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Items: 1 to 50 of 157

1.

HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons.

Kishinevsky S, Wang T, Rodina A, Chung SY, Xu C, Philip J, Taldone T, Joshi S, Alpaugh ML, Bolaender A, Gutbier S, Sandhu D, Fattahi F, Zimmer B, Shah SK, Chang E, Inda C, Koren J 3rd, Saurat NG, Leist M, Gross SS, Seshan VE, Klein C, Tomishima MJ, Erdjument-Bromage H, Neubert TA, Henrickson RC, Chiosis G, Studer L.

Nat Commun. 2018 Oct 19;9(1):4345. doi: 10.1038/s41467-018-06486-6.

2.

Untargeted Metabolite Profiling of Cerebrospinal Fluid Uncovers Biomarkers for Severity of Late Infantile Neuronal Ceroid Lipofuscinosis (CLN2, Batten Disease).

Sindelar M, Dyke JP, Deeb RS, Sondhi D, Kaminsky SM, Kosofsky BE, Ballon DJ, Crystal RG, Gross SS.

Sci Rep. 2018 Oct 15;8(1):15229. doi: 10.1038/s41598-018-33449-0.

3.

A universal SNP and small-indel variant caller using deep neural networks.

Poplin R, Chang PC, Alexander D, Schwartz S, Colthurst T, Ku A, Newburger D, Dijamco J, Nguyen N, Afshar PT, Gross SS, Dorfman L, McLean CY, DePristo MA.

Nat Biotechnol. 2018 Nov;36(10):983-987. doi: 10.1038/nbt.4235. Epub 2018 Sep 24.

PMID:
30247488
4.

Accelerated lipid catabolism and autophagy are cancer survival mechanisms under inhibited glutaminolysis.

Halama A, Kulinski M, Dib SS, Zaghlool SB, Siveen KS, Iskandarani A, Zierer J, Prabhu KS, Satheesh NJ, Bhagwat AM, Uddin S, Kastenmüller G, Elemento O, Gross SS, Suhre K.

Cancer Lett. 2018 Aug 28;430:133-147. doi: 10.1016/j.canlet.2018.05.017. Epub 2018 May 17.

5.

Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations.

Chen Q, Kirk K, Shurubor YI, Zhao D, Arreguin AJ, Shahi I, Valsecchi F, Primiano G, Calder EL, Carelli V, Denton TT, Beal MF, Gross SS, Manfredi G, D'Aurelio M.

Cell Metab. 2018 May 1;27(5):1007-1025.e5. doi: 10.1016/j.cmet.2018.03.002. Epub 2018 Apr 12.

PMID:
29657030
6.

Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure.

Leung KY, Pai YJ, Chen Q, Santos C, Calvani E, Sudiwala S, Savery D, Ralser M, Gross SS, Copp AJ, Greene NDE.

Cell Rep. 2017 Nov 14;21(7):1795-1808. doi: 10.1016/j.celrep.2017.10.072.

7.

Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer's disease-like pathology.

Nuriel T, Angulo SL, Khan U, Ashok A, Chen Q, Figueroa HY, Emrani S, Liu L, Herman M, Barrett G, Savage V, Buitrago L, Cepeda-Prado E, Fung C, Goldberg E, Gross SS, Hussaini SA, Moreno H, Small SA, Duff KE.

Nat Commun. 2017 Nov 13;8(1):1464. doi: 10.1038/s41467-017-01444-0.

8.

Blockade of alcohol escalation and "relapse" drinking by pharmacological FAAH inhibition in male and female C57BL/6J mice.

Zhou Y, Schwartz BI, Giza J, Gross SS, Lee FS, Kreek MJ.

Psychopharmacology (Berl). 2017 Oct;234(19):2955-2970. doi: 10.1007/s00213-017-4691-9. Epub 2017 Jul 20.

9.

A 12-Year-Old Boy with Multiple Scaly Papules.

Ronkainen SD, Gross SS, Polcari IC.

Pediatr Dermatol. 2017 Jan;34(1):97-98. doi: 10.1111/pde.13027. No abstract available.

PMID:
28054719
10.

