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Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner.

O'Reilly LA, Putoczki TL, Mielke LA, Low JT, Lin A, Preaudet A, Herold MJ, Yaprianto K, Tai L, Kueh A, Pacini G, Ferrero RL, Gugasyan R, Hu Y, Christie M, Wilcox S, Grumont R, Griffin MDW, O'Connor L, Smyth GK, Ernst M, Waring P, Gerondakis S, Strasser A.

Immunity. 2018 Mar 20;48(3):570-583.e8. doi: 10.1016/j.immuni.2018.03.003.


Corrigendum: NF-κB control of T cell development.

Gerondakis S, Fulford TS, Messina NL, Grumont RJ.

Nat Immunol. 2017 Sep 19;18(10):1173. doi: 10.1038/ni1017-1173a. No abstract available.


The Bacterial Peptidoglycan-Sensing Molecules NOD1 and NOD2 Promote CD8+ Thymocyte Selection.

Martinic MM, Caminschi I, O'Keeffe M, Thinnes TC, Grumont R, Gerondakis S, McKay DB, Nemazee D, Gavin AL.

J Immunol. 2017 Apr 1;198(7):2649-2660. doi: 10.4049/jimmunol.1601462. Epub 2017 Feb 15.


The NF-κB transcription factor RelA is required for the tolerogenic function of Foxp3(+) regulatory T cells.

Messina N, Fulford T, O'Reilly L, Loh WX, Motyer JM, Ellis D, McLean C, Naeem H, Lin A, Gugasyan R, Slattery RM, Grumont RJ, Gerondakis S.

J Autoimmun. 2016 Jun;70:52-62. doi: 10.1016/j.jaut.2016.03.017. Epub 2016 Apr 7.


The dual-specificity phosphatase 2 (DUSP2) does not regulate obesity-associated inflammation or insulin resistance in mice.

Lancaster GI, Kraakman MJ, Kammoun HL, Langley KG, Estevez E, Banerjee A, Grumont RJ, Febbraio MA, Gerondakis S.

PLoS One. 2014 Nov 6;9(11):e111524. doi: 10.1371/journal.pone.0111524. eCollection 2014.


c-Rel regulates Ezh2 expression in activated lymphocytes and malignant lymphoid cells.

Neo WH, Lim JF, Grumont R, Gerondakis S, Su IH.

J Biol Chem. 2014 Nov 14;289(46):31693-707. doi: 10.1074/jbc.M114.574517. Epub 2014 Sep 29.


NF-κB control of T cell development.

Gerondakis S, Fulford TS, Messina NL, Grumont RJ.

Nat Immunol. 2014 Jan;15(1):15-25. doi: 10.1038/ni.2785. Review. Erratum in: Nat Immunol. 2017 Sep 19;18(10 ):1173.


Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein.

Herold MJ, Rohrbeck L, Lang MJ, Grumont R, Gerondakis S, Tai L, Bouillet P, Kaufmann T, Strasser A.

EMBO Rep. 2013 Nov;14(11):992-8. doi: 10.1038/embor.2013.152. Epub 2013 Sep 24.


The TACI receptor regulates T-cell-independent marginal zone B cell responses through innate activation-induced cell death.

Figgett WA, Fairfax K, Vincent FB, Le Page MA, Katik I, Deliyanti D, Quah PS, Verma P, Grumont R, Gerondakis S, Hertzog P, O'Reilly LA, Strasser A, Mackay F.

Immunity. 2013 Sep 19;39(3):573-83. doi: 10.1016/j.immuni.2013.05.019. Epub 2013 Sep 5.


c-Rel: shaping CD4 regulatory T cell development in unexpected ways.

Gerondakis S, Fulford T, Grumont RJ.

Transcription. 2012 Sep-Oct;3(5):245-9. doi: 10.4161/trns.21309. Epub 2012 Sep 1.


NF-κB subunit specificity in hemopoiesis.

