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Prevalence and loads of torquetenovirus (TTV) in the European MARK-AGE Study population.

Giacconi R, Maggi F, Macera L, Spezia PG, Pistello M, Provinciali M, Piacenza F, Basso A, Bürkle A, Moreno-Villanueva M, Dollé MET, Jansen E, Grune T, Stuetz W, Gonos ES, Schön C, Bernhardt J, Grubeck-Loebenstein B, Sikora E, Dudkowska M, Janiszewska D, Toussaint O, Chainiaux FD, Franceschi C, Capri M, Hervonen A, Hurme M, Slagboom E, Breusing N, Mocchegiani E, Malavolta M.

J Gerontol A Biol Sci Med Sci. 2019 Dec 15. pii: glz293. doi: 10.1093/gerona/glz293. [Epub ahead of print]


CD28 and CD57 define four populations with distinct phenotypic properties within human CD8+ T cells.

Pangrazzi L, Reidla J, Carmona Arana JA, Naismith E, Miggitsch C, Meryk A, Keller M, Krause AAN, Melzer FL, Trieb K, Schirmer M, Grubeck-Loebenstein B, Weinberger B.

Eur J Immunol. 2020 Mar;50(3):363-379. doi: 10.1002/eji.201948362. Epub 2019 Dec 4.


Peripheral antibody concentrations are associated with highly differentiated T cells and inflammatory processes in the human bone marrow.

Naismith E, Pangrazzi L, Grasse M, Keller M, Miggitsch C, Weinberger B, Trieb K, Grubeck-Loebenstein B.

Immun Ageing. 2019 Aug 22;16:21. doi: 10.1186/s12979-019-0161-z. eCollection 2019.


Human bone marrow adipocytes display distinct immune regulatory properties.

Miggitsch C, Meryk A, Naismith E, Pangrazzi L, Ejaz A, Jenewein B, Wagner S, Nägele F, Fenkart G, Trieb K, Zwerschke W, Grubeck-Loebenstein B.

EBioMedicine. 2019 Aug;46:387-398. doi: 10.1016/j.ebiom.2019.07.023. Epub 2019 Jul 18.


Concentric and Eccentric Endurance Exercise Reverse Hallmarks of T-Cell Senescence in Pre-diabetic Subjects.

Philippe M, Gatterer H, Burtscher M, Weinberger B, Keller M, Grubeck-Loebenstein B, Fleckenstein J, Alack K, Krüger K.

Front Physiol. 2019 Jun 4;10:684. doi: 10.3389/fphys.2019.00684. eCollection 2019.


Fcμ receptor as a Costimulatory Molecule for T Cells.

Meryk A, Pangrazzi L, Hagen M, Hatzmann F, Jenewein B, Jakic B, Hermann-Kleiter N, Baier G, Jylhävä J, Hurme M, Trieb K, Grubeck-Loebenstein B.

Cell Rep. 2019 Mar 5;26(10):2681-2691.e5. doi: 10.1016/j.celrep.2019.02.024.


Immunological and morphological analysis of heterotopic ossification differs to healthy controls.

Trieb K, Meryk A, Senck S, Naismith E, Grubeck-Loebenstein B.

BMC Musculoskelet Disord. 2018 Sep 11;19(1):327. doi: 10.1186/s12891-018-2246-9.


GM-CSF improves the immune response to the diphtheria-component in a multivalent vaccine.

Grasse M, Meryk A, Miggitsch C, Grubeck-Loebenstein B.

Vaccine. 2018 Jul 25;36(31):4672-4680. doi: 10.1016/j.vaccine.2018.06.033. Epub 2018 Jun 28.


CD8+HLADR+ Regulatory T Cells Change With Aging: They Increase in Number, but Lose Checkpoint Inhibitory Molecules and Suppressive Function.

Lukas Yani S, Keller M, Melzer FL, Weinberger B, Pangrazzi L, Sopper S, Trieb K, Lobina M, Orrù V, Fiorillo E, Cucca F, Grubeck-Loebenstein B.

Front Immunol. 2018 Jun 4;9:1201. doi: 10.3389/fimmu.2018.01201. eCollection 2018.


Vaccination programs for older adults in an era of demographic change.

Doherty TM, Connolly MP, Del Giudice G, Flamaing J, Goronzy JJ, Grubeck-Loebenstein B, Lambert PH, Maggi S, McElhaney JE, Nagai H, Schaffner W, Schmidt-Ott R, Walsh E, Di Pasquale A.