Role of RPL39 in Metaplastic Breast Cancer.

Dave B, Gonzalez DD, Liu ZB, Li X, Wong H, Granados S, Ezzedine NE, Sieglaff DH, Ensor JE, Miller KD, Radovich M, KarinaEtrovic A, Gross SS, Elemento O, Mills GB, Gilcrease MZ, Chang JC.

J Natl Cancer Inst. 2016 Dec 31;109(6). doi: 10.1093/jnci/djw292. Print 2017 Jun.

11.

Reversible methylation of m6Am in the 5' cap controls mRNA stability.

Mauer J, Luo X, Blanjoie A, Jiao X, Grozhik AV, Patil DP, Linder B, Pickering BF, Vasseur JJ, Chen Q, Gross SS, Elemento O, Debart F, Kiledjian M, Jaffrey SR.

Nature. 2017 Jan 19;541(7637):371-375. doi: 10.1038/nature21022. Epub 2016 Dec 21.

12.

Metabolite profiling of whole murine embryos reveals metabolic perturbations associated with maternal valproate-induced neural tube closure defects.

Akimova D, Wlodarczyk BJ, Lin Y, Ross ME, Finnell RH, Chen Q, Gross SS.

Birth Defects Res. 2017 Jan 30;109(2):106-119. doi: 10.1002/bdra.23583.

13.

Metabolomics enables precision medicine: "A White Paper, Community Perspective".

Beger RD, Dunn W, Schmidt MA, Gross SS, Kirwan JA, Cascante M, Brennan L, Wishart DS, Oresic M, Hankemeier T, Broadhurst DI, Lane AN, Suhre K, Kastenmüller G, Sumner SJ, Thiele I, Fiehn O, Kaddurah-Daouk R; for “Precision Medicine and Pharmacometabolomics Task Group”-Metabolomics Society Initiative.

Metabolomics. 2016;12(10):149. Epub 2016 Sep 2.

14.

Genome-wide characteristics of de novo mutations in autism.

Yuen RK, Merico D, Cao H, Pellecchia G, Alipanahi B, Thiruvahindrapuram B, Tong X, Sun Y, Cao D, Zhang T, Wu X, Jin X, Zhou Z, Liu X, Nalpathamkalam T, Walker S, Howe JL, Wang Z, MacDonald JR, Chan A, D'Abate L, Deneault E, Siu MT, Tammimies K, Uddin M, Zarrei M, Wang M, Li Y, Wang J, Wang J, Yang H, Bookman M, Bingham J, Gross SS, Loy D, Pletcher M, Marshall CR, Anagnostou E, Zwaigenbaum L, Weksberg R, Fernandez BA, Roberts W, Szatmari P, Glazer D, Frey BJ, Ring RH, Xu X, Scherer SW.

NPJ Genom Med. 2016 Aug 3;1:160271-1602710.

15.

Celecoxib Alters the Intestinal Microbiota and Metabolome in Association with Reducing Polyp Burden.

Montrose DC, Zhou XK, McNally EM, Sue E, Yantiss RK, Gross SS, Leve ND, Karoly ED, Suen CS, Ling L, Benezra R, Pamer EG, Dannenberg AJ.

Cancer Prev Res (Phila). 2016 Sep;9(9):721-31. doi: 10.1158/1940-6207.CAPR-16-0095. Epub 2016 Jul 18.

16.

Pulmonary Abnormalities in Young, Light-Use Waterpipe (Hookah) Smokers.

Strulovici-Barel Y, Shaykhiev R, Salit J, Deeb RS, Krause A, Kaner RJ, Vincent TL, Agosto-Perez F, Wang G, Hollmann C, Shanmugam V, Almulla AM, Sattar H, Mahmoud M, Mezey JG, Gross SS, Staudt MR, Walters MS, Crystal RG.

Am J Respir Crit Care Med. 2016 Sep 1;194(5):587-95. doi: 10.1164/rccm.201512-2470OC.

17.

ANSID: A Solid-Phase Proteomic Approach for Identification and Relative Quantification of Aromatic Nitration Sites.

