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Items: 1 to 50 of 71


Behavioral adaptations in a relapsing mouse model of colitis.

Matisz CE, Vicentini FA, Hirota SA, Sharkey KA, Gruber AJ.

Physiol Behav. 2020 Mar 15;216:112802. doi: 10.1016/j.physbeh.2020.112802. Epub 2020 Jan 10.


Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments.

Molina LA, Ivan VE, Gruber AJ, Luczak A.

J Vis Exp. 2019 Nov 12;(153). doi: 10.3791/59812.


Reply to 'A different perspective on alternative cleavage and polyadenylation'.

Gruber AJ, Zavolan M.

Nat Rev Genet. 2020 Jan;21(1):63-64. doi: 10.1038/s41576-019-0199-y. No abstract available.


PolyASite 2.0: a consolidated atlas of polyadenylation sites from 3' end sequencing.

Herrmann CJ, Schmidt R, Kanitz A, Artimo P, Gruber AJ, Zavolan M.

Nucleic Acids Res. 2020 Jan 8;48(D1):D174-D179. doi: 10.1093/nar/gkz918.


Alternative cleavage and polyadenylation in health and disease.

Gruber AJ, Zavolan M.

Nat Rev Genet. 2019 Oct;20(10):599-614. doi: 10.1038/s41576-019-0145-z. Epub 2019 Jul 2. Review.


Distributed Encoding of Reinforcement in Rat Cortico-Striatal-Limbic Networks.

Donovan CH, Badenhorst CA, Gruber AJ.

Neuroscience. 2019 Aug 10;413:169-182. doi: 10.1016/j.neuroscience.2019.06.019. Epub 2019 Jun 21.


Phase of electroencephalography theta oscillation during stimulus encoding affects accuracy of memory recall.

Jalali A, Tata MS, Gruber AJ, Luczak A.

Neuroreport. 2019 Apr 10;30(6):404-408. doi: 10.1097/WNR.0000000000001215.


Lesions of lateral habenula attenuate win-stay but not lose-shift responses in a competitive choice task.

Thapa R, Donovan CH, Wong SA, Sutherland RJ, Gruber AJ.

Neurosci Lett. 2019 Jan 23;692:159-166. doi: 10.1016/j.neulet.2018.10.056. Epub 2018 Oct 31.


Terminal exon characterization with TECtool reveals an abundance of cell-specific isoforms.

Gruber AJ, Gypas F, Riba A, Schmidt R, Zavolan M.

Nat Methods. 2018 Oct;15(10):832-836. doi: 10.1038/s41592-018-0114-z. Epub 2018 Sep 10.


Lesions of ventrolateral striatum eliminate lose-shift but not win-stay behaviour in rats.

Thapa R, Gruber AJ.

Neurobiol Learn Mem. 2018 Nov;155:446-451. doi: 10.1016/j.nlm.2018.08.022. Epub 2018 Sep 1.


Single-cell mRNA profiling reveals the hierarchical response of miRNA targets to miRNA induction.

Rzepiela AJ, Ghosh S, Breda J, Vina-Vilaseca A, Syed AP, Gruber AJ, Eschbach K, Beisel C, van Nimwegen E, Zavolan M.

Mol Syst Biol. 2018 Aug 27;14(8):e8266. doi: 10.15252/msb.20188266.


Rat anterior cingulate cortex recalls features of remote reward locations after disfavoured reinforcements.

Mashhoori A, Hashemnia S, McNaughton BL, Euston DR, Gruber AJ.

Elife. 2018 Apr 17;7. pii: e29793. doi: 10.7554/eLife.29793.


Discovery of physiological and cancer-related regulators of 3' UTR processing with KAPAC.

Gruber AJ, Schmidt R, Ghosh S, Martin G, Gruber AR, van Nimwegen E, Zavolan M.

Genome Biol. 2018 Mar 28;19(1):44. doi: 10.1186/s13059-018-1415-3.


Lose-Shift Responding in Humans Is Promoted by Increased Cognitive Load.

Ivan VE, Banks PJ, Goodfellow K, Gruber AJ.

Front Integr Neurosci. 2018 Mar 8;12:9. doi: 10.3389/fnint.2018.00009. eCollection 2018.


