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Potent Activation of Indoleamine 2,3-Dioxygenase by Polysulfides.

Nelp MT, Zheng V, Davis KM, Stiefel KJE, Groves JT.

J Am Chem Soc. 2019 Sep 25;141(38):15288-15300. doi: 10.1021/jacs.9b07338. Epub 2019 Sep 11.


Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion.

Alieva NO, Efremov AK, Hu S, Oh D, Chen Z, Natarajan M, Ong HT, Jégou A, Romet-Lemonne G, Groves JT, Sheetz MP, Yan J, Bershadsky AD.

Nat Commun. 2019 Aug 9;10(1):3593. doi: 10.1038/s41467-019-10964-w.


Stochastic geometry sensing and polarization in a lipid kinase-phosphatase competitive reaction.

Hansen SD, Huang WYC, Lee YK, Bieling P, Christensen SM, Groves JT.

Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):15013-15022. doi: 10.1073/pnas.1901744116. Epub 2019 Jul 5.


Switch-like activation of Bruton's tyrosine kinase by membrane-mediated dimerization.

Chung JK, Nocka LM, Decker A, Wang Q, Kadlecek TA, Weiss A, Kuriyan J, Groves JT.

Proc Natl Acad Sci U S A. 2019 May 28;116(22):10798-10803. doi: 10.1073/pnas.1819309116. Epub 2019 May 10.


Hybrid Live Cell-Supported Membrane Interfaces for Signaling Studies.

Biswas KH, Groves JT.

Annu Rev Biophys. 2019 May 6;48:537-562. doi: 10.1146/annurev-biophys-070317-033330. Epub 2019 Apr 3.


A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS.

Huang WYC, Alvarez S, Kondo Y, Lee YK, Chung JK, Lam HYM, Biswas KH, Kuriyan J, Groves JT.

Science. 2019 Mar 8;363(6431):1098-1103. doi: 10.1126/science.aau5721. Epub 2019 Mar 7.


Mapping the stochastic sequence of individual ligand-receptor binding events to cellular activation: T cells act on the rare events.

Lin JJY, Low-Nam ST, Alfieri KN, McAffee DB, Fay NC, Groves JT.

Sci Signal. 2019 Jan 15;12(564). pii: eaat8715. doi: 10.1126/scisignal.aat8715.


Membrane Mechanics in Living Cells.

Groves JT.

Dev Cell. 2019 Jan 7;48(1):15-16. doi: 10.1016/j.devcel.2018.12.011.


Spatiomechanical Modulation of EphB4-Ephrin-B2 Signaling in Neural Stem Cell Differentiation.

Dong M, Spelke DP, Lee YK, Chung JK, Yu CH, Schaffer DV, Groves JT.

Biophys J. 2018 Sep 4;115(5):865-873. doi: 10.1016/j.bpj.2018.06.031. Epub 2018 Jul 23.


Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding.

Sibener LV, Fernandes RA, Kolawole EM, Carbone CB, Liu F, McAffee D, Birnbaum ME, Yang X, Su LF, Yu W, Dong S, Gee MH, Jude KM, Davis MM, Groves JT, Goddard WA 3rd, Heath JR, Evavold BD, Vale RD, Garcia KC.

Cell. 2018 Jul 26;174(3):672-687.e27. doi: 10.1016/j.cell.2018.06.017.


Membrane Reconstitution of Monoamine Oxidase Enzymes on Supported Lipid Bilayers.

Wang L, Biswas KH, Yoon BK, Kawakami LM, Park S, Groves JT, Li L, Huang W, Cho NJ.

Langmuir. 2018 Sep 11;34(36):10764-10773. doi: 10.1021/acs.langmuir.8b01348. Epub 2018 Aug 31.


Fabrication of Multicomponent, Spatially Segregated DNA and Protein-Functionalized Supported Membrane Microarray.

Biswas KH, Cho NJ, Groves JT.

Langmuir. 2018 Aug 21;34(33):9781-9788. doi: 10.1021/acs.langmuir.8b01364. Epub 2018 Aug 9.


A reevaluation of iron binding by Mycobactin J.

McQueen CF, Groves JT.

