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A prospective study of artificially sweetened beverage intake and cardiometabolic health among women at high risk.

Hinkle SN, Rawal S, Bjerregaard AA, Halldorsson TI, Li M, Ley SH, Wu J, Zhu Y, Chen L, Liu A, Grunnet LG, Rahman ML, Kampmann FB, Mills JL, Olsen SF, Zhang C.

Am J Clin Nutr. 2019 Jun 7. pii: nqz094. doi: 10.1093/ajcn/nqz094. [Epub ahead of print]


Diabetes in pregnancy and epigenetic mechanisms-how the first 9 months from conception might affect the child's epigenome and later risk of disease.

Hjort L, Novakovic B, Grunnet LG, Maple-Brown L, Damm P, Desoye G, Saffery R.

Lancet Diabetes Endocrinol. 2019 May 22. pii: S2213-8587(19)30078-6. doi: 10.1016/S2213-8587(19)30078-6. [Epub ahead of print] Review.


FOETAL for NCD-FOetal Exposure and Epidemiological Transitions: the role of Anaemia in early Life for Non-Communicable Diseases in later life: a prospective preconception study in rural Tanzania.

Hjort L, Lykke Møller S, Minja D, Msemo O, Nielsen BB, Lund Christensen D, Theander T, Nielsen K, Larsen LG, Grunnet LG, Groop L, Prasad R, Lusingu J, Schmiegelow C, Bygbjerg IC.

BMJ Open. 2019 May 22;9(5):e024861. doi: 10.1136/bmjopen-2018-024861.


Leukocyte telomere length is associated with elevated plasma glucose and HbA1c in young healthy men independent of birth weight.

Grunnet LG, Pilgaard K, Alibegovic A, Jensen CB, Hjort L, Ozanne SE, Bennett M, Vaag A, Brøns C.

Sci Rep. 2019 May 21;9(1):7639. doi: 10.1038/s41598-019-43387-0.


Diabetes & Women's Health (DWH) Study: an observational study of long-term health consequences of gestational diabetes, their determinants and underlying mechanisms in the USA and Denmark.

Zhang C, Olsen SF, Hinkle SN, Gore-Langton RE, Vaag A, Grunnet LG, Yeung EH, Bao W, Bowers K, Liu A, Mills JL, Sherman S, Gaskins AJ, Ley SH, Madsen CM, Chavarro JE, Hu FB; Diabetes & Women’s Health Study team.

BMJ Open. 2019 May 1;9(4):e025517. doi: 10.1136/bmjopen-2018-025517.


Prospective study of gestational diabetes and fatty liver scores 9 to 16 years after pregnancy.

Donnelly SR, Hinkle SN, Rawal S, Grunnet LG, Chavarro JE, Vaag A, Wu J, Damm P, Mills JL, Li M, Bjerregaard AA, Thuesen ACB, Gore-Langton RE, Francis EC, Ley SH, Hu FB, Tsai MY, Olsen SF, Zhang C.

J Diabetes. 2019 Apr 19. doi: 10.1111/1753-0407.12934. [Epub ahead of print]


TCF7L2 Expression Is Regulated by Cell Differentiation and Overfeeding in Human Adipose Tissue.

Justesen L, Ribel-Madsen R, Gillberg L, Hansen NS, Wulff AL, Grunnet LG, Brøns C.

Endocr Res. 2019 Feb 5:1-7. doi: 10.1080/07435800.2019.1573827. [Epub ahead of print]


Exposure to Gestational Diabetes Is a Stronger Predictor of Dysmetabolic Traits in Children Than Size at Birth.

Kampmann FB, Thuesen ACB, Hjort L, Olsen SF, Pires SM, Tetens I, Grunnet LG.

J Clin Endocrinol Metab. 2019 May 1;104(5):1766-1776. doi: 10.1210/jc.2018-02044.


Being born small-for-gestational-age is associated with an unfavourable dietary intake in Danish adolescent girls: findings from the Danish National Birth Cohort.

Kampmann FB, Grunnet LG, Halldorsson TI, Bjerregaard AA, Granstrøm C, Pires SM, Strøm M, Vaag AA, Tetens I, Olsen SF.

J Dev Orig Health Dis. 2018 Nov 13:1-9. doi: 10.1017/S2040174418000910. [Epub ahead of print]


Fish Intake in Pregnancy and Offspring Metabolic Parameters at Age 9⁻16-Does Gestational Diabetes Modify the Risk?

Maslova E, Hansen S, Strøm M, Halldorsson TI, Grunnet LG, Vaag AA, Olsen SF.

