Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 212

1.

Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death.

Richards KL, Milligan CJ, Richardson RJ, Jancovski N, Grunnet M, Jacobson LH, Undheim EAB, Mobli M, Chow CY, Herzig V, Csoti A, Panyi G, Reid CA, King GF, Petrou S.

Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E8077-E8085. doi: 10.1073/pnas.1804764115. Epub 2018 Aug 3.

2.

Pharmacological rescue of mutated Kv3.1 ion-channel linked to progressive myoclonus epilepsies.

Munch AS, Saljic A, Boddum K, Grunnet M, Hougaard C, Jespersen T.

Eur J Pharmacol. 2018 Aug 15;833:255-262. doi: 10.1016/j.ejphar.2018.06.015. Epub 2018 Jun 9.

PMID:
29894724
3.

The multimodal antidepressant vortioxetine may facilitate pyramidal cell firing by inhibition of 5-HT3 receptor expressing interneurons: An in vitro study in rat hippocampus slices.

Dale E, Grunnet M, Pehrson AL, Frederiksen K, Larsen PH, Nielsen J, Stensbøl TB, Ebert B, Yin H, Lu D, Liu H, Jensen TN, Yang CR, Sanchez C.

Brain Res. 2018 Jun 15;1689:1-11. doi: 10.1016/j.brainres.2017.12.025. Epub 2017 Dec 21.

PMID:
29274875
4.

Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca2+-Activated K+ Channels in Pigs.

Diness JG, Skibsbye L, Simó-Vicens R, Santos JL, Lundegaard P, Citerni C, Sauter DRP, Bomholtz SH, Svendsen JH, Olesen SP, Sørensen US, Jespersen T, Grunnet M, Bentzen BH.

Circ Arrhythm Electrophysiol. 2017 Oct;10(10). pii: e005125. doi: 10.1161/CIRCEP.117.005125.

5.

The sodium channel activator Lu AE98134 normalizes the altered firing properties of fast spiking interneurons in Dlx5/6+/- mice.

von Schoubye NL, Frederiksen K, Kristiansen U, Petersen AV, Dalby NO, Grunnet M, Jensen HS, Jespersen T, Sohal VS, Perrier JF.

Neurosci Lett. 2018 Jan 1;662:29-35. doi: 10.1016/j.neulet.2017.10.004. Epub 2017 Oct 5.

PMID:
28987817
6.

A new negative allosteric modulator, AP14145, for the study of small conductance calcium-activated potassium (KCa 2) channels.

Simó-Vicens R, Kirchhoff JE, Dolce B, Abildgaard L, Speerschneider T, Sørensen US, Grunnet M, Diness JG, Bentzen BH.

Br J Pharmacol. 2017 Dec;174(23):4396-4408. doi: 10.1111/bph.14043. Epub 2017 Oct 22.

PMID:
28925012
7.

PDE1A inhibition elicits cGMP-dependent relaxation of rat mesenteric arteries.

Khammy MM, Dalsgaard T, Larsen PH, Christoffersen CT, Clausen D, Rasmussen LK, Folkersen L, Grunnet M, Kehler J, Aalkjaer C, Nielsen J.

Br J Pharmacol. 2017 Nov;174(22):4186-4198. doi: 10.1111/bph.14034. Epub 2017 Oct 15.

PMID:
28910498
8.

A small molecule activator of Nav 1.1 channels increases fast-spiking interneuron excitability and GABAergic transmission in vitro and has anti-convulsive effects in vivo.

Frederiksen K, Lu D, Yang J, Jensen HS, Bastlund JF, Larsen PH, Liu H, Crestey F, Dekermendjian K, Badolo L, Laursen M, Hougaard C, Yang C, Svenstrup N, Grunnet M.

Eur J Neurosci. 2017 Aug;46(3):1887-1896. doi: 10.1111/ejn.13626. Epub 2017 Jul 20.

PMID:
28635024
9.

Novel selective PDE type 1 inhibitors cause vasodilatation and lower blood pressure in rats.

Laursen M, Beck L, Kehler J, Christoffersen CT, Bundgaard C, Mogensen S, Mow TJ, Pinilla E, Knudsen JS, Hedegaard ER, Grunnet M, Simonsen U.