Eur Geriatr Med. 2018;9(3):289-300. doi: 10.1007/s41999-018-0040-8. Epub 2018 Mar 19. Review.


Impaired Immune Response to Primary but Not to Booster Vaccination Against Hepatitis B in Older Adults.

Weinberger B, Haks MC, de Paus RA, Ottenhoff THM, Bauer T, Grubeck-Loebenstein B.

Front Immunol. 2018 May 15;9:1035. doi: 10.3389/fimmu.2018.01035. eCollection 2018.


Antioxidants linked with physical, cognitive and psychological frailty: Analysis of candidate biomarkers and markers derived from the MARK-AGE study.

Rietman ML, Spijkerman AMW, Wong A, van Steeg H, Bürkle A, Moreno-Villanueva M, Sindlinger T, Franceschi C, Grubeck-Loebenstein B, Bernhardt J, Slagboom PE, Toussaint O, Debacq-Chainiaux F, Sikora E, Gonos ES, Breusing N, Stuetz W, Weber D, Grune T, Basso A, Piacenza F, Malavolta M, Collino S, Jansen EHJM, Verschuren WMM, Dollé MET.

Mech Ageing Dev. 2019 Jan;177:135-143. doi: 10.1016/j.mad.2018.04.007. Epub 2018 Apr 30.


Fighting against a protean enemy: immunosenescence, vaccines, and healthy aging.

Del Giudice G, Goronzy JJ, Grubeck-Loebenstein B, Lambert PH, Mrkvan T, Stoddard JJ, Doherty TM.

NPJ Aging Mech Dis. 2017 Dec 21;4:1. doi: 10.1038/s41514-017-0020-0. eCollection 2018.


Zinc-Induced Metallothionein in Centenarian Offspring From a Large European Population: The MARK-AGE Project.

Giacconi R, Costarelli L, Piacenza F, Basso A, Bürkle A, Moreno-Villanueva M, Grune T, Weber D, Stuetz W, Gonos ES, Schön C, Grubeck-Loebenstein B, Sikora E, Toussaint O, Debacq-Chainiaux F, Franceschi C, Hervonen A, Slagboom E, Ciccarone F, Zampieri M, Caiafa P, Jansen E, Dollé MET, Breusing N, Mocchegiani E, Malavolta M.

J Gerontol A Biol Sci Med Sci. 2018 May 9;73(6):745-753. doi: 10.1093/gerona/glx192.


Protection against Tetanus and Diphtheria in Europe: The impact of age, gender and country of origin based on data from the MARK-AGE Study.

Weinberger B, Keller M, Putzer C, Breitenberger D, Koller B, Fiegl S, Moreno-Villanueva M, Bernhardt J, Franceschi C, Voutetakis K, Gonos ES, Hurme M, Sikora E, Toussaint O, Debacq-Chainiaux F, Grune T, Breusing N, Bürkle A, Grubeck-Loebenstein B.

Exp Gerontol. 2018 May;105:109-112. doi: 10.1016/j.exger.2017.08.037. Epub 2017 Oct 7.


Increased IL-15 Production and Accumulation of Highly Differentiated CD8+ Effector/Memory T Cells in the Bone Marrow of Persons with Cytomegalovirus.

Pangrazzi L, Naismith E, Meryk A, Keller M, Jenewein B, Trieb K, Grubeck-Loebenstein B.

Front Immunol. 2017 Jun 19;8:715. doi: 10.3389/fimmu.2017.00715. eCollection 2017.


Long-term maintenance of diphtheria-specific antibodies after booster vaccination is hampered by latent infection with Cytomegalovirus.

Weinberger B, Keller M, Grubeck-Loebenstein B.

Immun Ageing. 2017 Jun 26;14:16. doi: 10.1186/s12979-017-0099-y. eCollection 2017.


"Inflamm-aging" influences immune cell survival factors in human bone marrow.

Pangrazzi L, Meryk A, Naismith E, Koziel R, Lair J, Krismer M, Trieb K, Grubeck-Loebenstein B.

Eur J Immunol. 2017 Mar;47(3):481-492. doi: 10.1002/eji.201646570. Epub 2017 Jan 11.


Plasma Carotenoids, Tocopherols, and Retinol in the Age-Stratified (35-74 Years) General Population: A Cross-Sectional Study in Six European Countries.

