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Mild Obstructive Sleep Apnea Increases Hypertension Risk Challenging Traditional Severity Classification.

Bouloukaki I, Grote L, McNicholas WT, Hedner J, Verbraecken J, Parati G, Lombardi C, Basoglu OK, Pataka A, Marrone O, Steiropoulos P, Bonsignore MR, Schiza SE; ESADA network.

J Clin Sleep Med. 2020 Feb 11. doi: 10.5664/jcsm.8354. [Epub ahead of print]


Multimorbidity in COPD, does sleep matter?

Vanfleteren LE, Beghe B, Andersson A, Hansson D, Fabbri LM, Grote L.

Eur J Intern Med. 2020 Mar;73:7-15. doi: 10.1016/j.ejim.2019.12.032. Epub 2020 Jan 21. Review.


Periodic limb movements during sleep and blood pressure changes in sleep apnoea: Data from the European Sleep Apnoea Database.

Lombardi C, Parati G, Soranna D, Zambon A, Sliwinski P, Roisman G, Pepin JL, Schiza S, Riha R, Joppa P, Fietze I, Hedner J, Grote L; European Sleep Apnoea Database (ESADA) Collaborators.

Respirology. 2019 Dec 24. doi: 10.1111/resp.13760. [Epub ahead of print]


Occurrence and characterization of medulloblastoma in a patient with Curry-Jones syndrome.

Porath B, Farooki S, Gener M, Amudhavalli SM, Grote L, Cooley LD, Ginn K, Farooqi MS.

Clin Genet. 2020 Apr;97(4):670-671. doi: 10.1111/cge.13681. Epub 2019 Dec 11.


Carbonic anhydrase, obstructive sleep apnea and hypertension: Effects of intervention.

Hoff E, Zou D, Schiza S, Demir Y, Grote L, Bouloukaki I, Beydemir Ş, Eskandari D, Stenlöf K, Hedner J.

J Sleep Res. 2020 Apr;29(2):e12956. doi: 10.1111/jsr.12956. Epub 2019 Dec 6.


Spectrum of KV 2.1 Dysfunction in KCNB1-Associated Neurodevelopmental Disorders.

Kang SK, Vanoye CG, Misra SN, Echevarria DM, Calhoun JD, O'Connor JB, Fabre KL, McKnight D, Demmer L, Goldenberg P, Grote LE, Thiffault I, Saunders C, Strauss KA, Torkamani A, van der Smagt J, van Gassen K, Carson RP, Diaz J, Leon E, Jacher JE, Hannibal MC, Litwin J, Friedman NR, Schreiber A, Lynch B, Poduri A, Marsh ED, Goldberg EM, Millichap JJ, George AL Jr, Kearney JA.

Ann Neurol. 2019 Dec;86(6):899-912. doi: 10.1002/ana.25607. Epub 2019 Oct 24.


Sleep in chronic respiratory disease: COPD and hypoventilation disorders.

McNicholas WT, Hansson D, Schiza S, Grote L.

Eur Respir Rev. 2019 Sep 25;28(153). pii: 190064. doi: 10.1183/16000617.0064-2019. Print 2019 Sep 30. Review.


Unique sleep-stage transitions determined by obstructive sleep apnea severity, age and gender.

Wächter M, Kantelhardt JW, Bonsignore MR, Bouloukaki I, Escourrou P, Fietze I, Grote L, Korzybski D, Lombardi C, Marrone O, Paranicova I, Pataka A, Ryan S, Schiza SE, Sliwinski P, Steiropoulos P, Verbraecken J, Penzel T; ESADA Study Group.

J Sleep Res. 2020 Apr;29(2):e12895. doi: 10.1111/jsr.12895. Epub 2019 Jul 25.


The global burden of sleep apnoea.

Grote L.

Lancet Respir Med. 2019 Aug;7(8):645-647. doi: 10.1016/S2213-2600(19)30226-7. Epub 2019 Jul 9. No abstract available.


Hyperlipidaemia prevalence and cholesterol control in obstructive sleep apnoea: Data from the European sleep apnea database (ESADA).

Gunduz C, Basoglu OK, Hedner J, Bonsignore MR, Hein H, Staats R, Bouloukaki I, Roisman G, Pataka A, Sliwinski P, Ludka O, Pepin JL, Grote L; European Sleep Apnoea Database collaborators.

