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Active intermixing of indirect and direct neurons builds the striatal mosaic.

Tinterri A, Menardy F, Diana MA, Lokmane L, Keita M, Coulpier F, Lemoine S, Mailhes C, Mathieu B, Merchan-Sala P, Campbell K, Gyory I, Grosschedl R, Popa D, Garel S.

Nat Commun. 2018 Nov 9;9(1):4725. doi: 10.1038/s41467-018-07171-4.


Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and β1-integrin function.

Andreani V, Ramamoorthy S, Pandey A, Lupar E, Nutt SL, Lämmermann T, Grosschedl R.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9630-E9639. doi: 10.1073/pnas.1809739115. Epub 2018 Sep 26.


Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice.

Yanai H, Chiba S, Hangai S, Kometani K, Inoue A, Kimura Y, Abe T, Kiyonari H, Nishio J, Taguchi-Atarashi N, Mizushima Y, Negishi H, Grosschedl R, Taniguchi T.

Proc Natl Acad Sci U S A. 2018 May 15;115(20):5253-5258. doi: 10.1073/pnas.1803936115. Epub 2018 Apr 30.


Dynamic EBF1 occupancy directs sequential epigenetic and transcriptional events in B-cell programming.

Li R, Cauchy P, Ramamoorthy S, Boller S, Chavez L, Grosschedl R.

Genes Dev. 2018 Jan 15;32(2):96-111. doi: 10.1101/gad.309583.117. Epub 2018 Feb 9.


Defining B Cell Chromatin: Lessons from EBF1.

Boller S, Li R, Grosschedl R.

Trends Genet. 2018 Apr;34(4):257-269. doi: 10.1016/j.tig.2017.12.014. Epub 2018 Jan 11. Review.


Comprehensive Proteomic Investigation of Ebf1 Heterozygosity in Pro-B Lymphocytes Utilizing Data Independent Acquisition.

Musa YR, Boller S, Puchalska M, Grosschedl R, Mittler G.

J Proteome Res. 2018 Jan 5;17(1):76-85. doi: 10.1021/acs.jproteome.7b00369. Epub 2017 Dec 11.


The CCR4-NOT complex contributes to repression of Major Histocompatibility Complex class II transcription.

Rodríguez-Gil A, Ritter O, Saul VV, Wilhelm J, Yang CY, Grosschedl R, Imai Y, Kuba K, Kracht M, Schmitz ML.

Sci Rep. 2017 Jun 14;7(1):3547. doi: 10.1038/s41598-017-03708-7.


Interaction of CCR4-NOT with EBF1 regulates gene-specific transcription and mRNA stability in B lymphopoiesis.

Yang CY, Ramamoorthy S, Boller S, Rosenbaum M, Rodriguez Gil A, Mittler G, Imai Y, Kuba K, Grosschedl R.

Genes Dev. 2016 Oct 15;30(20):2310-2324. Epub 2016 Nov 2.


Enhancer decommissioning by Snail1-induced competitive displacement of TCF7L2 and down-regulation of transcriptional activators results in EPHB2 silencing.

Schnappauf O, Beyes S, Dertmann A, Freihen V, Frey P, Jägle S, Rose K, Michoel T, Grosschedl R, Hecht A.

Biochim Biophys Acta. 2016 Nov;1859(11):1353-1367. doi: 10.1016/j.bbagrm.2016.08.002. Epub 2016 Aug 5.


Satb2 Is Required for the Development of a Spinal Exteroceptive Microcircuit that Modulates Limb Position.

Hilde KL, Levine AJ, Hinckley CA, Hayashi M, Montgomery JM, Gullo M, Driscoll SP, Grosschedl R, Kohwi Y, Kohwi-Shigematsu T, Pfaff SL.

Neuron. 2016 Aug 17;91(4):763-776. doi: 10.1016/j.neuron.2016.07.014. Epub 2016 Jul 28.


Pioneering Activity of the C-Terminal Domain of EBF1 Shapes the Chromatin Landscape for B Cell Programming.