J Biol Inorg Chem. 2018 Oct;23(7):995-1007. doi: 10.1007/s00775-018-1592-2. Epub 2018 Jul 16.


mTORC1 Controls Phase Separation and the Biophysical Properties of the Cytoplasm by Tuning Crowding.

Delarue M, Brittingham GP, Pfeffer S, Surovtsev IV, Pinglay S, Kennedy KJ, Schaffer M, Gutierrez JI, Sang D, Poterewicz G, Chung JK, Plitzko JM, Groves JT, Jacobs-Wagner C, Engel BD, Holt LJ.

Cell. 2018 Jul 12;174(2):338-349.e20. doi: 10.1016/j.cell.2018.05.042. Epub 2018 Jun 21.


Spatially modulated ephrinA1:EphA2 signaling increases local contractility and global focal adhesion dynamics to promote cell motility.

Chen Z, Oh D, Biswas KH, Yu CH, Zaidel-Bar R, Groves JT.

Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):E5696-E5705. doi: 10.1073/pnas.1719961115. Epub 2018 Jun 4.


Site-selective 18F fluorination of unactivated C-H bonds mediated by a manganese porphyrin.

Liu W, Huang X, Placzek MS, Krska SW, McQuade P, Hooker JM, Groves JT.

Chem Sci. 2017 Dec 5;9(5):1168-1172. doi: 10.1039/c7sc04545j. eCollection 2018 Feb 7.


Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form.

Nelp MT, Kates PA, Hunt JT, Newitt JA, Balog A, Maley D, Zhu X, Abell L, Allentoff A, Borzilleri R, Lewis HA, Lin Z, Seitz SP, Yan C, Groves JT.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3249-3254. doi: 10.1073/pnas.1719190115. Epub 2018 Mar 12.


K-Ras4B Remains Monomeric on Membranes over a Wide Range of Surface Densities and Lipid Compositions.

Chung JK, Lee YK, Denson JP, Gillette WK, Alvarez S, Stephen AG, Groves JT.

Biophys J. 2018 Jan 9;114(1):137-145. doi: 10.1016/j.bpj.2017.10.042.


EGFR family and Src family kinase interactions: mechanics matters?

Chen Z, Oh D, Dubey AK, Yao M, Yang B, Groves JT, Sheetz M.

Curr Opin Cell Biol. 2018 Apr;51:97-102. doi: 10.1016/ Epub 2017 Dec 28. Review.


Oxygen Activation and Radical Transformations in Heme Proteins and Metalloporphyrins.

Huang X, Groves JT.

Chem Rev. 2018 Mar 14;118(5):2491-2553. doi: 10.1021/acs.chemrev.7b00373. Epub 2017 Dec 29. Review.


Interfacial Forces Dictate the Pathway of Phospholipid Vesicle Adsorption onto Silicon Dioxide Surfaces.

Biswas KH, Jackman JA, Park JH, Groves JT, Cho NJ.

Langmuir. 2018 Jan 30;34(4):1775-1782. doi: 10.1021/acs.langmuir.7b03799. Epub 2018 Jan 11.


Selective C-H Halogenation with a Highly Fluorinated Manganese Porphyrin.

Li G, Dilger AK, Cheng PT, Ewing WR, Groves JT.

Angew Chem Int Ed Engl. 2018 Jan 26;57(5):1251-1255. doi: 10.1002/anie.201710676. Epub 2017 Dec 28.


Allosteric Modulation of Grb2 Recruitment to the Intrinsically Disordered Scaffold Protein, LAT, by Remote Site Phosphorylation.

Huang WYC, Ditlev JA, Chiang HK, Rosen MK, Groves JT.

J Am Chem Soc. 2017 Dec 13;139(49):18009-18015. doi: 10.1021/jacs.7b09387. Epub 2017 Nov 28.


Early T cell receptor signals globally modulate ligand:receptor affinities during antigen discrimination.

Pielak RM, O'Donoghue GP, Lin JJ, Alfieri KN, Fay NC, Low-Nam ST, Groves JT.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12190-12195. doi: 10.1073/pnas.1613140114. Epub 2017 Oct 30.


Dynamic Scaling Analysis of Molecular Motion within the LAT:Grb2:SOS Protein Network on Membranes.

Huang WYC, Chiang HK, Groves JT.