J Intern Med. 2019 Dec;286(6):676-688. doi: 10.1111/joim.12952. Epub 2019 Jul 25.


Cancer prevalence is increased in females with sleep apnoea: data from the ESADA study.

Pataka A, Bonsignore MR, Ryan S, Riha RL, Pepin JL, Schiza S, Basoglu OK, Sliwinski P, Ludka O, Steiropoulos P, Anttalainen U, McNicholas WT, Hedner J, Grote L; ESADA study group.

Eur Respir J. 2019 Jun 20;53(6). pii: 1900091. doi: 10.1183/13993003.00091-2019. Print 2019 Jun. No abstract available.


Functional Printing of Conductive Silver-Nanowire Photopolymer Composites.

Glier TE, Akinsinde L, Paufler M, Otto F, Hashemi M, Grote L, Daams L, Neuber G, Grimm-Lebsanft B, Biebl F, Rukser D, Lippmann M, Ohm W, Schwartzkopf M, Brett CJ, Matsuyama T, Roth SV, Rübhausen M.

Sci Rep. 2019 Apr 23;9(1):6465. doi: 10.1038/s41598-019-42841-3.


Comment to the Editorial by KS Park and EW Kang "Is only fixed positive airway pressure a robust tool for kidney protection in patients with obstructive sleep apnea?"

Marrone O, Cibella F, Pépin JL, Grote L, Verbraecken J, Saaresranta T, Kvamme JA, Basoglu OK, Lombardi C, McNicholas WT, Hedner J, Bonsignore MR.

J Thorac Dis. 2019 Mar;11(Suppl 3):S480-S482. doi: 10.21037/jtd.2019.01.93. No abstract available.


A randomized trial to determine the impact of indacaterol/glycopyrronium on nighttime oxygenation and symptoms in patients with moderate-to-severe COPD: the DuoSleep study.

Lehmann S, Ringbæk T, Løkke A, Grote L, Hedner J, Lindberg E.

Int J Chron Obstruct Pulmon Dis. 2019 Jan 9;14:199-210. doi: 10.2147/COPD.S184127. eCollection 2019.


Use of the Clinical Global Impression scale in sleep apnea patients - Results from the ESADA database.

Dieltjens M, Verbraecken JA, Hedner J, Vanderveken OM, Steiropoulos P, Kvamme JA, Saaresranta T, Tkacova R, Marrone O, Dogas Z, Schiza S, Grote L; ESADA collaborators.

Sleep Med. 2019 Jul;59:56-65. doi: 10.1016/j.sleep.2018.10.028. Epub 2018 Nov 14.


Insomnia and cardiorespiratory fitness in a middle-aged population: the SCAPIS pilot study.

Zou D, Wennman H, Ekblom Ö, Grote L, Arvidsson D, Blomberg A, Torén K, Bergström G, Börjesson M, Hedner J.

Sleep Breath. 2019 Mar;23(1):319-326. doi: 10.1007/s11325-018-1765-9. Epub 2018 Dec 13.


Insomnia symptoms combined with nocturnal hypoxia associate with cardiovascular comorbidity in the European sleep apnea cohort (ESADA).

Anttalainen U, Grote L, Fietze I, Riha RL, Ryan S, Staats R, Hedner J, Saaresranta T; ESADA Study Collaborators.

Sleep Breath. 2019 Sep;23(3):805-814. doi: 10.1007/s11325-018-1757-9. Epub 2018 Nov 22.


Nasal high flow, but not supplemental O2, reduces peripheral vascular sympathetic activity during sleep in COPD patients.

Fricke K, Schneider H, Biselli P, Hansel NN, Zhang ZG, Sowho MO, Grote L.

Int J Chron Obstruct Pulmon Dis. 2018 Nov 2;13:3635-3643. doi: 10.2147/COPD.S166093. eCollection 2018.


Obstructive sleep apnoea independently predicts lipid levels: Data from the European Sleep Apnea Database.

Gündüz C, Basoglu OK, Hedner J, Zou D, Bonsignore MR, Hein H, Staats R, Pataka A, Barbe F, Sliwinski P, Kent BD, Pepin JL, Grote L; European Sleep Apnea Database Collaborators.

Respirology. 2018 Dec;23(12):1180-1189. doi: 10.1111/resp.13372. Epub 2018 Aug 21.


Clinical presentation of patients with suspected obstructive sleep apnea and self-reported physician-diagnosed asthma in the ESADA cohort.

