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Items: 43

1.

Coiled-coil Peptide Beacon: A Tuneable Conformational Switch for Protein Detection.

Mueller C, Grossmann TN.

Angew Chem Int Ed Engl. 2018 Nov 9. doi: 10.1002/anie.201811515. [Epub ahead of print]

PMID:
30411434
2.

Structural Analysis of the Interaction between the Bacterial Cell Division Proteins FtsQ and FtsB.

Kureisaite-Ciziene D, Varadajan A, McLaughlin SH, Glas M, Montón Silva A, Luirink R, Mueller C, den Blaauwen T, Grossmann TN, Luirink J, Löwe J.

MBio. 2018 Sep 11;9(5). pii: e01346-18. doi: 10.1128/mBio.01346-18.

3.

Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners.

Ortega Ugalde S, de Koning CP, Wallraven K, Bruyneel B, Vermeulen NPE, Grossmann TN, Bitter W, Commandeur JNM, Vos JC.

Appl Microbiol Biotechnol. 2018 Nov;102(21):9231-9242. doi: 10.1007/s00253-018-9299-4. Epub 2018 Aug 22.

4.

Protein-RNA interactions: structural characteristics and hotspot amino acids.

Krüger DM, Neubacher S, Grossmann TN.

RNA. 2018 Nov;24(11):1457-1465. doi: 10.1261/rna.066464.118. Epub 2018 Aug 9.

5.

In Situ Cyclization of Native Proteins: Structure-Based Design of a Bicyclic Enzyme.

Pelay-Gimeno M, Bange T, Hennig S, Grossmann TN.

Angew Chem Int Ed Engl. 2018 Aug 27;57(35):11164-11170. doi: 10.1002/anie.201804506. Epub 2018 Jun 21.

6.

Targeting β-catenin dependent Wnt signaling via peptidomimetic inhibitors in murine chondrocytes and OA cartilage.

Held A, Glas A, Dietrich L, Bollmann M, Brandstädter K, Grossmann TN, Lohmann CH, Pap T, Bertrand J.

Osteoarthritis Cartilage. 2018 Jun;26(6):818-823. doi: 10.1016/j.joca.2018.02.908. Epub 2018 Mar 17.

PMID:
29559252
7.

The Therapeutic Potential of PTEN Modulation: Targeting Strategies from Gene to Protein.

McLoughlin NM, Mueller C, Grossmann TN.

Cell Chem Biol. 2018 Jan 18;25(1):19-29. doi: 10.1016/j.chembiol.2017.10.009. Epub 2017 Nov 16. Review.

PMID:
29153852
8.

Oligonucleotides with Cationic Backbone and Their Hybridization with DNA: Interplay of Base Pairing and Electrostatic Attraction.

Schmidtgall B, Kuepper A, Meng M, Grossmann TN, Ducho C.

Chemistry. 2018 Feb 1;24(7):1544-1553. doi: 10.1002/chem.201704338. Epub 2017 Dec 27.

9.

Structure-Based Design of Non-natural Macrocyclic Peptides That Inhibit Protein-Protein Interactions.

Krüger DM, Glas A, Bier D, Pospiech N, Wallraven K, Dietrich L, Ottmann C, Koch O, Hennig S, Grossmann TN.

J Med Chem. 2017 Nov 9;60(21):8982-8988. doi: 10.1021/acs.jmedchem.7b01221. Epub 2017 Oct 27.

10.

Increased Conformational Flexibility of a Macrocycle-Receptor Complex Contributes to Reduced Dissociation Rates.

Glas A, Wamhoff EC, Krüger DM, Rademacher C, Grossmann TN.

Chemistry. 2017 Nov 16;23(64):16157-16161. doi: 10.1002/chem.201702776. Epub 2017 Aug 30.

11.

Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions.

Dietrich L, Rathmer B, Ewan K, Bange T, Heinrichs S, Dale TC, Schade D, Grossmann TN.

Cell Chem Biol. 2017 Aug 17;24(8):958-968.e5. doi: 10.1016/j.chembiol.2017.06.013. Epub 2017 Jul 27.

12.

Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets.

White MD, Klecker M, Hopkinson RJ, Weits DA, Mueller C, Naumann C, O'Neill R, Wickens J, Yang J, Brooks-Bartlett JC, Garman EF, Grossmann TN, Dissmeyer N, Flashman E.

Nat Commun. 2017 Mar 23;8:14690. doi: 10.1038/ncomms14690.

13.

New Modalities for Challenging Targets in Drug Discovery.

Valeur E, Guéret SM, Adihou H, Gopalakrishnan R, Lemurell M, Waldmann H, Grossmann TN, Plowright AT.

