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Histamine induces peripheral and central hypersensitivity to bladder distension via the histamine H1 receptor and TRPV1.

Grundy L, Caldwell A, Garcia Caraballo S, Erickson A, Schober G, Castro J, Harrington AM, Brierley SM.

Am J Physiol Renal Physiol. 2020 Feb 1;318(2):F298-F314. doi: 10.1152/ajprenal.00435.2019. Epub 2019 Dec 2.


Purinergic receptor mediated calcium signalling in urothelial cells.

Chess-Williams R, Sellers DJ, Brierley SM, Grundy D, Grundy L.

Sci Rep. 2019 Nov 6;9(1):16101. doi: 10.1038/s41598-019-52531-9.


Activation of pruritogenic TGR5, MrgprA3, and MrgprC11 on colon-innervating afferents induces visceral hypersensitivity.

Castro J, Harrington AM, Lieu T, Garcia-Caraballo S, Maddern J, Schober G, O'Donnell T, Grundy L, Lumsden AL, Miller P, Ghetti A, Steinhoff MS, Poole DP, Dong X, Chang L, Bunnett NW, Brierley SM.

JCI Insight. 2019 Oct 17;4(20). pii: 131712. doi: 10.1172/jci.insight.131712.


Serotonin exerts a direct modulatory role on bladder afferent firing in mice.

Konthapakdee N, Grundy L, O'Donnell T, Garcia-Caraballo S, Brierley SM, Grundy D, Daly DM.

J Physiol. 2019 Nov;597(21):5247-5264. doi: 10.1113/JP278751. Epub 2019 Oct 13.


Innate immune response to bacterial urinary tract infection sensitises high-threshold bladder afferents and recruits silent nociceptors.

Brierley SM, Goh KGK, Sullivan MJ, Moore KH, Ulett GC, Grundy L.

Pain. 2020 Jan;161(1):202-210. doi: 10.1097/j.pain.0000000000001692.


Linaclotide treatment reduces endometriosis-associated vaginal hyperalgesia and mechanical allodynia through viscerovisceral cross-talk.

Ge P, Ren J, Harrington AM, Grundy L, Castro J, Brierley SM, Hannig G.

Pain. 2019 Nov;160(11):2566-2579. doi: 10.1097/j.pain.0000000000001657.


Colonic afferent input and dorsal horn neuron activation differs between the thoracolumbar and lumbosacral spinal cord.

Harrington AM, Caraballo SG, Maddern JE, Grundy L, Castro J, Brierley SM.

Am J Physiol Gastrointest Liver Physiol. 2019 Sep 1;317(3):G285-G303. doi: 10.1152/ajpgi.00013.2019. Epub 2019 Jun 12.


Difference between approximate and rigorously measured transference numbers in fluorinated electrolytes.

Shah DB, Nguyen HQ, Grundy LS, Olson KR, Mecham SJ, DeSimone JM, Balsara NP.

Phys Chem Chem Phys. 2019 Apr 21;21(15):7857-7866. doi: 10.1039/c9cp00216b. Epub 2019 Mar 27.


EFHC1, implicated in juvenile myoclonic epilepsy, functions at the cilium and synapse to modulate dopamine signaling.

Loucks CM, Park K, Walker DS, McEwan AH, Timbers TA, Ardiel EL, Grundy LJ, Li C, Johnson JL, Kennedy J, Blacque OE, Schafer W, Rankin CH, Leroux MR.

Elife. 2019 Feb 27;8. pii: e37271. doi: 10.7554/eLife.37271.


Mechanisms Underlying Overactive Bladder and Interstitial Cystitis/Painful Bladder Syndrome.

Grundy L, Caldwell A, Brierley SM.

Front Neurosci. 2018 Dec 12;12:931. doi: 10.3389/fnins.2018.00931. eCollection 2018. Review.


Translating peripheral bladder afferent mechanosensitivity to neuronal activation within the lumbosacral spinal cord of mice.

Grundy L, Harrington AM, Caldwell A, Castro J, Staikopoulos V, Zagorodnyuk VP, Brookes SJH, Spencer NJ, Brierley SM.

Pain. 2019 Apr;160(4):793-804. doi: 10.1097/j.pain.0000000000001453.


Visceral Pain.

Grundy L, Erickson A, Brierley SM.

Annu Rev Physiol. 2019 Feb 10;81:261-284. doi: 10.1146/annurev-physiol-020518-114525. Epub 2018 Oct 31.


Chronic linaclotide treatment reduces colitis-induced neuroplasticity and reverses persistent bladder dysfunction.