Br J Pharmacol. 2017 Aug;174(15):2563-2575. doi: 10.1111/bph.13868. Epub 2017 Jul 5.

10.

Effect of antiarrhythmic drugs on small conductance calcium - activated potassium channels.

Simó-Vicens R, Sauter DRP, Grunnet M, Diness JG, Bentzen BH.

Eur J Pharmacol. 2017 May 15;803:118-123. doi: 10.1016/j.ejphar.2017.03.039. Epub 2017 Mar 18.

PMID:
28322838
11.

Kv3.1/Kv3.2 channel positive modulators enable faster activating kinetics and increase firing frequency in fast-spiking GABAergic interneurons.

Boddum K, Hougaard C, Xiao-Ying Lin J, von Schoubye NL, Jensen HS, Grunnet M, Jespersen T.

Neuropharmacology. 2017 May 15;118:102-112. doi: 10.1016/j.neuropharm.2017.02.024. Epub 2017 Feb 24.

12.

Antiarrhythmic effect of the Ca2+-activated K+ (SK) channel inhibitor ICA combined with either amiodarone or dofetilide in an isolated heart model of atrial fibrillation.

Kirchhoff JE, Diness JG, Abildgaard L, Sheykhzade M, Grunnet M, Jespersen T.

Pflugers Arch. 2016 Nov;468(11-12):1853-1863. Epub 2016 Oct 8.

PMID:
27722784
13.

Preradiation Chemotherapy for Adult High-risk Medulloblastoma: A Trial of the ECOG-ACRIN Cancer Research Group (E4397).

Moots PL, O'Neill A, Londer H, Mehta M, Blumenthal DT, Barger GR, Grunnet ML, Grossman S, Gilbert MR, Schiff D.

Am J Clin Oncol. 2018 Jun;41(6):588-594. doi: 10.1097/COC.0000000000000326.

PMID:
27635620
14.

pH-dependent inhibition of K₂P3.1 prolongs atrial refractoriness in whole hearts.

Skarsfeldt MA, Jepps TA, Bomholtz SH, Abildgaard L, Sørensen US, Gregers E, Svendsen JH, Diness JG, Grunnet M, Schmitt N, Olesen SP, Bentzen BH.

Pflugers Arch. 2016 Apr;468(4):643-54. doi: 10.1007/s00424-015-1779-0. Epub 2016 Jan 5.

PMID:
26729267
15.

Combined gating and trafficking defect in Kv11.1 manifests as a malignant long QT syndrome phenotype in a large Danish p.F29L founder family.

Kanters JK, Skibsbye L, Hedley PL, Dembic M, Liang B, Hagen CM, Eschen O, Grunnet M, Christiansen M, Jespersen T.

Scand J Clin Lab Invest. 2015;75(8):699-709. doi: 10.3109/00365513.2015.1091090. Epub 2015 Sep 24.

PMID:
26403377
16.

Late Sodium Current in Human Atrial Cardiomyocytes from Patients in Sinus Rhythm and Atrial Fibrillation.

Poulet C, Wettwer E, Grunnet M, Jespersen T, Fabritz L, Matschke K, Knaut M, Ravens U.

PLoS One. 2015 Jun 29;10(6):e0131432. doi: 10.1371/journal.pone.0131432. eCollection 2015.

17.

Identification and electrophysiological evaluation of 2-methylbenzamide derivatives as Nav1.1 modulators.

Crestey F, Frederiksen K, Jensen HS, Dekermendjian K, Larsen PH, Bastlund JF, Lu D, Liu H, Yang CR, Grunnet M, Svenstrup N.

ACS Chem Neurosci. 2015 Aug 19;6(8):1302-8. doi: 10.1021/acschemneuro.5b00147. Epub 2015 Jul 8.

PMID:
26114759
18.

Antiarrhythmic Effect of Either Negative Modulation or Blockade of Small Conductance Ca2+-activated K+ Channels on Ventricular Fibrillation in Guinea Pig Langendorff-perfused Heart.

Diness JG, Kirchhoff JE, Sheykhzade M, Jespersen T, Grunnet M.

J Cardiovasc Pharmacol. 2015 Sep;66(3):294-9. doi: 10.1097/FJC.0000000000000278.

