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Items: 1 to 50 of 83

1.

Active-Site Tryptophan, the Target of Antineoplastic C-Terminal Binding Protein Inhibitors, Mediates Inhibitor Disruption of CtBP Oligomerization and Transcription Coregulatory Activities.

Dcona MM, Damle PK, Zarate-Perez F, Morris BL, Nawaz Z, Dennis MJ, Deng X, Korwar S, Singh SJ, Ellis KC, Royer WE, Bandyopadhyay D, Escalante C, Grossman SR.

Mol Pharmacol. 2019 Jul;96(1):99-108. doi: 10.1124/mol.118.114363. Epub 2019 Apr 29.

PMID:
31036695
2.

DBC1 Regulates p53 Stability via Inhibition of CBP-Dependent p53 Polyubiquitination.

Akande OE, Damle PK, Pop M, Sherman NE, Szomju BB, Litovchick LV, Grossman SR.

Cell Rep. 2019 Mar 19;26(12):3323-3335.e4. doi: 10.1016/j.celrep.2019.02.076.

3.

An intestinal stem cell niche in Apc mutated neoplasia targetable by CtBP inhibition.

Chawla AT, Cororaton AD, Idowu MO, Damle PK, Szomju B, Ellis KC, Patel BB, Grossman SR.

Oncotarget. 2018 Aug 21;9(65):32408-32418. doi: 10.18632/oncotarget.25784. eCollection 2018 Aug 21.

4.

Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk.

Reshef YA, Finucane HK, Kelley DR, Gusev A, Kotliar D, Ulirsch JC, Hormozdiari F, Nasser J, O'Connor L, van de Geijn B, Loh PR, Grossman SR, Bhatia G, Gazal S, Palamara PF, Pinello L, Patterson N, Adams RP, Price AL.

Nat Genet. 2018 Oct;50(10):1483-1493. doi: 10.1038/s41588-018-0196-7. Epub 2018 Sep 3.

5.

Positional specificity of different transcription factor classes within enhancers.

Grossman SR, Engreitz J, Ray JP, Nguyen TH, Hacohen N, Lander ES.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7222-E7230. doi: 10.1073/pnas.1804663115. Epub 2018 Jul 9.

6.

Gastrointestinal Stromal Tumors: The GIST of Precision Medicine.

Mei L, Smith SC, Faber AC, Trent J, Grossman SR, Stratakis CA, Boikos SA.

Trends Cancer. 2018 Jan;4(1):74-91. doi: 10.1016/j.trecan.2017.11.006. Epub 2017 Dec 23. Review.

PMID:
29413424
7.

Classification of gastrointestinal stromal tumor syndromes.

Gopie P, Mei L, Faber AC, Grossman SR, Smith SC, Boikos SA.

Endocr Relat Cancer. 2018 Feb;25(2):R49-R58. doi: 10.1530/ERC-17-0329. Epub 2017 Nov 23. Review.

PMID:
29170162
8.

CtBP- an emerging oncogene and novel small molecule drug target: Advances in the understanding of its oncogenic action and identification of therapeutic inhibitors.

Dcona MM, Morris BL, Ellis KC, Grossman SR.

Cancer Biol Ther. 2017 Jun 3;18(6):379-391. doi: 10.1080/15384047.2017.1323586. Epub 2017 May 22. Review.

9.

Gain-of-function p53 activates multiple signaling pathways to induce oncogenicity in lung cancer cells.

Vaughan CA, Singh S, Grossman SR, Windle B, Deb SP, Deb S.

Mol Oncol. 2017 Jun;11(6):696-711. doi: 10.1002/1878-0261.12068. Epub 2017 May 8.

10.

Transforming activity and therapeutic targeting of C-terminal-binding protein 2 in Apc-mutated neoplasia.

Sumner ET, Chawla AT, Cororaton AD, Koblinski JE, Kovi RC, Love IM, Szomju BB, Korwar S, Ellis KC, Grossman SR.

