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Multifaceted actions of Zeb2 in postnatal neurogenesis from the ventricular-subventricular zone to the olfactory bulb.

Deryckere A, Stappers E, Dries R, Peyre E, van den Berghe V, Conidi A, Zampeta FI, Francis A, Bresseleers M, Stryjewska A, Vanlaer R, Maas E, Smal IV, van IJcken WFJ, Grosveld FG, Nguyen L, Huylebroeck D, Seuntjens E.

Development. 2020 Apr 6. pii: dev.184861. doi: 10.1242/dev.184861. [Epub ahead of print]


Integrative and perturbation-based analysis of the transcriptional dynamics of TGFβ/BMP system components in transition from embryonic stem cells to neural progenitors.

Dries R, Stryjewska A, Coddens K, Okawa S, Notelaers T, Birkhoff J, Dekker M, Verfaillie CM, Del Sol A, Mulugeta E, Conidi A, Grosveld FG, Huylebroeck D.

Stem Cells. 2020 Feb;38(2):202-217. doi: 10.1002/stem.3111. Epub 2019 Dec 13.


The dynamic emergence of GATA1 complexes identified in in vitro ES differentiation and in vivo mouse fetal liver.

Yu X, Martella A, Kolovos P, Stevens M, Stadhouders R, Grosveld FG, Andrieu-Soler C.

Haematologica. 2019 Oct 3. pii: haematol.2019.216010. doi: 10.3324/haematol.2019.216010. [Epub ahead of print]


A Novel Role for GATA3 in Mesangial Cells in Glomerular Development and Injury.

Grigorieva IV, Oszwald A, Grigorieva EF, Schachner H, Neudert B, Ostendorf T, Floege J, Lindenmeyer MT, Cohen CD, Panzer U, Aigner C, Schmidt A, Grosveld F, Thakker RV, Rees AJ, Kain R.

J Am Soc Nephrol. 2019 Sep;30(9):1641-1658. doi: 10.1681/ASN.2018111143. Epub 2019 Aug 12.


Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein.

Widjaja I, Wang C, van Haperen R, Gutiérrez-Álvarez J, van Dieren B, Okba NMA, Raj VS, Li W, Fernandez-Delgado R, Grosveld F, van Kuppeveld FJM, Haagmans BL, Enjuanes L, Drabek D, Bosch BJ.

Emerg Microbes Infect. 2019;8(1):516-530. doi: 10.1080/22221751.2019.1597644.


The mouse KLF1 Nan variant impairs nuclear condensation and erythroid maturation.

Cantú I, van de Werken HJG, Gillemans N, Stadhouders R, Heshusius S, Maas A, Esteghamat F, Ozgur Z, van IJcken WFJ, Grosveld F, von Lindern M, Philipsen S, van Dijk TB.

PLoS One. 2019 Mar 28;14(3):e0208659. doi: 10.1371/journal.pone.0208659. eCollection 2019.


Forces driving the three-dimensional folding of eukaryotic genomes.

Rada-Iglesias A, Grosveld FG, Papantonis A.

Mol Syst Biol. 2018 Jun 1;14(6):e8214. doi: 10.15252/msb.20188214. Review.


Investigation of the spatial structure and interactions of the genome at sub-kilobase-pair resolution using T2C.

Kolovos P, Brouwer RWW, Kockx CEM, Lesnussa M, Kepper N, Zuin J, Imam AMA, van de Werken HJG, Wendt KS, Knoch TA, van IJcken WFJ, Grosveld F.

Nat Protoc. 2018 Mar;13(3):459-477. doi: 10.1038/nprot.2017.132. Epub 2018 Feb 8.


PRC2 Facilitates the Regulatory Topology Required for Poised Enhancer Function during Pluripotent Stem Cell Differentiation.

Cruz-Molina S, Respuela P, Tebartz C, Kolovos P, Nikolic M, Fueyo R, van Ijcken WFJ, Grosveld F, Frommolt P, Bazzi H, Rada-Iglesias A.

Cell Stem Cell. 2017 May 4;20(5):689-705.e9. doi: 10.1016/j.stem.2017.02.004. Epub 2017 Mar 9.


Expression Cloning and Production of Human Heavy-Chain-Only Antibodies from Murine Transgenic Plasma Cells.

