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Items: 1 to 50 of 74

1.

Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours.

Jones DTW, Banito A, Grünewald TGP, Haber M, Jäger N, Kool M, Milde T, Molenaar JJ, Nabbi A, Pugh TJ, Schleiermacher G, Smith MA, Westermann F, Pfister SM.

Nat Rev Cancer. 2019 Jul 12. doi: 10.1038/s41568-019-0169-x. [Epub ahead of print] Review.

PMID:
31300807
2.

DNA methylation profiling distinguishes Ewing-like sarcoma with EWSR1-NFATc2 fusion from Ewing sarcoma.

Koelsche C, Kriegsmann M, Kommoss FKF, Stichel D, Kriegsmann K, Vokuhl C, Grünewald TGP, Romero-Pérez L, Kirchner T, de Alava E, Diaz-Martin J, Hartmann W, Baumhoer D, Antonescu CR, Szuhai K, Flucke U, Dirksen U, Pfister SM, Jones DTW, Mechtersheimer G, von Deimling A.

J Cancer Res Clin Oncol. 2019 May;145(5):1273-1281. doi: 10.1007/s00432-019-02895-2. Epub 2019 Mar 20.

PMID:
30895378
3.

Targeting the CALCB/RAMP1 axis inhibits growth of Ewing sarcoma.

Dallmayer M, Li J, Ohmura S, Alba Rubio R, Baldauf MC, Hölting TLB, Musa J, Knott MML, Stein S, Cidre-Aranaz F, Wehweck FS, Romero-Pérez L, Gerke JS, Orth MF, Marchetto A, Kirchner T, Bach H, Sannino G, Grünewald TGP.

Cell Death Dis. 2019 Feb 11;10(2):116. doi: 10.1038/s41419-019-1372-0.

4.

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity.

Vriens K, Christen S, Parik S, Broekaert D, Yoshinaga K, Talebi A, Dehairs J, Escalona-Noguero C, Schmieder R, Cornfield T, Charlton C, Romero-Pérez L, Rossi M, Rinaldi G, Orth MF, Boon R, Kerstens A, Kwan SY, Faubert B, Méndez-Lucas A, Kopitz CC, Chen T, Fernandez-Garcia J, Duarte JAG, Schmitz AA, Steigemann P, Najimi M, Hägebarth A, Van Ginderachter JA, Sokal E, Gotoh N, Wong KK, Verfaillie C, Derua R, Munck S, Yuneva M, Beretta L, DeBerardinis RJ, Swinnen JV, Hodson L, Cassiman D, Verslype C, Christian S, Grünewald S, Grünewald TGP, Fendt SM.

Nature. 2019 Feb;566(7744):403-406. doi: 10.1038/s41586-019-0904-1. Epub 2019 Feb 6.

PMID:
30728499
5.

Sequence-dependent cross-resistance of combined radiotherapy plus BRAFV600E inhibition in melanoma.

Shannan B, Matschke J, Chauvistré H, Vogel F, Klein D, Meier F, Westphal D, Bruns J, Rauschenberg R, Utikal J, Forschner A, Berking C, Terheyden P, Dabrowski E, Gutzmer R, Rafei-Shamsabadi D, Meiss F, Heinzerling L, Zimmer L, Livingstone E, Váraljai R, Hoewner A, Horn S, Klode J, Stuschke M, Scheffler B, Marchetto A, Sannino G, Grünewald TGP, Schadendorf D, Jendrossek V, Roesch A.

Eur J Cancer. 2019 Mar;109:137-153. doi: 10.1016/j.ejca.2018.12.024. Epub 2019 Feb 2.

PMID:
30721788
6.

Functional genomics identifies AMPD2 as a new prognostic marker for undifferentiated pleomorphic sarcoma.

Orth MF, Gerke JS, Knösel T, Altendorf-Hofmann A, Musa J, Alba-Rubio R, Stein S, Hölting TLB, Cidre-Aranaz F, Romero-Pérez L, Dallmayer M, Baldauf MC, Marchetto A, Sannino G, Knott MML, Wehweck F, Ohmura S, Li J, Hakozaki M, Kirchner T, Dandekar T, Butt E, Grünewald TGP.