Boller S, Ramamoorthy S, Akbas D, Nechanitzky R, Burger L, Murr R, Schübeler D, Grosschedl R.

Immunity. 2016 Mar 15;44(3):527-541. doi: 10.1016/j.immuni.2016.02.021.


SUMOylation Blocks the Ubiquitin-Mediated Degradation of the Nephronophthisis Gene Product Glis2/NPHP7.

Ramachandran H, Herfurth K, Grosschedl R, Schäfer T, Walz G.

PLoS One. 2015 Jun 17;10(6):e0130275. doi: 10.1371/journal.pone.0130275. eCollection 2015.


The regulatory network of B-cell differentiation: a focused view of early B-cell factor 1 function.

Boller S, Grosschedl R.

Immunol Rev. 2014 Sep;261(1):102-15. doi: 10.1111/imr.12206. Review.


Satb2 Regulates the Differentiation of Both Callosal and Subcerebral Projection Neurons in the Developing Cerebral Cortex.

Leone DP, Heavner WE, Ferenczi EA, Dobreva G, Huguenard JR, Grosschedl R, McConnell SK.

Cereb Cortex. 2015 Oct;25(10):3406-19. doi: 10.1093/cercor/bhu156. Epub 2014 Jul 17.


MZB1 is a GRP94 cochaperone that enables proper immunoglobulin heavy chain biosynthesis upon ER stress.

Rosenbaum M, Andreani V, Kapoor T, Herp S, Flach H, Duchniewicz M, Grosschedl R.

Genes Dev. 2014 Jun 1;28(11):1165-78. doi: 10.1101/gad.240762.114.


Establishment and maintenance of B cell identity.

Grosschedl R.

Cold Spring Harb Symp Quant Biol. 2013;78:23-30. doi: 10.1101/sqb.2013.78.020057. Epub 2014 Apr 14.


Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma.

Okosun J, Bödör C, Wang J, Araf S, Yang CY, Pan C, Boller S, Cittaro D, Bozek M, Iqbal S, Matthews J, Wrench D, Marzec J, Tawana K, Popov N, O'Riain C, O'Shea D, Carlotti E, Davies A, Lawrie CH, Matolcsy A, Calaminici M, Norton A, Byers RJ, Mein C, Stupka E, Lister TA, Lenz G, Montoto S, Gribben JG, Fan Y, Grosschedl R, Chelala C, Fitzgibbon J.

Nat Genet. 2014 Feb;46(2):176-181. doi: 10.1038/ng.2856. Epub 2013 Dec 22.


Transcription factor EBF1 is essential for the maintenance of B cell identity and prevention of alternative fates in committed cells.

Nechanitzky R, Akbas D, Scherer S, Györy I, Hoyler T, Ramamoorthy S, Diefenbach A, Grosschedl R.

Nat Immunol. 2013 Aug;14(8):867-75. doi: 10.1038/ni.2641. Epub 2013 Jun 30.


Sensory map transfer to the neocortex relies on pretarget ordering of thalamic axons.

Lokmane L, Proville R, Narboux-Nême N, Györy I, Keita M, Mailhes C, Léna C, Gaspar P, Grosschedl R, Garel S.

Curr Biol. 2013 May 6;23(9):810-6. doi: 10.1016/j.cub.2013.03.062. Epub 2013 Apr 25.


The transcription factor early B-cell factor 1 regulates bone formation in an osteoblast-nonautonomous manner.

Zee T, Boller S, Györy I, Makinistoglu MP, Tuckermann JP, Grosschedl R, Karsenty G.

FEBS Lett. 2013 Mar 18;587(6):711-6. doi: 10.1016/j.febslet.2013.01.049. Epub 2013 Feb 5.


A network of genetic repression and derepression specifies projection fates in the developing neocortex.

Srinivasan K, Leone DP, Bateson RK, Dobreva G, Kohwi Y, Kohwi-Shigematsu T, Grosschedl R, McConnell SK.

Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19071-8. doi: 10.1073/pnas.1216793109. Epub 2012 Nov 9.