Oncogene. 2017 Aug 17;36(33):4810-4816. doi: 10.1038/onc.2017.106. Epub 2017 Apr 17.

11.

Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication.

Singh S, Vaughan CA, Frum RA, Grossman SR, Deb S, Palit Deb S.

J Clin Invest. 2017 May 1;127(5):1839-1855. doi: 10.1172/JCI87724. Epub 2017 Apr 10.

12.

Systematic dissection of genomic features determining transcription factor binding and enhancer function.

Grossman SR, Zhang X, Wang L, Engreitz J, Melnikov A, Rogov P, Tewhey R, Isakova A, Deplancke B, Bernstein BE, Mikkelsen TS, Lander ES.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1291-E1300. doi: 10.1073/pnas.1621150114. Epub 2017 Jan 30.

13.

Systematic mapping of functional enhancer-promoter connections with CRISPR interference.

Fulco CP, Munschauer M, Anyoha R, Munson G, Grossman SR, Perez EM, Kane M, Cleary B, Lander ES, Engreitz JM.

Science. 2016 Nov 11;354(6313):769-773. Epub 2016 Sep 29.

14.

Design, synthesis, and biological evaluation of substrate-competitive inhibitors of C-terminal Binding Protein (CtBP).

Korwar S, Morris BL, Parikh HI, Coover RA, Doughty TW, Love IM, Hilbert BJ, Royer WE Jr, Kellogg GE, Grossman SR, Ellis KC.

Bioorg Med Chem. 2016 Jun 15;24(12):2707-15. doi: 10.1016/j.bmc.2016.04.037. Epub 2016 Apr 20.

15.

Constitutive Activation of DNA Damage Checkpoint Signaling Contributes to Mutant p53 Accumulation via Modulation of p53 Ubiquitination.

Frum RA, Love IM, Damle PK, Mukhopadhyay ND, Palit Deb S, Deb S, Grossman SR.

Mol Cancer Res. 2016 May;14(5):423-36. doi: 10.1158/1541-7786.MCR-15-0363. Epub 2016 Mar 10.

16.

Addiction of lung cancer cells to GOF p53 is promoted by up-regulation of epidermal growth factor receptor through multiple contacts with p53 transactivation domain and promoter.

Vaughan CA, Pearsall I, Singh S, Windle B, Deb SP, Grossman SR, Yeudall WA, Deb S.

Oncotarget. 2016 Mar 15;7(11):12426-46. doi: 10.18632/oncotarget.6998.

17.

Treatment of peritoneal carcinomatosis with intraperitoneal administration of Ad-hARF.

Rajeshkumar BR, Paliwal S, Lambert L, Grossman SR, Whalen GF.

J Surg Res. 2015 Jul;197(1):85-90. doi: 10.1016/j.jss.2015.03.048. Epub 2015 Mar 26.

PMID:
25935465
18.

Structure-guided design of a high affinity inhibitor to human CtBP.

Hilbert BJ, Morris BL, Ellis KC, Paulsen JL, Schiffer CA, Grossman SR, Royer WE Jr.

ACS Chem Biol. 2015 Apr 17;10(4):1118-27. doi: 10.1021/cb500820b. Epub 2015 Jan 30.

19.

Inhibition of C-terminal binding protein attenuates transcription factor 4 signaling to selectively target colon cancer stem cells.

Patel J, Baranwal S, Love IM, Patel NJ, Grossman SR, Patel BB.

Cell Cycle. 2014;13(22):3506-18. doi: 10.4161/15384101.2014.958407.

20.

RNA-RNA interactions enable specific targeting of noncoding RNAs to nascent Pre-mRNAs and chromatin sites.

Engreitz JM, Sirokman K, McDonel P, Shishkin AA, Surka C, Russell P, Grossman SR, Chow AY, Guttman M, Lander ES.

Cell. 2014 Sep 25;159(1):188-199. doi: 10.1016/j.cell.2014.08.018.