Sex differences in rat decision-making: The confounding role of extraneous feeder sampling between trials.

Donovan CH, Wong SA, Randolph SH, Stark RA, Gibb RL, Gruber AJ.

Behav Brain Res. 2018 Apr 16;342:62-69. doi: 10.1016/j.bbr.2018.01.018. Epub 2018 Feb 4.


Feeder Approach between Trials Is Increased by Uncertainty and Affects Subsequent Choices.

Gruber AJ, Thapa R, Randolph SH.

eNeuro. 2018 Jan 8;4(6). pii: ENEURO.0437-17.2017. doi: 10.1523/ENEURO.0437-17.2017. eCollection 2017 Nov-Dec.


3' End Sequencing Library Preparation with A-seq2.

Martin G, Schmidt R, Gruber AJ, Ghosh S, Keller W, Zavolan M.

J Vis Exp. 2017 Oct 10;(128). doi: 10.3791/56129.


Acute Δ-9-tetrahydrocannabinol administration in female rats attenuates immediate responses following losses but not multi-trial reinforcement learning from wins.

Wong SA, Randolph SH, Ivan VE, Gruber AJ.

Behav Brain Res. 2017 Sep 29;335:136-144. doi: 10.1016/j.bbr.2017.08.009. Epub 2017 Aug 12.


Implicit Valuation of the Near-Miss is Dependent on Outcome Context.

Banks PJ, Tata MS, Bennett PJ, Sekuler AB, Gruber AJ.

J Gambl Stud. 2018 Mar;34(1):181-197. doi: 10.1007/s10899-017-9705-3.


TFAP2A is a component of the ZEB1/2 network that regulates TGFB1-induced epithelial to mesenchymal transition.

Dimitrova Y, Gruber AJ, Mittal N, Ghosh S, Dimitriades B, Mathow D, Grandy WA, Christofori G, Zavolan M.

Biol Direct. 2017 Apr 17;12(1):8. doi: 10.1186/s13062-017-0180-7.


Corrigendum: Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells.

Hölzer M, Krähling V, Amman F, Barth E, Bernhart SH, Carmelo VA, Collatz M, Doose G, Eggenhofer F, Ewald J, Fallmann J, Feldhahn LM, Fricke M, Gebauer J, Gruber AJ, Hufsky F, Indrischek H, Kanton S, Linde J, Mostajo N, Ochsenreiter R, Riege K, Rivarola-Duarte L, Sahyoun AH, Saunders SJ, Seemann SE, Tanzer A, Vogel B, Wehner S, Wolfinger MT, Backofen R, Gorodkin J, Grosse I, Hofacker I, Hoffmann S, Kaleta C, Stadler PF, Becker S, Marz M.

Sci Rep. 2017 Jan 11;7:39421. doi: 10.1038/srep39421. No abstract available.


Computational Properties of the Hippocampus Increase the Efficiency of Goal-Directed Foraging through Hierarchical Reinforcement Learning.

Chalmers E, Luczak A, Gruber AJ.

Front Comput Neurosci. 2016 Dec 12;10:128. doi: 10.3389/fncom.2016.00128. eCollection 2016.


Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells.

Hölzer M, Krähling V, Amman F, Barth E, Bernhart SH, Carmelo VA, Collatz M, Doose G, Eggenhofer F, Ewald J, Fallmann J, Feldhahn LM, Fricke M, Gebauer J, Gruber AJ, Hufsky F, Indrischek H, Kanton S, Linde J, Mostajo N, Ochsenreiter R, Riege K, Rivarola-Duarte L, Sahyoun AH, Saunders SJ, Seemann SE, Tanzer A, Vogel B, Wehner S, Wolfinger MT, Backofen R, Gorodkin J, Grosse I, Hofacker I, Hoffmann S, Kaleta C, Stadler PF, Becker S, Marz M.

Sci Rep. 2016 Oct 7;6:34589. doi: 10.1038/srep34589. Erratum in: Sci Rep. 2017 Jan 11;7:39421.


A comprehensive analysis of 3' end sequencing data sets reveals novel polyadenylation signals and the repressive role of heterogeneous ribonucleoprotein C on cleavage and polyadenylation.