PMID:
25978690
19.

Decline in CA19-9 during chemotherapy predicts survival in four independent cohorts of patients with inoperable bile duct cancer.

Grunnet M, Christensen IJ, Lassen U, Jensen LH, Lydolph M, Knox JJ, McNamara MG, Jitlal M, Wasan H, Bridgewater J, Valle JW, Mau-Sorensen M.

Eur J Cancer. 2015 Jul;51(11):1381-8. doi: 10.1016/j.ejca.2015.04.011. Epub 2015 May 9.

PMID:
25971532
20.

Antiarrhythmic Mechanisms of SK Channel Inhibition in the Rat Atrium.

Skibsbye L, Wang X, Axelsen LN, Bomholtz SH, Nielsen MS, Grunnet M, Bentzen BH, Jespersen T.

J Cardiovasc Pharmacol. 2015 Aug;66(2):165-76. doi: 10.1097/FJC.0000000000000259.

PMID:
25856531
21.

Biophysical characterization of KV3.1 potassium channel activating compounds.

Taskin B, von Schoubye NL, Sheykhzade M, Bastlund JF, Grunnet M, Jespersen T.

Eur J Pharmacol. 2015 Jul 5;758:164-70. doi: 10.1016/j.ejphar.2015.03.061. Epub 2015 Apr 3.

PMID:
25845309
22.

Role of Calcium-activated Potassium Channels in Atrial Fibrillation Pathophysiology and Therapy.

Diness JG, Bentzen BH, Sørensen US, Grunnet M.

J Cardiovasc Pharmacol. 2015 Nov;66(5):441-8. doi: 10.1097/FJC.0000000000000249. Review.

23.

Common and rare variants in SCN10A modulate the risk of atrial fibrillation.

Jabbari J, Olesen MS, Yuan L, Nielsen JB, Liang B, Macri V, Christophersen IE, Nielsen N, Sajadieh A, Ellinor PT, Grunnet M, Haunsø S, Holst AG, Svendsen JH, Jespersen T.

Circ Cardiovasc Genet. 2015 Feb;8(1):64-73. doi: 10.1161/HCG.0000000000000022. Erratum in: Circ Cardiovasc Genet. 2016 Feb;9(1):100.

24.

Cardiac SK channels: Friend or foe?

Grunnet M.

Heart Rhythm. 2015 May;12(5):1016-7. doi: 10.1016/j.hrthm.2015.02.007. Epub 2015 Feb 9. No abstract available.

PMID:
25678058
25.

TOP1 gene copy numbers are increased in cancers of the bile duct and pancreas.

Grunnet M, Calatayud D, Schultz NA, Hasselby JP, Mau-Sørensen M, Brünner N, Stenvang J.

Scand J Gastroenterol. 2015 Apr;50(4):485-94. doi: 10.3109/00365521.2014.980318. Epub 2015 Jan 23.

PMID:
25615400
26.

Crucial role of astrocytes in temporal lobe epilepsy.

Steinhäuser C, Grunnet M, Carmignoto G.

Neuroscience. 2016 May 26;323:157-69. doi: 10.1016/j.neuroscience.2014.12.047. Epub 2015 Jan 13. Review.

PMID:
25592426
27.

Pharmacologic inhibition of small-conductance calcium-activated potassium (SK) channels by NS8593 reveals atrial antiarrhythmic potential in horses.

Haugaard MM, Hesselkilde EZ, Pehrson S, Carstensen H, Flethøj M, Præstegaard KF, Sørensen US, Diness JG, Grunnet M, Buhl R, Jespersen T.

Heart Rhythm. 2015 Apr;12(4):825-35. doi: 10.1016/j.hrthm.2014.12.028. Epub 2014 Dec 24.

PMID:
25542425
28.

Synergistic antiarrhythmic effect of combining inhibition of Ca²⁺-activated K⁺ (SK) channels and voltage-gated Na⁺ channels in an isolated heart model of atrial fibrillation.

Kirchhoff JE, Diness JG, Sheykhzade M, Grunnet M, Jespersen T.

Heart Rhythm. 2015 Feb;12(2):409-18. doi: 10.1016/j.hrthm.2014.12.010. Epub 2014 Dec 10.