Stuetz W, Weber D, Dollé ME, Jansen E, Grubeck-Loebenstein B, Fiegl S, Toussaint O, Bernhardt J, Gonos ES, Franceschi C, Sikora E, Moreno-Villanueva M, Breusing N, Grune T, Bürkle A.

Nutrients. 2016 Sep 30;8(10). pii: E614.


Booster vaccination against tetanus and diphtheria: insufficient protection against diphtheria in young and elderly adults.

Grasse M, Meryk A, Schirmer M, Grubeck-Loebenstein B, Weinberger B.

Immun Ageing. 2016 Sep 5;13(1):26. doi: 10.1186/s12979-016-0081-0. eCollection 2016.


Age-dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK-AGE study.

Ciccarone F, Malavolta M, Calabrese R, Guastafierro T, Bacalini MG, Reale A, Franceschi C, Capri M, Hervonen A, Hurme M, Grubeck-Loebenstein B, Koller B, Bernhardt J, Schӧn C, Slagboom PE, Toussaint O, Sikora E, Gonos ES, Breusing N, Grune T, Jansen E, Dollé M, Moreno-Villanueva M, Sindlinger T, Bürkle A, Zampieri M, Caiafa P.

Aging Cell. 2016 Aug;15(4):755-65. doi: 10.1111/acel.12485. Epub 2016 May 11.


CD58/CD2 Is the Primary Costimulatory Pathway in Human CD28-CD8+ T Cells.

Leitner J, Herndler-Brandstetter D, Zlabinger GJ, Grubeck-Loebenstein B, Steinberger P.

J Immunol. 2015 Jul 15;195(2):477-87. doi: 10.4049/jimmunol.1401917. Epub 2015 Jun 3.


[Immunogerontology - Research into aging].

Grubeck-Loebenstein B.

Z Rheumatol. 2015 Jun;74(5):435-7. doi: 10.1007/s00393-014-1562-1. German. No abstract available.


The stimulatory effect of the TLR4-mediated adjuvant glucopyranosyl lipid A is well preserved in old age.

Weinberger B, Joos C, Reed SG, Coler R, Grubeck-Loebenstein B.

Biogerontology. 2016 Feb;17(1):177-87. doi: 10.1007/s10522-015-9576-x. Epub 2015 May 9.


MARK-AGE population: From the human model to new insights.

Capri M, Moreno-Villanueva M, Cevenini E, Pini E, Scurti M, Borelli V, Palmas MG, Zoli M, Schön C, Siepelmeyer A, Bernhardt J, Fiegl S, Zondag G, de Craen AJ, Hervonen A, Hurme M, Sikora E, Gonos ES, Voutetakis K, Toussaint O, Debacq-Chainiaux F, Grubeck-Loebenstein B, Bürkle A, Franceschi C.

Mech Ageing Dev. 2015 Nov;151:13-7. doi: 10.1016/j.mad.2015.03.010. Epub 2015 Apr 2. Review. No abstract available.


MARK-AGE biomarkers of ageing.

Bürkle A, Moreno-Villanueva M, Bernhard J, Blasco M, Zondag G, Hoeijmakers JH, Toussaint O, Grubeck-Loebenstein B, Mocchegiani E, Collino S, Gonos ES, Sikora E, Gradinaru D, Dollé M, Salmon M, Kristensen P, Griffiths HR, Libert C, Grune T, Breusing N, Simm A, Franceschi C, Capri M, Talbot D, Caiafa P, Friguet B, Slagboom PE, Hervonen A, Hurme M, Aspinall R.

Mech Ageing Dev. 2015 Nov;151:2-12. doi: 10.1016/j.mad.2015.03.006. Epub 2015 Mar 24. Review.


How sex and age affect immune responses, susceptibility to infections, and response to vaccination.

Giefing-Kröll C, Berger P, Lepperdinger G, Grubeck-Loebenstein B.

Aging Cell. 2015 Jun;14(3):309-21. doi: 10.1111/acel.12326. Epub 2015 Feb 26. Review.


[Principles of biological aging].

Schosserer M, Grubeck-Loebenstein B, Grillari J.

Z Gerontol Geriatr. 2015 Apr;48(3):285-94. doi: 10.1007/s00391-015-0857-4. Epub 2015 Feb 21. German.


Plasma cell numbers decrease in bone marrow of old patients.

Pritz T, Lair J, Ban M, Keller M, Weinberger B, Krismer M, Grubeck-Loebenstein B.

Eur J Immunol. 2015 Mar;45(3):738-46. doi: 10.1002/eji.201444878. Epub 2014 Dec 23.


