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Lyon, a critical place for performing Virology research.

Gerlier D, Gruffat H, Mahieux R.

Virologie (Montrouge). 2019 Mar 1;23(2):43-44. doi: 10.1684/vir.2019.0766. French. No abstract available.


Interplay between the Epigenetic Enzyme Lysine (K)-Specific Demethylase 2B and Epstein-Barr Virus Infection.

Vargas-Ayala RC, Jay A, Manara F, Maroui MA, Hernandez-Vargas H, Diederichs A, Robitaille A, Sirand C, Ceraolo MG, Romero-Medina MC, Cros MP, Cuenin C, Durand G, Le Calvez-Kelm F, Mundo L, Leoncini L, Manet E, Herceg Z, Gruffat H, Accardi R.

J Virol. 2019 Jun 14;93(13). pii: e00273-19. doi: 10.1128/JVI.00273-19. Print 2019 Jul 1.


[SRSF3: from mRNA decay to mRNA nuclear export. Epstein-Barr virus helps to make a choice].

Gruffat H, Mure F, Manet E.

Med Sci (Paris). 2019 Feb;35(2):103-105. doi: 10.1051/medsci/2019015. Epub 2019 Feb 18. French. No abstract available.


The splicing factor SRSF3 is functionally connected to the nuclear RNA exosome for intronless mRNA decay.

Mure F, Corbin A, Benbahouche NEH, Bertrand E, Manet E, Gruffat H.

Sci Rep. 2018 Aug 27;8(1):12901. doi: 10.1038/s41598-018-31078-1.


EBNA1: Oncogenic Activity, Immune Evasion and Biochemical Functions Provide Targets for Novel Therapeutic Strategies against Epstein-Barr Virus- Associated Cancers.

Wilson JB, Manet E, Gruffat H, Busson P, Blondel M, Fahraeus R.

Cancers (Basel). 2018 Apr 6;10(4). pii: E109. doi: 10.3390/cancers10040109. Review.


[EBV/KSHV co-infection: an effective partnership].

Gruffat H, Manet E.

Med Sci (Paris). 2018 Jan;34(1):79-82. doi: 10.1051/medsci/20183401017. Epub 2018 Jan 31. Review. French.


Epstein-Barr Virus Protein EB2 Stimulates Translation Initiation of mRNAs through Direct Interactions with both Poly(A)-Binding Protein and Eukaryotic Initiation Factor 4G.

Mure F, Panthu B, Zanella-Cléon I, Delolme F, Manet E, Ohlmann T, Gruffat H.

J Virol. 2018 Jan 17;92(3). pii: e01917-17. doi: 10.1128/JVI.01917-17. Print 2018 Feb 1.


Interference with the production of infectious viral particles and bimodal inhibition of replication are broadly conserved antiviral properties of IFITMs.

Tartour K, Nguyen XN, Appourchaux R, Assil S, Barateau V, Bloyet LM, Burlaud Gaillard J, Confort MP, Escudero-Perez B, Gruffat H, Hong SS, Moroso M, Reynard O, Reynard S, Decembre E, Ftaich N, Rossi A, Wu N, Arnaud F, Baize S, Dreux M, Gerlier D, Paranhos-Baccala G, Volchkov V, Roingeard P, Cimarelli A.

PLoS Pathog. 2017 Sep 28;13(9):e1006610. doi: 10.1371/journal.ppat.1006610. eCollection 2017 Sep.


Viral driven epigenetic events alter the expression of cancer-related genes in Epstein-Barr-virus naturally infected Burkitt lymphoma cell lines.

Hernandez-Vargas H, Gruffat H, Cros MP, Diederichs A, Sirand C, Vargas-Ayala RC, Jay A, Durand G, Le Calvez-Kelm F, Herceg Z, Manet E, Wild CP, Tommasino M, Accardi R.

Sci Rep. 2017 Jul 19;7(1):5852. doi: 10.1038/s41598-017-05713-2.


Epstein-Barr virus nuclear antigen 1 interacts with regulator of chromosome condensation 1 dynamically throughout the cell cycle.

Deschamps T, Bazot Q, Leske DM, MacLeod R, Mompelat D, Tafforeau L, Lotteau V, Maréchal V, Baillie GS, Gruffat H, Wilson JB, Manet E.

J Gen Virol. 2017 Feb;98(2):251-265. doi: 10.1099/jgv.0.000681.


Herpesvirus Late Gene Expression: A Viral-Specific Pre-initiation Complex Is Key.