Grundy L, Harrington AM, Castro J, Garcia-Caraballo S, Deiteren A, Maddern J, Rychkov GY, Ge P, Peters S, Feil R, Miller P, Ghetti A, Hannig G, Kurtz CB, Silos-Santiago I, Brierley SM.

JCI Insight. 2018 Oct 4;3(19). pii: 121841. doi: 10.1172/jci.insight.121841.


Neuropeptides encoded by nlp-49 modulate locomotion, arousal and egg-laying behaviours in Caenorhabditis elegans via the receptor SEB-3.

Chew YL, Grundy LJ, Brown AEX, Beets I, Schafer WR.

Philos Trans R Soc Lond B Biol Sci. 2018 Sep 10;373(1758). pii: 20170368. doi: 10.1098/rstb.2017.0368.


An open-source platform for analyzing and sharing worm-behavior data.

Javer A, Currie M, Lee CW, Hokanson J, Li K, Martineau CN, Yemini E, Grundy LJ, Li C, Ch'ng Q, Schafer WR, Nollen EAA, Kerr R, Brown AEX.

Nat Methods. 2018 Sep;15(9):645-646. doi: 10.1038/s41592-018-0112-1. No abstract available.


Tetrodotoxin-sensitive voltage-gated sodium channels regulate bladder afferent responses to distension.

Grundy L, Erickson A, Caldwell A, Garcia-Caraballo S, Rychkov G, Harrington A, Brierley SM.

Pain. 2018 Dec;159(12):2573-2584. doi: 10.1097/j.pain.0000000000001368.


NKA enhances bladder-afferent mechanosensitivity via urothelial and detrusor activation.

Grundy L, Chess-Williams R, Brierley SM, Mills K, Moore KH, Mansfield K, Rose'Meyer R, Sellers D, Grundy D.

Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F1174-F1185. doi: 10.1152/ajprenal.00106.2018. Epub 2018 Jun 13.


NaV1.1 inhibition can reduce visceral hypersensitivity.

Salvatierra J, Castro J, Erickson A, Li Q, Braz J, Gilchrist J, Grundy L, Rychkov GY, Deiteren A, Rais R, King GF, Slusher BS, Basbaum A, Pasricha PJ, Brierley SM, Bosmans F.

JCI Insight. 2018 Jun 7;3(11). pii: 121000. doi: 10.1172/jci.insight.121000. eCollection 2018 Jun 7.


Rapid Production of Internally Structured Colloids by Flash Nanoprecipitation of Block Copolymer Blends.

Grundy LS, Lee VE, Li N, Sosa C, Mulhearn WD, Liu R, Register RA, Nikoubashman A, Prud'homme RK, Panagiotopoulos AZ, Priestley RD.

ACS Nano. 2018 May 22;12(5):4660-4668. doi: 10.1021/acsnano.8b01260. Epub 2018 May 8.


Contribution of membrane receptor signalling to chronic visceral pain.

Sadeghi M, Erickson A, Castro J, Deiteren A, Harrington AM, Grundy L, Adams DJ, Brierley SM.

Int J Biochem Cell Biol. 2018 May;98:10-23. doi: 10.1016/j.biocel.2018.02.017. Epub 2018 Mar 21. Review.


Voltage-gated sodium channels: (NaV )igating the field to determine their contribution to visceral nociception.

Erickson A, Deiteren A, Harrington AM, Garcia-Caraballo S, Castro J, Caldwell A, Grundy L, Brierley SM.

J Physiol. 2018 Mar 1;596(5):785-807. doi: 10.1113/JP273461. Epub 2018 Feb 6. Review.


TRPV1 enhances the afferent response to P2X receptor activation in the mouse urinary bladder.

Grundy L, Daly DM, Chapple C, Grundy D, Chess-Williams R.

Sci Rep. 2018 Jan 9;8(1):197. doi: 10.1038/s41598-017-18136-w.


Stapleless Laparoscopic Sleeve Gastrectomy: Reasoning and Technical Insights.

Catanzano M, Grundy L, Bekheit M.

Obes Surg. 2018 Mar;28(3):854-861. doi: 10.1007/s11695-017-3058-y.


Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain.

Castro J, Grundy L, Deiteren A, Harrington AM, O'Donnell T, Maddern J, Moore J, Garcia-Caraballo S, Rychkov GY, Yu R, Kaas Q, Craik DJ, Adams DJ, Brierley SM.

Br J Pharmacol. 2018 Jun;175(12):2384-2398. doi: 10.1111/bph.14115. Epub 2018 Feb 13.


Identifying unique subtypes of spinal afferent nerve endings within the urinary bladder of mice.