Gruber AJ, Schmidt R, Gruber AR, Martin G, Ghosh S, Belmadani M, Keller W, Zavolan M.

Genome Res. 2016 Aug;26(8):1145-59. doi: 10.1101/gr.202432.115. Epub 2016 Jul 5.


Opposing effects of acute and chronic d-amphetamine on decision-making in rats.

Wong SA, Thapa R, Badenhorst CA, Briggs AR, Sawada JA, Gruber AJ.

Neuroscience. 2017 Mar 14;345:218-228. doi: 10.1016/j.neuroscience.2016.04.021. Epub 2016 Apr 23.


The role of the medial prefrontal cortex in updating reward value and avoiding perseveration.

Laskowski CS, Williams RJ, Martens KM, Gruber AJ, Fisher KG, Euston DR.

Behav Brain Res. 2016 Jun 1;306:52-63. doi: 10.1016/j.bbr.2016.03.007. Epub 2016 Mar 7.


Comparative assessment of methods for the computational inference of transcript isoform abundance from RNA-seq data.

Kanitz A, Gypas F, Gruber AJ, Gruber AR, Martin G, Zavolan M.

Genome Biol. 2015 Jul 23;16:150. doi: 10.1186/s13059-015-0702-5.


Exploiting the multiplexing capabilities of tandem mass tags for high-throughput estimation of cellular protein abundances by mass spectrometry.

Ahrné E, Martinez-Segura A, Syed AP, Vina-Vilaseca A, Gruber AJ, Marguerat S, Schmidt A.

Methods. 2015 Sep 1;85:100-107. doi: 10.1016/j.ymeth.2015.04.032. Epub 2015 May 4.


A RecA protein surface required for activation of DNA polymerase V.

Gruber AJ, Erdem AL, Sabat G, Karata K, Jaszczur MM, Vo DD, Olsen TM, Woodgate R, Goodman MF, Cox MM.

PLoS Genet. 2015 Mar 26;11(3):e1005066. doi: 10.1371/journal.pgen.1005066. eCollection 2015 Mar.


Function of the N-terminal segment of the RecA-dependent nuclease Ref.

Gruber AJ, Olsen TM, Dvorak RH, Cox MM.

Nucleic Acids Res. 2015 Feb 18;43(3):1795-803. doi: 10.1093/nar/gku1330. Epub 2015 Jan 23.


Multigenerational prenatal stress increases the coherence of brain signaling among cortico-striatal-limbic circuits in adult rats.

Skelin I, Needham MA, Molina LM, Metz GA, Gruber AJ.

Neuroscience. 2015 Mar 19;289:270-8. doi: 10.1016/j.neuroscience.2015.01.009. Epub 2015 Jan 14.


Global 3' UTR shortening has a limited effect on protein abundance in proliferating T cells.

Gruber AR, Martin G, Müller P, Schmidt A, Gruber AJ, Gumienny R, Mittal N, Jayachandran R, Pieters J, Keller W, van Nimwegen E, Zavolan M.

Nat Commun. 2014 Nov 21;5:5465. doi: 10.1038/ncomms6465.


Embryonic stem cell-specific microRNAs contribute to pluripotency by inhibiting regulators of multiple differentiation pathways.

Gruber AJ, Grandy WA, Balwierz PJ, Dimitrova YA, Pachkov M, Ciaudo C, Nimwegen Ev, Zavolan M.

Nucleic Acids Res. 2014 Aug;42(14):9313-26. doi: 10.1093/nar/gku544. Epub 2014 Jul 16.


Lesions of dorsal striatum eliminate lose-switch responding but not mixed-response strategies in rats.

Skelin I, Hakstol R, VanOyen J, Mudiayi D, Molina LA, Holec V, Hong NS, Euston DR, McDonald RJ, Gruber AJ.

Eur J Neurosci. 2014 May;39(10):1655-63. doi: 10.1111/ejn.12518. Epub 2014 Mar 6.


Pegylated IFN-α regulates hepatic gene expression through transient Jak/STAT activation.

