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Rapid approach to complex boronic acids.

Neochoritis CG, Shaabani S, Ahmadianmoghaddam M, Zarganes-Tzitzikas T, Gao L, Novotná M, Mitríková T, Romero AR, Irianti MI, Xu R, Olechno J, Ellson R, Helan V, Kossenjans M, Groves MR, Dömling A.

Sci Adv. 2019 Jul 5;5(7):eaaw4607. doi: 10.1126/sciadv.aaw4607. eCollection 2019 Jul.


Stapled Peptides Inhibitors: A New Window for Target Drug Discovery.

Ali AM, Atmaj J, Van Oosterwijk N, Groves MR, Dömling A.

Comput Struct Biotechnol J. 2019 Feb 19;17:263-281. doi: 10.1016/j.csbj.2019.01.012. eCollection 2019. Review.


Oligomeric protein interference validates druggability of aspartate interconversion in Plasmodium falciparum.

Batista FA, Bosch SS, Butzloff S, Lunev S, Meissner KA, Linzke M, Romero AR, Wang C, Müller IB, Dömling ASS, Groves MR, Wrenger C.

Microbiologyopen. 2019 Feb 28:e779. doi: 10.1002/mbo3.779. [Epub ahead of print]


The (R)-enantiomer of the 6-chromanol derivate SUL-121 improves renal graft perfusion via antagonism of the α1-adrenoceptor.

Nakladal D, Buikema H, Romero AR, Lambooy SPH, Bouma J, Krenning G, Vogelaar P, van der Graaf AC, Groves MR, Kyselovic J, Henning RH, Deelman LE.

Sci Rep. 2019 Jan 9;9(1):13. doi: 10.1038/s41598-018-36788-0.


Artificial Macrocycles as IL-17A/IL-17RA Antagonists.

Wang W, Groves MR, Dömling A.

Medchemcomm. 2018 Jan 1;9(1):22-26. doi: 10.1039/C7MD00464H. Epub 2017 Oct 25.


Afatinib in Osimertinib-Resistant EGFR ex19del/T790M/P794L Mutated NSCLC.

van Kempen LC, Wang H, Aguirre ML, Spatz A, Kasymjanova G, Vilacha JF, Groves MR, Agulnik J, Small D.

J Thorac Oncol. 2018 Sep;13(9):e161-e163. doi: 10.1016/j.jtho.2018.04.020. Epub 2018 Apr 25. No abstract available.


Isolation and molecular characterization of novel glucarpidases: Enzymes to improve the antibody directed enzyme pro-drug therapy for cancer treatment.

Rashidi FB, AlQhatani AD, Bashraheel SS, Shaabani S, Groves MR, Dömling A, Goda SK.

PLoS One. 2018 Apr 26;13(4):e0196254. doi: 10.1371/journal.pone.0196254. eCollection 2018.


Oligomeric interfaces as a tool in drug discovery: Specific interference with activity of malate dehydrogenase of Plasmodium falciparum in vitro.

Lunev S, Butzloff S, Romero AR, Linzke M, Batista FA, Meissner KA, Müller IB, Adawy A, Wrenger C, Groves MR.

PLoS One. 2018 Apr 25;13(4):e0195011. doi: 10.1371/journal.pone.0195011. eCollection 2018.


Identification of a non-competitive inhibitor of Plasmodium falciparum aspartate transcarbamoylase.

Lunev S, Bosch SS, Batista FA, Wang C, Li J, Linzke M, Kruithof P, Chamoun G, Dömling ASS, Wrenger C, Groves MR.

Biochem Biophys Res Commun. 2018 Mar 11;497(3):835-842. doi: 10.1016/j.bbrc.2018.02.112. Epub 2018 Feb 21.


The Pex4p-Pex22p complex from Hansenula polymorpha: biophysical analysis, crystallization and X-ray diffraction characterization.

Ali AM, Atmaj J, Adawy A, Lunev S, Van Oosterwijk N, Yan SR, Williams C, Groves MR.

Acta Crystallogr F Struct Biol Commun. 2018 Feb 1;74(Pt 2):76-81. doi: 10.1107/S2053230X17018428. Epub 2018 Jan 26.


Tyrosine kinase inhibitor sensitive PDGFRΑ mutations in GIST: Two cases and review of the literature.

Boonstra PA, Gietema JA, Suurmeijer AJH, Groves MR, de Assis Batista F, Schuuring E, Reyners AKL.

