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Variability of blood eosinophils in patients in a clinic for severe asthma.

Rakowski E, Zhao S, Liu M, Ahuja S, Durmus N, Grunig G, Curotto de Lafaille M, Wu Y, Reibman J.

Clin Exp Allergy. 2019 Feb;49(2):163-170. doi: 10.1111/cea.13310. Epub 2019 Jan 14.


Pathobiology, pathology and genetics of pulmonary hypertension: Update from the Cologne Consensus Conference 2018.

Olschewski A, Berghausen EM, Eichstaedt CA, Fleischmann BK, Grünig E, Grünig G, Hansmann G, Harbaum L, Hennigs JK, Jonigk D, Kuebler WM, Kwapiszewska G, Pullamsetti SS, Stacher E, Weissmann N, Wenzel D, Schermuly RT.

Int J Cardiol. 2018 Dec 1;272S:4-10. doi: 10.1016/j.ijcard.2018.09.070. Epub 2018 Sep 20. Review.


An RNA Sensor Protects against Pulmonary Hypertension.

Grunig G, Durmus N.

Am J Respir Crit Care Med. 2019 Jan 15;199(2):138-140. doi: 10.1164/rccm.201807-1363ED. No abstract available.


Circulating MicroRNA Markers for Pulmonary Hypertension in Supervised Exercise Intervention and Nightly Oxygen Intervention.

Grunig G, Eichstaedt CA, Verweyen J, Durmus N, Saxer S, Krafsur G, Stenmark K, Ulrich S, Grünig E, Pylawka S.

Front Physiol. 2018 Jul 25;9:955. doi: 10.3389/fphys.2018.00955. eCollection 2018.


Air Pollution Exposure with Fine Dust. Responses in the Pulmonary Vasculature and the Right Heart.

Durmus N, Grunig G.

Ann Am Thorac Soc. 2018 Apr;15(Supplement_2):S126. doi: 10.1513/AnnalsATS.201707-599MG.


Polymorphonuclear Leukocytes in Pulmonary Hypertension and Fibrosis: Not Always What They Appear to Be.

Durmus N, Grunig G.

Am J Respir Cell Mol Biol. 2018 Feb;58(2):135-137. doi: 10.1165/rcmb.2017-0336ED. No abstract available.


The inflammatory cell landscape in the lungs of patients with idiopathic pulmonary arterial hypertension.

Marsh LM, Jandl K, Grünig G, Foris V, Bashir M, Ghanim B, Klepetko W, Olschewski H, Olschewski A, Kwapiszewska G.

Eur Respir J. 2018 Jan 25;51(1). pii: 1701214. doi: 10.1183/13993003.01214-2017. Print 2018 Jan.


PVDOMICS: A Multi-Center Study to Improve Understanding of Pulmonary Vascular Disease Through Phenomics.

Hemnes AR, Beck GJ, Newman JH, Abidov A, Aldred MA, Barnard J, Berman Rosenzweig E, Borlaug BA, Chung WK, Comhair SAA, Erzurum SC, Frantz RP, Gray MP, Grunig G, Hassoun PM, Hill NS, Horn EM, Hu B, Lempel JK, Maron BA, Mathai SC, Olman MA, Rischard FP, Systrom DM, Tang WHW, Waxman AB, Xiao L, Yuan JX, Leopold JA; PVDOMICS Study Group.

Circ Res. 2017 Oct 27;121(10):1136-1139. doi: 10.1161/CIRCRESAHA.117.311737. No abstract available.


Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease.

Jian J, Tian QY, Hettinghouse A, Zhao S, Liu H, Wei J, Grunig G, Zhang W, Setchell KDR, Sun Y, Overkleeft HS, Chan GL, Liu CJ.

EBioMedicine. 2016 Nov;13:212-224. doi: 10.1016/j.ebiom.2016.10.010. Epub 2016 Oct 24.


[Pathobiology, pathology and genetics of pulmonary hypertension: Recommendations of the Cologne Consensus Conference 2016].

Olschewski A, Berghausen EM, Eichstaedt CA, Fleischmann BK, Grünig E, Grünig G, Hansmann G, Harbaum L, Hennigs JK, Jonigk D, Kübler WM, Kwapiszewska G, Pullamsetti SS, Stacher E, Weissmann N, Wenzel D, Schermuly RT.

Dtsch Med Wochenschr. 2016 Oct;141(S 01):S4-S9. Epub 2016 Oct 19. German.