Biophys J. 2017 Oct 17;113(8):1807-1813. doi: 10.1016/j.bpj.2017.08.024.


Alkyl Isocyanates via Manganese-Catalyzed C-H Activation for the Preparation of Substituted Ureas.

Huang X, Zhuang T, Kates PA, Gao H, Chen X, Groves JT.

J Am Chem Soc. 2017 Nov 1;139(43):15407-15413. doi: 10.1021/jacs.7b07658. Epub 2017 Oct 18.


Two-step membrane binding by the bacterial SRP receptor enable efficient and accurate Co-translational protein targeting.

Hwang Fu YH, Huang WYC, Shen K, Groves JT, Miller T, Shan SO.

Elife. 2017 Jul 28;6. pii: e25885. doi: 10.7554/eLife.25885.


The Enigmatic P450 Decarboxylase OleT Is Capable of, but Evolved To Frustrate, Oxygen Rebound Chemistry.

Hsieh CH, Huang X, Amaya JA, Rutland CD, Keys CL, Groves JT, Austin RN, Makris TM.

Biochemistry. 2017 Jul 5;56(26):3347-3357. doi: 10.1021/acs.biochem.7b00338. Epub 2017 Jun 26.


Mechanism of SOS PR-domain autoinhibition revealed by single-molecule assays on native protein from lysate.

Lee YK, Low-Nam ST, Chung JK, Hansen SD, Lam HYM, Alvarez S, Groves JT.

Nat Commun. 2017 Apr 28;8:15061. doi: 10.1038/ncomms15061.


Dynamic Cellular Interactions with Extracellular Matrix Triggered by Biomechanical Tuning of Low-Rigidity, Supported Lipid Membranes.

Vafaei S, Tabaei SR, Biswas KH, Groves JT, Cho NJ.

Adv Healthc Mater. 2017 May;6(10). doi: 10.1002/adhm.201700243. Epub 2017 Mar 30.


Fast Hydrogen Atom Abstraction by a Hydroxo Iron(III) Porphyrazine.

Gao H, Groves JT.

J Am Chem Soc. 2017 Mar 22;139(11):3938-3941. doi: 10.1021/jacs.6b13091. Epub 2017 Mar 8.


Beyond ferryl-mediated hydroxylation: 40 years of the rebound mechanism and C-H activation.

Huang X, Groves JT.

J Biol Inorg Chem. 2017 Apr;22(2-3):185-207. doi: 10.1007/s00775-016-1414-3. Epub 2016 Dec 1. Review.


Sustained α-catenin Activation at E-cadherin Junctions in the Absence of Mechanical Force.

Biswas KH, Hartman KL, Zaidel-Bar R, Groves JT.

Biophys J. 2016 Sep 6;111(5):1044-52. doi: 10.1016/j.bpj.2016.06.027.


One-way membrane trafficking of SOS in receptor-triggered Ras activation.

Christensen SM, Tu HL, Jun JE, Alvarez S, Triplet MG, Iwig JS, Yadav KK, Bar-Sagi D, Roose JP, Groves JT.

Nat Struct Mol Biol. 2016 Sep;23(9):838-46. doi: 10.1038/nsmb.3275. Epub 2016 Aug 8.


Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS.

Huang WY, Yan Q, Lin WC, Chung JK, Hansen SD, Christensen SM, Tu HL, Kuriyan J, Groves JT.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8218-23. doi: 10.1073/pnas.1602602113. Epub 2016 Jul 1.


Graphene-Templated Supported Lipid Bilayer Nanochannels.

Li W, Chung JK, Lee YK, Groves JT.

Nano Lett. 2016 Aug 10;16(8):5022-6. doi: 10.1021/acs.nanolett.6b01798. Epub 2016 Jul 6.


Size-dependent, stochastic nature of lipid exchange between nano-vesicles and model membranes.

Tabaei SR, Gillissen JJ, Vafaei S, Groves JT, Cho NJ.

Nanoscale. 2016 Jul 21;8(27):13513-20. doi: 10.1039/c6nr03817d. Epub 2016 Jun 29.


A Microbead Supported Membrane-Based Fluorescence Imaging Assay Reveals Intermembrane Receptor-Ligand Complex Dimension with Nanometer Precision.