Vaccines for the elderly.

Del Giudice G, Weinberger B, Grubeck-Loebenstein B.

Gerontology. 2015;61(3):203-10. doi: 10.1159/000366162. Epub 2014 Nov 13. Review.


The aging bone marrow and its impact on immune responses in old age.

Pritz T, Weinberger B, Grubeck-Loebenstein B.

Immunol Lett. 2014 Nov;162(1 Pt B):310-5. doi: 10.1016/j.imlet.2014.06.016. Epub 2014 Jul 8. Review.


Characterization of the inflammatory infiltrate in Streptococcus pneumoniae pneumonia in young and elderly patients.

Menter T, Giefing-Kroell C, Grubeck-Loebenstein B, Tzankov A.

Pathobiology. 2014;81(3):160-7. doi: 10.1159/000360165. Epub 2014 Apr 15.


New advances in CMV and immunosenescence.

Sansoni P, Vescovini R, Fagnoni FF, Akbar A, Arens R, Chiu YL, Cičin-Šain L, Dechanet-Merville J, Derhovanessian E, Ferrando-Martinez S, Franceschi C, Frasca D, Fulöp T, Furman D, Gkrania-Klotsas E, Goodrum F, Grubeck-Loebenstein B, Hurme M, Kern F, Lilleri D, López-Botet M, Maier AB, Marandu T, Marchant A, Matheï C, Moss P, Muntasell A, Remmerswaal EB, Riddell NE, Rothe K, Sauce D, Shin EC, Simanek AM, Smithey MJ, Söderberg-Nauclér C, Solana R, Thomas PG, van Lier R, Pawelec G, Nikolich-Zugich J.

Exp Gerontol. 2014 Jul;55:54-62. doi: 10.1016/j.exger.2014.03.020. Epub 2014 Apr 3.


T cell receptor-mediated activation is a potent inducer of macroautophagy in human CD8(+)CD28(+) T cells but not in CD8(+)CD28(-) T cells.

Arnold CR, Pritz T, Brunner S, Knabb C, Salvenmoser W, Holzwarth B, Thedieck K, Grubeck-Loebenstein B.

Exp Gerontol. 2014 Jun;54:75-83. doi: 10.1016/j.exger.2014.01.018. Epub 2014 Jan 24.


Effect of different immunosuppressive drugs on immune cells from young and old healthy persons.

Welzl K, Kern G, Mayer G, Weinberger B, Säemann MD, Sturm G, Grubeck-Loebenstein B, Koppelstaetter C.

Gerontology. 2014;60(3):229-38. doi: 10.1159/000356020. Epub 2014 Jan 16.


Recall responses to tetanus and diphtheria vaccination are frequently insufficient in elderly persons.

Weinberger B, Schirmer M, Matteucci Gothe R, Siebert U, Fuchs D, Grubeck-Loebenstein B.

PLoS One. 2013 Dec 11;8(12):e82967. doi: 10.1371/journal.pone.0082967. eCollection 2013.


How immunosuppressive therapy affects T cells from kidney transplanted patients of different age: the role of latent cytomegalovirus infection.

Welzl K, Weinberger B, Kronbichler A, Sturm G, Kern G, Mayer G, Grubeck-Loebenstein B, Koppelstaetter C.

Clin Exp Immunol. 2014 Apr;176(1):112-9. doi: 10.1111/cei.12205.


What is aging?

Grubeck-Loebenstein B.

Transfus Med Hemother. 2012 Oct;39(5):299-300. doi: 10.1159/000342230. No abstract available.


High-resolution quantitative metabolome analysis of urine by automated flow injection NMR.

Da Silva L, Godejohann M, Martin FP, Collino S, Bürkle A, Moreno-Villanueva M, Bernhardt J, Toussaint O, Grubeck-Loebenstein B, Gonos ES, Sikora E, Grune T, Breusing N, Franceschi C, Hervonen A, Spraul M, Moco S.

Anal Chem. 2013 Jun 18;85(12):5801-9. doi: 10.1021/ac4004776. Epub 2013 May 29.


The gracefully aging immune system.

Boraschi D, Aguado MT, Dutel C, Goronzy J, Louis J, Grubeck-Loebenstein B, Rappuoli R, Del Giudice G.

Sci Transl Med. 2013 May 15;5(185):185ps8. doi: 10.1126/scitranslmed.3005624. Review.


Bone marrow T cells from the femur are similar to iliac crest derived cells in old age and represent a useful tool for studying the aged immune system.