Drabek D, Janssens R, de Boer E, Rademaker R, Kloess J, Skehel J, Grosveld F.

Front Immunol. 2016 Dec 19;7:619. doi: 10.3389/fimmu.2016.00619. eCollection 2016.


The detailed 3D multi-loop aggregate/rosette chromatin architecture and functional dynamic organization of the human and mouse genomes.

Knoch TA, Wachsmuth M, Kepper N, Lesnussa M, Abuseiris A, Ali Imam AM, Kolovos P, Zuin J, Kockx CEM, Brouwer RWW, van de Werken HJG, van IJcken WFJ, Wendt KS, Grosveld FG.

Epigenetics Chromatin. 2016 Dec 24;9:58. doi: 10.1186/s13072-016-0089-x. eCollection 2016.


Macrophage production and activation are dependent on TRIM33.

Gallouet AS, Ferri F, Petit V, Parcelier A, Lewandowski D, Gault N, Barroca V, Le Gras S, Soler E, Grosveld F, Davidson I, Romeo PH.

Oncotarget. 2017 Jan 17;8(3):5111-5122. doi: 10.18632/oncotarget.13872.


Exploiting native forces to capture chromosome conformation in mammalian cell nuclei.

Brant L, Georgomanolis T, Nikolic M, Brackley CA, Kolovos P, van Ijcken W, Grosveld FG, Marenduzzo D, Papantonis A.

Mol Syst Biol. 2016 Dec 9;12(12):891. doi: 10.15252/msb.20167311.


Binding of nuclear factor κB to noncanonical consensus sites reveals its multimodal role during the early inflammatory response.

Kolovos P, Georgomanolis T, Koeferle A, Larkin JD, Brant L, Nikolicć M, Gusmao EG, Zirkel A, Knoch TA, van Ijcken WF, Cook PR, Costa IG, Grosveld FG, Papantonis A.

Genome Res. 2016 Nov;26(11):1478-1489. Epub 2016 Sep 15.


ASH1L (a histone methyltransferase protein) is a novel candidate globin gene regulator revealed by genetic study of an English family with beta-thalassaemia unlinked to the beta-globin locus.

Breton A, Theodorou A, Aktuna S, Sonzogni L, Darling D, Chan L, Menzel S, van der Spek PJ, Swagemakers SM, Grosveld F, Philipsen S, Thein SL.

Br J Haematol. 2016 Nov;175(3):525-530. doi: 10.1111/bjh.14256. Epub 2016 Jul 19.


Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem Cells.

Stryjewska A, Dries R, Pieters T, Verstappen G, Conidi A, Coddens K, Francis A, Umans L, van IJcken WF, Berx G, van Grunsven LA, Grosveld FG, Goossens S, Haigh JJ, Huylebroeck D.

Stem Cells. 2017 Mar;35(3):611-625. doi: 10.1002/stem.2521. Epub 2016 Nov 8.


Investigation of Factors Determining the Enhanced Permeability and Retention Effect in Subcutaneous Xenografts.

Bolkestein M, de Blois E, Koelewijn SJ, Eggermont AM, Grosveld F, de Jong M, Koning GA.

J Nucl Med. 2016 Apr;57(4):601-7. doi: 10.2967/jnumed.115.166173. Epub 2015 Dec 30.


Control of developmentally primed erythroid genes by combinatorial co-repressor actions.

Stadhouders R, Cico A, Stephen T, Thongjuea S, Kolovos P, Baymaz HI, Yu X, Demmers J, Bezstarosti K, Maas A, Barroca V, Kockx C, Ozgur Z, van Ijcken W, Arcangeli ML, Andrieu-Soler C, Lenhard B, Grosveld F, Soler E.

Nat Commun. 2015 Nov 23;6:8893. doi: 10.1038/ncomms9893.


The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors.

Caputo L, Witzel HR, Kolovos P, Cheedipudi S, Looso M, Mylona A, van IJcken WF, Laugwitz KL, Evans SM, Braun T, Soler E, Grosveld F, Dobreva G.

Cell Stem Cell. 2015 Sep 3;17(3):287-99. doi: 10.1016/j.stem.2015.08.007. Epub 2015 Aug 27.


The core spliceosome as target and effector of non-canonical ATM signalling.