Association Between Progranulin and Gaucher Disease.

Jian J, Zhao S, Tian QY, Liu H, Zhao Y, Chen WC, Grunig G, Torres PA, Wang BC, Zeng B, Pastores G, Tang W, Sun Y, Grabowski GA, Kong MX, Wang G, Chen Y, Liang F, Overkleeft HS, Saunders-Pullman R, Chan GL, Liu CJ.

EBioMedicine. 2016 Sep;11:127-137. doi: 10.1016/j.ebiom.2016.08.004. Epub 2016 Aug 4.


Challenges and Current Efforts in the Development of Biomarkers for Chronic Inflammatory and Remodeling Conditions of the Lungs.

Grunig G, Baghdassarian A, Park SH, Pylawka S, Bleck B, Reibman J, Berman-Rosenzweig E, Durmus N.

Biomark Insights. 2016 Feb 16;10(Suppl 4):59-72. doi: 10.4137/BMI.S29514. eCollection 2015. Review.


Spotlight on Inflammation in Pulmonary Hypertension.

Grunig G, Durmus N.

Am J Respir Crit Care Med. 2015 Oct 15;192(8):913-5. doi: 10.1164/rccm.201507-1426ED. No abstract available.


The Effects of Antigen-Specific IgG1 Antibody for the Pulmonary-Hypertension-Phenotype and B Cells for Inflammation in Mice Exposed to Antigen and Fine Particles from Air Pollution.

Park SH, Chen WC, Durmus N, Bleck B, Reibman J, Riemekasten G, Grunig G.

PLoS One. 2015 Jun 16;10(6):e0129910. doi: 10.1371/journal.pone.0129910. eCollection 2015.


Coexpression of type 2 immune targets in sputum-derived epithelial and dendritic cells from asthmatic subjects.

Bleck B, Kazeros A, Bakal K, Garcia-Medina L, Adams A, Liu M, Lee RA, Tse DB, Chiu A, Grunig G, Egan JP 3rd, Reibman J.

J Allergy Clin Immunol. 2015 Sep;136(3):619-627.e5. doi: 10.1016/j.jaci.2014.12.1950. Epub 2015 Mar 23. Erratum in: J Allergy Clin Immunol. 2016 Feb;137(2):649.


Interleukin 13- and interleukin 17A-induced pulmonary hypertension phenotype due to inhalation of antigen and fine particles from air pollution.

Park SH, Chen WC, Esmaeil N, Lucas B, Marsh LM, Reibman J, Grunig G.

Pulm Circ. 2014 Dec;4(4):654-68. doi: 10.1086/678511.


[Pulmonary arterial hypertension--a disease of the immune system?].

Riemekasten G, Kuebler WM, Schermuly R, Seyfarth HJ, Behr J, Grohe C, Hoeper MM, Olschewski A, Kwapiszewska G, Ulrich S, Voswinckel R, Weissmann N, Worth H, Viales RR, Pullamsetti SS, Grunig G.

Dtsch Med Wochenschr. 2014 Dec;139 Suppl 4:S116-20. doi: 10.1055/s-0034-1387452. Epub 2014 Dec 9. Review. German. No abstract available.


[Epigenetics and genetics of pulmonary arterial hypertension--new insights from the last years].

Kwapiszewska G, Viales RR, Ehlken N, Eichstaedt CA, Riemekasten G, Grünig G, Mäder I, Schröder T, Klose H, Hinderhofer K, Fischer C, Ulrich S, Grünig E, Olschewski A.

Dtsch Med Wochenschr. 2014 Dec;139 Suppl 4:S111-5. doi: 10.1055/s-0034-1387454. Epub 2014 Dec 9. Review. German. No abstract available.


Perspective: ambient air pollution: inflammatory response and effects on the lung's vasculature.

Grunig G, Marsh LM, Esmaeil N, Jackson K, Gordon T, Reibman J, Kwapiszewska G, Park SH.

Pulm Circ. 2014 Mar;4(1):25-35. doi: 10.1086/674902. Review.


Dust events, pulmonary diseases and immune system.

Esmaeil N, Gharagozloo M, Rezaei A, Grunig G.

Am J Clin Exp Immunol. 2014 Feb 27;3(1):20-9. eCollection 2014. Review.


Short-term inhalation of cadmium oxide nanoparticles alters pulmonary dynamics associated with lung injury, inflammation, and repair in a mouse model.