PMID:
25496982
29.

Targeting α4β2 nicotinic acetylcholine receptors in central nervous system disorders: perspectives on positive allosteric modulation as a therapeutic approach.

Grupe M, Grunnet M, Bastlund JF, Jensen AA.

Basic Clin Pharmacol Toxicol. 2015 Mar;116(3):187-200. doi: 10.1111/bcpt.12361. Epub 2014 Dec 29. Review.

30.

A fatal case of primary basaloid squamous cell carcinoma in the intrahepatic bile ducts.

Kirkegaard J, Grunnet M, Hasselby JP.

Case Rep Pathol. 2014;2014:410849. doi: 10.1155/2014/410849. Epub 2014 Oct 7.

31.

BK channel activators and their therapeutic perspectives.

Bentzen BH, Olesen SP, Rønn LC, Grunnet M.

Front Physiol. 2014 Oct 9;5:389. doi: 10.3389/fphys.2014.00389. eCollection 2014. Review.

32.

Antiarrhythmic and electrophysiologic effects of flecainide on acutely induced atrial fibrillation in healthy horses.

Haugaard MM, Pehrson S, Carstensen H, Flethøj M, Hesselkilde EZ, Praestegaard KF, Diness JG, Grunnet M, Jespersen T, Buhl R.

J Vet Intern Med. 2015 Jan;29(1):339-47. doi: 10.1111/jvim.12496. Epub 2014 Oct 18.

33.

NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions.

Nausch B, Rode F, Jørgensen S, Nardi A, Korsgaard MP, Hougaard C, Bonev AD, Brown WD, Dyhring T, Strøbæk D, Olesen SP, Christophersen P, Grunnet M, Nelson MT, Rønn LC.

J Pharmacol Exp Ther. 2014 Sep;350(3):520-30. doi: 10.1124/jpet.113.212662. Epub 2014 Jun 20.

34.

Serum tumor markers in bile duct cancer--a review.

Grunnet M, Mau-Sørensen M.

Biomarkers. 2014 Sep;19(6):437-43. doi: 10.3109/1354750X.2014.923048. Epub 2014 May 23. Review.

PMID:
24857368
35.

Small-conductance calcium-activated potassium (SK) channels contribute to action potential repolarization in human atria.

Skibsbye L, Poulet C, Diness JG, Bentzen BH, Yuan L, Kappert U, Matschke K, Wettwer E, Ravens U, Grunnet M, Christ T, Jespersen T.

Cardiovasc Res. 2014 Jul 1;103(1):156-67. doi: 10.1093/cvr/cvu121. Epub 2014 May 9.

PMID:
24817686
36.

Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia.

Schmitt N, Grunnet M, Olesen SP.

Physiol Rev. 2014 Apr;94(2):609-53. doi: 10.1152/physrev.00022.2013. Review.

37.

Flecainide provocation reveals concealed brugada syndrome in a long QT syndrome family with a novel L1786Q mutation in SCN5A.

Kanters JK, Yuan L, Hedley PL, Stoevring B, Jons C, Bloch Thomsen PE, Grunnet M, Christiansen M, Jespersen T.

Circ J. 2014;78(5):1136-43. Epub 2014 Mar 6.

38.

Prognostic significance of circulating intact and cleaved forms of urokinase plasminogen activator receptor in inoperable chemotherapy treated cholangiocarcinoma patients.

Grunnet M, Christensen IJ, Lassen U, Jensen LH, Lydolph M, Lund IK, Thurison T, Høyer-Hansen G, Mau-Sørensen M.

Clin Biochem. 2014 May;47(7-8):599-604. doi: 10.1016/j.clinbiochem.2014.01.030. Epub 2014 Feb 12.

PMID:
24530340
39.

Kv7 channels as targets for anti-epileptic and psychiatric drug-development.

Grunnet M, Strøbæk D, Hougaard C, Christophersen P.

Eur J Pharmacol. 2014 Mar 5;726:133-7. doi: 10.1016/j.ejphar.2014.01.017. Epub 2014 Jan 20. Review.

PMID:
24457124
40.

Therapeutic potential of Na(V)1.1 activators.

Jensen HS, Grunnet M, Bastlund JF.