Oncotarget. 2017 Nov 26;8(65):109836-109847. doi: 10.18632/oncotarget.22663. eCollection 2017 Dec 12.


Structural insights into K48-linked ubiquitin chain formation by the Pex4p-Pex22p complex.

Groves MR, Schroer CFE, Middleton AJ, Lunev S, Danda N, Ali AM, Marrink SJ, Williams C.

Biochem Biophys Res Commun. 2018 Feb 5;496(2):562-567. doi: 10.1016/j.bbrc.2017.12.150. Epub 2017 Dec 28.


A Systematic Protein Refolding Screen Method using the DGR Approach Reveals that Time and Secondary TSA are Essential Variables.

Wang Y, van Oosterwijk N, Ali AM, Adawy A, Anindya AL, Dömling ASS, Groves MR.

Sci Rep. 2017 Aug 24;7(1):9355. doi: 10.1038/s41598-017-09687-z.


DXS as a target for structure-based drug design.

Gierse RM, Redeem E, Diamanti E, Wrenger C, Groves MR, Hirsch AK.

Future Med Chem. 2017 Jul;9(11):1277-1294. doi: 10.4155/fmc-2016-0239. Epub 2017 Jun 21. Review.


Crystal structure of truncated human coatomer protein complex subunit ζ1 (Copζ1).

Lunev S, Semmelink MF, Xian JL, Ma KY, Leenders AJ, Dömling AS, Shtutman M, Groves MR.

Acta Crystallogr F Struct Biol Commun. 2017 Jan 1;73(Pt 1):1-8. doi: 10.1107/S2053230X16018896. Epub 2017 Jan 1.


Crystal structure of truncated aspartate transcarbamoylase from Plasmodium falciparum.

Lunev S, Bosch SS, Batista Fde A, Wrenger C, Groves MR.

Acta Crystallogr F Struct Biol Commun. 2016 Jul;72(Pt 7):523-33. doi: 10.1107/S2053230X16008475. Epub 2016 Jun 22.


Data collection with a tailored X-ray beam size at 2.69 Å wavelength (4.6 keV): sulfur SAD phasing of Cdc23(Nterm).

Cianci M, Groves MR, Barford D, Schneider TR.

Acta Crystallogr D Struct Biol. 2016 Mar;72(Pt 3):403-12. doi: 10.1107/S2059798315010268. Epub 2016 Mar 1.


Drug Target Validation Methods in Malaria - Protein Interference Assay (PIA) as a Tool for Highly Specific Drug Target Validation.

Meissner KA, Lunev S, Wang YZ, Linzke M, de Assis Batista F, Wrenger C, Groves MR.

Curr Drug Targets. 2017;18(9):1069-1085. doi: 10.2174/1389450117666160201115003. Review.


Tomography of a Cryo-immobilized Yeast Cell Using Ptychographic Coherent X-Ray Diffractive Imaging.

Giewekemeyer K, Hackenberg C, Aquila A, Wilke RN, Groves MR, Jordanova R, Lamzin VS, Borchers G, Saksl K, Zozulya AV, Sprung M, Mancuso AP.

Biophys J. 2015 Nov 3;109(9):1986-95. doi: 10.1016/j.bpj.2015.08.047.


Enzyme kinetics and inhibition of histone acetyltransferase KAT8.

Wapenaar H, van der Wouden PE, Groves MR, Rotili D, Mai A, Dekker FJ.

Eur J Med Chem. 2015 Nov 13;105:289-96. doi: 10.1016/j.ejmech.2015.10.016. Epub 2015 Oct 22.


Purification, crystallization and preliminary X-ray diffraction analysis of pyridoxal kinase from Plasmodium falciparum (PfPdxK).

Kronenberger T, Lunev S, Wrenger C, Groves MR.

Acta Crystallogr F Struct Biol Commun. 2014 Nov;70(Pt 11):1550-5. doi: 10.1107/S2053230X14019864. Epub 2014 Oct 25.


Iron binding at specific sites within the octameric HbpS protects streptomycetes from iron-mediated oxidative stress.

Wedderhoff I, Kursula I, Groves MR, Ortiz de Orué Lucana D.

PLoS One. 2013 Aug 27;8(8):e71579. doi: 10.1371/journal.pone.0071579. eCollection 2013.


A unique Oct4 interface is crucial for reprogramming to pluripotency.