Gruffat H, Marchione R, Manet E.

Front Microbiol. 2016 Jun 6;7:869. doi: 10.3389/fmicb.2016.00869. eCollection 2016. Review.


The mycotoxin aflatoxin B1 stimulates Epstein-Barr virus-induced B-cell transformation in in vitro and in vivo experimental models.

Accardi R, Gruffat H, Sirand C, Fusil F, Gheit T, Hernandez-Vargas H, Le Calvez-Kelm F, Traverse-Glehen A, Cosset FL, Manet E, Wild CP, Tommasino M.

Carcinogenesis. 2015 Nov;36(11):1440-51. doi: 10.1093/carcin/bgv142. Epub 2015 Sep 30.


In vitro translation of mRNAs that are in their native ribonucleoprotein complexes.

Panthu B, Mure F, Gruffat H, Ohlmann T.

Biochem J. 2015 Nov 15;472(1):111-9. doi: 10.1042/BJ20150772. Epub 2015 Sep 8.


TLR9 transcriptional regulation in response to double-stranded DNA viruses.

Zannetti C, Parroche P, Panaye M, Roblot G, Gruffat H, Manet E, Debaud AL, Plumas J, Vey N, Caux C, Bendriss-Vermare N, Hasan UA.

J Immunol. 2014 Oct 1;193(7):3398-408. doi: 10.4049/jimmunol.1400249. Epub 2014 Sep 5.


Epstein-Barr virus late gene transcription depends on the assembly of a virus-specific preinitiation complex.

Aubry V, Mure F, Mariamé B, Deschamps T, Wyrwicz LS, Manet E, Gruffat H.

J Virol. 2014 Nov;88(21):12825-38. doi: 10.1128/JVI.02139-14. Epub 2014 Aug 27.


Epstein-Barr virus nuclear antigen 3A protein regulates CDKN2B transcription via interaction with MIZ-1.

Bazot Q, Deschamps T, Tafforeau L, Siouda M, Leblanc P, Harth-Hertle ML, Rabourdin-Combe C, Lotteau V, Kempkes B, Tommasino M, Gruffat H, Manet E.

Nucleic Acids Res. 2014 Sep;42(15):9700-16. doi: 10.1093/nar/gku697. Epub 2014 Aug 4.


Epstein-Barr virus down-regulates tumor suppressor DOK1 expression.

Siouda M, Frecha C, Accardi R, Yue J, Cuenin C, Gruffat H, Manet E, Herceg Z, Sylla BS, Tommasino M.

PLoS Pathog. 2014 May 8;10(5):e1004125. doi: 10.1371/journal.ppat.1004125. eCollection 2014 May.


Epstein - Barr virus transforming protein LMP-1 alters B cells gene expression by promoting accumulation of the oncoprotein ΔNp73α.

Accardi R, Fathallah I, Gruffat H, Mariggiò G, Le Calvez-Kelm F, Voegele C, Bartosch B, Hernandez-Vargas H, McKay J, Sylla BS, Manet E, Tommasino M.

PLoS Pathog. 2013 Mar;9(3):e1003186. doi: 10.1371/journal.ppat.1003186. Epub 2013 Mar 14.


Drosophila Yemanuclein and HIRA cooperate for de novo assembly of H3.3-containing nucleosomes in the male pronucleus.

Orsi GA, Algazeery A, Meyer RE, Capri M, Sapey-Triomphe LM, Horard B, Gruffat H, Couble P, Aït-Ahmed O, Loppin B.

PLoS Genet. 2013;9(2):e1003285. doi: 10.1371/journal.pgen.1003285. Epub 2013 Feb 7.


Interaction of Ubinuclein-1, a nuclear and adhesion junction protein, with the 14-3-3 epsilon protein in epithelial cells: implication of the PKA pathway.

Conti A, Sueur C, Lupo J, Brazzolotto X, Burmeister WP, Manet E, Gruffat H, Morand P, Boyer V.

Eur J Cell Biol. 2013 Mar;92(3):105-11. doi: 10.1016/j.ejcb.2012.12.001. Epub 2013 Feb 8.


Epstein-Barr virus protein EB2 stimulates cytoplasmic mRNA accumulation by counteracting the deleterious effects of SRp20 on viral mRNAs.

Juillard F, Bazot Q, Mure F, Tafforeau L, Macri C, Rabourdin-Combe C, Lotteau V, Manet E, Gruffat H.