Nuriel T, Whitehouse J, Ma Y, Mercer EJ, Brown N, Gross SS.

Front Chem. 2016 Jan 7;3:70. doi: 10.3389/fchem.2015.00070. eCollection 2015.

18.

Serum Metabolite Biomarkers Discriminate Healthy Smokers from COPD Smokers.

Chen Q, Deeb RS, Ma Y, Staudt MR, Crystal RG, Gross SS.

PLoS One. 2015 Dec 16;10(12):e0143937. doi: 10.1371/journal.pone.0143937. eCollection 2015.

19.
20.

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.

Yun J, Mullarky E, Lu C, Bosch KN, Kavalier A, Rivera K, Roper J, Chio II, Giannopoulou EG, Rago C, Muley A, Asara JM, Paik J, Elemento O, Chen Z, Pappin DJ, Dow LE, Papadopoulos N, Gross SS, Cantley LC.

Science. 2015 Dec 11;350(6266):1391-6. doi: 10.1126/science.aaa5004. Epub 2015 Nov 5.

21.

Smoking-Associated Disordering of the Airway Basal Stem/Progenitor Cell Metabotype.

Deeb RS, Walters MS, Strulovici-Barel Y, Chen Q, Gross SS, Crystal RG.

Am J Respir Cell Mol Biol. 2016 Feb;54(2):231-40. doi: 10.1165/rcmb.2015-0055OC.

22.

Urine Metabolite Profiles Predictive of Human Kidney Allograft Status.

Suhre K, Schwartz JE, Sharma VK, Chen Q, Lee JR, Muthukumar T, Dadhania DM, Ding R, Ikle DN, Bridges ND, Williams NM, Kastenmüller G, Karoly ED, Mohney RP, Abecassis M, Friedewald J, Knechtle SJ, Becker YT, Samstein B, Shaked A, Gross SS, Suthanthiran M.

J Am Soc Nephrol. 2016 Feb;27(2):626-36. doi: 10.1681/ASN.2015010107. Epub 2015 Jun 5.

23.

Inhibition of iNOS as a novel effective targeted therapy against triple-negative breast cancer.

Granados-Principal S, Liu Y, Guevara ML, Blanco E, Choi DS, Qian W, Patel T, Rodriguez AA, Cusimano J, Weiss HL, Zhao H, Landis MD, Dave B, Gross SS, Chang JC.

Breast Cancer Res. 2015 Feb 22;17:25. doi: 10.1186/s13058-015-0527-x.

24.

Analyses of the transcriptome and metabolome demonstrate that HIF1α mediates altered tumor metabolism in clear cell renal cell carcinoma.

Minton DR, Fu L, Chen Q, Robinson BD, Gross SS, Nanus DM, Gudas LJ.

PLoS One. 2015 Apr 1;10(4):e0120649. doi: 10.1371/journal.pone.0120649. eCollection 2015.

25.

A requirement for Gch1 and tetrahydrobiopterin in embryonic development.

Douglas G, Hale AB, Crabtree MJ, Ryan BJ, Hansler A, Watschinger K, Gross SS, Lygate CA, Alp NJ, Channon KM.

Dev Biol. 2015 Mar 1;399(1):129-138. doi: 10.1016/j.ydbio.2014.12.025. Epub 2014 Dec 31.

26.

Untargeted metabolite profiling of murine embryos to reveal metabolic perturbations associated with neural tube closure defects.

Hansler A, Chen Q, Gray JD, Ross ME, Finnell RH, Gross SS.

Birth Defects Res A Clin Mol Teratol. 2014 Aug;100(8):623-32. doi: 10.1002/bdra.23272. Epub 2014 Aug 13.

27.

Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling.

Dave B, Granados-Principal S, Zhu R, Benz S, Rabizadeh S, Soon-Shiong P, Yu KD, Shao Z, Li X, Gilcrease M, Lai Z, Chen Y, Huang TH, Shen H, Liu X, Ferrari M, Zhan M, Wong ST, Kumaraswami M, Mittal V, Chen X, Gross SS, Chang JC.

Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8838-43. doi: 10.1073/pnas.1320769111. Epub 2014 May 29.

