Sort by
Items per page

Send to

Choose Destination

Search results

Items: 31


Anti-tubercular activity of novel 4-anilinoquinolines and 4-anilinoquinazolines.

Asquith CRM, Fleck N, Torrice CD, Crona DJ, Grundner C, Zuercher WJ.

Bioorg Med Chem Lett. 2019 Sep 15;29(18):2695-2699. doi: 10.1016/j.bmcl.2019.07.012. Epub 2019 Jul 10.


To fight tuberculosis, fund basic research.

Grundner C.

PLoS Biol. 2018 Sep 25;16(9):e3000037. doi: 10.1371/journal.pbio.3000037. eCollection 2018 Sep.


Mycobacterium tuberculosis Rv3651 is a triple sensor-domain protein.

Abendroth J, Frando A, Phan IQ, Staker BL, Myler PJ, Edwards TE, Grundner C.

Protein Sci. 2018 Feb;27(2):568-572. doi: 10.1002/pro.3343. Epub 2017 Dec 5.


A Global Survey of ATPase Activity in Plasmodium falciparum Asexual Blood Stages and Gametocytes.

Ortega C, Frando A, Webb-Robertson BJ, Anderson LN, Fleck N, Flannery EL, Fishbaugher M, Murphree TA, Hansen JR, Smith RD, Kappe SHI, Wright AT, Grundner C.

Mol Cell Proteomics. 2018 Jan;17(1):111-120. doi: 10.1074/mcp.RA117.000088. Epub 2017 Oct 27.


Systematic Survey of Serine Hydrolase Activity in Mycobacterium tuberculosis Defines Changes Associated with Persistence.

Ortega C, Anderson LN, Frando A, Sadler NC, Brown RW, Smith RD, Wright AT, Grundner C.

Cell Chem Biol. 2016 Feb 18;23(2):290-298. doi: 10.1016/j.chembiol.2016.01.003. Epub 2016 Feb 4.


Crystal structures of Mycobacterial MeaB and MMAA-like GTPases.

Edwards TE, Baugh L, Bullen J, Baydo RO, Witte P, Thompkins K, Phan IQ, Abendroth J, Clifton MC, Sankaran B, Van Voorhis WC, Myler PJ, Staker BL, Grundner C, Lorimer DD.

J Struct Funct Genomics. 2015 Jun;16(2):91-9. doi: 10.1007/s10969-015-9197-2. Epub 2015 Apr 2.


Agents of change - concepts in Mycobacterium tuberculosis Ser/Thr/Tyr phosphosignalling.

Sherman DR, Grundner C.

Mol Microbiol. 2014 Oct;94(2):231-41. doi: 10.1111/mmi.12747. Epub 2014 Aug 25. Review.


Mycobacterium tuberculosis supports protein tyrosine phosphorylation.

Kusebauch U, Ortega C, Ollodart A, Rogers RS, Sherman DR, Moritz RL, Grundner C.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9265-70. doi: 10.1073/pnas.1323894111. Epub 2014 Jun 9.


Mycobacterium tuberculosis Ser/Thr protein kinase B mediates an oxygen-dependent replication switch.

Ortega C, Liao R, Anderson LN, Rustad T, Ollodart AR, Wright AT, Sherman DR, Grundner C.

PLoS Biol. 2014 Jan;12(1):e1001746. doi: 10.1371/journal.pbio.1001746. Epub 2014 Jan 7.


Mycobacterium tuberculosis Rv2179c protein establishes a new exoribonuclease family with broad phylogenetic distribution.

Abendroth J, Ollodart A, Andrews ES, Myler PJ, Staker BL, Edwards TE, Arcus VL, Grundner C.

J Biol Chem. 2014 Jan 24;289(4):2139-47. doi: 10.1074/jbc.M113.525683. Epub 2013 Dec 4.


Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase.

Hatzios SK, Baer CE, Rustad TR, Siegrist MS, Pang JM, Ortega C, Alber T, Grundner C, Sherman DR, Bertozzi CR.

Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):E5069-77. doi: 10.1073/pnas.1321205110. Epub 2013 Dec 5.


Identification of widespread adenosine nucleotide binding in Mycobacterium tuberculosis.

Ansong C, Ortega C, Payne SH, Haft DH, Chauvignè-Hines LM, Lewis MP, Ollodart AR, Purvine SO, Shukla AK, Fortuin S, Smith RD, Adkins JN, Grundner C, Wright AT.

Chem Biol. 2013 Jan 24;20(1):123-33. doi: 10.1016/j.chembiol.2012.11.008.


Mycobacterium thermoresistibile as a source of thermostable orthologs of Mycobacterium tuberculosis proteins.

Edwards TE, Liao R, Phan I, Myler PJ, Grundner C.

Protein Sci. 2012 Jul;21(7):1093-6. doi: 10.1002/pro.2084. Epub 2012 May 24.


Structure and substrate recognition of the Staphylococcus aureus protein tyrosine phosphatase PtpA.

Vega C, Chou S, Engel K, Harrell ME, Rajagopal L, Grundner C.