Tresini M, Warmerdam DO, Kolovos P, Snijder L, Vrouwe MG, Demmers JA, van IJcken WF, Grosveld FG, Medema RH, Hoeijmakers JH, Mullenders LH, Vermeulen W, Marteijn JA.

Nature. 2015 Jul 2;523(7558):53-8. doi: 10.1038/nature14512. Epub 2015 Jun 24.


TAF10 Interacts with the GATA1 Transcription Factor and Controls Mouse Erythropoiesis.

Papadopoulos P, Gutiérrez L, Demmers J, Scheer E, Pourfarzad F, Papageorgiou DN, Karkoulia E, Strouboulis J, van de Werken HJ, van der Linden R, Vandenberghe P, Dekkers DH, Philipsen S, Grosveld F, Tora L.

Mol Cell Biol. 2015 Jun;35(12):2103-18. doi: 10.1128/MCB.01370-14. Epub 2015 Apr 13.


A novel TGFβ modulator that uncouples R-Smad/I-Smad-mediated negative feedback from R-Smad/ligand-driven positive feedback.

Gu W, Monteiro R, Zuo J, Simões FC, Martella A, Andrieu-Soler C, Grosveld F, Sauka-Spengler T, Patient R.

PLoS Biol. 2015 Feb 9;13(2):e1002051. doi: 10.1371/journal.pbio.1002051. eCollection 2015 Feb.


Long-range gene regulation and novel therapeutic applications.

van den Heuvel A, Stadhouders R, Andrieu-Soler C, Grosveld F, Soler E.

Blood. 2015 Mar 5;125(10):1521-5. doi: 10.1182/blood-2014-11-567925. Epub 2015 Jan 23. Review.


TNFα signalling primes chromatin for NF-κB binding and induces rapid and widespread nucleosome repositioning.

Diermeier S, Kolovos P, Heizinger L, Schwartz U, Georgomanolis T, Zirkel A, Wedemann G, Grosveld F, Knoch TA, Merkl R, Cook PR, Längst G, Papantonis A.

Genome Biol. 2014 Dec 3;15(12):536. doi: 10.1186/s13059-014-0536-6.


NLS-tagging: an alternative strategy to tag nuclear proteins.

Giraud G, Stadhouders R, Conidi A, Dekkers DH, Huylebroeck D, Demmers JA, Soler E, Grosveld FG.

Nucleic Acids Res. 2014 Dec 1;42(21). doi: 10.1093/nar/gku869. Epub 2014 Sep 26.


Differentiated type II pneumocytes can be reprogrammed by ectopic Sox2 expression.

Kapere Ochieng J, Schilders K, Kool H, Buscop-van Kempen M, Boerema-De Munck A, Grosveld F, Wijnen R, Tibboel D, Rottier RJ.

PLoS One. 2014 Sep 11;9(9):e107248. doi: 10.1371/journal.pone.0107248. eCollection 2014.


Angiopoietin-like protein 3 promotes preservation of stemness during ex vivo expansion of murine hematopoietic stem cells.

Farahbakhshian E, Verstegen MM, Visser TP, Kheradmandkia S, Geerts D, Arshad S, Riaz N, Grosveld F, van Til NP, Meijerink JP.

PLoS One. 2014 Aug 29;9(8):e105642. doi: 10.1371/journal.pone.0105642. eCollection 2014.


Dynamic microtubules catalyze formation of navigator-TRIO complexes to regulate neurite extension.

van Haren J, Boudeau J, Schmidt S, Basu S, Liu Z, Lammers D, Demmers J, Benhari J, Grosveld F, Debant A, Galjart N.

Curr Biol. 2014 Aug 4;24(15):1778-85. doi: 10.1016/j.cub.2014.06.037. Epub 2014 Jul 24.


Targeted Chromatin Capture (T2C): a novel high resolution high throughput method to detect genomic interactions and regulatory elements.

Kolovos P, van de Werken HJ, Kepper N, Zuin J, Brouwer RW, Kockx CE, Wendt KS, van IJcken WF, Grosveld F, Knoch TA.

Epigenetics Chromatin. 2014 Jun 16;7:10. doi: 10.1186/1756-8935-7-10. eCollection 2014.


Targeting epigenetics to speed up repair.

Soler E, Grosveld F.