Bonsignore MR, Pepin JL, Anttalainen U, Schiza SE, Basoglu OK, Pataka A, Steiropoulos P, Dogas Z, Grote L, Hedner J, McNicholas WT, Marrone O; ESADA Study Group.

J Sleep Res. 2018 Dec;27(6):e12729. doi: 10.1111/jsr.12729. Epub 2018 Jul 11.


Correction to: Incidental diagnosis of tuberous sclerosis complex by exome sequencing in three families with subclinical findings.

Caylor RC, Grote L, Thiffault I, Farrow EG, Willig L, Soden S, Amudhavalli SM, Nopper AJ, Horii KA, Fleming E, Jenkins J, Welsh H, Ilyas M, Engleman K, Abdelmoity A, Saunders CJ.

Neurogenetics. 2018 Dec;19(4):261-262. doi: 10.1007/s10048-018-0554-8.


Certification of fitness to drive in sleep apnea patients: Are we doing the right thing?

Grote L, Svedmyr S, Hedner J.

J Sleep Res. 2018 Dec;27(6):e12719. doi: 10.1111/jsr.12719. Epub 2018 Jul 1.


Incidental diagnosis of tuberous sclerosis complex by exome sequencing in three families with subclinical findings.

Caylor RC, Grote L, Thiffault I, Farrow EG, Willig L, Soden S, Amudhavalli SM, Nopper AJ, Horii KA, Fleming E, Jenkins J, Welsh H, Ilyas M, Engleman K, Abdelmoity A, Saunders CJ.

Neurogenetics. 2018 Aug;19(3):205-213. doi: 10.1007/s10048-018-0551-y. Epub 2018 Jun 20. Erratum in: Neurogenetics. 2018 Jul 11;:.


Chronic pulmonary disease is associated with pain spreading and restless legs syndrome in middle-aged women-a population-based study.

Ding Z, Stehlik R, Hedner J, Ulfberg J, Grote L.

Sleep Breath. 2019 Mar;23(1):135-142. doi: 10.1007/s11325-018-1673-z. Epub 2018 Jun 4.


Challenges and perspectives in obstructive sleep apnoea: Report by an ad hoc working group of the Sleep Disordered Breathing Group of the European Respiratory Society and the European Sleep Research Society.

Randerath W, Bassetti CL, Bonsignore MR, Farre R, Ferini-Strambi L, Grote L, Hedner J, Kohler M, Martinez-Garcia MA, Mihaicuta S, Montserrat J, Pepin JL, Pevernagie D, Pizza F, Polo O, Riha R, Ryan S, Verbraecken J, McNicholas WT.

Eur Respir J. 2018 Sep 16;52(3). pii: 1702616. doi: 10.1183/13993003.02616-2017. Print 2018 Sep. Review.


Change in weight and central obesity by positive airway pressure treatment in obstructive sleep apnea patients: longitudinal data from the ESADA cohort.

Basoglu OK, Zou D, Tasbakan MS, Hedner J, Ryan S, Verbraecken J, Escourrou P, Antalainen U, Kvamme JA, Bonsignore MR, Schiza S, Grote L; ESADA Study Group.

J Sleep Res. 2018 Dec;27(6):e12705. doi: 10.1111/jsr.12705. Epub 2018 May 24.


Morning cortisol and fasting glucose are elevated in women with chronic widespread pain independent of comorbid restless legs syndrome.

Stehlik R, Ulfberg J, Zou D, Hedner J, Grote L.

Scand J Pain. 2018 Apr 25;18(2):187-194. doi: 10.1515/sjpain-2018-0026.


Drug-Induced Sleep-Disordered Breathing and Ventilatory Impairment.

Grote L.

Sleep Med Clin. 2018 Jun;13(2):161-168. doi: 10.1016/j.jsmc.2018.03.003. Review.


Reductions in dead space ventilation with nasal high flow depend on physiological dead space volume: metabolic hood measurements during sleep in patients with COPD and controls.

Biselli P, Fricke K, Grote L, Braun AT, Kirkness J, Smith P, Schwartz A, Schneider H.

Eur Respir J. 2018 May 30;51(5). pii: 1702251. doi: 10.1183/13993003.02251-2017. Print 2018 May.


Fixed But Not Autoadjusting Positive Airway Pressure Attenuates the Time-dependent Decline in Glomerular Filtration Rate in Patients With OSA.