J Mol Biol. 2011 Oct 14;413(1):24-31. doi: 10.1016/j.jmb.2011.08.015. Epub 2011 Aug 17.


Design and synthesis of nonpeptidic, small molecule inhibitors for the Mycobacterium tuberculosis protein tyrosine phosphatase PtpB.

Rawls KA, Grundner C, Ellman JA.

Org Biomol Chem. 2010 Sep 21;8(18):4066-70. doi: 10.1039/c0ob00182a. Epub 2010 Jul 19.


The Trypanosoma brucei life cycle switch TbPTP1 is structurally conserved and dephosphorylates the nucleolar protein NOPP44/46.

Chou S, Jensen BC, Parsons M, Alber T, Grundner C.

J Biol Chem. 2010 Jul 16;285(29):22075-81. doi: 10.1074/jbc.M110.108860. Epub 2010 May 5.


Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.

Rawls KA, Lang PT, Takeuchi J, Imamura S, Baguley TD, Grundner C, Alber T, Ellman JA.

Bioorg Med Chem Lett. 2009 Dec 15;19(24):6851-4. doi: 10.1016/j.bmcl.2009.10.090. Epub 2009 Oct 25.


Protein tyrosine phosphatase PtpA is not required for Mycobacterium tuberculosis growth in mice.

Grundner C, Cox JS, Alber T.

FEMS Microbiol Lett. 2008 Oct;287(2):181-4. doi: 10.1111/j.1574-6968.2008.01309.x. Epub 2008 Aug 22.


Increased human immunodeficiency virus type 1 Env expression and antibody induction using an enhanced alphavirus vector.

Forsell MN, McInerney GM, Dosenovic P, Hidmark AS, Eriksson C, Liljeström P, Grundner C, Karlsson Hedestam GB.

J Gen Virol. 2007 Oct;88(Pt 10):2774-9.


Fragment-based substrate activity screening method for the identification of potent inhibitors of the Mycobacterium tuberculosis phosphatase PtpB.

Soellner MB, Rawls KA, Grundner C, Alber T, Ellman JA.

J Am Chem Soc. 2007 Aug 8;129(31):9613-5. Epub 2007 Jul 18. No abstract available.


Structural basis for selective inhibition of Mycobacterium tuberculosis protein tyrosine phosphatase PtpB.

Grundner C, Perrin D, Hooft van Huijsduijnen R, Swinnen D, Gonzalez J, Gee CL, Wells TN, Alber T.

Structure. 2007 Apr;15(4):499-509.


Structure/function studies of Ser/Thr and Tyr protein phosphorylation in Mycobacterium tuberculosis.

Greenstein AE, Grundner C, Echols N, Gay LM, Lombana TN, Miecskowski CA, Pullen KE, Sung PY, Alber T.

J Mol Microbiol Biotechnol. 2005;9(3-4):167-81. Review.


Analysis of the neutralizing antibody response elicited in rabbits by repeated inoculation with trimeric HIV-1 envelope glycoproteins.

Grundner C, Li Y, Louder M, Mascola J, Yang X, Sodroski J, Wyatt R.

Virology. 2005 Jan 5;331(1):33-46.


Factors limiting the immunogenicity of HIV-1 gp120 envelope glycoproteins.

Grundner C, Pancera M, Kang JM, Koch M, Sodroski J, Wyatt R.

Virology. 2004 Dec 5;330(1):233-48.


Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1.

Labrijn AF, Poignard P, Raja A, Zwick MB, Delgado K, Franti M, Binley J, Vivona V, Grundner C, Huang CC, Venturi M, Petropoulos CJ, Wrin T, Dimitrov DS, Robinson J, Kwong PD, Wyatt RT, Sodroski J, Burton DR.

J Virol. 2003 Oct;77(19):10557-65.


Structure-based, targeted deglycosylation of HIV-1 gp120 and effects on neutralization sensitivity and antibody recognition.

Koch M, Pancera M, Kwong PD, Kolchinsky P, Grundner C, Wang L, Hendrickson WA, Sodroski J, Wyatt R.

Virology. 2003 Sep 1;313(2):387-400.


Tyrosine sulfation of human antibodies contributes to recognition of the CCR5 binding region of HIV-1 gp120.

Choe H, Li W, Wright PL, Vasilieva N, Venturi M, Huang CC, Grundner C, Dorfman T, Zwick MB, Wang L, Rosenberg ES, Kwong PD, Burton DR, Robinson JE, Sodroski JG, Farzan M.

Cell. 2003 Jul 25;114(2):161-70.


Solid-phase proteoliposomes containing human immunodeficiency virus envelope glycoproteins.

Grundner C, Mirzabekov T, Sodroski J, Wyatt R.

J Virol. 2002 Apr;76(7):3511-21.


Expression of two nblA-homologous genes is required for phycobilisome degradation in nitrogen-starved Synechocystis sp. PCC6803.

Baier K, Nicklisch S, Grundner C, Reinecke J, Lockau W.

FEMS Microbiol Lett. 2001 Feb 5;195(1):35-9.

Supplemental Content

Loading ...
Support Center