Nutrients. 2018 Oct 17;10(10). pii: E1534. doi: 10.3390/nu10101534.


Risk factors of pre-hypertension and hypertension among non-pregnant women of reproductive age in northeastern Tanzania: a community based cross-sectional study.

Msemo OA, Schmiegelow C, Nielsen BB, Kousholt H, Grunnet LG, Christensen DL, Lusingu JPA, Møller SL, Kavishe RA, Minja DTR, Bygbjerg IC.

Trop Med Int Health. 2018 Nov;23(11):1176-1187. doi: 10.1111/tmi.13149. Epub 2018 Oct 2.


Maternal glycemic index and glycemic load in pregnancy and offspring metabolic health in childhood and adolescence-a cohort study of 68,471 mother-offspring dyads from the Danish National Birth Cohort.

Maslova E, Hansen S, Grunnet LG, Strøm M, Bjerregaard AA, Hjort L, Kampmann FB, Madsen CM, Thuesen ACB, Bech BH, Halldorsson TI, Vaag AA, Zhang C, Olsen SF.

Eur J Clin Nutr. 2018 Sep 24. doi: 10.1038/s41430-018-0316-6. [Epub ahead of print]


Gestational diabetes and maternal obesity are associated with epigenome-wide methylation changes in children.

Hjort L, Martino D, Grunnet LG, Naeem H, Maksimovic J, Olsson AH, Zhang C, Ling C, Olsen SF, Saffery R, Vaag AA.

JCI Insight. 2018 Sep 6;3(17). pii: 122572. doi: 10.1172/jci.insight.122572. eCollection 2018 Sep 6.


Lactation Duration and Long-Term Thyroid Function: A Study among Women with Gestational Diabetes.

Panuganti PL, Hinkle SN, Rawal S, Grunnet LG, Lin Y, Liu A, Thuesen ACB, Ley SH, Olesen SF, Zhang C.

Nutrients. 2018 Jul 21;10(7). pii: E938. doi: 10.3390/nu10070938.


Genetic variants of gestational diabetes mellitus: a study of 112 SNPs among 8722 women in two independent populations.

Ding M, Chavarro J, Olsen S, Lin Y, Ley SH, Bao W, Rawal S, Grunnet LG, Thuesen ACB, Mills JL, Yeung E, Hinkle SN, Zhang W, Vaag A, Liu A, Hu FB, Zhang C.

Diabetologia. 2018 Aug;61(8):1758-1768. doi: 10.1007/s00125-018-4637-8. Epub 2018 Jun 12.


NKX6.1 induced pluripotent stem cell reporter lines for isolation and analysis of functionally relevant neuronal and pancreas populations.

Gupta SK, Wesolowska-Andersen A, Ringgaard AK, Jaiswal H, Song L, Hastoy B, Ingvorsen C, Taheri-Ghahfarokhi A, Magnusson B, Maresca M, Jensen RR, Beer NL, Fels JJ, Grunnet LG, Thomas MK, Gloyn AL, Hicks R, McCarthy MI, Hansson M, Honoré C.

Stem Cell Res. 2018 May;29:220-231. doi: 10.1016/j.scr.2018.04.010. Epub 2018 Apr 23.


Gestational Diabetes Mellitus and Renal Function: A Prospective Study With 9- to 16-Year Follow-up After Pregnancy.

Rawal S, Olsen SF, Grunnet LG, Ma RC, Hinkle SN, Granström C, Wu J, Yeung E, Mills JL, Zhu Y, Bao W, Ley SH, Hu FB, Damm P, Vaag A, Tsai MY, Zhang C.

Diabetes Care. 2018 Jul;41(7):1378-1384. doi: 10.2337/dc17-2629. Epub 2018 May 4.


Telomere length is reduced in 9- to 16-year-old girls exposed to gestational diabetes in utero.

Hjort L, Vryer R, Grunnet LG, Burgner D, Olsen SF, Saffery R, Vaag A.

Diabetologia. 2018 Apr;61(4):870-880. doi: 10.1007/s00125-018-4549-7. Epub 2018 Jan 23.


The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates.

Tsonkova VG, Sand FW, Wolf XA, Grunnet LG, Kirstine Ringgaard A, Ingvorsen C, Winkel L, Kalisz M, Dalgaard K, Bruun C, Fels JJ, Helgstrand C, Hastrup S, Öberg FK, Vernet E, Sandrini MPB, Shaw AC, Jessen C, Grønborg M, Hald J, Willenbrock H, Madsen D, Wernersson R, Hansson L, Jensen JN, Plesner A, Alanentalo T, Petersen MBK, Grapin-Botton A, Honoré C, Ahnfelt-Rønne J, Hecksher-Sørensen J, Ravassard P, Madsen OD, Rescan C, Frogne T.