Satb1 and Satb2 are dispensable for X chromosome inactivation in mice.

Nechanitzky R, Dávila A, Savarese F, Fietze S, Grosschedl R.

Dev Cell. 2012 Oct 16;23(4):866-71. doi: 10.1016/j.devcel.2012.09.018.


Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis.

Skokowa J, Klimiankou M, Klimenkova O, Lan D, Gupta K, Hussein K, Carrizosa E, Kusnetsova I, Li Z, Sustmann C, Ganser A, Zeidler C, Kreipe HH, Burkhardt J, Grosschedl R, Welte K.

Nat Med. 2012 Oct;18(10):1550-9. doi: 10.1038/nm.2958. Epub 2012 Sep 23.


miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2.

Wei J, Shi Y, Zheng L, Zhou B, Inose H, Wang J, Guo XE, Grosschedl R, Karsenty G.

J Cell Biol. 2012 May 14;197(4):509-21. doi: 10.1083/jcb.201201057. Epub 2012 May 7.


Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferation, and survival of B cells.

Györy I, Boller S, Nechanitzky R, Mandel E, Pott S, Liu E, Grosschedl R.

Genes Dev. 2012 Apr 1;26(7):668-82. doi: 10.1101/gad.187328.112. Epub 2012 Mar 19.


Roles of SATB2 in osteogenic differentiation and bone regeneration.

Zhang J, Tu Q, Grosschedl R, Kim MS, Griffin T, Drissi H, Yang P, Chen J.

Tissue Eng Part A. 2011 Jul;17(13-14):1767-76. doi: 10.1089/ten.TEA.2010.0503. Epub 2011 Apr 21.


Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells.

Flach H, Rosenbaum M, Duchniewicz M, Kim S, Zhang SL, Cahalan MD, Mittler G, Grosschedl R.

Immunity. 2010 Nov 24;33(5):723-35. doi: 10.1016/j.immuni.2010.11.013.


Early B cell factor 2 regulates hematopoietic stem cell homeostasis in a cell-nonautonomous manner.

Kieslinger M, Hiechinger S, Dobreva G, Consalez GG, Grosschedl R.

Cell Stem Cell. 2010 Oct 8;7(4):496-507. doi: 10.1016/j.stem.2010.07.015.


Structure of an Ebf1:DNA complex reveals unusual DNA recognition and structural homology with Rel proteins.

Treiber N, Treiber T, Zocher G, Grosschedl R.

Genes Dev. 2010 Oct 15;24(20):2270-5. doi: 10.1101/gad.1976610. Epub 2010 Sep 28.


Memories of lost enhancers.

Sen R, Grosschedl R.

Genes Dev. 2010 May 15;24(10):973-9. doi: 10.1101/gad.1930610.


Early B cell factor 1 regulates B cell gene networks by activation, repression, and transcription- independent poising of chromatin.

Treiber T, Mandel EM, Pott S, Györy I, Firner S, Liu ET, Grosschedl R.

Immunity. 2010 May 28;32(5):714-25. doi: 10.1016/j.immuni.2010.04.013. Epub 2010 May 6.


Transcription control of early B cell differentiation.

Mandel EM, Grosschedl R.

Curr Opin Immunol. 2010 Apr;22(2):161-7. doi: 10.1016/j.coi.2010.01.010. Epub 2010 Feb 9. Review.


Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression.

Savarese F, Dávila A, Nechanitzky R, De La Rosa-Velazquez I, Pereira CF, Engelke R, Takahashi K, Jenuwein T, Kohwi-Shigematsu T, Fisher AG, Grosschedl R.

Genes Dev. 2009 Nov 15;23(22):2625-38. doi: 10.1101/gad.1815709.


Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.

Dawlaty MM, Malureanu L, Jeganathan KB, Kao E, Sustmann C, Tahk S, Shuai K, Grosschedl R, van Deursen JM.

Cell. 2008 Apr 4;133(1):103-15. doi: 10.1016/j.cell.2008.01.045.