Nucleic Acids Res. 2012 Aug;40(14):6834-49. doi: 10.1093/nar/gks319. Epub 2012 Apr 13.


The Epstein-Barr virus BcRF1 gene product is a TBP-like protein with an essential role in late gene expression.

Gruffat H, Kadjouf F, Mariamé B, Manet E.

J Virol. 2012 Jun;86(11):6023-32. doi: 10.1128/JVI.00159-12. Epub 2012 Mar 28.


Identification of new interacting partners of the shuttling protein ubinuclein (Ubn-1).

Lupo J, Conti A, Sueur C, Coly PA, Couté Y, Hunziker W, Burmeister WP, Germi R, Manet E, Gruffat H, Morand P, Boyer V.

Exp Cell Res. 2012 Mar 10;318(5):509-20. doi: 10.1016/j.yexcr.2011.12.020. Epub 2012 Jan 4.


Functional mechanisms of the cellular prion protein (PrP(C)) associated anti-HIV-1 properties.

Alais S, Soto-Rifo R, Balter V, Gruffat H, Manet E, Schaeffer L, Darlix JL, Cimarelli A, Raposo G, Ohlmann T, Leblanc P.

Cell Mol Life Sci. 2012 Apr;69(8):1331-52. doi: 10.1007/s00018-011-0879-z. Epub 2011 Nov 11.


Homozygous deletion of EPB41 genuine AUG-containing exons results in mRNA splicing defects, NMD activation and protein 4.1R complete deficiency in hereditary elliptocytosis.

Baklouti F, Morinière M, Haj-Khélil A, Fénéant-Thibault M, Gruffat H, Couté Y, Ninot A, Guitton C, Delaunay J.

Blood Cells Mol Dis. 2011 Oct 15;47(3):158-65. doi: 10.1016/j.bcmd.2011.07.001. Epub 2011 Aug 11.


The nuclear and adherent junction complex component protein ubinuclein negatively regulates the productive cycle of Epstein-Barr virus in epithelial cells.

Gruffat H, Lupo J, Morand P, Boyer V, Manet E.

J Virol. 2011 Jan;85(2):784-94. doi: 10.1128/JVI.01397-10. Epub 2010 Nov 17.


EBV latent membrane protein 1 is a negative regulator of TLR9.

Fathallah I, Parroche P, Gruffat H, Zannetti C, Johansson H, Yue J, Manet E, Tommasino M, Sylla BS, Hasan UA.

J Immunol. 2010 Dec 1;185(11):6439-47. doi: 10.4049/jimmunol.0903459. Epub 2010 Oct 27.


Epstein-Barr virus protein EB2 contains an N-terminal transferable nuclear export signal that promotes nucleocytoplasmic export by directly binding TAP/NXF1.

Juillard F, Hiriart E, Sergeant N, Vingtdeux-Didier V, Drobecq H, Sergeant A, Manet E, Gruffat H.

J Virol. 2009 Dec;83(24):12759-68. doi: 10.1128/JVI.01276-09. Epub 2009 Sep 30.


Translation of intronless RNAs is strongly stimulated by the Epstein-Barr virus mRNA export factor EB2.

Ricci EP, Mure F, Gruffat H, Decimo D, Medina-Palazon C, Ohlmann T, Manet E.

Nucleic Acids Res. 2009 Aug;37(15):4932-43. doi: 10.1093/nar/gkp497. Epub 2009 Jun 15.


Methylation-dependent binding of the epstein-barr virus BZLF1 protein to viral promoters.

Dickerson SJ, Xing Y, Robinson AR, Seaman WT, Gruffat H, Kenney SC.

PLoS Pathog. 2009 Mar;5(3):e1000356. doi: 10.1371/journal.ppat.1000356. Epub 2009 Mar 27.


Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos).

Aho S, Lupo J, Coly PA, Sabine A, Castellazzi M, Morand P, Sergeant A, Manet E, Boyer V, Gruffat H.

Biol Cell. 2009 Jun;101(6):319-34. doi: 10.1042/BC20080072.


The Epstein-Barr virus (EBV) protein EB is an mRNA export factor essential for virus production.

Sergeant A, Gruffat H, Manet E.

Front Biosci. 2008 May 1;13:3798-813.


Overexpression of MBNL1 fetal isoforms and modified splicing of Tau in the DM1 brain: two individual consequences of CUG trinucleotide repeats.