Dill MT, Makowska Z, Trincucci G, Gruber AJ, Vogt JE, Filipowicz M, Calabrese D, Krol I, Lau DT, Terracciano L, van Nimwegen E, Roth V, Heim MH.

J Clin Invest. 2014 Apr;124(4):1568-81. doi: 10.1172/JCI70408. Epub 2014 Feb 24.


ISMARA: automated modeling of genomic signals as a democracy of regulatory motifs.

Balwierz PJ, Pachkov M, Arnold P, Gruber AJ, Zavolan M, van Nimwegen E.

Genome Res. 2014 May;24(5):869-84. doi: 10.1101/gr.169508.113. Epub 2014 Feb 10.


Acute NMDA receptor antagonism disrupts synchronization of action potential firing in rat prefrontal cortex.

Molina LA, Skelin I, Gruber AJ.

PLoS One. 2014 Jan 17;9(1):e85842. doi: 10.1371/journal.pone.0085842. eCollection 2014. Erratum in: PLoS One. 2014;9(7):e104110.


Modulation of epigenetic regulators and cell fate decisions by miRNAs.

Gruber AJ, Zavolan M.

Epigenomics. 2013 Dec;5(6):671-83. doi: 10.2217/epi.13.65. Review.


Formation and reverberation of sequential neural activity patterns evoked by sensory stimulation are enhanced during cortical desynchronization.

Bermudez Contreras EJ, Schjetnan AG, Muhammad A, Bartho P, McNaughton BL, Kolb B, Gruber AJ, Luczak A.

Neuron. 2013 Aug 7;79(3):555-66. doi: 10.1016/j.neuron.2013.06.013.


The role of medial prefrontal cortex in memory and decision making.

Euston DR, Gruber AJ, McNaughton BL.

Neuron. 2012 Dec 20;76(6):1057-70. doi: 10.1016/j.neuron.2012.12.002. Review.


Orbitofrontal cortex supports behavior and learning using inferred but not cached values.

Jones JL, Esber GR, McDannald MA, Gruber AJ, Hernandez A, Mirenzi A, Schoenbaum G.

Science. 2012 Nov 16;338(6109):953-6. doi: 10.1126/science.1227489.


Context, emotion, and the strategic pursuit of goals: interactions among multiple brain systems controlling motivated behavior.

Gruber AJ, McDonald RJ.

Front Behav Neurosci. 2012 Aug 3;6:50. doi: 10.3389/fnbeh.2012.00050. eCollection 2012.


More is less: a disinhibited prefrontal cortex impairs cognitive flexibility.

Gruber AJ, Calhoon GG, Shusterman I, Schoenbaum G, Roesch MR, O'Donnell P.

J Neurosci. 2010 Dec 15;30(50):17102-10. doi: 10.1523/JNEUROSCI.4623-10.2010.


Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits.

Niwa M, Kamiya A, Murai R, Kubo K, Gruber AJ, Tomita K, Lu L, Tomisato S, Jaaro-Peled H, Seshadri S, Hiyama H, Huang B, Kohda K, Noda Y, O'Donnell P, Nakajima K, Sawa A, Nabeshima T.

Neuron. 2010 Feb 25;65(4):480-9. doi: 10.1016/j.neuron.2010.01.019.


The nucleus accumbens: a switchboard for goal-directed behaviors.

Gruber AJ, Hussain RJ, O'Donnell P.

PLoS One. 2009;4(4):e5062. doi: 10.1371/journal.pone.0005062. Epub 2009 Apr 7.


Cortically activated interneurons shape spatial aspects of cortico-accumbens processing.

Gruber AJ, Powell EM, O'Donnell P.

J Neurophysiol. 2009 Apr;101(4):1876-82. doi: 10.1152/jn.91002.2008. Epub 2009 Jan 28.


Dopamine modulation in the basal ganglia locks the gate to working memory.

Gruber AJ, Dayan P, Gutkin BS, Solla SA.

J Comput Neurosci. 2006 Apr;20(2):153-66. Epub 2006 Apr 22.


Attributes of long-term heavy cannabis users: a case-control study.

Gruber AJ, Pope HG, Hudson JI, Yurgelun-Todd D.

Psychol Med. 2003 Nov;33(8):1415-22.


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