Mol Metab. 2018 Feb;8:144-157. doi: 10.1016/j.molmet.2017.12.007. Epub 2017 Dec 19.


Designing a retrievable and scalable cell encapsulation device for potential treatment of type 1 diabetes.

An D, Chiu A, Flanders JA, Song W, Shou D, Lu YC, Grunnet LG, Winkel L, Ingvorsen C, Christophersen NS, Fels JJ, Sand FW, Ji Y, Qi L, Pardo Y, Luo D, Silberstein M, Fan J, Ma M.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E263-E272. doi: 10.1073/pnas.1708806115. Epub 2017 Dec 26.


Adiposity, Dysmetabolic Traits, and Earlier Onset of Female Puberty in Adolescent Offspring of Women With Gestational Diabetes Mellitus: A Clinical Study Within the Danish National Birth Cohort.

Grunnet LG, Hansen S, Hjort L, Madsen CM, Kampmann FB, Thuesen ACB, Granstrømi C, Strøm M, Maslova E, Frikke-Schmidt R, Damm P, Chavarro JE, Hu FB, Olsen SF, Vaag A.

Diabetes Care. 2017 Dec;40(12):1746-1755. doi: 10.2337/dc17-0514. Epub 2017 Oct 16.


Maternal protein intake in pregnancy and offspring metabolic health at age 9-16 y: results from a Danish cohort of gestational diabetes mellitus pregnancies and controls.

Maslova E, Hansen S, Grunnet LG, Strøm M, Bjerregaard AA, Hjort L, Kampmann FB, Madsen CM, Baun Thuesen AC, Bech BH, Halldorsson TI, Vaag AA, Olsen SF.

Am J Clin Nutr. 2017 Aug;106(2):623-636. doi: 10.3945/ajcn.115.128637. Epub 2017 Jul 5.


Maternal consumption of artificially sweetened beverages during pregnancy, and offspring growth through 7 years of age: a prospective cohort study.

Zhu Y, Olsen SF, Mendola P, Halldorsson TI, Rawal S, Hinkle SN, Yeung EH, Chavarro JE, Grunnet LG, Granström C, Bjerregaard AA, Hu FB, Zhang C.

Int J Epidemiol. 2017 Oct 1;46(5):1499-1508. doi: 10.1093/ije/dyx095.


Microchimerism of male origin in a cohort of Danish girls.

Müller AC, Jakobsen MA, Barington T, Vaag AA, Grunnet LG, Olsen SF, Kamper-Jørgensen M.

Chimerism. 2015 Oct 2;6(4):65-71. doi: 10.1080/19381956.2016.1218583. Epub 2016 Aug 11.


A common variation of the PTEN gene is associated with peripheral insulin resistance.

Grinder-Hansen L, Ribel-Madsen R, Wojtaszewski JF, Poulsen P, Grunnet LG, Vaag A.

Diabetes Metab. 2016 Sep;42(4):280-4. doi: 10.1016/j.diabet.2016.03.003. Epub 2016 Apr 8.


Growth and obesity through the first 7 y of life in association with levels of maternal glycemia during pregnancy: a prospective cohort study.

Zhu Y, Olsen SF, Mendola P, Yeung EH, Vaag A, Bowers K, Liu A, Bao W, Li S, Madsen C, Grunnet LG, Granström C, Hansen S, Martin K, Chavarro JE, Hu FB, Langhoff-Roos J, Damm P, Zhang C.

Am J Clin Nutr. 2016 Mar;103(3):794-800. doi: 10.3945/ajcn.115.121780. Epub 2016 Jan 27.


Adipose tissue transcriptomics and epigenomics in low birthweight men and controls: role of high-fat overfeeding.

Gillberg L, Perfilyev A, Brøns C, Thomasen M, Grunnet LG, Volkov P, Rosqvist F, Iggman D, Dahlman I, Risérus U, Rönn T, Nilsson E, Vaag A, Ling C.

Diabetologia. 2016 Apr;59(4):799-812. doi: 10.1007/s00125-015-3852-9. Epub 2016 Jan 11.


Are hepatic and soleus lipid content, assessed by magnetic resonance spectroscopy, associated with low birth weight or insulin resistance in a rural Indian population of healthy young men?

