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Items: 45

1.

Cysteine 180 Is a Redox Sensor Modulating the Activity of Human Pyridoxal 5'-Phosphate Histidine Decarboxylase.

Rossignoli G, Grottesi A, Bisello G, Montioli R, Borri Voltattorni C, Paiardini A, Bertoldi M.

Biochemistry. 2018 Nov 6;57(44):6336-6348. doi: 10.1021/acs.biochem.8b00625. Epub 2018 Oct 29.

PMID:
30346159
2.

Structural investigation of nucleophosmin interaction with the tumor suppressor Fbw7╬│.

Di Matteo A, Franceschini M, Paiardini A, Grottesi A, Chiarella S, Rocchio S, Di Natale C, Marasco D, Vitagliano L, Travaglini-Allocatelli C, Federici L.

Oncogenesis. 2017 Sep 18;6(9):e379. doi: 10.1038/oncsis.2017.78.

3.

Lethal digenic mutations in the K+ channels Kir4.1 (KCNJ10) and SLACK (KCNT1) associated with severe-disabling seizures and neurodevelopmental delay.

Hasan S, Balobaid A, Grottesi A, Dabbagh O, Cenciarini M, Rawashdeh R, Al-Sagheir A, Bove C, Macchioni L, Pessia M, Al-Owain M, D'Adamo MC.

J Neurophysiol. 2017 Oct 1;118(4):2402-2411. doi: 10.1152/jn.00284.2017. Epub 2017 Jul 26.

4.

Molecular dynamics recipes for genome research.

Biagini T, Chillemi G, Mazzoccoli G, Grottesi A, Fusilli C, Capocefalo D, Castellana S, Vescovi AL, Mazza T.

Brief Bioinform. 2018 Sep 28;19(5):853-862. doi: 10.1093/bib/bbx006.

PMID:
28334084
5.

Thermal compaction of the intrinsically disordered protein tau: entropic, structural, and hydrophobic factors.

Battisti A, Ciasca G, Grottesi A, Tenenbaum A.

Phys Chem Chem Phys. 2017 Mar 28;19(12):8435-8446. doi: 10.1039/c6cp07683a. Epub 2017 Mar 13.

PMID:
28287224
6.

Gain-of-function defects of astrocytic Kir4.1 channels in children with autism spectrum disorders and epilepsy.

Sicca F, Ambrosini E, Marchese M, Sforna L, Servettini I, Valvo G, Brignone MS, Lanciotti A, Moro F, Grottesi A, Catacuzzeno L, Baldini S, Hasan S, D'Adamo MC, Franciolini F, Molinari P, Santorelli FM, Pessia M.

Sci Rep. 2016 Sep 28;6:34325. doi: 10.1038/srep34325.

7.

Effect of DNA on the conformational dynamics of the endonucleases I-DmoI as provided by molecular dynamics simulations.

Grottesi A, Cecconi S, Molina R, D'abramo M.

Biopolymers. 2016 Dec;105(12):898-904. doi: 10.1002/bip.22933.

PMID:
27506595
8.

A Calsequestrin-1 Mutation Associated with a Skeletal Muscle Disease Alters Sarcoplasmic Ca2+ Release.

D'Adamo MC, Sforna L, Visentin S, Grottesi A, Servettini L, Guglielmi L, Macchioni L, Saredi S, Curcio M, De Nuccio C, Hasan S, Corazzi L, Franciolini F, Mora M, Catacuzzeno L, Pessia M.

PLoS One. 2016 May 19;11(5):e0155516. doi: 10.1371/journal.pone.0155516. eCollection 2016.

9.

Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channels.

Kopljar I, Grottesi A, de Block T, Rainier JD, Tytgat J, Labro AJ, Snyders DJ.

Neuropharmacology. 2016 Aug;107:160-167. doi: 10.1016/j.neuropharm.2016.03.010. Epub 2016 Mar 5.

PMID:
26956727
10.

Novel phenotype associated with a mutation in the KCNA1(Kv1.1) gene.

D'Adamo MC, Gallenm├╝ller C, Servettini I, Hartl E, Tucker SJ, Arning L, Biskup S, Grottesi A, Guglielmi L, Imbrici P, Bernasconi P, Di Giovanni G, Franciolini F, Catacuzzeno L, Pessia M, Klopstock T.

Front Physiol. 2015 Jan 15;5:525. doi: 10.3389/fphys.2014.00525. eCollection 2014.

11.

Modeling conformational transitions in kinases by molecular dynamics simulations: achievements, difficulties, and open challenges.