21.

Pancreatic cancer-specific cell death induced in vivo by cytoplasmic-delivered polyinosine-polycytidylic acid.

Bhoopathi P, Quinn BA, Gui Q, Shen XN, Grossman SR, Das SK, Sarkar D, Fisher PB, Emdad L.

Cancer Res. 2014 Nov 1;74(21):6224-35. doi: 10.1158/0008-5472.CAN-14-0819. Epub 2014 Sep 9.

22.

Mechanisms of mutant p53 stabilization in cancer.

Frum RA, Grossman SR.

Subcell Biochem. 2014;85:187-97. doi: 10.1007/978-94-017-9211-0_10.

PMID:
25201195
23.

NIAM's tangled web of growth control.

Love IM, Grossman SR.

Cell Cycle. 2014;13(11):1660. doi: 10.4161/cc.29150. Epub 2014 May 8. No abstract available.

24.

Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design.

Hilbert BJ, Grossman SR, Schiffer CA, Royer WE Jr.

FEBS Lett. 2014 May 2;588(9):1743-8. doi: 10.1016/j.febslet.2014.03.026. Epub 2014 Mar 19.

25.

A Phase II Trial of Cetuximab, Gemcitabine, 5-Fluorouracil, and Radiation Therapy in Locally Advanced Nonmetastatic Pancreatic Adenocarcinoma.

Cetin V, Piperdi B, Bathini V, Walsh WV, Yunus S, Tseng JF, Whalen GF, Wassef WY, Kadish SP, Fitzgerald TJ, Mikule C, Wang Y, Grossman SR.

Gastrointest Cancer Res. 2013 Jul;6(4 Suppl 1):S2-9.

26.

Detecting natural selection in genomic data.

Vitti JJ, Grossman SR, Sabeti PC.

Annu Rev Genet. 2013;47:97-120. doi: 10.1146/annurev-genet-111212-133526. Review.

PMID:
24274750
27.

The human oncoprotein MDM2 induces replication stress eliciting early intra-S-phase checkpoint response and inhibition of DNA replication origin firing.

Frum RA, Singh S, Vaughan C, Mukhopadhyay ND, Grossman SR, Windle B, Deb S, Deb SP.

Nucleic Acids Res. 2014 Jan;42(2):926-40. doi: 10.1093/nar/gkt944. Epub 2013 Oct 24.

28.

Identifying recent adaptations in large-scale genomic data.

Grossman SR, Andersen KG, Shlyakhter I, Tabrizi S, Winnicki S, Yen A, Park DJ, Griesemer D, Karlsson EK, Wong SH, Cabili M, Adegbola RA, Bamezai RN, Hill AV, Vannberg FO, Rinn JL; 1000 Genomes Project, Lander ES, Schaffner SF, Sabeti PC.

Cell. 2013 Feb 14;152(4):703-13. doi: 10.1016/j.cell.2013.01.035.

29.

Gain-of-Function Activity of Mutant p53 in Lung Cancer through Up-Regulation of Receptor Protein Tyrosine Kinase Axl.

Vaughan CA, Singh S, Windle B, Yeudall WA, Frum R, Grossman SR, Deb SP, Deb S.

Genes Cancer. 2012 Jul;3(7-8):491-502. doi: 10.1177/1947601912462719.

30.

CtBP2 Promotes Human Cancer Cell Migration by Transcriptional Activation of Tiam1.

Paliwal S, Ho N, Parker D, Grossman SR.

Genes Cancer. 2012 Jul;3(7-8):481-90. doi: 10.1177/1947601912463695.

31.

It Takes 15 to Tango: Making Sense of the Many Ubiquitin Ligases of p53.

Love IM, Grossman SR.

Genes Cancer. 2012 Mar;3(3-4):249-63. doi: 10.1177/1947601912455198.

32.

p53 Ubiquitination and proteasomal degradation.

Love IM, Shi D, Grossman SR.