Livingstone RS, Grunnet LG, Thomas N, Eapen A, Antonisamy B, Mohan VR, Spurgeon R, Frank ID, Bygbjerg IC, Vaag A.

Diabet Med. 2016 Mar;33(3):365-70. doi: 10.1111/dme.12852. Epub 2015 Aug 18.


Long-term risk of type 2 diabetes mellitus in relation to BMI and weight change among women with a history of gestational diabetes mellitus: a prospective cohort study.

Bao W, Yeung E, Tobias DK, Hu FB, Vaag AA, Chavarro JE, Mills JL, Grunnet LG, Bowers K, Ley SH, Kiely M, Olsen SF, Zhang C.

Diabetologia. 2015 Jun;58(6):1212-9. doi: 10.1007/s00125-015-3537-4. Epub 2015 Mar 22.


Effects of an outdoor bicycle-based intervention in healthy rural Indian men with normal and low birth weight.

Madsen C, Mogensen P, Thomas N, Christensen DL, Bygbjerg IC, Mohan V, Inbakumari M, Nadig SV, Alex R, Geetanjali FS, Westgate K, Brage S, Vaag A, Grunnet LG.

J Dev Orig Health Dis. 2015 Feb;6(1):27-37. doi: 10.1017/S2040174414000609. Epub 2014 Dec 17.


Altering β-cell number through stable alteration of miR-21 and miR-34a expression.

Backe MB, Novotny GW, Christensen DP, Grunnet LG, Mandrup-Poulsen T.

Islets. 2014;6(1):e27754. doi: 10.4161/isl.27754.


Glucose tolerance is associated with differential expression of microRNAs in skeletal muscle: results from studies of twins with and without type 2 diabetes.

Bork-Jensen J, Scheele C, Christophersen DV, Nilsson E, Friedrichsen M, Fernandez-Twinn DS, Grunnet LG, Litman T, Holmstrøm K, Vind B, Højlund K, Beck-Nielsen H, Wojtaszewski J, Ozanne SE, Pedersen BK, Poulsen P, Vaag A.

Diabetologia. 2015 Feb;58(2):363-73. doi: 10.1007/s00125-014-3434-2. Epub 2014 Nov 19.


Genetic, nongenetic and epigenetic risk determinants in developmental programming of type 2 diabetes.

Vaag A, Brøns C, Gillberg L, Hansen NS, Hjort L, Arora GP, Thomas N, Broholm C, Ribel-Madsen R, Grunnet LG.

Acta Obstet Gynecol Scand. 2014 Nov;93(11):1099-108. doi: 10.1111/aogs.12494. Epub 2014 Sep 30. Review.


Genetic versus Non-Genetic Regulation of miR-103, miR-143 and miR-483-3p Expression in Adipose Tissue and Their Metabolic Implications-A Twin Study.

Bork-Jensen J, Thuesen AC, Bang-Bertelsen CH, Grunnet LG, Pociot F, Beck-Nielsen H, Ozanne SE, Poulsen P, Vaag A.

Genes (Basel). 2014 Jul 9;5(3):508-17. doi: 10.3390/genes5030508.


Physical activity and sedentary behaviors associated with risk of progression from gestational diabetes mellitus to type 2 diabetes mellitus: a prospective cohort study.

Bao W, Tobias DK, Bowers K, Chavarro J, Vaag A, Grunnet LG, Strøm M, Mills J, Liu A, Kiely M, Zhang C.

JAMA Intern Med. 2014 Jul;174(7):1047-55. doi: 10.1001/jamainternmed.2014.1795.


Rationale, design, and method of the Diabetes & Women's Health study--a study of long-term health implications of glucose intolerance in pregnancy and their determinants.

Zhang C, Hu FB, Olsen SF, Vaag A, Gore-Langton R, Chavarro JE, Bao W, Yeung E, Bowers K, Grunnet LG, Sherman S, Kiely M, Strøm M, Hansen S, Liu A, Mills J, Fan R; DWH study team.

Acta Obstet Gynecol Scand. 2014 Nov;93(11):1123-30. doi: 10.1111/aogs.12425. Epub 2014 Jun 9.


Macrophage contact dependent and independent TLR4 mechanisms induce β-cell dysfunction and apoptosis in a mouse model of type 2 diabetes.

Cucak H, Mayer C, Tonnesen M, Thomsen LH, Grunnet LG, Rosendahl A.

PLoS One. 2014 Mar 3;9(3):e90685. doi: 10.1371/journal.pone.0090685. eCollection 2014.


Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection.