Spencer NJ, Greenheigh S, Kyloh M, Hibberd TJ, Sharma H, Grundy L, Brierley SM, Harrington AM, Beckett EA, Brookes SJ, Zagorodnyuk VP.

J Comp Neurol. 2018 Mar 1;526(4):707-720. doi: 10.1002/cne.24362. Epub 2017 Dec 15.


Cross-organ sensitization between the colon and bladder: to pee or not to pee?

Grundy L, Brierley SM.

Am J Physiol Gastrointest Liver Physiol. 2018 Mar 1;314(3):G301-G308. doi: 10.1152/ajpgi.00272.2017. Epub 2017 Nov 16. Review.


Correction: automated and controlled mechanical stimulation and functional imaging in vivo in C. elegans.

Cho Y, Porto DA, Hwang H, Grundy LJ, Schafer WR, Lu H.

Lab Chip. 2017 Nov 7;17(22):3935. doi: 10.1039/c7lc90104f.


Inorganic Nanoparticles/Metal Organic Framework Hybrid Membrane Reactors for Efficient Photocatalytic Conversion of CO2.

Maina JW, Schütz JA, Grundy L, Des Ligneris E, Yi Z, Kong L, Pozo-Gonzalo C, Ionescu M, Dumée LF.

ACS Appl Mater Interfaces. 2017 Oct 11;9(40):35010-35017. doi: 10.1021/acsami.7b11150. Epub 2017 Sep 29.


Positive Impact of an Aortic Center Designation.

Tanious A, Wooster M, Giarelli M, Armstrong PA, Johnson B, Illig KA, Zwiebel B, Grundy LS, Hooker R, Caldeira C, Back MA, Shames ML.

Ann Vasc Surg. 2018 Jan;46:142-146. doi: 10.1016/j.avsg.2017.08.009. Epub 2017 Sep 5.


Automated and controlled mechanical stimulation and functional imaging in vivo in C. elegans.

Cho Y, Porto DA, Hwang H, Grundy LJ, Schafer WR, Lu H.

Lab Chip. 2017 Jul 25;17(15):2609-2618. doi: 10.1039/c7lc00465f. Erratum in: Lab Chip. 2017 Nov 7;17 (22):3935.


Combining Precipitation and Vitrification to Control the Number of Surface Patches on Polymer Nanocolloids.

Sosa C, Lee VE, Grundy LS, Burroughs MJ, Liu R, Prud'homme RK, Priestley RD.

Langmuir. 2017 Jun 13;33(23):5835-5842. doi: 10.1021/acs.langmuir.7b01021. Epub 2017 Jun 1.


Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1.

Inserra MC, Israel MR, Caldwell A, Castro J, Deuis JR, Harrington AM, Keramidas A, Garcia-Caraballo S, Maddern J, Erickson A, Grundy L, Rychkov GY, Zimmermann K, Lewis RJ, Brierley SM, Vetter I.

Sci Rep. 2017 Feb 22;7:42810. doi: 10.1038/srep42810.


The Bright Fluorescent Protein mNeonGreen Facilitates Protein Expression Analysis In Vivo.

Hostettler L, Grundy L, Käser-Pébernard S, Wicky C, Schafer WR, Glauser DA.

G3 (Bethesda). 2017 Feb 9;7(2):607-615. doi: 10.1534/g3.116.038133.


How prepared are UK medical graduates for practice? A rapid review of the literature 2009-2014.

Monrouxe LV, Grundy L, Mann M, John Z, Panagoulas E, Bullock A, Mattick K.

BMJ Open. 2017 Jan 13;7(1):e013656. doi: 10.1136/bmjopen-2016-013656. Review.


Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain.

Osteen JD, Herzig V, Gilchrist J, Emrick JJ, Zhang C, Wang X, Castro J, Garcia-Caraballo S, Grundy L, Rychkov GY, Weyer AD, Dekan Z, Undheim EA, Alewood P, Stucky CL, Brierley SM, Basbaum AI, Bosmans F, King GF, Julius D.

Nature. 2016 Jun 23;534(7608):494-9. doi: 10.1038/nature17976. Epub 2016 Jun 6.


PACRG, a protein linked to ciliary motility, mediates cellular signaling.

Loucks CM, Bialas NJ, Dekkers MP, Walker DS, Grundy LJ, Li C, Inglis PN, Kida K, Schafer WR, Blacque OE, Jansen G, Leroux MR.

Mol Biol Cell. 2016 Jul 1;27(13):2133-44. doi: 10.1091/mbc.E15-07-0490. Epub 2016 May 18.


α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABAB receptors.