Cell-type-specific function of BCL9 involves a transcriptional activation domain that synergizes with beta-catenin.

Sustmann C, Flach H, Ebert H, Eastman Q, Grosschedl R.

Mol Cell Biol. 2008 May;28(10):3526-37. doi: 10.1128/MCB.01986-07. Epub 2008 Mar 17.


Multitasking of interferon regulatory factor-4 in early B cells.

Nielsen P, Grosschedl R.

Immunity. 2008 Mar;28(3):295-7. doi: 10.1016/j.immuni.2008.02.007. Review.


Satb2 regulates callosal projection neuron identity in the developing cerebral cortex.

Alcamo EA, Chirivella L, Dautzenberg M, Dobreva G, Fariñas I, Grosschedl R, McConnell SK.

Neuron. 2008 Feb 7;57(3):364-77. doi: 10.1016/j.neuron.2007.12.012.


Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5.

Pongubala JM, Northrup DL, Lancki DW, Medina KL, Treiber T, Bertolino E, Thomas M, Grosschedl R, Allman D, Singh H.

Nat Immunol. 2008 Feb;9(2):203-15. doi: 10.1038/ni1555. Epub 2008 Jan 6.


Dynamics and interplay of nuclear architecture, genome organization, and gene expression.

Schneider R, Grosschedl R.

Genes Dev. 2007 Dec 1;21(23):3027-43. Review.


PIAS proteins as repressors of Oct4 function.

Tolkunova E, Malashicheva A, Parfenov VN, Sustmann C, Grosschedl R, Tomilin A.

J Mol Biol. 2007 Dec 14;374(5):1200-12. Epub 2007 Oct 3.


Wnt signaling interacts with Shh to regulate taste papilla development.

Iwatsuki K, Liu HX, Grónder A, Singer MA, Lane TF, Grosschedl R, Mistretta CM, Margolskee RF.

Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2253-8. Epub 2007 Feb 6.


Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5.

Roessler S, Györy I, Imhof S, Spivakov M, Williams RR, Busslinger M, Fisher AG, Grosschedl R.

Mol Cell Biol. 2007 Jan;27(2):579-94. Epub 2006 Nov 13.


LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia.

Skokowa J, Cario G, Uenalan M, Schambach A, Germeshausen M, Battmer K, Zeidler C, Lehmann U, Eder M, Baum C, Grosschedl R, Stanulla M, Scherr M, Welte K.

Nat Med. 2006 Oct;12(10):1191-7. Epub 2006 Sep 24. Erratum in: Nat Med. 2006 Nov;12(11):1329.


Genetic interaction between Lef1 and Alx4 is required for early embryonic development.

Boras-Granic K, Grosschedl R, Hamel PA.

Int J Dev Biol. 2006;50(7):601-10.


Blurring cis and trans in gene regulation.

Savarese F, Grosschedl R.

Cell. 2006 Jul 28;126(2):248-50.


FOXtrot and RAGtime in B cells.

Savarese F, Grosschedl R.

Nat Immunol. 2006 Aug;7(8):793-4. No abstract available.


The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis.

Bischof O, Schwamborn K, Martin N, Werner A, Sustmann C, Grosschedl R, Dejean A.

Mol Cell. 2006 Jun 23;22(6):783-94.


SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation.

Dobreva G, Chahrour M, Dautzenberg M, Chirivella L, Kanzler B, Fariñas I, Karsenty G, Grosschedl R.

Cell. 2006 Jun 2;125(5):971-86.


Lef1 is required for the transition of Wnt signaling from mesenchymal to epithelial cells in the mouse embryonic mammary gland.

Boras-Granic K, Chang H, Grosschedl R, Hamel PA.

Dev Biol. 2006 Jul 1;295(1):219-31. Epub 2006 Apr 3.


Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination.

Olson LE, Tollkuhn J, Scafoglio C, Krones A, Zhang J, Ohgi KA, Wu W, Taketo MM, Kemler R, Grosschedl R, Rose D, Li X, Rosenfeld MG.

Cell. 2006 May 5;125(3):593-605.

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