Cell Stem Cell. 2014 May 1;14(5):553-4. doi: 10.1016/j.stem.2014.04.018.


Sox2 regulates the emergence of lung basal cells by directly activating the transcription of Trp63.

Ochieng JK, Schilders K, Kool H, Boerema-De Munck A, Buscop-Van Kempen M, Gontan C, Smits R, Grosveld FG, Wijnen RM, Tibboel D, Rottier RJ.

Am J Respir Cell Mol Biol. 2014 Aug;51(2):311-22. doi: 10.1165/rcmb.2013-0419OC.


HBS1L-MYB intergenic variants modulate fetal hemoglobin via long-range MYB enhancers.

Stadhouders R, Aktuna S, Thongjuea S, Aghajanirefah A, Pourfarzad F, van Ijcken W, Lenhard B, Rooks H, Best S, Menzel S, Grosveld F, Thein SL, Soler E.

J Clin Invest. 2014 Apr;124(4):1699-710. doi: 10.1172/JCI71520. Epub 2014 Mar 10.


Pre-B cell receptor signaling induces immunoglobulin κ locus accessibility by functional redistribution of enhancer-mediated chromatin interactions.

Stadhouders R, de Bruijn MJ, Rother MB, Yuvaraj S, Ribeiro de Almeida C, Kolovos P, Van Zelm MC, van Ijcken W, Grosveld F, Soler E, Hendriks RW.

PLoS Biol. 2014 Feb 18;12(2):e1001791. doi: 10.1371/journal.pbio.1001791. eCollection 2014 Feb.


Transcription in the context of the 3D nucleus.

Wendt KS, Grosveld FG.

Curr Opin Genet Dev. 2014 Apr;25:62-7. doi: 10.1016/j.gde.2013.11.020. Epub 2014 Feb 15. Review.


Genetic variation in regulatory DNA elements: the case of OCA2 transcriptional regulation.

Visser M, Kayser M, Grosveld F, Palstra RJ.

Pigment Cell Melanoma Res. 2014 Mar;27(2):169-77. doi: 10.1111/pcmr.12210. Review.


Cohesin and CTCF differentially affect chromatin architecture and gene expression in human cells.

Zuin J, Dixon JR, van der Reijden MI, Ye Z, Kolovos P, Brouwer RW, van de Corput MP, van de Werken HJ, Knoch TA, van IJcken WF, Grosveld FG, Ren B, Wendt KS.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):996-1001. doi: 10.1073/pnas.1317788111. Epub 2013 Dec 13.


Identification of multiple subsets of ventral interneurons and differential distribution along the rostrocaudal axis of the developing spinal cord.

Francius C, Harris A, Rucchin V, Hendricks TJ, Stam FJ, Barber M, Kurek D, Grosveld FG, Pierani A, Goulding M, Clotman F.

PLoS One. 2013 Aug 15;8(8):e70325. doi: 10.1371/journal.pone.0070325. eCollection 2013.


Locus-specific proteomics by TChP: targeted chromatin purification.

Pourfarzad F, Aghajanirefah A, de Boer E, Ten Have S, Bryn van Dijk T, Kheradmandkia S, Stadhouders R, Thongjuea S, Soler E, Gillemans N, von Lindern M, Demmers J, Philipsen S, Grosveld F.

Cell Rep. 2013 Aug 15;4(3):589-600. doi: 10.1016/j.celrep.2013.07.004. Epub 2013 Aug 1.


r3Cseq: an R/Bioconductor package for the discovery of long-range genomic interactions from chromosome conformation capture and next-generation sequencing data.

Thongjuea S, Stadhouders R, Grosveld FG, Soler E, Lenhard B.

Nucleic Acids Res. 2013 Jul;41(13):e132. doi: 10.1093/nar/gkt373. Epub 2013 May 13.


In vivo live imaging of RNA polymerase II transcription factories in primary cells.

Ghamari A, van de Corput MP, Thongjuea S, van Cappellen WA, van Ijcken W, van Haren J, Soler E, Eick D, Lenhard B, Grosveld FG.

Genes Dev. 2013 Apr 1;27(7):767-77. doi: 10.1101/gad.216200.113. Erratum in: Genes Dev. 2013 Jun 15;27(12):1434. Genes Dev. 2013 May 15;27(10):1216.