28.

Huntingtin protein is essential for mitochondrial metabolism, bioenergetics and structure in murine embryonic stem cells.

Ismailoglu I, Chen Q, Popowski M, Yang L, Gross SS, Brivanlou AH.

Dev Biol. 2014 Jul 15;391(2):230-40. doi: 10.1016/j.ydbio.2014.04.005. Epub 2014 Apr 26.

29.

KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability.

Abbott GW, Tai KK, Neverisky DL, Hansler A, Hu Z, Roepke TK, Lerner DJ, Chen Q, Liu L, Zupan B, Toth M, Haynes R, Huang X, Demirbas D, Buccafusca R, Gross SS, Kanda VA, Berry GT.

Sci Signal. 2014 Mar 4;7(315):ra22. doi: 10.1126/scisignal.2005025.

31.

Automated cellular annotation for high-resolution images of adult Caenorhabditis elegans.

Aerni SJ, Liu X, Do CB, Gross SS, Nguyen A, Guo SD, Long F, Peng H, Kim SS, Batzoglou S.

Bioinformatics. 2013 Jul 1;29(13):i18-26. doi: 10.1093/bioinformatics/btt223.

32.

S-sulfhydration/desulfhydration and S-nitrosylation/denitrosylation: a common paradigm for gasotransmitter signaling by H2S and NO.

Lu C, Kavalier A, Lukyanov E, Gross SS.

Methods. 2013 Aug 1;62(2):177-81. doi: 10.1016/j.ymeth.2013.05.020. Epub 2013 Jun 27. Review.

33.

Anxiety-associated alternative polyadenylation of the serotonin transporter mRNA confers translational regulation by hnRNPK.

Yoon Y, McKenna MC, Rollins DA, Song M, Nuriel T, Gross SS, Xu G, Glatt CE.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11624-9. doi: 10.1073/pnas.1301485110. Epub 2013 Jun 24.

34.

Characterization of a cellular denitrase activity that reverses nitration of cyclooxygenase.

Deeb RS, Nuriel T, Cheung C, Summers B, Lamon BD, Gross SS, Hajjar DP.

Am J Physiol Heart Circ Physiol. 2013 Sep 1;305(5):H687-98. doi: 10.1152/ajpheart.00876.2012. Epub 2013 Jun 21.

35.

Glutamine supplementation alleviates vasculopathy and corrects metabolic profile in an in vivo model of endothelial cell dysfunction.

Addabbo F, Chen Q, Patel DP, Rabadi M, Ratliff B, Zhang F, Jasmin JF, Wolin M, Lisanti M, Gross SS, Goligorsky MS.

PLoS One. 2013 Jun 11;8(6):e65458. doi: 10.1371/journal.pone.0065458. Print 2013.

36.

Unbiased metabolite profiling indicates that a diminished thymidine pool is the underlying mechanism of colon cancer chemoprevention by alpha-difluoromethylornithine.

Witherspoon M, Chen Q, Kopelovich L, Gross SS, Lipkin SM.

Cancer Discov. 2013 Sep;3(9):1072-81. doi: 10.1158/2159-8290.CD-12-0305. Epub 2013 Jun 14.

37.

Application of combined omics platforms to accelerate biomedical discovery in diabesity.

Kurland IJ, Accili D, Burant C, Fischer SM, Kahn BB, Newgard CB, Ramagiri S, Ronnett GV, Ryals JA, Sanders M, Shambaugh J, Shockcor J, Gross SS.

Ann N Y Acad Sci. 2013 May;1287:1-16. doi: 10.1111/nyas.12116. Epub 2013 May 9.

38.

Untargeted plasma metabolite profiling reveals the broad systemic consequences of xanthine oxidoreductase inactivation in mice.

Chen Q, Park HC, Goligorsky MS, Chander P, Fischer SM, Gross SS.

PLoS One. 2012;7(6):e37149. doi: 10.1371/journal.pone.0037149. Epub 2012 Jun 18.

39.

Excretion of anti-angiogenic proteins in patients with chronic allograft dysfunction.