Christensen DP, Gysemans C, Lundh M, Dahllöf MS, Noesgaard D, Schmidt SF, Mandrup S, Birkbak N, Workman CT, Piemonti L, Blaabjerg L, Monzani V, Fossati G, Mascagni P, Paraskevas S, Aikin RA, Billestrup N, Grunnet LG, Dinarello CA, Mathieu C, Mandrup-Poulsen T.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1055-9. doi: 10.1073/pnas.1320850111. Epub 2014 Jan 6.


Accumulation of M1-like macrophages in type 2 diabetic islets is followed by a systemic shift in macrophage polarization.

Cucak H, Grunnet LG, Rosendahl A.

J Leukoc Biol. 2014 Jan;95(1):149-60. doi: 10.1189/jlb.0213075. Epub 2013 Sep 5.


The lysine deacetylase inhibitor Givinostat inhibits β-cell IL-1β induced IL-1β transcription and processing.

Dahllöf MS, Christensen DP, Lundh M, Dinarello CA, Mascagni P, Grunnet LG, Mandrup-Poulsen T.

Islets. 2012 Nov-Dec;4(6):417-22. doi: 10.4161/isl.23541.


The triglyceride content in skeletal muscle is associated with hepatic but not peripheral insulin resistance in elderly twins.

Grunnet LG, Laurila E, Hansson O, Almgren P, Groop L, Brøns C, Poulsen P, Vaag A.

J Clin Endocrinol Metab. 2012 Dec;97(12):4571-7. doi: 10.1210/jc.2012-2061. Epub 2012 Oct 9.


Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines.

Hansen JB, Tonnesen MF, Madsen AN, Hagedorn PH, Friberg J, Grunnet LG, Heller RS, Nielsen AØ, Størling J, Baeyens L, Anker-Kitai L, Qvortrup K, Bouwens L, Efrat S, Aalund M, Andrews NC, Billestrup N, Karlsen AE, Holst B, Pociot F, Mandrup-Poulsen T.

Cell Metab. 2012 Oct 3;16(4):449-61. doi: 10.1016/j.cmet.2012.09.001. Epub 2012 Sep 20.


Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children.

Lundh M, Christensen DP, Damgaard Nielsen M, Richardson SJ, Dahllöf MS, Skovgaard T, Berthelsen J, Dinarello CA, Stevenazzi A, Mascagni P, Grunnet LG, Morgan NG, Mandrup-Poulsen T.

Diabetologia. 2012 Sep;55(9):2421-31. doi: 10.1007/s00125-012-2615-0. Epub 2012 Jul 7.


Transporter function and cyclic AMP turnover in normal colonic mucosa from patients with and without colorectal neoplasia.

Kleberg K, Jensen GM, Christensen DP, Lundh M, Grunnet LG, Knuhtsen S, Poulsen SS, Hansen MB, Bindslev N.

BMC Gastroenterol. 2012 Jun 26;12:78.


The thrifty phenotype hypothesis revisited.

Vaag AA, Grunnet LG, Arora GP, Brøns C.

Diabetologia. 2012 Aug;55(8):2085-8. doi: 10.1007/s00125-012-2589-y. Epub 2012 May 30.


Born with low birth weight in rural Southern India: what are the metabolic consequences 20 years later?

Thomas N, Grunnet LG, Poulsen P, Christopher S, Spurgeon R, Inbakumari M, Livingstone R, Alex R, Mohan VR, Antonisamy B, Geethanjali FS, Karol R, Vaag A, Bygbjerg IC.

Eur J Endocrinol. 2012 Apr;166(4):647-55. doi: 10.1530/EJE-11-0870. Epub 2012 Jan 16.


Cytokines and type 1 diabetes: a numbers game.

Grunnet LG, Mandrup-Poulsen T.

Diabetes. 2011 Mar;60(3):697-9. doi: 10.2337/db10-1782. No abstract available.


Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus.

Christensen DP, Dahllöf M, Lundh M, Rasmussen DN, Nielsen MD, Billestrup N, Grunnet LG, Mandrup-Poulsen T.

Mol Med. 2011 May-Jun;17(5-6):378-90. doi: 10.2119/molmed.2011.00021. Epub 2011 Jan 25. Review.


Direct demonstration of NCAM cis-dimerization and inhibitory effect of palmitoylation using the BRET2 technique.

Kulahin N, Grunnet LG, Lundh M, Christensen DP, Jorgensen R, Heding A, Billestrup N, Berezin V, Bock E, Mandrup-Poulsen T.

FEBS Lett. 2011 Jan 3;585(1):58-64. doi: 10.1016/j.febslet.2010.11.043. Epub 2010 Nov 26.

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