Int J Cancer. 2019 Feb 15;144(4):859-867. doi: 10.1002/ijc.31903. Epub 2018 Dec 4.

PMID:
30267407
7.

Hepatitis B virus large surface protein is priming for hepatocellular carcinoma development via induction of cytokinesis failure.

Musa J, Li J, Grünewald TG.

J Pathol. 2019 Jan;247(1):6-8. doi: 10.1002/path.5169. Epub 2018 Nov 16.

PMID:
30246253
8.

Systematic identification of cancer-specific MHC-binding peptides with RAVEN.

Baldauf MC, Gerke JS, Kirschner A, Blaeschke F, Effenberger M, Schober K, Rubio RA, Kanaseki T, Kiran MM, Dallmayer M, Musa J, Akpolat N, Akatli AN, Rosman FC, Özen Ö, Sugita S, Hasegawa T, Sugimura H, Baumhoer D, Knott MML, Sannino G, Marchetto A, Li J, Busch DH, Feuchtinger T, Ohmura S, Orth MF, Thiel U, Kirchner T, Grünewald TGP.

Oncoimmunology. 2018 Jul 23;7(9):e1481558. doi: 10.1080/2162402X.2018.1481558. eCollection 2018.

9.

The DNA-polymorphism rs849142 is associated with skin toxicity induced by targeted anti-EGFR therapy using cetuximab.

Froelich MF, Stintzing S, Kumbrink J, Grünewald TGP, Mansmann U, Heinemann V, Kirchner T, Jung A.

Oncotarget. 2018 Jul 13;9(54):30279-30288. doi: 10.18632/oncotarget.25689. eCollection 2018 Jul 13.

10.

Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility.

Machiela MJ, Grünewald TGP, Surdez D, Reynaud S, Mirabeau O, Karlins E, Rubio RA, Zaidi S, Grossetete-Lalami S, Ballet S, Lapouble E, Laurence V, Michon J, Pierron G, Kovar H, Gaspar N, Kontny U, González-Neira A, Picci P, Alonso J, Patino-Garcia A, Corradini N, Bérard PM, Freedman ND, Rothman N, Dagnall CL, Burdett L, Jones K, Manning M, Wyatt K, Zhou W, Yeager M, Cox DG, Hoover RN, Khan J, Armstrong GT, Leisenring WM, Bhatia S, Robison LL, Kulozik AE, Kriebel J, Meitinger T, Metzler M, Hartmann W, Strauch K, Kirchner T, Dirksen U, Morton LM, Mirabello L, Tucker MA, Tirode F, Chanock SJ, Delattre O.

Nat Commun. 2018 Aug 9;9(1):3184. doi: 10.1038/s41467-018-05537-2.

11.

Ewing sarcoma.

Grünewald TGP, Cidre-Aranaz F, Surdez D, Tomazou EM, de Álava E, Kovar H, Sorensen PH, Delattre O, Dirksen U.

Nat Rev Dis Primers. 2018 Jul 5;4(1):5. doi: 10.1038/s41572-018-0003-x. Review.

PMID:
29977059
12.

Are EWSR1-NFATc2-positive sarcomas really Ewing sarcomas?

Baldauf MC, Gerke JS, Orth MF, Dallmayer M, Baumhoer D, de Alava E, Hartmann W, Kirchner T, Grünewald TGP.

Mod Pathol. 2018 Jun;31(6):997-999. doi: 10.1038/s41379-018-0009-7. Epub 2018 Jun 12. No abstract available.

13.

Robust diagnosis of Ewing sarcoma by immunohistochemical detection of super-enhancer-driven EWSR1-ETS targets.

Baldauf MC, Orth MF, Dallmayer M, Marchetto A, Gerke JS, Rubio RA, Kiran MM, Musa J, Knott MML, Ohmura S, Li J, Akpolat N, Akatli AN, Özen Ö, Dirksen U, Hartmann W, de Alava E, Baumhoer D, Sannino G, Kirchner T, Grünewald TGP.