Dhaenens CM, Schraen-Maschke S, Tran H, Vingtdeux V, Ghanem D, Leroy O, Delplanque J, Vanbrussel E, Delacourte A, Vermersch P, Maurage CA, Gruffat H, Sergeant A, Mahadevan MS, Ishiura S, Buée L, Cooper TA, Caillet-Boudin ML, Charlet-Berguerand N, Sablonnière B, Sergeant N.

Exp Neurol. 2008 Apr;210(2):467-78. doi: 10.1016/j.expneurol.2007.11.020. Epub 2007 Dec 4.


Protein kinase CK2 phosphorylation of EB2 regulates its function in the production of Epstein-Barr virus infectious viral particles.

Medina-Palazon C, Gruffat H, Mure F, Filhol O, Vingtdeux-Didier V, Drobecq H, Cochet C, Sergeant N, Sergeant A, Manet E.

J Virol. 2007 Nov;81(21):11850-60. Epub 2007 Aug 15.


Epstein-Barr virus mRNA export factor EB2 is essential for intranuclear capsid assembly and production of gp350.

Batisse J, Manet E, Middeldorp J, Sergeant A, Gruffat H.

J Virol. 2005 Nov;79(22):14102-11.


Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export.

Hiriart E, Gruffat H, Buisson M, Mikaelian I, Keppler S, Meresse P, Mercher T, Bernard OA, Sergeant A, Manet E.

J Biol Chem. 2005 Nov 4;280(44):36935-45. Epub 2005 Aug 29.


Cellular uptake of the EBV transcription factor EB1/Zta.

Mahot S, Fender P, Vivès RR, Caron C, Perrissin M, Gruffat H, Sergeant A, Drouet E.

Virus Res. 2005 Jun;110(1-2):187-93.


The BRRF1 early gene of Epstein-Barr virus encodes a transcription factor that enhances induction of lytic infection by BRLF1.

Hong GK, Delecluse HJ, Gruffat H, Morrison TE, Feng WH, Sergeant A, Kenney SC.

J Virol. 2004 May;78(10):4983-92.


Transcription factor cCP2 controls gene expression in chicken embryonic stem cells.

Acloque H, Mey A, Birot AM, Gruffat H, Pain B, Samarut J.

Nucleic Acids Res. 2004 Apr 23;32(7):2259-71. Print 2004.


[Latency vs lytic cycle of Epstein-Barr virus: regulation of a viral gene expression is the clue].

Gruffat H, Manet E, Sergeant A.

Pathol Biol (Paris). 2004 Mar;52(2):63-5. French. No abstract available.


A region of the Epstein-Barr virus (EBV) mRNA export factor EB2 containing an arginine-rich motif mediates direct binding to RNA.

Hiriart E, Bardouillet L, Manet E, Gruffat H, Penin F, Montserret R, Farjot G, Sergeant A.

J Biol Chem. 2003 Sep 26;278(39):37790-8. Epub 2003 Jul 12.


A novel function for the Epstein-Barr virus transcription factor EB1/Zta: induction of transcription of the hIL-10 gene.

Mahot S, Sergeant A, Drouet E, Gruffat H.

J Gen Virol. 2003 Apr;84(Pt 4):965-74.


A novel nuclear export signal and a REF interaction domain both promote mRNA export by the Epstein-Barr virus EB2 protein.

Hiriart E, Farjot G, Gruffat H, Nguyen MV, Sergeant A, Manet E.

J Biol Chem. 2003 Jan 3;278(1):335-42. Epub 2002 Oct 25.


Epstein-Barr virus mRNA export factor EB2 is essential for production of infectious virus.

Gruffat H, Batisse J, Pich D, Neuhierl B, Manet E, Hammerschmidt W, Sergeant A.

J Virol. 2002 Oct;76(19):9635-44.


Kaposi's sarcoma-associated herpesvirus and Kaposi's sarcoma.

Gruffat H, Sergeant A, Manet E.

Microbes Infect. 2000 May;2(6):671-80. Review.


Characterization of the epstein-barr virus BRRF1 gene, located between early genes BZLF1 and BRLF1.

Segouffin-Cariou C, Farjot G, Sergeant A, Gruffat H.

J Gen Virol. 2000 Jul;81(Pt 7):1791-9.


Ubinuclein, a novel nuclear protein interacting with cellular and viral transcription factors.

Aho S, Buisson M, Pajunen T, Ryoo YW, Giot JF, Gruffat H, Sergeant A, Uitto J.

J Cell Biol. 2000 Mar 20;148(6):1165-76.

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