Blum JL, Rosenblum LK, Grunig G, Beasley MB, Xiong JQ, Zelikoff JT.

Inhal Toxicol. 2014 Jan;26(1):48-58. doi: 10.3109/08958378.2013.851746.


T cell-derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia.

Fogli LK, Sundrud MS, Goel S, Bajwa S, Jensen K, Derudder E, Sun A, Coffre M, Uyttenhove C, Van Snick J, Schmidt-Supprian M, Rao A, Grunig G, Durbin J, Casola S, Rajewsky K, Koralov SB.

J Immunol. 2013 Sep 15;191(6):3100-11. doi: 10.4049/jimmunol.1301360. Epub 2013 Aug 21. Erratum in: J Immunol. 2013 Nov 15;191(10):5318. Casola, Stefano S [corrected to Casola, Stefano].


Interleukin 13 and the evolution of asthma therapy.

Grünig G, Corry DB, Reibman J, Wills-Karp M.

Am J Clin Exp Immunol. 2012 Jun 30;1(1):20-27.


MicroRNA-375 regulation of thymic stromal lymphopoietin by diesel exhaust particles and ambient particulate matter in human bronchial epithelial cells.

Bleck B, Grunig G, Chiu A, Liu M, Gordon T, Kazeros A, Reibman J.

J Immunol. 2013 Apr 1;190(7):3757-63. doi: 10.4049/jimmunol.1201165. Epub 2013 Mar 1.


Modification of hemodynamic and immune responses to exposure with a weak antigen by the expression of a hypomorphic BMPR2 gene.

Park SH, Chen WC, Hoffman C, Marsh LM, West J, Grunig G.

PLoS One. 2013;8(1):e55180. doi: 10.1371/journal.pone.0055180. Epub 2013 Jan 29.


Right ventricular systolic pressure measurements in combination with harvest of lung and immune tissue samples in mice.

Chen WC, Park SH, Hoffman C, Philip C, Robinson L, West J, Grunig G.

J Vis Exp. 2013 Jan 16;(71):e50023. doi: 10.3791/50023.


Prenatal exposure to allergen, DNA methylation, and allergy in grandoffspring mice.

Niedzwiecki M, Zhu H, Corson L, Grunig G, Factor PH, Chu S, Jiang H, Miller RL.

Allergy. 2012 Jul;67(7):904-10. doi: 10.1111/j.1398-9995.2012.02841.x. Epub 2012 May 14.


Interleukin-19: a constituent of the regulome that controls antigen presenting cells in the lungs and airway responses to microbial products.

Hoffman C, Park SH, Daley E, Emson C, Louten J, Sisco M, de Waal Malefyt R, Grunig G.

PLoS One. 2011;6(11):e27629. doi: 10.1371/journal.pone.0027629. Epub 2011 Nov 15.


Exposure to inhaled nickel nanoparticles causes a reduction in number and function of bone marrow endothelial progenitor cells.

Liberda EN, Cuevas AK, Gillespie PA, Grunig G, Qu Q, Chen LC.

Inhal Toxicol. 2010 Dec;22 Suppl 2:95-9. doi: 10.3109/08958378.2010.515269. Epub 2010 Oct 11. Erratum in: Inhal Toxicol. 2013 Mar;25(4):233.


Prenatal allergen and diesel exhaust exposure and their effects on allergy in adult offspring mice.

Corson L, Zhu H, Quan C, Grunig G, Ballaney M, Jin X, Perera FP, Factor PH, Chen LC, Miller RL.

Allergy Asthma Clin Immunol. 2010 May 11;6(1):7. doi: 10.1186/1710-1492-6-7.


Blimp-1 attenuates Th1 differentiation by repression of ifng, tbx21, and bcl6 gene expression.

Cimmino L, Martins GA, Liao J, Magnusdottir E, Grunig G, Perez RK, Calame KL.

J Immunol. 2008 Aug 15;181(4):2338-47.


Pulmonary arterial remodeling induced by a Th2 immune response.

Daley E, Emson C, Guignabert C, de Waal Malefyt R, Louten J, Kurup VP, Hogaboam C, Taraseviciene-Stewart L, Voelkel NF, Rabinovitch M, Grunig E, Grunig G.

J Exp Med. 2008 Feb 18;205(2):361-72. doi: 10.1084/jem.20071008. Epub 2008 Jan 28.


Time-dependent alterations in gene expression of interleukin-8 in the bronchial epithelium of horses with recurrent airway obstruction.