Gerondakis S, Banerjee A, Grigoriadis G, Vasanthakumar A, Gugasyan R, Sidwell T, Grumont RJ.

Immunol Rev. 2012 Mar;246(1):272-85. doi: 10.1111/j.1600-065X.2011.01090.x. Review.


The NF-κB1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties.

Gugasyan R, Horat E, Kinkel SA, Ross F, Grigoriadis G, Gray D, O'Keeffe M, Berzins SP, Belz GT, Grumont RJ, Banerjee A, Strasser A, Godfrey DI, Tsichlis PN, Gerondakis S.

EMBO J. 2012 Feb 1;31(3):692-706. doi: 10.1038/emboj.2011.435. Epub 2011 Nov 29.


c-Rel controls multiple discrete steps in the thymic development of Foxp3+ CD4 regulatory T cells.

Grigoriadis G, Vasanthakumar A, Banerjee A, Grumont R, Overall S, Gleeson P, Shannon F, Gerondakis S.

PLoS One. 2011;6(10):e26851. doi: 10.1371/journal.pone.0026851. Epub 2011 Oct 31.


Distinct roles in NKT cell maturation and function for the different transcription factors in the classical NF-κB pathway.

Stankovic S, Gugasyan R, Kyparissoudis K, Grumont R, Banerjee A, Tsichlis P, Gerondakis S, Godfrey DI.

Immunol Cell Biol. 2011 Feb;89(2):294-303. doi: 10.1038/icb.2010.93. Epub 2010 Aug 10.


c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells.

Isomura I, Palmer S, Grumont RJ, Bunting K, Hoyne G, Wilkinson N, Banerjee A, Proietto A, Gugasyan R, Wu L, McNally A, Steptoe RJ, Thomas R, Shannon MF, Gerondakis S.

J Exp Med. 2009 Dec 21;206(13):3001-14. doi: 10.1084/jem.20091411. Epub 2009 Dec 7. Erratum in: J Exp Med.2010 Apr 12;207(4):899. Li, Wu [corrected to Wu, Li].


NF-kappaB1 and c-Rel cooperate to promote the survival of TLR4-activated B cells by neutralizing Bim via distinct mechanisms.

Banerjee A, Grumont R, Gugasyan R, White C, Strasser A, Gerondakis S.

Blood. 2008 Dec 15;112(13):5063-73. doi: 10.1182/blood-2007-10-120832. Epub 2008 Sep 19.


The nuclear factor-kappaB and p53 pathways function independently in primary cells and transformed fibroblasts responding to genotoxic damage.

Nesic D, Grumont R, Gerondakis S.

Mol Cancer Res. 2008 Jul;6(7):1193-203. doi: 10.1158/1541-7786.MCR-07-2125. Epub 2008 Jun 26.


Regulating B-cell activation and survival in response to TLR signals.

Gerondakis S, Grumont RJ, Banerjee A.

Immunol Cell Biol. 2007 Aug-Sep;85(6):471-5. Epub 2007 Jul 17. Review.


Unravelling the complexities of the NF-kappaB signalling pathway using mouse knockout and transgenic models.

Gerondakis S, Grumont R, Gugasyan R, Wong L, Isomura I, Ho W, Banerjee A.

Oncogene. 2006 Oct 30;25(51):6781-99. Review.


Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1.

Jeffrey KL, Brummer T, Rolph MS, Liu SM, Callejas NA, Grumont RJ, Gillieron C, Mackay F, Grey S, Camps M, Rommel C, Gerondakis SD, Mackay CR.

Nat Immunol. 2006 Mar;7(3):274-83. Epub 2006 Feb 12.


Distinct roles for the NF-kappaB1 and c-Rel transcription factors in the differentiation and survival of plasmacytoid and conventional dendritic cells activated by TLR-9 signals.

O'Keeffe M, Grumont RJ, Hochrein H, Fuchsberger M, Gugasyan R, Vremec D, Shortman K, Gerondakis S.