Angew Chem Int Ed Engl. 2017 Aug 21;56(35):10294-10323. doi: 10.1002/anie.201611914. Epub 2017 Jul 24. Review.

PMID:
28186380
14.

Translocation of an Intracellular Protein via Peptide-Directed Ligation.

Stiller C, Krüger DM, Brauckhoff N, Schmidt M, Janning P, Salamon H, Grossmann TN.

ACS Chem Biol. 2017 Feb 17;12(2):504-509. doi: 10.1021/acschembio.6b01013. Epub 2017 Jan 3.

PMID:
28001046
15.

Constraining an Irregular Peptide Secondary Structure through Ring-Closing Alkyne Metathesis.

Cromm PM, Wallraven K, Glas A, Bier D, Fürstner A, Ottmann C, Grossmann TN.

Chembiochem. 2016 Oct 17;17(20):1915-1919. doi: 10.1002/cbic.201600362. Epub 2016 Sep 6.

16.

Selective Protein Hyperpolarization in Cell Lysates Using Targeted Dynamic Nuclear Polarization.

Viennet T, Viegas A, Kuepper A, Arens S, Gelev V, Petrov O, Grossmann TN, Heise H, Etzkorn M.

Angew Chem Int Ed Engl. 2016 Aug 26;55(36):10746-50. doi: 10.1002/anie.201603205. Epub 2016 Jun 28.

PMID:
27351143
17.

Protease-Resistant and Cell-Permeable Double-Stapled Peptides Targeting the Rab8a GTPase.

Cromm PM, Spiegel J, Küchler P, Dietrich L, Kriegesmann J, Wendt M, Goody RS, Waldmann H, Grossmann TN.

ACS Chem Biol. 2016 Aug 19;11(8):2375-82. doi: 10.1021/acschembio.6b00386. Epub 2016 Jul 11.

PMID:
27336832
18.

Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides.

Cromm PM, Schaubach S, Spiegel J, Fürstner A, Grossmann TN, Waldmann H.

Nat Commun. 2016 Apr 14;7:11300. doi: 10.1038/ncomms11300.

19.

Direct Modulation of Small GTPase Activity and Function.

Cromm PM, Spiegel J, Grossmann TN, Waldmann H.

Angew Chem Int Ed Engl. 2015 Nov 9;54(46):13516-37. doi: 10.1002/anie.201504357. Epub 2015 Oct 16. Review.

PMID:
26470842
20.

Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes.

Lee CU, Hahne G, Hanske J, Bange T, Bier D, Rademacher C, Hennig S, Grossmann TN.

Angew Chem Int Ed Engl. 2015 Nov 9;54(46):13796-800. doi: 10.1002/anie.201506338. Epub 2015 Sep 29.

21.

Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.

Pelay-Gimeno M, Glas A, Koch O, Grossmann TN.

Angew Chem Int Ed Engl. 2015 Jul 27;54(31):8896-927. doi: 10.1002/anie.201412070. Epub 2015 Jun 26. Review.

22.

Hydrocarbon stapled peptides as modulators of biological function.

Cromm PM, Spiegel J, Grossmann TN.

ACS Chem Biol. 2015 Jun 19;10(6):1362-75. doi: 10.1021/cb501020r. Epub 2015 Mar 31. Review.

PMID:
25798993
23.

Small-molecule modulation of Ras signaling.

Spiegel J, Cromm PM, Zimmermann G, Grossmann TN, Waldmann H.

Nat Chem Biol. 2014 Aug;10(8):613-22. doi: 10.1038/nchembio.1560. Epub 2014 Jun 15. Review.

PMID:
24929527
24.

Modulators of protein-protein interactions.

Milroy LG, Grossmann TN, Hennig S, Brunsveld L, Ottmann C.

Chem Rev. 2014 May 14;114(9):4695-748. doi: 10.1021/cr400698c. Epub 2014 Apr 15. Review. No abstract available.

PMID:
24735440
25.

Protein-templated peptide ligation.

Brauckhoff N, Hahne G, Yeh JT, Grossmann TN.

Angew Chem Int Ed Engl. 2014 Apr 22;53(17):4337-40. doi: 10.1002/anie.201400681. Epub 2014 Mar 18.

PMID:
24644125
26.

Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction.

Glas A, Bier D, Hahne G, Rademacher C, Ottmann C, Grossmann TN.

Angew Chem Int Ed Engl. 2014 Feb 24;53(9):2489-93. doi: 10.1002/anie.201310082. Epub 2014 Feb 6.

PMID:
24504455
27.

Direct targeting of Rab-GTPase-effector interactions.

Spiegel J, Cromm PM, Itzen A, Goody RS, Grossmann TN, Waldmann H.

Angew Chem Int Ed Engl. 2014 Feb 24;53(9):2498-503. doi: 10.1002/anie.201308568. Epub 2014 Jan 31.