Oncotarget. 2017 Aug 4;9(2):1587-1601. doi: 10.18632/oncotarget.20098. eCollection 2018 Jan 5.

14.

PRC1: Linking Cytokinesis, Chromosomal Instability, and Cancer Evolution.

Li J, Dallmayer M, Kirchner T, Musa J, Grünewald TGP.

Trends Cancer. 2018 Jan;4(1):59-73. doi: 10.1016/j.trecan.2017.11.002. Epub 2017 Dec 16. Review.

PMID:
29413422
15.

PBX3 Is Part of an EMT Regulatory Network and Indicates Poor Outcome in Colorectal Cancer.

Lamprecht S, Kaller M, Schmidt EM, Blaj C, Schiergens TS, Engel J, Jung A, Hermeking H, Grünewald TGP, Kirchner T, Horst D.

Clin Cancer Res. 2018 Apr 15;24(8):1974-1986. doi: 10.1158/1078-0432.CCR-17-2572. Epub 2018 Feb 1.

16.

[The role of focal adhesions in Ewing's sarcoma].

Steinestel K, Grünewald TGP, Hartmann W.

Pathologe. 2017 Nov;38(Suppl 2):169-171. doi: 10.1007/s00292-017-0354-1. German. No abstract available.

PMID:
28939918
17.

[Functional genomics of Ewing sarcoma].

Grünewald TGP.

Pathologe. 2017 Nov;38(Suppl 2):198-201. doi: 10.1007/s00292-017-0332-7. Review. German.

PMID:
28849372
18.

Epithelial-to-Mesenchymal and Mesenchymal-to-Epithelial Transition in Mesenchymal Tumors: A Paradox in Sarcomas?

Sannino G, Marchetto A, Kirchner T, Grünewald TGP.

Cancer Res. 2017 Sep 1;77(17):4556-4561. doi: 10.1158/0008-5472.CAN-17-0032. Epub 2017 Aug 15. Review.

19.

Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries.

Boeva V, Louis-Brennetot C, Peltier A, Durand S, Pierre-Eugène C, Raynal V, Etchevers HC, Thomas S, Lermine A, Daudigeos-Dubus E, Geoerger B, Orth MF, Grünewald TGP, Diaz E, Ducos B, Surdez D, Carcaboso AM, Medvedeva I, Deller T, Combaret V, Lapouble E, Pierron G, Grossetête-Lalami S, Baulande S, Schleiermacher G, Barillot E, Rohrer H, Delattre O, Janoueix-Lerosey I.

Nat Genet. 2017 Sep;49(9):1408-1413. doi: 10.1038/ng.3921. Epub 2017 Jul 24.

PMID:
28740262
20.

MYBL2 (B-Myb): a central regulator of cell proliferation, cell survival and differentiation involved in tumorigenesis.

Musa J, Aynaud MM, Mirabeau O, Delattre O, Grünewald TG.

Cell Death Dis. 2017 Jun 22;8(6):e2895. doi: 10.1038/cddis.2017.244. Review.

21.

Ewing sarcoma partial regression without GvHD by chondromodulin-I/HLA-A*02:01-specific allorestricted T cell receptor transgenic T cells.

Thiel U, Schober SJ, Einspieler I, Kirschner A, Thiede M, Schirmer D, Gall K, Blaeschke F, Schmidt O, Jabar S, Ranft A, Alba Rubío R, Dirksen U, Grunewald TGP, Sorensen PH, Richter GHS, von Lüttichau IT, Busch DH, Burdach SEG.

Oncoimmunology. 2017 Apr 12;6(5):e1312239. doi: 10.1080/2162402X.2017.1312239. eCollection 2017.

22.

Next steps in Ewing sarcoma (epi-)genomics.

Sannino G, Orth MF, Grünewald TG.

Future Oncol. 2017 Jun;13(14):1207-1211. doi: 10.2217/fon-2017-0159. Epub 2017 Jun 7. No abstract available.

23.

MRD response in a refractory paediatric T-ALL patient through anti-programmed cell death 1 (PD-1) Ab treatment associated with induction of fatal GvHD.