Blood. 2005 Nov 15;106(10):3457-64. Epub 2005 Jul 21.


The mitogen-induced increase in T cell size involves PKC and NFAT activation of Rel/NF-kappaB-dependent c-myc expression.

Grumont R, Lock P, Mollinari M, Shannon FM, Moore A, Gerondakis S.

Immunity. 2004 Jul;21(1):19-30.


The transcription factors c-rel and RelA control epidermal development and homeostasis in embryonic and adult skin via distinct mechanisms.

Gugasyan R, Voss A, Varigos G, Thomas T, Grumont RJ, Kaur P, Grigoriadis G, Gerondakis S.

Mol Cell Biol. 2004 Jul;24(13):5733-45.


The combined absence of NF-kappa B1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells.

Pohl T, Gugasyan R, Grumont RJ, Strasser A, Metcalf D, Tarlinton D, Sha W, Baltimore D, Gerondakis S.

Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4514-9.


c-Rel regulates interleukin 12 p70 expression in CD8(+) dendritic cells by specifically inducing p35 gene transcription.

Grumont R, Hochrein H, O'Keeffe M, Gugasyan R, White C, Caminschi I, Cook W, Gerondakis S.

J Exp Med. 2001 Oct 15;194(8):1021-32.


Rel/NF-kappaB transcription factors: key mediators of B-cell activation.

Gugasyan R, Grumont R, Grossmann M, Nakamura Y, Pohl T, Nesic D, Gerondakis S.

Immunol Rev. 2000 Aug;176:134-40. Review.


Interleukin (IL)-4 is a major regulatory cytokine governing bioactive IL-12 production by mouse and human dendritic cells.

Hochrein H, O'Keeffe M, Luft T, Vandenabeele S, Grumont RJ, Maraskovsky E, Shortman K.

J Exp Med. 2000 Sep 18;192(6):823-33.


Genetic approaches in mice to understand Rel/NF-kappaB and IkappaB function: transgenics and knockouts.

Gerondakis S, Grossmann M, Nakamura Y, Pohl T, Grumont R.

Oncogene. 1999 Nov 22;18(49):6888-95. Review.


New insights into the roles of ReL/NF-kappa B transcription factors in immune function, hemopoiesis and human disease.

Grossmann M, Nakamura Y, Grumont R, Gerondakis S.

Int J Biochem Cell Biol. 1999 Oct;31(10):1209-19. Review.


The regulation and roles of Rel/NF-kappa B transcription factors during lymphocyte activation.

Gerondakis S, Grumont R, Rourke I, Grossmann M.

Curr Opin Immunol. 1998 Jun;10(3):353-9. Review.


Activation of the mitogen-activated protein kinase pathway induces transcription of the PAC-1 phosphatase gene.

Grumont RJ, Rasko JE, Strasser A, Gerondakis S.

Mol Cell Biol. 1996 Jun;16(6):2913-21.


Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor.

Gerondakis S, Strasser A, Metcalf D, Grigoriadis G, Scheerlinck JY, Grumont RJ.

Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3405-9.


Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

Köntgen F, Grumont RJ, Strasser A, Metcalf D, Li R, Tarlinton D, Gerondakis S.

Genes Dev. 1995 Aug 15;9(16):1965-77.


The subunit composition of NF-kappa B complexes changes during B-cell development.

Grumont RJ, Gerondakis S.

Cell Growth Differ. 1994 Dec;5(12):1321-31.


Structure of the gene encoding the murine dual specificity tyrosine-threonine phosphatase PAC1.

Gerondakis S, Economou C, Grumont RJ.

Genomics. 1994 Nov 1;24(1):182-4.


The activity of a 70 kilodalton I kappa B molecule identical to the carboxyl terminus of the p105 NF-kappa B precursor is modulated by protein kinase A.

Gerondakis S, Morrice N, Richardson IB, Wettenhall R, Fecondo J, Grumont RJ.

Cell Growth Differ. 1993 Aug;4(8):617-27.


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