Next generation sequencing of SNPs for non-invasive prenatal diagnosis: challenges and feasibility as illustrated by an application to β-thalassaemia.

Papasavva T, van Ijcken WF, Kockx CE, van den Hout MC, Kountouris P, Kythreotis L, Kalogirou E, Grosveld FG, Kleanthous M.

Eur J Hum Genet. 2013 Dec;21(12):1403-10. doi: 10.1038/ejhg.2013.47. Epub 2013 Apr 10.


Balancing of histone H3K4 methylation states by the Kdm5c/SMCX histone demethylase modulates promoter and enhancer function.

Outchkourov NS, Muiño JM, Kaufmann K, van Ijcken WF, Groot Koerkamp MJ, van Leenen D, de Graaf P, Holstege FC, Grosveld FG, Timmers HT.

Cell Rep. 2013 Apr 25;3(4):1071-9. doi: 10.1016/j.celrep.2013.02.030. Epub 2013 Mar 28.


Genomewide DNA methylation analysis identifies novel methylated genes in non-small-cell lung carcinomas.

Carvalho RH, Hou J, Haberle V, Aerts J, Grosveld F, Lenhard B, Philipsen S.

J Thorac Oncol. 2013 May;8(5):562-73. doi: 10.1097/JTO.0b013e3182863ed2.


Hypoxia inducible factor 3α plays a critical role in alveolarization and distal epithelial cell differentiation during mouse lung development.

Huang Y, Kapere Ochieng J, Kempen MB, Munck AB, Swagemakers S, van Ijcken W, Grosveld F, Tibboel D, Rottier RJ.

PLoS One. 2013;8(2):e57695. doi: 10.1371/journal.pone.0057695. Epub 2013 Feb 25. Erratum in: PLoS One. 2015;10(3):e0119359.


Epigenetics & chromatin: interactions and processes.

Henikoff S, Grosveld F.

Epigenetics Chromatin. 2013 Feb 27;6(1):2. doi: 10.1186/1756-8935-6-2.


Multiplexed chromosome conformation capture sequencing for rapid genome-scale high-resolution detection of long-range chromatin interactions.

Stadhouders R, Kolovos P, Brouwer R, Zuin J, van den Heuvel A, Kockx C, Palstra RJ, Wendt KS, Grosveld F, van Ijcken W, Soler E.

Nat Protoc. 2013 Mar;8(3):509-24. doi: 10.1038/nprot.2013.018. Epub 2013 Feb 14.


MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16.

Yin H, Pasut A, Soleimani VD, Bentzinger CF, Antoun G, Thorn S, Seale P, Fernando P, van Ijcken W, Grosveld F, Dekemp RA, Boushel R, Harper ME, Rudnicki MA.

Cell Metab. 2013 Feb 5;17(2):210-24. doi: 10.1016/j.cmet.2013.01.004.


Genome-wide analysis shows that Ldb1 controls essential hematopoietic genes/pathways in mouse early development and reveals novel players in hematopoiesis.

Mylona A, Andrieu-Soler C, Thongjuea S, Martella A, Soler E, Jorna R, Hou J, Kockx C, van Ijcken W, Lenhard B, Grosveld F.

Blood. 2013 Apr 11;121(15):2902-13. doi: 10.1182/blood-2012-11-467654. Epub 2013 Feb 6.


Erythropoiesis and globin switching in compound Klf1::Bcl11a mutant mice.

Esteghamat F, Gillemans N, Bilic I, van den Akker E, Cantù I, van Gent T, Klingmüller U, van Lom K, von Lindern M, Grosveld F, Bryn van Dijk T, Busslinger M, Philipsen S.

Blood. 2013 Mar 28;121(13):2553-62. doi: 10.1182/blood-2012-06-434530. Epub 2013 Jan 29.


Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1.

van den Berghe V, Stappers E, Vandesande B, Dimidschstein J, Kroes R, Francis A, Conidi A, Lesage F, Dries R, Cazzola S, Berx G, Kessaris N, Vanderhaeghen P, van Ijcken W, Grosveld FG, Goossens S, Haigh JJ, Fishell G, Goffinet A, Aerts S, Huylebroeck D, Seuntjens E.

Neuron. 2013 Jan 9;77(1):70-82. doi: 10.1016/j.neuron.2012.11.009.

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