doi: 10.1016/j.stem.2009.06.008.

23.

Dissecting nucleosome free regions by a segmental semi-Markov model.

Sun W, Xie W, Xu F, Grunstein M, Li KC.

PLoS One. 2009;4(3):e4721. doi: 10.1371/journal.pone.0004721. Epub 2009 Mar 6.

24.

Th2 cytokine-induced upregulation of 11beta-hydroxysteroid dehydrogenase-1 facilitates glucocorticoid suppression of proasthmatic airway smooth muscle function.

Hu A, Fatma S, Cao J, Grunstein JS, Nino G, Grumbach Y, Grunstein MM.

Am J Physiol Lung Cell Mol Physiol. 2009 May;296(5):L790-803. doi: 10.1152/ajplung.90572.2008. Epub 2009 Feb 27.

25.

Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells.

Xie W, Song C, Young NL, Sperling AS, Xu F, Sridharan R, Conway AE, Garcia BA, Plath K, Clark AT, Grunstein M.

Mol Cell. 2009 Feb 27;33(4):417-27. doi: 10.1016/j.molcel.2009.02.004.

26.

A ncRNA modulates histone modification and mRNA induction in the yeast GAL gene cluster.

Houseley J, Rubbi L, Grunstein M, Tollervey D, Vogelauer M.

Mol Cell. 2008 Dec 5;32(5):685-95. doi: 10.1016/j.molcel.2008.09.027.

27.

Cell cycle- and chaperone-mediated regulation of H3K56ac incorporation in yeast.

Kaplan T, Liu CL, Erkmann JA, Holik J, Grunstein M, Kaufman PD, Friedman N, Rando OJ.

PLoS Genet. 2008 Nov;4(11):e1000270. doi: 10.1371/journal.pgen.1000270. Epub 2008 Nov 21.

28.

ORMDL3 variants associated with asthma susceptibility in North Americans of European ancestry.

Sleiman PM, Annaiah K, Imielinski M, Bradfield JP, Kim CE, Frackelton EC, Glessner JT, Eckert AW, Otieno FG, Santa E, Thomas K, Smith RM, Glaberson W, Garris M, Gunnlaugsson S, Chiavacci RM, Allen J, Spergel J, Grundmeier R, Grunstein MM, Magnusson M, Bisgaard H, Grant SF, Hakonarson H.

J Allergy Clin Immunol. 2008 Dec;122(6):1225-7. doi: 10.1016/j.jaci.2008.06.041. Epub 2008 Aug 28. No abstract available.

PMID:
18760456
29.

Adenovirus small e1a alters global patterns of histone modification.

Horwitz GA, Zhang K, McBrian MA, Grunstein M, Kurdistani SK, Berk AJ.

Science. 2008 Aug 22;321(5892):1084-5. doi: 10.1126/science.1155544.

30.

Prolonged heterologous beta2-adrenoceptor desensitization promotes proasthmatic airway smooth muscle function via PKA/ERK1/2-mediated phosphodiesterase-4 induction.

Hu A, Nino G, Grunstein JS, Fatma S, Grunstein MM.

Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1055-67. doi: 10.1152/ajplung.00021.2008. Epub 2008 Mar 21.

31.

Sir2 deacetylates histone H3 lysine 56 to regulate telomeric heterochromatin structure in yeast.

Xu F, Zhang Q, Zhang K, Xie W, Grunstein M.

Mol Cell. 2007 Sep 21;27(6):890-900.

32.

Specific functions for the fission yeast Sirtuins Hst2 and Hst4 in gene regulation and retrotransposon silencing.

Durand-Dubief M, Sinha I, Fagerström-Billai F, Bonilla C, Wright A, Grunstein M, Ekwall K.

EMBO J. 2007 May 16;26(10):2477-88. Epub 2007 Apr 19.

33.

Functions of site-specific histone acetylation and deacetylation.

Shahbazian MD, Grunstein M.

Annu Rev Biochem. 2007;76:75-100. Review.

PMID:
17362198
34.

Superantigen presentation by airway smooth muscle to CD4+ T lymphocytes elicits reciprocal proasthmatic changes in airway function.

Veler H, Hu A, Fatma S, Grunstein JS, DeStephan CM, Campbell D, Orange JS, Grunstein MM.