PMID:
24481744
28.

Direct targeting of β-catenin: Inhibition of protein-protein interactions for the inactivation of Wnt signaling.

Hahne G, Grossmann TN.

Bioorg Med Chem. 2013 Jul 15;21(14):4020-6. doi: 10.1016/j.bmc.2013.02.050. Epub 2013 Mar 22.

PMID:
23566764
29.

Chemical biology 2012: from drug targets to biological systems and back.

Socher E, Grossmann TN.

Chembiochem. 2013 Jan 2;14(1):23-7. doi: 10.1002/cbic.201200697. Epub 2012 Nov 26.

PMID:
23184865
30.

Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin.

Grossmann TN, Yeh JT, Bowman BR, Chu Q, Moellering RE, Verdine GL.

Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):17942-7. doi: 10.1073/pnas.1208396109. Epub 2012 Oct 15.

31.

Reversible covalent inhibition of a protein target.

Lee CU, Grossmann TN.

Angew Chem Int Ed Engl. 2012 Aug 27;51(35):8699-700. doi: 10.1002/anie.201203341. Epub 2012 Jul 13. No abstract available.

PMID:
22806944
32.

DNA-instructed acyl transfer reactions for the synthesis of bioactive peptides.

Erben A, Grossmann TN, Seitz O.

Bioorg Med Chem Lett. 2011 Sep 1;21(17):4993-7. doi: 10.1016/j.bmcl.2011.05.027. Epub 2011 May 14.

PMID:
21664815
33.

Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis.

Kim YW, Grossmann TN, Verdine GL.

Nat Protoc. 2011 Jun;6(6):761-71. doi: 10.1038/nprot.2011.324. Epub 2011 May 12.

PMID:
21637196
34.

DNA-triggered synthesis and bioactivity of proapoptotic peptides.

Erben A, Grossmann TN, Seitz O.

Angew Chem Int Ed Engl. 2011 Mar 14;50(12):2828-32. doi: 10.1002/anie.201007103. Epub 2011 Feb 21. No abstract available.

PMID:
21387498
35.

Photo-thermal haptotropism in cyclopentadienylcobalt complexes of linear phenylenes: intercyclobutadiene metal migration.

Albright TA, Dosa PI, Grossmann TN, Khrustalev VN, Oloba OA, Padilla R, Paubelle R, Stanger A, Timofeeva TV, Vollhardt KP.

Angew Chem Int Ed Engl. 2009;48(52):9853-7. doi: 10.1002/anie.200905088. No abstract available.

PMID:
19943301
36.

Nucleic acid templated reactions: consequences of probe reactivity and readout strategy for amplified signaling and sequence selectivity.

Grossmann TN, Seitz O.

Chemistry. 2009 Jul 6;15(27):6723-30. doi: 10.1002/chem.200900025.

PMID:
19496097
37.

New aspects in fragmentation of peptide nucleic acids: comparison of positive and negative ions by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry.

Ziehe M, Grossmann TN, Seitz O, Linscheid MW.

Rapid Commun Mass Spectrom. 2009 Apr;23(8):1132-8. doi: 10.1002/rcm.3979.

PMID:
19280610
38.

Recognizing and controlling biomolecules with "Smart" hybridization-based switches.

Seitz O, Grossmann TN, Thurley S, Röglin L.

Nucleic Acids Symp Ser (Oxf). 2008;(52):29-30. doi: 10.1093/nass/nrn015.

PMID:
18776237
39.

Achieving turnover in DNA-templated reactions.

Grossmann TN, Strohbach A, Seitz O.

Chembiochem. 2008 Sep 22;9(14):2185-92. doi: 10.1002/cbic.200800290. Review. No abstract available.

PMID:
18752239
40.

Target-catalyzed transfer reactions for the amplified detection of RNA.

Grossmann TN, Röglin L, Seitz O.

Angew Chem Int Ed Engl. 2008;47(37):7119-22. doi: 10.1002/anie.200801355. No abstract available.

PMID:
18677727
41.

Triplex molecular beacons as modular probes for DNA detection.

Grossmann TN, Röglin L, Seitz O.

Angew Chem Int Ed Engl. 2007;46(27):5223-5. No abstract available.

PMID:
17535003
42.

Inducing the replacement of PNA in DNA.PNA duplexes by DNA.

Grossmann TN, Sasaki S, Ritzefeld M, Choi SW, Maruyama A, Seitz O.

Bioorg Med Chem. 2008 Jan 1;16(1):34-9. Epub 2007 May 6.

PMID:
17513114
43.

DNA-catalyzed transfer of a reporter group.

Grossmann TN, Seitz O.

J Am Chem Soc. 2006 Dec 13;128(49):15596-7.

PMID:
17147362

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