D'Abramo M, Besker N, Chillemi G, Grottesi A.

Front Genet. 2014 May 13;5:128. doi: 10.3389/fgene.2014.00128. eCollection 2014. Review.

12.

Genetically induced dysfunctions of Kir2.1 channels: implications for short QT3 syndrome and autism-epilepsy phenotype.

Ambrosini E, Sicca F, Brignone MS, D'Adamo MC, Napolitano C, Servettini I, Moro F, Ruan Y, Guglielmi L, Pieroni S, Servillo G, Lanciotti A, Valvo G, Catacuzzeno L, Franciolini F, Molinari P, Marchese M, Grottesi A, Guerrini R, Santorelli FM, Priori S, Pessia M.

Hum Mol Genet. 2014 Sep 15;23(18):4875-86. doi: 10.1093/hmg/ddu201. Epub 2014 May 2.

13.

Parametrisation of the free energy of ATP binding to wild-type and mutant Kir6.2 potassium channels.

Moran O, Grottesi A, Chadburn AJ, Tammaro P.

Biophys Chem. 2013 Jan;171:76-83. doi: 10.1016/j.bpc.2012.10.006. Epub 2012 Nov 16.

PMID:
23219002
14.

Conformational switch of a flexible loop in human laminin receptor determines laminin-1 interaction.

Di Giovanni C, Grottesi A, Lavecchia A.

Eur Biophys J. 2012 Mar;41(3):353-8. doi: 10.1007/s00249-012-0793-9.

PMID:
22290616
15.

Autism with seizures and intellectual disability: possible causative role of gain-of-function of the inwardly-rectifying K+ channel Kir4.1.

Sicca F, Imbrici P, D'Adamo MC, Moro F, Bonatti F, Brovedani P, Grottesi A, Guerrini R, Masi G, Santorelli FM, Pessia M.

Neurobiol Dis. 2011 Jul;43(1):239-47. doi: 10.1016/j.nbd.2011.03.016. Epub 2011 Mar 31.

PMID:
21458570
16.

Episodic ataxia type 1 mutations affect fast inactivation of K+ channels by a reduction in either subunit surface expression or affinity for inactivation domain.

Imbrici P, D'Adamo MC, Grottesi A, Biscarini A, Pessia M.

Am J Physiol Cell Physiol. 2011 Jun;300(6):C1314-22. doi: 10.1152/ajpcell.00456.2010. Epub 2011 Feb 9.

17.

Contribution of the central hydrophobic residue in the PXP motif of voltage-dependent K+ channels to S6 flexibility and gating properties.

Imbrici P, Grottesi A, D'Adamo MC, Mannucci R, Tucker SJ, Pessia M.

Channels (Austin). 2009 Jan-Feb;3(1):39-45. Epub 2009 Jan 3.

PMID:
19202350
18.

Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues.

Labro AJ, Raes AL, Grottesi A, Van Hoorick D, Sansom MS, Snyders DJ.

J Gen Physiol. 2008 Dec;132(6):667-80. doi: 10.1085/jgp.200810048.

19.

Ion channel gates: comparative analysis of energy barriers.

Tai K, Haider S, Grottesi A, Sansom MS.

Eur Biophys J. 2009 Apr;38(4):347-54. doi: 10.1007/s00249-008-0377-x. Epub 2008 Oct 16.

PMID:
18923825
20.

Insight into the mechanism of inactivation and pH sensitivity in potassium channels from molecular dynamics simulations.

Stansfeld PJ, Grottesi A, Sands ZA, Sansom MS, Gedeck P, Gosling M, Cox B, Stanfield PR, Mitcheson JS, Sutcliffe MJ.

Biochemistry. 2008 Jul 15;47(28):7414-22. doi: 10.1021/bi800475j. Epub 2008 Jun 18.

PMID:
18558719
21.

A Kv channel with an altered activation gate sequence displays both "fast" and "slow" activation kinetics.

Labro AJ, Grottesi A, Sansom MS, Raes AL, Snyders DJ.

Am J Physiol Cell Physiol. 2008 Jun;294(6):C1476-84. doi: 10.1152/ajpcell.00479.2007. Epub 2008 Apr 2.

22.

Diverse driving forces underlie the invariant occurrence of the T42A, E139D, I282V and T468M SHP2 amino acid substitutions causing Noonan and LEOPARD syndromes.

Martinelli S, Torreri P, Tinti M, Stella L, Bocchinfuso G, Flex E, Grottesi A, Ceccarini M, Palleschi A, Cesareni G, Castagnoli L, Petrucci TC, Gelb BD, Tartaglia M.