Moskowitz-Kassai E, Mackelaite L, Chen J, Patel K, Dadhania DM, Gross SS, Chander P, Delaney V, Deng L, Chen L, Cui X, Suthanthiran M, Goligorsky MS.

Nephrol Dial Transplant. 2012 Feb;27(2):494-7. doi: 10.1093/ndt/gfr638. Epub 2012 Jan 17.

40.

Congenital mucinous eccrine nevi in an infant with chronic granulomatous disease.

Gross SS, Fridlington E, Stone MS.

Arch Dermatol. 2012 Jan;148(1):140-2. doi: 10.1001/archdermatol.2011.1527. No abstract available.

PMID:
22250260
41.

Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90.

Moulick K, Ahn JH, Zong H, Rodina A, Cerchietti L, Gomes DaGama EM, Caldas-Lopes E, Beebe K, Perna F, Hatzi K, Vu LP, Zhao X, Zatorska D, Taldone T, Smith-Jones P, Alpaugh M, Gross SS, Pillarsetty N, Ku T, Lewis JS, Larson SM, Levine R, Erdjument-Bromage H, Guzman ML, Nimer SD, Melnick A, Neckers L, Chiosis G.

Nat Chem Biol. 2011 Sep 25;7(11):818-26. doi: 10.1038/nchembio.670.

42.

Discovery and biological characterization of 1-(1H-indol-3-yl)-9H-pyrido[3,4-b]indole as an aryl hydrocarbon receptor activator generated by photoactivation of tryptophan by sunlight.

Diani-Moore S, Ma Y, Labitzke E, Tao H, David Warren J, Anderson J, Chen Q, Gross SS, Rifkind AB.

Chem Biol Interact. 2011 Sep 5;193(2):119-28. doi: 10.1016/j.cbi.2011.05.010. Epub 2011 Jun 22.

43.

Protein nitrotryptophan: formation, significance and identification.

Nuriel T, Hansler A, Gross SS.

J Proteomics. 2011 Oct 19;74(11):2300-12. doi: 10.1016/j.jprot.2011.05.032. Epub 2011 Jun 6. Review.

44.

The scavenger receptor CD36 contributes to the neurotoxicity of bone marrow-derived monocytes through peroxynitrite production.

Zhou P, Qian L, Gallo EF, Deeb RS, Anrather J, Gross SS, Iadecola C.

Neurobiol Dis. 2011 Jun;42(3):292-9. doi: 10.1016/j.nbd.2011.01.019. Epub 2011 Feb 3.

45.
46.

Physical evidence for substrate binding in preventing cyclooxygenase inactivation under nitrative stress.

Deeb RS, Cheung C, Nuriel T, Lamon BD, Upmacis RK, Gross SS, Hajjar DP.

J Am Chem Soc. 2010 Mar 24;132(11):3914-22. doi: 10.1021/ja910578y.

47.

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models.

Caldas-Lopes E, Cerchietti L, Ahn JH, Clement CC, Robles AI, Rodina A, Moulick K, Taldone T, Gozman A, Guo Y, Wu N, de Stanchina E, White J, Gross SS, Ma Y, Varticovski L, Melnick A, Chiosis G.

Proc Natl Acad Sci U S A. 2009 May 19;106(20):8368-73. doi: 10.1073/pnas.0903392106. Epub 2009 May 5.

48.

Neutral loss of isocyanic acid in peptide CID spectra: a novel diagnostic marker for mass spectrometric identification of protein citrullination.

Hao G, Wang D, Gu J, Shen Q, Gross SS, Wang Y.

J Am Soc Mass Spectrom. 2009 Apr;20(4):723-7. doi: 10.1016/j.jasms.2008.12.012. Epub 2008 Dec 30.

49.

Urinary proteomic analysis of chronic allograft nephropathy.

O'Riordan E, Orlova TN, Mendelev N, Patschan D, Kemp R, Chander PN, Hu R, Hao G, Gross SS, Iozzo RV, Delaney V, Goligorsky MS.

Proteomics Clin Appl. 2008 Jul;2(7-8):1025-35. doi: 10.1002/prca.200780137.

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