Esch D, Vahokoski J, Groves MR, Pogenberg V, Cojocaru V, Vom Bruch H, Han D, Drexler HC, Araúzo-Bravo MJ, Ng CK, Jauch R, Wilmanns M, Schöler HR.

Nat Cell Biol. 2013 Mar;15(3):295-301. doi: 10.1038/ncb2680. Epub 2013 Feb 3.


Elucidation of haem-binding sites in the actinobacterial protein HbpS.

Torda AE, Groves MR, Wedderhoff I, Ortiz de Orué Lucana D.

FEMS Microbiol Lett. 2013 May;342(2):106-12. doi: 10.1111/1574-6968.12093. Epub 2013 Feb 21.


Internal structure of an intact Convallaria majalis pollen grain observed with X-ray Fresnel coherent diffractive imaging.

Mancuso AP, Groves MR, Polozhentsev OE, Williams GJ, McNulty I, Antony C, Santarella-Mellwig R, Soldatov AV, Lamzin V, Peele AG, Nugent KA, Vartanyants IA.

Opt Express. 2012 Nov 19;20(24):26778-85. doi: 10.1364/OE.20.026778.


Cytometric quantification of singlet oxygen in the human malaria parasite Plasmodium falciparum.

Butzloff S, Groves MR, Wrenger C, Müller IB.

Cytometry A. 2012 Aug;81(8):698-703. doi: 10.1002/cyto.a.22081. Epub 2012 Jun 26.


Crystallization and preliminary X-ray diffraction of malate dehydrogenase from Plasmodium falciparum.

Wrenger C, Müller IB, Butzloff S, Jordanova R, Lunev S, Groves MR.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jun 1;68(Pt 6):659-62. doi: 10.1107/S1744309112014571. Epub 2012 May 23.


Aspartate aminotransferase: bridging carbohydrate and energy metabolism in Plasmodium falciparum.

Wrenger C, Muller IB, Silber AM, Jordanova R, Lamzin VS, Groves MR.

Curr Drug Metab. 2012 Mar;13(3):332-6. Review.


Novel redox-sensing modules: accessory protein- and nucleic acid-mediated signaling.

Siedenburg G, Groves MR, Ortiz de Orué Lucana D.

Antioxid Redox Signal. 2012 Apr 1;16(7):668-77. doi: 10.1089/ars.2011.4290. Epub 2012 Jan 6. Review.


Dynamic substrate enhancement for the identification of specific, second-site-binding fragments targeting a set of protein tyrosine phosphatases.

Schmidt MF, Groves MR, Rademann J.

Chembiochem. 2011 Nov 25;12(17):2640-6. doi: 10.1002/cbic.201100414. Epub 2011 Nov 3.


ROS-Mediated Signalling in Bacteria: Zinc-Containing Cys-X-X-Cys Redox Centres and Iron-Based Oxidative Stress.

Ortiz de Orué Lucana D, Wedderhoff I, Groves MR.

J Signal Transduct. 2012;2012:605905. doi: 10.1155/2012/605905. Epub 2011 Sep 29.


Specific inhibition of the aspartate aminotransferase of Plasmodium falciparum.

Wrenger C, Müller IB, Schifferdecker AJ, Jain R, Jordanova R, Groves MR.

J Mol Biol. 2011 Jan 28;405(4):956-71. doi: 10.1016/j.jmb.2010.11.018. Epub 2010 Nov 16.


Quantitive evaluation of macromolecular crystallization experiments using 1,8-ANS fluorescence.

Watts D, Müller-Dieckmann J, Tsakanova G, Lamzin VS, Groves MR.

Acta Crystallogr D Biol Crystallogr. 2010 Aug;66(Pt 8):901-8. doi: 10.1107/S0907444910020664. Epub 2010 Jul 10.


Purification, crystallization and preliminary X-ray analysis of the aspartate aminotransferase of Plasmodium falciparum.

Jain R, Jordanova R, Müller IB, Wrenger C, Groves MR.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Apr 1;66(Pt 4):409-12. doi: 10.1107/S1744309110003933. Epub 2010 Mar 31.


The vitamin B1 metabolism of Staphylococcus aureus is controlled at enzymatic and transcriptional levels.

Müller IB, Bergmann B, Groves MR, Couto I, Amaral L, Begley TP, Walter RD, Wrenger C.

PLoS One. 2009 Nov 3;4(11):e7656. doi: 10.1371/journal.pone.0007656.


Fatty acid- and retinoid-binding proteins have distinct binding pockets for the two types of cargo.