Boekstegers AM, Blaeschke F, Schmid I, Wiebking V, Immler S, Hoffmann F, Bochmann K, Müller S, Grünewald TGP, Feucht J, Feuchtinger T.

Bone Marrow Transplant. 2017 Aug;52(8):1221-1224. doi: 10.1038/bmt.2017.107. Epub 2017 Jun 5. No abstract available.

PMID:
28581460
24.

Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells.

Elia I, Broekaert D, Christen S, Boon R, Radaelli E, Orth MF, Verfaillie C, Grünewald TGP, Fendt SM.

Nat Commun. 2017 May 11;8:15267. doi: 10.1038/ncomms15267.

25.

Pappalysin-1 T cell receptor transgenic allo-restricted T cells kill Ewing sarcoma in vitro and in vivo.

Kirschner A, Thiede M, Grünewald TG, Alba Rubio R, Richter GH, Kirchner T, Busch DH, Burdach S, Thiel U.

Oncoimmunology. 2017 Jan 17;6(2):e1273301. doi: 10.1080/2162402X.2016.1273301. eCollection 2017.

26.

Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis.

Christen S, Lorendeau D, Schmieder R, Broekaert D, Metzger K, Veys K, Elia I, Buescher JM, Orth MF, Davidson SM, Grünewald TG, De Bock K, Fendt SM.

Cell Rep. 2016 Oct 11;17(3):837-848. doi: 10.1016/j.celrep.2016.09.042.

27.

Bone marrow involvement identifies a subgroup of advanced Ewing sarcoma patients with fatal outcome irrespective of therapy in contrast to curable patients with multiple bone metastases but unaffected marrow.

Thiel U, Wawer A, von Luettichau I, Bender HU, Blaeschke F, Grunewald TG, Steinborn M, Röper B, Bonig H, Klingebiel T, Bader P, Koscielniak E, Paulussen M, Dirksen U, Juergens H, Kolb HJ, Burdach SE.

Oncotarget. 2016 Oct 25;7(43):70959-70968. doi: 10.18632/oncotarget.10938.

28.

Transgenic antigen-specific, HLA-A*02:01-allo-restricted cytotoxic T cells recognize tumor-associated target antigen STEAP1 with high specificity.

Schirmer D, Grünewald TG, Klar R, Schmidt O, Wohlleber D, Rubío RA, Uckert W, Thiel U, Bohne F, Busch DH, Krackhardt AM, Burdach S, Richter GH.

Oncoimmunology. 2016 Apr 25;5(6):e1175795. doi: 10.1080/2162402X.2016.1175795. eCollection 2016 Jun.

29.

Lysosome-associated membrane glycoprotein 1 predicts fratricide amongst T cell receptor transgenic CD8+ T cells directed against tumor-associated antigens.

Kirschner A, Thiede M, Blaeschke F, Richter GH, Gerke JS, Baldauf MC, Grünewald TG, Busch DH, Burdach S, Thiel U.

Oncotarget. 2016 Aug 30;7(35):56584-56597. doi: 10.18632/oncotarget.10647.

30.

EWS-FLI1-mediated suppression of the RAS-antagonist Sprouty 1 (SPRY1) confers aggressiveness to Ewing sarcoma.

Cidre-Aranaz F, Grünewald TG, Surdez D, García-García L, Carlos Lázaro J, Kirchner T, González-González L, Sastre A, García-Miguel P, López-Pérez SE, Monzón S, Delattre O, Alonso J.

Oncogene. 2017 Feb 9;36(6):766-776. doi: 10.1038/onc.2016.244. Epub 2016 Jul 4.

PMID:
27375017
31.

Cooperation between somatic mutations and germline susceptibility variants in tumorigenesis - a dangerous liaison.

Grünewald TG, Delattre O.

Mol Cell Oncol. 2015 Oct 6;3(3):e1086853. doi: 10.1080/23723556.2015.1086853. eCollection 2016 May.

32.

Human HLA-A*02:01/CHM1+ allo-restricted T cell receptor transgenic CD8+ T cells specifically inhibit Ewing sarcoma growth in vitro and in vivo.