Marrone O, Cibella F, Pépin JL, Grote L, Verbraecken J, Saaresranta T, Kvamme JA, Basoglu OK, Lombardi C, McNicholas WT, Hedner J, Bonsignore MR; ESADA Network.

Chest. 2018 Aug;154(2):326-334. doi: 10.1016/j.chest.2018.04.020. Epub 2018 Apr 24.


Dual Molecular Effects of Dominant RORA Mutations Cause Two Variants of Syndromic Intellectual Disability with Either Autism or Cerebellar Ataxia.

Guissart C, Latypova X, Rollier P, Khan TN, Stamberger H, McWalter K, Cho MT, Kjaergaard S, Weckhuysen S, Lesca G, Besnard T, Õunap K, Schema L, Chiocchetti AG, McDonald M, de Bellescize J, Vincent M, Van Esch H, Sattler S, Forghani I, Thiffault I, Freitag CM, Barbouth DS, Cadieux-Dion M, Willaert R, Guillen Sacoto MJ, Safina NP, Dubourg C, Grote L, Carré W, Saunders C, Pajusalu S, Farrow E, Boland A, Karlowicz DH, Deleuze JF, Wojcik MH, Pressman R, Isidor B, Vogels A, Van Paesschen W, Al-Gazali L, Al Shamsi AM, Claustres M, Pujol A, Sanders SJ, Rivier F, Leboucq N, Cogné B, Sasorith S, Sanlaville D, Retterer K, Odent S, Katsanis N, Bézieau S, Koenig M, Davis EE, Pasquier L, Küry S.

Am J Hum Genet. 2018 May 3;102(5):744-759. doi: 10.1016/j.ajhg.2018.02.021. Epub 2018 Apr 12.


Acetazolamide Reduces Blood Pressure and Sleep-Disordered Breathing in Patients With Hypertension and Obstructive Sleep Apnea: A Randomized Controlled Trial.

Eskandari D, Zou D, Grote L, Hoff E, Hedner J.

J Clin Sleep Med. 2018 Mar 15;14(3):309-317. doi: 10.5664/jcsm.6968.


The Effect of Dietary Nitrate on Nocturnal Sleep-Disordered Breathing and Arterial Oxygen Desaturation at High Altitude.

Patrician A, Engan H, Lundsten D, Grote L, Vigetun-Haughey H, Schagatay E.

High Alt Med Biol. 2018 Mar;19(1):21-27. doi: 10.1089/ham.2017.0039. Epub 2017 Dec 6.


REM Sleep Imposes a Vascular Load in COPD Patients Independent of Sleep Apnea.

Grote L, Sommermeyer D, Ficker J, Randerath W, Penzel T, Fietze I, Sanner B, Hedner J, Schneider H.

COPD. 2017 Dec;14(6):565-572. doi: 10.1080/15412555.2017.1365119. Epub 2017 Sep 26.


Perceived sleep deficit is a strong predictor of RLS in multisite pain - A population based study in middle aged females.

Stehlik R, Ulfberg J, Zou D, Hedner J, Grote L.

Scand J Pain. 2017 Oct;17:1-7. doi: 10.1016/j.sjpain.2017.06.003. Epub 2017 Jul 4.


Association between left atrial enlargement and obstructive sleep apnea in a general population of 71-year-old men.

Holtstrand Hjälm H, Fu M, Hansson PO, Zhong Y, Caidahl K, Mandalenakis Z, Morales D, Ergatoudes C, Rosengren A, Grote L, Thunström E.

J Sleep Res. 2018 Apr;27(2):252-258. doi: 10.1111/jsr.12585. Epub 2017 Aug 24.


Independent associations between arterial bicarbonate, apnea severity and hypertension in obstructive sleep apnea.

Eskandari D, Zou D, Grote L, Schneider H, Penzel T, Hedner J.

Respir Res. 2017 Jun 28;18(1):130. doi: 10.1186/s12931-017-0607-9.


Three-year clinical outcomes of relapsing multiple sclerosis patients treated with dimethyl fumarate in a United States community health center.

Smoot K, Spinelli KJ, Stuchiner T, Lucas L, Chen C, Grote L, Baraban E, Kresa-Reahl K, Cohan S.

Mult Scler. 2018 Jun;24(7):942-950. doi: 10.1177/1352458517709956. Epub 2017 May 24.


Definition, discrimination, diagnosis and treatment of central breathing disturbances during sleep.