Biswas KH, Groves JT.

Langmuir. 2016 Jul 5;32(26):6775-80. doi: 10.1021/acs.langmuir.6b01377. Epub 2016 Jun 20.


Monitoring the Waiting Time Sequence of Single Ras GTPase Activation Events Using Liposome Functionalized Zero-Mode Waveguides.

Christensen SM, Triplet MG, Rhodes C, Iwig JS, Tu HL, Stamou D, Groves JT.

Nano Lett. 2016 Apr 13;16(4):2890-5. doi: 10.1021/acs.nanolett.6b00969. Epub 2016 Mar 30.


Covalent Ras Dimerization on Membrane Surfaces through Photosensitized Oxidation.

Chung JK, Lee YK, Lam HY, Groves JT.

J Am Chem Soc. 2016 Feb 17;138(6):1800-3. doi: 10.1021/jacs.5b12648. Epub 2016 Feb 8.


Dynamic Organization of Myristoylated Src in the Live Cell Plasma Membrane.

Smith AW, Huang HH, Endres NF, Rhodes C, Groves JT.

J Phys Chem B. 2016 Feb 11;120(5):867-76. doi: 10.1021/acs.jpcb.5b08887. Epub 2016 Jan 29.


Corrigendum: Targeted Fluorination with the Fluoride Ion by Manganese-Catalyzed Decarboxylation.

Huang X, Liu W, Hooker JM, Groves JT.

Angew Chem Int Ed Engl. 2015 Nov 23;54(48):14215. doi: 10.1002/anie.201509229. No abstract available.


Cholesterol-Enriched Domain Formation Induced by Viral-Encoded, Membrane-Active Amphipathic Peptide.

Hanson JM, Gettel DL, Tabaei SR, Jackman J, Kim MC, Sasaki DY, Groves JT, Liedberg B, Cho NJ, Parikh AN.

Biophys J. 2016 Jan 5;110(1):176-87. doi: 10.1016/j.bpj.2015.11.032.


Negative membrane curvature catalyzes nucleation of endosomal sorting complex required for transport (ESCRT)-III assembly.

Lee IH, Kai H, Carlson LA, Groves JT, Hurley JH.

Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15892-7. doi: 10.1073/pnas.1518765113. Epub 2015 Dec 14.


Diffusion of GPI-anchored proteins is influenced by the activity of dynamic cortical actin.

Saha S, Lee IH, Polley A, Groves JT, Rao M, Mayor S.

Mol Biol Cell. 2015 Nov 5;26(22):4033-45. doi: 10.1091/mbc.E15-06-0397. Epub 2015 Sep 16.


E-cadherin junction formation involves an active kinetic nucleation process.

Biswas KH, Hartman KL, Yu CH, Harrison OJ, Song H, Smith AW, Huang WY, Lin WC, Guo Z, Padmanabhan A, Troyanovsky SM, Dustin ML, Shapiro L, Honig B, Zaidel-Bar R, Groves JT.

Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):10932-7. doi: 10.1073/pnas.1513775112. Epub 2015 Aug 19. Erratum in: Proc Natl Acad Sci U S A. 2016 Nov 14;:. Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7870.


Manganese Catalyzed C-H Halogenation.

Liu W, Groves JT.

Acc Chem Res. 2015 Jun 16;48(6):1727-35. doi: 10.1021/acs.accounts.5b00062. Epub 2015 Jun 4.


Manganese-catalyzed late-stage aliphatic C-H azidation.

Huang X, Bergsten TM, Groves JT.

J Am Chem Soc. 2015 Apr 29;137(16):5300-3. doi: 10.1021/jacs.5b01983. Epub 2015 Apr 14.


Heme-thiolate ferryl of aromatic peroxygenase is basic and reactive.

Wang X, Ullrich R, Hofrichter M, Groves JT.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3686-91. doi: 10.1073/pnas.1503340112. Epub 2015 Mar 10.


Importin-β modulates the permeability of the nuclear pore complex in a Ran-dependent manner.

Lowe AR, Tang JH, Yassif J, Graf M, Huang WY, Groves JT, Weis K, Liphardt JT.

Elife. 2015 Mar 6;4. doi: 10.7554/eLife.04052.

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