Blaeschke F, Thiel U, Kirschner A, Thiede M, Rubio RA, Schirmer D, Kirchner T, Richter GHS, Mall S, Klar R, Riddell S, Busch DH, Krackhardt A, Grunewald TG, Burdach S.

Oncotarget. 2016 Jul 12;7(28):43267-43280. doi: 10.18632/oncotarget.9218.

33.

[Cooperation between a somatic mutation and a genetic susceptibility variant in Ewing sarcoma].

Grünewald TG, Gilardi-Hebenstreit P, Charnay P, Delattre O.

Med Sci (Paris). 2016 Apr;32(4):323-6. doi: 10.1051/medsci/20163204004. Epub 2016 May 2. French. No abstract available.

34.

Editorial: Biology-Driven Targeted Therapy of Pediatric Soft-Tissue and Bone Tumors: Current Opportunities and Future Challenges.

Grünewald TG, Fulda S.

Front Oncol. 2016 Feb 18;6:39. doi: 10.3389/fonc.2016.00039. eCollection 2016. No abstract available.

35.

Acute stress enhances the expression of neuroprotection- and neurogenesis-associated genes in the hippocampus of a mouse restraint model.

Sannino G, Pasqualini L, Ricciardelli E, Montilla P, Soverchia L, Ruggeri B, Falcinelli S, Renzi A, Ludka C, Kirchner T, Grünewald TG, Ciccocioppo R, Ubaldi M, Hardiman G.

Oncotarget. 2016 Feb 23;7(8):8455-65. doi: 10.18632/oncotarget.7225.

36.

Eukaryotic initiation factor 4E-binding protein 1 (4E-BP1): a master regulator of mRNA translation involved in tumorigenesis.

Musa J, Orth MF, Dallmayer M, Baldauf M, Pardo C, Rotblat B, Kirchner T, Leprivier G, Grünewald TG.

Oncogene. 2016 Sep 8;35(36):4675-88. doi: 10.1038/onc.2015.515. Epub 2016 Feb 1. Review.

PMID:
26829052
37.

The second European interdisciplinary Ewing sarcoma research summit--A joint effort to deconstructing the multiple layers of a complex disease.

Kovar H, Amatruda J, Brunet E, Burdach S, Cidre-Aranaz F, de Alava E, Dirksen U, van der Ent W, Grohar P, Grünewald TG, Helman L, Houghton P, Iljin K, Korsching E, Ladanyi M, Lawlor E, Lessnick S, Ludwig J, Meltzer P, Metzler M, Mora J, Moriggl R, Nakamura T, Papamarkou T, Radic Sarikas B, Rédini F, Richter GH, Rossig C, Schadler K, Schäfer BW, Scotlandi K, Sheffield NC, Shelat A, Snaar-Jagalska E, Sorensen P, Stegmaier K, Stewart E, Sweet-Cordero A, Szuhai K, Tirado OM, Tirode F, Toretsky J, Tsafou K, Üren A, Zinovyev A, Delattre O.

Oncotarget. 2016 Feb 23;7(8):8613-24. doi: 10.18632/oncotarget.6937. Review.

38.

Next steps in preventing Ewing sarcoma progression.

Knott MM, Dallmayer M, Grünewald TG.

Future Oncol. 2016 Jan;12(1):1-4. doi: 10.2217/fon.15.298. Epub 2015 Nov 30. No abstract available.

39.

Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite.

Grünewald TG, Bernard V, Gilardi-Hebenstreit P, Raynal V, Surdez D, Aynaud MM, Mirabeau O, Cidre-Aranaz F, Tirode F, Zaidi S, Perot G, Jonker AH, Lucchesi C, Le Deley MC, Oberlin O, Marec-Bérard P, Véron AS, Reynaud S, Lapouble E, Boeva V, Rio Frio T, Alonso J, Bhatia S, Pierron G, Cancel-Tassin G, Cussenot O, Cox DG, Morton LM, Machiela MJ, Chanock SJ, Charnay P, Delattre O.

Nat Genet. 2015 Sep;47(9):1073-8. doi: 10.1038/ng.3363. Epub 2015 Jul 27.

40.

The LPA1/ZEB1/miR-21-activation pathway regulates metastasis in basal breast cancer.