Methods Mol Biol. 2013;962:63-73. doi: 10.1007/978-1-62703-236-0_5.

PMID:
23150437
33.

The histone acetyltransferase PCAF regulates p21 transcription through stress-induced acetylation of histone H3.

Love IM, Sekaric P, Shi D, Grossman SR, Androphy EJ.

Cell Cycle. 2012 Jul 1;11(13):2458-66. doi: 10.4161/cc.20864. Epub 2012 Jul 1.

34.

Genome-wide scans provide evidence for positive selection of genes implicated in Lassa fever.

Andersen KG, Shylakhter I, Tabrizi S, Grossman SR, Happi CT, Sabeti PC.

Philos Trans R Soc Lond B Biol Sci. 2012 Mar 19;367(1590):868-77. doi: 10.1098/rstb.2011.0299.

35.

Detecting novel associations in large data sets.

Reshef DN, Reshef YA, Finucane HK, Grossman SR, McVean G, Turnbaugh PJ, Lander ES, Mitzenmacher M, Sabeti PC.

Science. 2011 Dec 16;334(6062):1518-24. doi: 10.1126/science.1205438.

36.

The ARF tumor suppressor inhibits tumor cell colonization independent of p53 in a novel mouse model of pancreatic ductal adenocarcinoma metastasis.

Muniz VP, Barnes JM, Paliwal S, Zhang X, Tang X, Chen S, Zamba KD, Cullen JJ, Meyerholz DK, Meyers S, Davis JN, Grossman SR, Henry MD, Quelle DE.

Mol Cancer Res. 2011 Jul;9(7):867-77. doi: 10.1158/1541-7786.MCR-10-0475. Epub 2011 Jun 2.

37.

Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum.

Van Tyne D, Park DJ, Schaffner SF, Neafsey DE, Angelino E, Cortese JF, Barnes KG, Rosen DM, Lukens AK, Daniels RF, Milner DA Jr, Johnson CA, Shlyakhter I, Grossman SR, Becker JS, Yamins D, Karlsson EK, Ndiaye D, Sarr O, Mboup S, Happi C, Furlotte NA, Eskin E, Kang HM, Hartl DL, Birren BW, Wiegand RC, Lander ES, Wirth DF, Volkman SK, Sabeti PC.

PLoS Genet. 2011 Apr;7(4):e1001383. doi: 10.1371/journal.pgen.1001383. Epub 2011 Apr 21.

38.

Ancient and recent adaptive evolution of primate non-homologous end joining genes.

Demogines A, East AM, Lee JH, Grossman SR, Sabeti PC, Paull TT, Sawyer SL.

PLoS Genet. 2010 Oct 21;6(10):e1001169. doi: 10.1371/journal.pgen.1001169.

39.

Therapeutic targeting of C-terminal binding protein in human cancer.

Straza MW, Paliwal S, Kovi RC, Rajeshkumar B, Trenh P, Parker D, Whalen GF, Lyle S, Schiffer CA, Grossman SR.

Cell Cycle. 2010 Sep 15;9(18):3740-50. doi: 10.4161/cc.9.18.12936. Epub 2010 Sep 8.

40.
41.

Integrating common and rare genetic variation in diverse human populations.