Randerath W, Verbraecken J, Andreas S, Arzt M, Bloch KE, Brack T, Buyse B, De Backer W, Eckert DJ, Grote L, Hagmeyer L, Hedner J, Jennum P, La Rovere MT, Miltz C, McNicholas WT, Montserrat J, Naughton M, Pepin JL, Pevernagie D, Sanner B, Testelmans D, Tonia T, Vrijsen B, Wijkstra P, Levy P.

Eur Respir J. 2017 Jan 18;49(1). pii: 1600959. doi: 10.1183/13993003.00959-2016. Print 2017 Jan.


Nasal high-flow therapy reduces work of breathing compared with oxygen during sleep in COPD and smoking controls: a prospective observational study.

Biselli PJ, Kirkness JP, Grote L, Fricke K, Schwartz AR, Smith P, Schneider H.

J Appl Physiol (1985). 2017 Jan 1;122(1):82-88. doi: 10.1152/japplphysiol.00279.2016. Epub 2016 Nov 4.


Vascular stiffness determined from a nocturnal digital pulse wave signal: association with sleep, sleep-disordered breathing, and hypertension.

Svedmyr S, Zou D, Sommermeyer D, Ficker JH, Randerath W, Fietze I, Sanner B, Hedner J, Grote L.

J Hypertens. 2016 Dec;34(12):2427-2433.


Clinical Phenotypes and Comorbidity in European Sleep Apnoea Patients.

Saaresranta T, Hedner J, Bonsignore MR, Riha RL, McNicholas WT, Penzel T, Anttalainen U, Kvamme JA, Pretl M, Sliwinski P, Verbraecken J, Grote L; ESADA Study Group.

PLoS One. 2016 Oct 4;11(10):e0163439. doi: 10.1371/journal.pone.0163439. eCollection 2016.


Parameters of Overnight Pulse Wave under Treatment in Obstructive Sleep Apnea.

Randerath WJ, Treml M, Priegnitz C, Hedner J, Sommermeyer D, Zou D, Ficker JH, Fietze I, Penzel T, Sanner B, Grote L.

Respiration. 2016;92(3):136-43. doi: 10.1159/000448248. Epub 2016 Aug 31.


Chronic kidney disease in European patients with obstructive sleep apnea: the ESADA cohort study.

Marrone O, Battaglia S, Steiropoulos P, Basoglu OK, Kvamme JA, Ryan S, Pepin JL, Verbraecken J, Grote L, Hedner J, Bonsignore MR; ESADA study group.

J Sleep Res. 2016 Dec;25(6):739-745. doi: 10.1111/jsr.12426. Epub 2016 May 18.


Optimizing the Management of Heart Failure With Preserved Ejection Fraction in the Elderly by Targeting Comorbidities (OPTIMIZE-HFPEF).

Fu M, Zhou J, Thunström E, Almgren T, Grote L, Bollano E, Schaufelberger M, Johansson MC, Petzold M, Swedberg K, Andersson B.

J Card Fail. 2016 Jul;22(7):539-44. doi: 10.1016/j.cardfail.2016.01.011. Epub 2016 Jan 25.


Detection of cardiovascular risk from a photoplethysmographic signal using a matching pursuit algorithm.

Sommermeyer D, Zou D, Ficker JH, Randerath W, Fischer C, Penzel T, Sanner B, Hedner J, Grote L.

Med Biol Eng Comput. 2016 Jul;54(7):1111-21. doi: 10.1007/s11517-015-1410-8. Epub 2015 Nov 4.


The diagnostic method has a strong influence on classification of obstructive sleep apnea.

Escourrou P, Grote L, Penzel T, Mcnicholas WT, Verbraecken J, Tkacova R, Riha RL, Hedner J; ESADA Study Group.

J Sleep Res. 2015 Dec;24(6):730-8. doi: 10.1111/jsr.12318. Epub 2015 Aug 14.


A novel epileptic encephalopathy mutation in KCNB1 disrupts Kv2.1 ion selectivity, expression, and localization.

Thiffault I, Speca DJ, Austin DC, Cobb MM, Eum KS, Safina NP, Grote L, Farrow EG, Miller N, Soden S, Kingsmore SF, Trimmer JS, Saunders CJ, Sack JT.

J Gen Physiol. 2015 Nov;146(5):399-410. doi: 10.1085/jgp.201511444.

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