Jordanova R, Groves MR, Kostova E, Woltersdorf C, Liebau E, Tucker PA.

J Biol Chem. 2009 Dec 18;284(51):35818-26. doi: 10.1074/jbc.M109.022731.


Mobility of the conserved glycine 155 is required for formation of the active plasmodial Pdx1 dodecamer.

Knöckel J, Jordanova R, Müller IB, Wrenger C, Groves MR.

Biochim Biophys Acta. 2009 May;1790(5):347-50. doi: 10.1016/j.bbagen.2009.02.016. Epub 2009 Mar 9.


The three-component signalling system HbpS-SenS-SenR as an example of a redox sensing pathway in bacteria.

Ortiz de Orué Lucana D, Groves MR.

Amino Acids. 2009 Sep;37(3):479-86. doi: 10.1007/s00726-009-0260-9. Epub 2009 Mar 4. Review.


The oligomeric assembly of the novel haem-degrading protein HbpS is essential for interaction with its cognate two-component sensor kinase.

Ortiz de Orué Lucana D, Bogel G, Zou P, Groves MR.

J Mol Biol. 2009 Mar 6;386(4):1108-22.


Methods for protein characterization by mass spectrometry, thermal shift (ThermoFluor) assay, and multiangle or static light scattering.

Nettleship JE, Brown J, Groves MR, Geerlof A.

Methods Mol Biol. 2008;426:299-318. doi: 10.1007/978-1-60327-058-8_19.


Crystallization and preliminary characterization of a novel haem-binding protein of Streptomyces reticuli.

Zou P, Groves MR, Viale-Bouroncle SD, Ortiz de Orué Lucana D.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 May 1;64(Pt 5):386-90. doi: 10.1107/S1744309108008348. Epub 2008 Apr 5.


The assembly of the plasmodial PLP synthase complex follows a defined course.

Müller IB, Knöckel J, Groves MR, Jordanova R, Ealick SE, Walter RD, Wrenger C.

PLoS One. 2008 Mar 19;3(3):e1815. doi: 10.1371/journal.pone.0001815.


A method for the general identification of protein crystals in crystallization experiments using a noncovalent fluorescent dye.

Groves MR, Müller IB, Kreplin X, Müller-Dieckmann J.

Acta Crystallogr D Biol Crystallogr. 2007 Apr;63(Pt 4):526-35. Epub 2007 Mar 16.


Octameric alcohol oxidase dissociates into stable, soluble monomers upon incubation with dimethylsulfoxide.

Visser NV, Wang D, Stanley WA, Groves MR, Wilmanns M, Veenhuis M, van der Klei IJ.

Arch Biochem Biophys. 2007 Mar 15;459(2):208-13. Epub 2007 Jan 23.


The impact of protein characterization in structural proteomics.

Geerlof A, Brown J, Coutard B, Egloff MP, Enguita FJ, Fogg MJ, Gilbert RJ, Groves MR, Haouz A, Nettleship JE, Nordlund P, Owens RJ, Ruff M, Sainsbury S, Svergun DI, Wilmanns M.

Acta Crystallogr D Biol Crystallogr. 2006 Oct;62(Pt 10):1125-36. Epub 2006 Sep 19. Review.


Structural analysis of the human Golgi-associated plant pathogenesis related protein GAPR-1 implicates dimerization as a regulatory mechanism.

Serrano RL, Kuhn A, Hendricks A, Helms JB, Sinning I, Groves MR.

J Mol Biol. 2004 May 21;339(1):173-83.


Crystallization of a Golgi-associated PR-1-related protein (GAPR-1) that localizes to lipid-enriched microdomains.

Groves MR, Kuhn A, Hendricks A, Radke S, Serrano RL, Helms JB, Sinning I.

Acta Crystallogr D Biol Crystallogr. 2004 Apr;60(Pt 4):730-2. Epub 2004 Mar 23.


Definition of domain boundaries and crystallization of the SMN Tudor domain.

Sprangers R, Selenko P, Sattler M, Sinning I, Groves MR.

Acta Crystallogr D Biol Crystallogr. 2003 Feb;59(Pt 2):366-8. Epub 2003 Jan 23.


Functional characterization of recombinant chloroplast signal recognition particle.

Groves MR, Mant A, Kuhn A, Koch J, Dübel S, Robinson C, Sinning I.

J Biol Chem. 2001 Jul 27;276(30):27778-86. Epub 2001 May 16.

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