Sahay D, Leblanc R, Grunewald TG, Ambatipudi S, Ribeiro J, Clézardin P, Peyruchaud O.

Oncotarget. 2015 Aug 21;6(24):20604-20.

41.

LASP1, a Newly Identified Melanocytic Protein with a Possible Role in Melanin Release, but Not in Melanoma Progression.

Vaman V S A, Poppe H, Houben R, Grunewald TG, Goebeler M, Butt E.

PLoS One. 2015 Jun 10;10(6):e0129219. doi: 10.1371/journal.pone.0129219. eCollection 2015.

42.

Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis.

El-Naggar AM, Veinotte CJ, Cheng H, Grunewald TG, Negri GL, Somasekharan SP, Corkery DP, Tirode F, Mathers J, Khan D, Kyle AH, Baker JH, LePard NE, McKinney S, Hajee S, Bosiljcic M, Leprivier G, Tognon CE, Minchinton AI, Bennewith KL, Delattre O, Wang Y, Dellaire G, Berman JN, Sorensen PH.

Cancer Cell. 2015 May 11;27(5):682-97. doi: 10.1016/j.ccell.2015.04.003.

43.

Tumour-derived exosomes: Tiny envelopes for big stories.

Miller IV, Grunewald TG.

Biol Cell. 2015 Sep;107(9):287-305. doi: 10.1111/boc.201400095. Epub 2015 Jun 9. Review.

PMID:
25923825
44.

YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1.

Somasekharan SP, El-Naggar A, Leprivier G, Cheng H, Hajee S, Grunewald TG, Zhang F, Ng T, Delattre O, Evdokimova V, Wang Y, Gleave M, Sorensen PH.

J Cell Biol. 2015 Mar 30;208(7):913-29. doi: 10.1083/jcb.201411047. Epub 2015 Mar 23.

45.

An update on the LIM and SH3 domain protein 1 (LASP1): a versatile structural, signaling, and biomarker protein.

Orth MF, Cazes A, Butt E, Grunewald TG.

Oncotarget. 2015 Jan 1;6(1):26-42. Review.

46.
47.

LASP1 is a novel BCR-ABL substrate and a phosphorylation-dependent binding partner of CRKL in chronic myeloid leukemia.

Frietsch JJ, Kastner C, Grunewald TG, Schweigel H, Nollau P, Ziermann J, Clement JH, La Rosée P, Hochhaus A, Butt E.

Oncotarget. 2014 Jul 30;5(14):5257-71.

48.

Anti-oxidative stress response genes: bioinformatic analysis of their expression and relevance in multiple cancers.

Rotblat B, Grunewald TG, Leprivier G, Melino G, Knight RA.

Oncotarget. 2013 Dec;4(12):2577-90.

49.

Allogeneic stem cell transplantation for patients with advanced rhabdomyosarcoma: a retrospective assessment.

Thiel U, Koscielniak E, Blaeschke F, Grunewald TG, Badoglio M, Diaz MA, Paillard C, Prete A, Ussowicz M, Lang P, Fagioli F, Lutz P, Ehninger G, Schneider P, Santucci A, Bader P, Gruhn B, Faraci M, Antunovic P, Styczynski J, Krüger WH, Castagna L, Rohrlich P, Ouachée-Chardin M, Salmon A, Peters C, Bregni M, Burdach S; Solid Tumour Working Party and the Paediatric Disease Working Party of the European Group for Blood and Marrow Transplantation.

Br J Cancer. 2013 Nov 12;109(10):2523-32. doi: 10.1038/bjc.2013.630. Epub 2013 Oct 22.

50.

The Zyxin-related protein thyroid receptor interacting protein 6 (TRIP6) is overexpressed in Ewing's sarcoma and promotes migration, invasion and cell growth.

Grunewald TG, Willier S, Janik D, Unland R, Reiss C, Prazeres da Costa O, Buch T, Dirksen U, Richter GH, Neff F, Burdach S, Butt E.

Biol Cell. 2013 Nov;105(11):535-47. doi: 10.1111/boc.201300041. Epub 2013 Sep 18.

PMID:
24033704

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