Hum Mol Genet. 2008 Jul 1;17(13):2018-29. doi: 10.1093/hmg/ddn099. Epub 2008 Mar 27.

23.

Outer membrane proteins: comparing X-ray and NMR structures by MD simulations in lipid bilayers.

Cox K, Bond PJ, Grottesi A, Baaden M, Sansom MS.

Eur Biophys J. 2008 Feb;37(2):131-41. Epub 2007 Jun 6.

PMID:
17551722
24.

Vstx1, a modifier of Kv channel gating, localizes to the interfacial region of lipid bilayers.

Bemporad D, Sands ZA, Wee CL, Grottesi A, Sansom MS.

Biochemistry. 2006 Oct 3;45(39):11844-55.

PMID:
17002285
25.

The intrinsic flexibility of the Kv voltage sensor and its implications for channel gating.

Sands ZA, Grottesi A, Sansom MS.

Biophys J. 2006 Mar 1;90(5):1598-606. Epub 2005 Dec 2.

26.
27.

Molecular simulations and lipid-protein interactions: potassium channels and other membrane proteins.

Sansom MS, Bond PJ, Deol SS, Grottesi A, Haider S, Sands ZA.

Biochem Soc Trans. 2005 Nov;33(Pt 5):916-20.

PMID:
16246010
28.

Potassium channels: complete and undistorted.

Grottesi A, Sands ZA, Sansom MS.

Curr Biol. 2005 Sep 20;15(18):R771-4. Review.

29.

Molecular dynamics simulation approaches to K channels: conformational flexibility and physiological function.

Grottesi A, Domene C, Haider S, Sansom MS.

IEEE Trans Nanobioscience. 2005 Mar;4(1):112-20.

PMID:
15816177
30.
31.

Voltage-gated ion channels.

Sands Z, Grottesi A, Sansom MS.

Curr Biol. 2005 Jan 26;15(2):R44-7. Review. No abstract available.

32.

Early events in protein aggregation: molecular flexibility and hydrophobicity/charge interaction in amyloid peptides as studied by molecular dynamics simulations.

Valerio M, Colosimo A, Conti F, Giuliani A, Grottesi A, Manetti C, Zbilut JP.

Proteins. 2005 Jan 1;58(1):110-8.

PMID:
15526299
33.
34.

Choledochal cyst in a pediatric patient: creation of a bilijejunal anastomosis with surgical staples. A case report.

Vallasciani S, Pintus C, Grottesi A, Riccioni M.

Pediatr Med Chir. 2003 Jul-Aug;25(4):281-4.

PMID:
15070273
35.

Ion channel gating: insights via molecular simulations.

Beckstein O, Biggin PC, Bond P, Bright JN, Domene C, Grottesi A, Holyoake J, Sansom MS.

FEBS Lett. 2003 Nov 27;555(1):85-90. Review.

36.
37.

Proposal for a variant of the Duhamel technique of preputioplasty.

Grottesi A, Steyaert H.

Plast Reconstr Surg. 2003 Jan;111(1):499-500. No abstract available.

PMID:
12496634
38.

Dynamic effects of mutations within two loops of cytochrome c551 from Pseudomonas aeruginosa.

Ceruso MA, Grottesi A, Di Nola A.

Proteins. 2003 Feb 1;50(2):222-9.

PMID:
12486716
39.

Molecular dynamics study of a hyperthermophilic and a mesophilic rubredoxin.

Grottesi A, Ceruso MA, Colosimo A, Di Nola A.

Proteins. 2002 Feb 15;46(3):287-94.

PMID:
11835504
40.

Thyroid tumors in children and adolescents: preoperative study.

Ardito G, Pintus C, Revelli L, Grottesi A, Modugno R, Vincenzoni C, Fadda G, Perrelli L.

Eur J Pediatr Surg. 2001 Jun;11(3):154-7.

PMID:
11475109
41.

An original technique for bladder autoaugmentation with protective abdominal rectus muscle flaps: an experimental study in rats.

Manzoni C, Grottesi A, D'Urzo C, Pintus C, Fadda G, Perrelli L.

J Surg Res. 2001 Aug;99(2):169-74.

PMID:
11469883
42.

Effects of core-packing on the structure, function, and mechanics of a four-helix-bundle protein ROP.

Ceruso MA, Grottesi A, Di Nola A.

Proteins. 1999 Sep 1;36(4):436-46.

PMID:
10450085
43.

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