J Immunol. 2007 Mar 15;178(6):3627-36.

35.
36.

Genome-wide patterns of histone modifications in yeast.

Millar CB, Grunstein M.

Nat Rev Mol Cell Biol. 2006 Sep;7(9):657-66. Epub 2006 Aug 16. Review.

PMID:
16912715
37.

Regulation of Toll-like receptor 4-induced proasthmatic changes in airway smooth muscle function by opposing actions of ERK1/2 and p38 MAPK signaling.

Shan X, Hu A, Veler H, Fatma S, Grunstein JS, Chuang S, Grunstein MM.

Am J Physiol Lung Cell Mol Physiol. 2006 Sep;291(3):L324-33. Epub 2006 Mar 31.

38.

Acetylation of H2AZ Lys 14 is associated with genome-wide gene activity in yeast.

Millar CB, Xu F, Zhang K, Grunstein M.

Genes Dev. 2006 Mar 15;20(6):711-22.

39.

Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex.

Keogh MC, Kurdistani SK, Morris SA, Ahn SH, Podolny V, Collins SR, Schuldiner M, Chin K, Punna T, Thompson NJ, Boone C, Emili A, Weissman JS, Hughes TR, Strahl BD, Grunstein M, Greenblatt JF, Buratowski S, Krogan NJ.

Cell. 2005 Nov 18;123(4):593-605.

40.

Acetylation of yeast histone H4 lysine 16: a switch for protein interactions in heterochromatin and euchromatin.

Millar CB, Kurdistani SK, Grunstein M.

Cold Spring Harb Symp Quant Biol. 2004;69:193-200. Review. No abstract available.

PMID:
16117649
41.

Genomewide analysis of nucleosome density histone acetylation and HDAC function in fission yeast.

Wirén M, Silverstein RA, Sinha I, Walfridsson J, Lee HM, Laurenson P, Pillus L, Robyr D, Grunstein M, Ekwall K.

EMBO J. 2005 Aug 17;24(16):2906-18. Epub 2005 Aug 4.

42.

Histone H2B ubiquitylation controls processive methylation but not monomethylation by Dot1 and Set1.

Shahbazian MD, Zhang K, Grunstein M.

Mol Cell. 2005 Jul 22;19(2):271-7.

43.

Proasthmatic effects and mechanisms of action of the dust mite allergen, Der p 1, in airway smooth muscle.

Grunstein MM, Veler H, Shan X, Larson J, Grunstein JS, Chuang S.

J Allergy Clin Immunol. 2005 Jul;116(1):94-101.

PMID:
15990780
44.

Global histone modification patterns predict risk of prostate cancer recurrence.

Seligson DB, Horvath S, Shi T, Yu H, Tze S, Grunstein M, Kurdistani SK.

Nature. 2005 Jun 30;435(7046):1262-6.

PMID:
15988529
45.

Acetylation in histone H3 globular domain regulates gene expression in yeast.

Xu F, Zhang K, Grunstein M.

Cell. 2005 May 6;121(3):375-85.

46.

Role and regulation of interleukin-1 molecules in pro-asthmatic sensitised airway smooth muscle.

Whelan R, Kim C, Chen M, Leiter J, Grunstein MM, Hakonarson H.

Eur Respir J. 2004 Oct;24(4):559-67.

47.

Mapping global histone acetylation patterns to gene expression.

Kurdistani SK, Tavazoie S, Grunstein M.

Cell. 2004 Jun 11;117(6):721-33.

48.

Analysis of genome-wide histone acetylation state and enzyme binding using DNA microarrays.

Robyr D, Kurdistani SK, Grunstein M.

Methods Enzymol. 2004;376:289-304. No abstract available.

PMID:
14975313
49.

Centromere silencing and function in fission yeast is governed by the amino terminus of histone H3.

Mellone BG, Ball L, Suka N, Grunstein MR, Partridge JF, Allshire RC.

Curr Biol. 2003 Oct 14;13(20):1748-57.

50.

Autocrine regulation of airway smooth muscle responsiveness.

Hakonarson H, Grunstein MM.

Respir Physiol Neurobiol. 2003 Sep 16;137(2-3):263-76. Review.

PMID:
14516731

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