Ainsworth DM, Wagner B, Franchini M, Grünig G, Erb HN, Tan JY.

Am J Vet Res. 2006 Apr;67(4):669-77.


Inhibition of acid-induced lung injury by hyperosmolar sucrose in rats.

Safdar Z, Yiming M, Grunig G, Bhattacharya J.

Am J Respir Crit Care Med. 2005 Oct 15;172(8):1002-7. Epub 2005 Aug 18.


Aerosolized hyaluronan limits airspace enlargement in a mouse model of cigarette smoke-induced pulmonary emphysema.

Cantor JO, Cerreta JM, Ochoa M, Ma S, Chow T, Grunig G, Turino GM.

Exp Lung Res. 2005 May;31(4):417-30.


IL-13 regulates the immune response to inhaled antigens.

Padilla J, Daley E, Chow A, Robinson K, Parthasarathi K, McKenzie AN, Tschernig T, Kurup VP, Donaldson DD, Grunig G.

J Immunol. 2005 Jun 15;174(12):8097-105.


Molecular regulation of Th2 immunity by dendritic cells.

Grunig G, Banz A, de Waal Malefyt R.

Pharmacol Ther. 2005 Apr;106(1):75-96. Epub 2004 Dec 20. Review.


Productive infection of primary murine astrocytes, lymphocytes, and macrophages by human immunodeficiency virus type 1 in culture.

Nitkiewicz J, Chao W, Bentsman G, Li J, Kim SY, Choi SY, Grunig G, Gelbard H, Potash MJ, Volsky DJ.

J Neurovirol. 2004 Dec;10(6):400-8.


Recurrent airway obstruction (RAO) in horses is characterized by IFN-gamma and IL-8 production in bronchoalveolar lavage cells.

Ainsworth DM, Grünig G, Matychak MB, Young J, Wagner B, Erb HN, Antczak DF.

Vet Immunol Immunopathol. 2003 Nov 15;96(1-2):83-91.


IL-13 and adenosine: partners in a molecular dance?

Grünig G.

J Clin Invest. 2003 Aug;112(3):329-31.


Interleukin-13 and interferon modulators of dendritic cell migration in the lungs.

Hwang J, Yen D, Tschernig T, Rennick D, Grunig G.

Chest. 2003 Mar;123(3 Suppl):439S. Review. No abstract available.


Animal models of allergic bronchopulmonary aspergillosis.

Grunig G, Kurup VP.

Front Biosci. 2003 Jan 1;8:e157-71. Review.


Animal models of allergic bronchopulmonary aspergillosis.

Kurup VP, Grunig G.

Mycopathologia. 2002;153(4):165-77. Review.


Roles of interleukin-13 and interferon-gamma in lung inflammation.

Grünig G, Ford JG, Donaldson DD, Venkayya R, McArthur C, Hansell E, Kurup VA, Warnock M, Rennick D.

Chest. 2002 Mar;121(3 Suppl):88S. No abstract available.


The Th2 lymphocyte products IL-4 and IL-13 rapidly induce airway hyperresponsiveness through direct effects on resident airway cells.

Venkayya R, Lam M, Willkom M, Grünig G, Corry DB, Erle DJ.

Am J Respir Cell Mol Biol. 2002 Feb;26(2):202-8.


Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types.

Lee JH, Kaminski N, Dolganov G, Grunig G, Koth L, Solomon C, Erle DJ, Sheppard D.

Am J Respir Cell Mol Biol. 2001 Oct;25(4):474-85.


Il-13 and IFN-gamma: interactions in lung inflammation.

Ford JG, Rennick D, Donaldson DD, Venkayya R, McArthur C, Hansell E, Kurup VP, Warnock M, Grünig G.

J Immunol. 2001 Aug 1;167(3):1769-77.


Role of IL-10 in invasive aspergillosis: increased resistance of IL-10 gene knockout mice to lethal systemic aspergillosis.

Clemons KV, Grunig G, Sobel RA, Mirels LF, Rennick DM, Stevens DA.

Clin Exp Immunol. 2000 Nov;122(2):186-91.


Depletion of eosinophils in mice through the use of antibodies specific for C-C chemokine receptor 3 (CCR3).

Grimaldi JC, Yu NX, Grunig G, Seymour BW, Cottrez F, Robinson DS, Hosken N, Ferlin WG, Wu X, Soto H, O'Garra A, Howard MC, Coffman RL.

J Leukoc Biol. 1999 Jun;65(6):846-53.


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