International HapMap 3 Consortium, Altshuler DM, Gibbs RA, Peltonen L, Altshuler DM, Gibbs RA, Peltonen L, Dermitzakis E, Schaffner SF, Yu F, Peltonen L, Dermitzakis E, Bonnen PE, Altshuler DM, Gibbs RA, de Bakker PI, Deloukas P, Gabriel SB, Gwilliam R, Hunt S, Inouye M, Jia X, Palotie A, Parkin M, Whittaker P, Yu F, Chang K, Hawes A, Lewis LR, Ren Y, Wheeler D, Gibbs RA, Muzny DM, Barnes C, Darvishi K, Hurles M, Korn JM, Kristiansson K, Lee C, McCarrol SA, Nemesh J, Dermitzakis E, Keinan A, Montgomery SB, Pollack S, Price AL, Soranzo N, Bonnen PE, Gibbs RA, Gonzaga-Jauregui C, Keinan A, Price AL, Yu F, Anttila V, Brodeur W, Daly MJ, Leslie S, McVean G, Moutsianas L, Nguyen H, Schaffner SF, Zhang Q, Ghori MJ, McGinnis R, McLaren W, Pollack S, Price AL, Schaffner SF, Takeuchi F, Grossman SR, Shlyakhter I, Hostetter EB, Sabeti PC, Adebamowo CA, Foster MW, Gordon DR, Licinio J, Manca MC, Marshall PA, Matsuda I, Ngare D, Wang VO, Reddy D, Rotimi CN, Royal CD, Sharp RR, Zeng C, Brooks LD, McEwen JE.

Nature. 2010 Sep 2;467(7311):52-8. doi: 10.1038/nature09298.

42.

Infants' ability to parse continuous actions: further evidence.

Hespos SJ, Grossman SR, Saylor MM.

Neural Netw. 2010 Oct-Nov;23(8-9):1026-32. doi: 10.1016/j.neunet.2010.07.010. Epub 2010 Aug 5.

PMID:
20729035
43.

Comparison of histopathology and RT-qPCR amplification of guanylyl cyclase C for detection of colon cancer metastases in lymph nodes.

Haince JF, Houde M, Beaudry G, L'espĂ©rance S, Garon G, Desaulniers M, Hafer LJ, Heald JI, Lyle S, Grossman SR, TĂȘtu B, Sargent DJ, Fradet Y.

J Clin Pathol. 2010 Jun;63(6):530-7. doi: 10.1136/jcp.2009.072983.

PMID:
20498026
44.

Mdm2 facilitates the association of p53 with the proteasome.

Kulikov R, Letienne J, Kaur M, Grossman SR, Arts J, Blattner C.

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10038-43. doi: 10.1073/pnas.0911716107. Epub 2010 May 17.

45.

A composite of multiple signals distinguishes causal variants in regions of positive selection.

Grossman SR, Shlyakhter I, Karlsson EK, Byrne EH, Morales S, Frieden G, Hostetter E, Angelino E, Garber M, Zuk O, Lander ES, Schaffner SF, Sabeti PC.

Science. 2010 Feb 12;327(5967):883-6. doi: 10.1126/science.1183863. Epub 2010 Jan 7. Erratum in: Science. 2012 Feb17;335(6070):796. Shylakhter, Ilya [corrected to Shlyakhter, Ilya]..

46.

CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53.

Shi D, Pop MS, Kulikov R, Love IM, Kung AL, Grossman SR.

Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16275-80. doi: 10.1073/pnas.0904305106. Epub 2009 Sep 4. Erratum in: Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18427. Kung, Andrew [corrected to Kung, Andrew L].

47.

An ARF/CtBP2 complex regulates BH3-only gene expression and p53-independent apoptosis.

Kovi RC, Paliwal S, Pande S, Grossman SR.

Cell Death Differ. 2010 Mar;17(3):513-21. doi: 10.1038/cdd.2009.140. Epub 2009 Oct 2.

48.

The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells.

Naidu SR, Love IM, Imbalzano AN, Grossman SR, Androphy EJ.

Oncogene. 2009 Jul 9;28(27):2492-501. doi: 10.1038/onc.2009.121. Epub 2009 May 18.

49.

Infants' ability to parse continuous actions.

Hespos SJ, Saylor MM, Grossman SR.

Dev Psychol. 2009 Mar;45(2):575-85. doi: 10.1037/a0014145.

PMID:
19271840
50.

Occam's dull razor: MDM2 and P/CAF keep Chk2 in check the hard way.

Grossman SR.

Cell Cycle. 2009 Feb 15;8(4):515. Epub 2009 Feb 15. No abstract available.

PMID:
19221470

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