Pritz T, Landgraf-Rauf K, Herndler-Brandstetter D, Rauf R, Lair J, Gassner R, Weinberger B, Krismer M, Grubeck-Loebenstein B.

Immun Ageing. 2013 May 4;10(1):17. doi: 10.1186/1742-4933-10-17.


NKG2D stimulated T-cell autoreactivity in giant cell arteritis and polymyalgia rheumatica.

Dejaco C, Duftner C, Al-Massad J, Wagner AD, Park JK, Fessler J, Aigelsreiter A, Hafner F, Vega S, Sterlacci W, Grubeck-Loebenstein B, Tzankov A, Ness T, Boiardi L, Salvarani C, Schirmer M.

Ann Rheum Dis. 2013 Nov;72(11):1852-9. doi: 10.1136/annrheumdis-2012-201660. Epub 2013 Feb 15.


CMV and Immunosenescence: from basics to clinics.

Solana R, Tarazona R, Aiello AE, Akbar AN, Appay V, Beswick M, Bosch JA, Campos C, Cantisán S, Cicin-Sain L, Derhovanessian E, Ferrando-Martínez S, Frasca D, Fulöp T, Govind S, Grubeck-Loebenstein B, Hill A, Hurme M, Kern F, Larbi A, López-Botet M, Maier AB, McElhaney JE, Moss P, Naumova E, Nikolich-Zugich J, Pera A, Rector JL, Riddell N, Sanchez-Correa B, Sansoni P, Sauce D, van Lier R, Wang GC, Wills MR, Zieliński M, Pawelec G.

Immun Ageing. 2012 Oct 31;9(1):23. doi: 10.1186/1742-4933-9-23.


Vaccines for the elderly.

Weinberger B, Grubeck-Loebenstein B.

Clin Microbiol Infect. 2012 Oct;18 Suppl 5:100-8. doi: 10.1111/j.1469-0691.2012.03944.x. Epub 2012 Aug 6. Review.


The effect of chronological age on the inflammatory response of human fibroblasts.

Wolf J, Weinberger B, Arnold CR, Maier AB, Westendorp RG, Grubeck-Loebenstein B.

Exp Gerontol. 2012 Sep;47(9):749-53. doi: 10.1016/j.exger.2012.07.001. Epub 2012 Jul 9.


Age affects quantity but not quality of antibody responses after vaccination with an inactivated flavivirus vaccine against tick-borne encephalitis.

Stiasny K, Aberle JH, Keller M, Grubeck-Loebenstein B, Heinz FX.

PLoS One. 2012;7(3):e34145. doi: 10.1371/journal.pone.0034145. Epub 2012 Mar 26.


The immunoregulatory effects of CMV-infection in human fibroblasts and the impact on cellular senescence.

Wolf J, Weinberger B, Grubeck-Loebenstein B.

Immun Ageing. 2012 Mar 29;9:1. doi: 10.1186/1742-4933-9-1.


Upregulation of miR-24 is associated with a decreased DNA damage response upon etoposide treatment in highly differentiated CD8(+) T cells sensitizing them to apoptotic cell death.

Brunner S, Herndler-Brandstetter D, Arnold CR, Wiegers GJ, Villunger A, Hackl M, Grillari J, Moreno-Villanueva M, Bürkle A, Grubeck-Loebenstein B.

Aging Cell. 2012 Aug;11(4):579-87. doi: 10.1111/j.1474-9726.2012.00819.x. Epub 2012 Apr 18.


The impact of aging on memory T cell phenotype and function in the human bone marrow.

Herndler-Brandstetter D, Landgraf K, Tzankov A, Jenewein B, Brunauer R, Laschober GT, Parson W, Kloss F, Gassner R, Lepperdinger G, Grubeck-Loebenstein B.

J Leukoc Biol. 2012 Feb;91(2):197-205. doi: 10.1189/jlb.0611299. Epub 2011 Oct 19.


Mucosal memory CD8⁺ T cells are selected in the periphery by an MHC class I molecule.

Huang Y, Park Y, Wang-Zhu Y, Larange A, Arens R, Bernardo I, Olivares-Villagómez D, Herndler-Brandstetter D, Abraham N, Grubeck-Loebenstein B, Schoenberger SP, Van Kaer L, Kronenberg M, Teitell MA, Cheroutre H.

Nat Immunol. 2011 Oct 2;12(11):1086-95. doi: 10.1038/ni.2106.

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