Trends Pharmacol Sci. 2014 Mar;35(3):113-8. doi: 10.1016/j.tips.2013.12.007. Epub 2014 Jan 16.

PMID:
24439681
41.

Neuropharmacological modulation of the P3-like event-related potential in a rat two-tone auditory discrimination task with modafinil and NS9283, a positive allosteric modulator of α4β2 nAChRs.

Grupe M, Grunnet M, Laursen B, Bastlund JF.

Neuropharmacology. 2014 Apr;79:444-55. doi: 10.1016/j.neuropharm.2013.12.008. Epub 2013 Dec 17.

PMID:
24361451
42.

Structural insight into concealed long QT type 1.

Grunnet M.

Heart Rhythm. 2014 Mar;11(3):469-70. doi: 10.1016/j.hrthm.2013.12.006. Epub 2013 Dec 7. No abstract available.

PMID:
24321237
43.

Role of small-conductance calcium-activated potassium channels in atrial electrophysiology and fibrillation in the dog.

Qi XY, Diness JG, Brundel BJ, Zhou XB, Naud P, Wu CT, Huang H, Harada M, Aflaki M, Dobrev D, Grunnet M, Nattel S.

Circulation. 2014 Jan 28;129(4):430-40. doi: 10.1161/CIRCULATIONAHA.113.003019. Epub 2013 Nov 4.

PMID:
24190961
44.

Biophysical and pharmacological characterization of α6-containing nicotinic acetylcholine receptors expressed in HEK293 cells.

Rasmussen AH, Strøbæk D, Dyhring T, Jensen ML, Peters D, Grunnet M, Timmermann DB, Ahring PK.

Brain Res. 2014 Jan 13;1542:1-11. doi: 10.1016/j.brainres.2013.10.024. Epub 2013 Oct 21.

PMID:
24157862
45.

G-protein-coupled inward rectifier potassium current contributes to ventricular repolarization.

Liang B, Nissen JD, Laursen M, Wang X, Skibsbye L, Hearing MC, Andersen MN, Rasmussen HB, Wickman K, Grunnet M, Olesen SP, Jespersen T.

Cardiovasc Res. 2014 Jan 1;101(1):175-84. doi: 10.1093/cvr/cvt240. Epub 2013 Oct 22.

46.

Selective potentiation of (α4)3(β2)2 nicotinic acetylcholine receptors augments amplitudes of prefrontal acetylcholine- and nicotine-evoked glutamatergic transients in rats.

Grupe M, Paolone G, Jensen AA, Sandager-Nielsen K, Sarter M, Grunnet M.

Biochem Pharmacol. 2013 Nov 15;86(10):1487-96. doi: 10.1016/j.bcp.2013.09.005. Epub 2013 Sep 16.

47.

Tissue inhibitor of metalloproteinase 1 (TIMP-1) as a biomarker in gastric cancer: a review.

Grunnet M, Mau-Sørensen M, Brünner N.

Scand J Gastroenterol. 2013 Aug;48(8):899-905. doi: 10.3109/00365521.2013.812235. Epub 2013 Jul 8. Review.

PMID:
23834019
48.

Anti-hypertensive treatment preserves appetite suppression while preventing cardiovascular adverse effects of tesofensine in rats.

Bentzen BH, Grunnet M, Hyveled-Nielsen L, Sundgreen C, Lassen JB, Hansen HH.

Obesity (Silver Spring). 2013 May;21(5):985-92. doi: 10.1002/oby.20122.

49.

A non-cardiomyocyte autonomous mechanism of cardioprotection involving the SLO1 BK channel.

Wojtovich AP, Nadtochiy SM, Urciuoli WR, Smith CO, Grunnet M, Nehrke K, Brookes PS.

PeerJ. 2013 Mar 5;1:e48. doi: 10.7717/peerj.48. Print 2013.

50.

GIRK channel activation via adenosine or muscarinic receptors has similar effects on rat atrial electrophysiology.

Wang X, Liang B, Skibsbye L, Olesen SP, Grunnet M, Jespersen T.

J Cardiovasc Pharmacol. 2013 Aug;62(2):192-8. doi: 10.1097/FJC.0b013e3182965221.

PMID:
23609329

Supplemental Content

Loading ...
Support Center