Castro J, Harrington AM, Garcia-Caraballo S, Maddern J, Grundy L, Zhang J, Page G, Miller PE, Craik DJ, Adams DJ, Brierley SM.

Gut. 2017 Jun;66(6):1083-1094. doi: 10.1136/gutjnl-2015-310971. Epub 2016 Feb 17.


A Rapid Review of the Factors Affecting Healthcare Students' Satisfaction with Small-Group, Active Learning Methods.

Kilgour JM, Grundy L, Monrouxe LV.

Teach Learn Med. 2016;28(1):15-25. doi: 10.1080/10401334.2015.1107484. Review.


Changes in Postural Syntax Characterize Sensory Modulation and Natural Variation of C. elegans Locomotion.

Schwarz RF, Branicky R, Grundy LJ, Schafer WR, Brown AE.

PLoS Comput Biol. 2015 Aug 21;11(8):e1004322. doi: 10.1371/journal.pcbi.1004322. eCollection 2015 Aug.


Translational potential of a mouse in vitro bioassay in predicting gastrointestinal adverse drug reactions in Phase I clinical trials.

Keating C, Ewart L, Grundy L, Valentin JP, Grundy D.

Neurogastroenterol Motil. 2014 Jul;26(7):980-9. doi: 10.1111/nmo.12349. Epub 2014 May 11.


Coblation-assisted Lewis and MacKay operation (CobLAMO): new technique for tongue reduction in sleep apnoea surgery.

MacKay SG, Jefferson N, Grundy L, Lewis R.

J Laryngol Otol. 2013 Dec;127(12):1222-5. doi: 10.1017/S0022215113002971. Epub 2013 Nov 19.


A database of Caenorhabditis elegans behavioral phenotypes.

Yemini E, Jucikas T, Grundy LJ, Brown AE, Schafer WR.

Nat Methods. 2013 Sep;10(9):877-9. doi: 10.1038/nmeth.2560. Epub 2013 Jul 14.


Heart rate variability and extubation readiness in extremely preterm infants.

Kaczmarek J, Chawla S, Marchica C, Dwaihy M, Grundy L, Sant'Anna GM.

Neonatology. 2013;104(1):42-8. doi: 10.1159/000347101. Epub 2013 May 24.


Total vitamin D assay comparison of the Roche Diagnostics "Vitamin D total" electrochemiluminescence protein binding assay with the Chromsystems HPLC method in a population with both D2 and D3 forms of vitamin D.

Abdel-Wareth L, Haq A, Turner A, Khan S, Salem A, Mustafa F, Hussein N, Pallinalakam F, Grundy L, Patras G, Rajah J.

Nutrients. 2013 Mar 22;5(3):971-80. doi: 10.3390/nu5030971.


A dictionary of behavioral motifs reveals clusters of genes affecting Caenorhabditis elegans locomotion.

Brown AE, Yemini EI, Grundy LJ, Jucikas T, Schafer WR.

Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):791-6. doi: 10.1073/pnas.1211447110. Epub 2012 Dec 24.


Where do AMU nurses perceive their educational needs? Results of the 20:10 project.

Jepson J, Whitley S, Subbe CP, Grundy L.

Acute Med. 2012;11(1):18-22.


Spatial asymmetry in the mechanosensory phenotypes of the C. elegans DEG/ENaC gene mec-10.

Chatzigeorgiou M, Grundy L, Kindt KS, Lee WH, Driscoll M, Schafer WR.

J Neurophysiol. 2010 Dec;104(6):3334-44. doi: 10.1152/jn.00330.2010. Epub 2010 Sep 29.


Challenges in designing an All-Wales professional development programme to empower ward sisters and charge nurses.

Jasper MA, Grundy L, Curry E, Jones L.

J Nurs Manag. 2010 Sep;18(6):645-53. doi: 10.1111/j.1365-2834.2010.01159.x.


The validation of an in vitro colonic motility assay as a biomarker for gastrointestinal adverse drug reactions.

Keating C, Martinez V, Ewart L, Gibbons S, Grundy L, Valentin JP, Grundy D.

Toxicol Appl Pharmacol. 2010 Jun 15;245(3):299-309. doi: 10.1016/j.taap.2010.03.014. Epub 2010 Mar 27.


TIPS versus peritoneovenous shunt in the treatment of medically intractable ascites: a prospective randomized trial.

Rosemurgy AS, Zervos EE, Clark WC, Thometz DP, Black TJ, Zwiebel BR, Kudryk BT, Grundy LS, Carey LC.

Ann Surg. 2004 Jun;239(6):883-9; discussion 889-91.

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