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Items: 1 to 50 of 130

1.

Lipid-independent control of endothelial and neuronal TRPC3 channels by light.

Tiapko O, Shrestha N, Lindinger S, Guedes de la Cruz G, Graziani A, Klec C, Butorac C, Graier WF, Kubista H, Freichel M, Birnbaumer L, Romanin C, Glasnov T, Groschner K.

Chem Sci. 2019 Jan 15;10(9):2837-2842. doi: 10.1039/c8sc05536j. eCollection 2019 Mar 7.

2.

Photopharmacology and opto-chemogenetics of TRPC channels-some therapeutic visions.

Curcic S, Tiapko O, Groschner K.

Pharmacol Ther. 2019 Aug;200:13-26. doi: 10.1016/j.pharmthera.2019.04.003. Epub 2019 Apr 8. Review.

3.

A novel STIM1-Orai1 gating interface essential for CRAC channel activation.

Butorac C, Muik M, Derler I, Stadlbauer M, Lunz V, Krizova A, Lindinger S, Schober R, Frischauf I, Bhardwaj R, Hediger MA, Groschner K, Romanin C.

Cell Calcium. 2019 May;79:57-67. doi: 10.1016/j.ceca.2019.02.009. Epub 2019 Feb 23.

4.

A single point mutation in the TRPC3 lipid-recognition window generates supersensitivity to benzimidazole channel activators.

Svobodova B, Lichtenegger M, Platzer D, Di Giuro CML, de la Cruz GG, Glasnov T, Schreibmayer W, Groschner K.

Cell Calcium. 2019 May;79:27-34. doi: 10.1016/j.ceca.2019.02.007. Epub 2019 Feb 16.

5.

TRPC-mediated Ca2+ signaling and control of cellular functions.

Curcic S, Schober R, Schindl R, Groschner K.

Semin Cell Dev Biol. 2019 Mar 1. pii: S1084-9521(18)30072-7. doi: 10.1016/j.semcdb.2019.02.001. [Epub ahead of print] Review.

PMID:
30738858
6.

STIM1 and Orai1 regulate Ca2+ microdomains for activation of transcription.

Schober R, Waldherr L, Schmidt T, Graziani A, Stilianu C, Legat L, Groschner K, Schindl R.

Biochim Biophys Acta Mol Cell Res. 2019 Jul;1866(7):1079-1091. doi: 10.1016/j.bbamcr.2018.11.001. Epub 2018 Nov 6. Review.

PMID:
30408546
7.

Non-Orai Partners of STIM Proteins: Role in ER-PM Communication and Ca2+ Signaling.

Groschner K, Shrestha N, Fameli N.

In: Kozak JA, Putney JW Jr., editors. Calcium Entry Channels in Non-Excitable Cells. Boca Raton (FL): CRC Press/Taylor & Francis; 2018. Chapter 10.

8.

Revelation of an enigmatic signaling machinery-First insights into the mammalian TRPC architecture.

Groschner K, Tiapko O.

Cell Calcium. 2018 Sep;74:144-146. doi: 10.1016/j.ceca.2018.07.006. Epub 2018 Jul 19. Review.

PMID:
30053695
9.

TRPC3 as a Target of Novel Therapeutic Interventions.

Tiapko O, Groschner K.

Cells. 2018 Jul 22;7(7). pii: E83. doi: 10.3390/cells7070083. Review.

10.

An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel.

Lichtenegger M, Tiapko O, Svobodova B, Stockner T, Glasnov TN, Schreibmayer W, Platzer D, de la Cruz GG, Krenn S, Schober R, Shrestha N, Schindl R, Romanin C, Groschner K.

Nat Chem Biol. 2018 Apr;14(4):396-404. doi: 10.1038/s41589-018-0015-6. Epub 2018 Mar 19.

11.

Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription.

Frischauf I, Litviňuková M, Schober R, Zayats V, Svobodová B, Bonhenry D, Lunz V, Cappello S, Tociu L, Reha D, Stallinger A, Hochreiter A, Pammer T, Butorac C, Muik M, Groschner K, Bogeski I, Ettrich RH, Romanin C, Schindl R.

Sci Signal. 2017 Nov 28;10(507). pii: eaao0358. doi: 10.1126/scisignal.aao0358.

12.

Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo.

Bischof H, Rehberg M, Stryeck S, Artinger K, Eroglu E, Waldeck-Weiermair M, Gottschalk B, Rost R, Deak AT, Niedrist T, Vujic N, Lindermuth H, Prassl R, Pelzmann B, Groschner K, Kratky D, Eller K, Rosenkranz AR, Madl T, Plesnila N, Graier WF, Malli R.

Nat Commun. 2017 Nov 10;8(1):1422. doi: 10.1038/s41467-017-01615-z.

13.

Cardiovascular and Hemostatic Disorders: SOCE in Cardiovascular Cells: Emerging Targets for Therapeutic Intervention.

Groschner K, Shrestha N, Fameli N.

Adv Exp Med Biol. 2017;993:473-503. doi: 10.1007/978-3-319-57732-6_24. Review.

PMID:
28900929
14.

Dipeptidyl peptidase-4 independent cardiac dysfunction links saxagliptin to heart failure.

Koyani CN, Kolesnik E, Wölkart G, Shrestha N, Scheruebel S, Trummer C, Zorn-Pauly K, Hammer A, Lang P, Reicher H, Maechler H, Groschner K, Mayer B, Rainer PP, Sourij H, Sattler W, Malle E, Pelzmann B, von Lewinski D.

Biochem Pharmacol. 2017 Dec 1;145:64-80. doi: 10.1016/j.bcp.2017.08.021. Epub 2017 Aug 30.

15.

Na +/Ca2+ exchangers and Orai channels jointly refill endoplasmic reticulum (ER) Ca2+ via ER nanojunctions in vascular endothelial cells.

Di Giuro CML, Shrestha N, Malli R, Groschner K, van Breemen C, Fameli N.

Pflugers Arch. 2017 Oct;469(10):1287-1299. doi: 10.1007/s00424-017-1989-8. Epub 2017 May 11.

16.

Intensified Microwave-Assisted N-Acylation Procedure - Synthesis and Activity Evaluation of TRPC3 Channel Agonists with a 1,3-Dihydro-2H-benzo[d]imidazol-2-one Core.

de la Cruz GG, Svobodova B, Lichtenegger M, Tiapko O, Groschner K, Glasnov T.

Synlett. 2017 Apr;28(6):695-700. doi: 10.1055/s-0036-1589472.

17.

Corrigendum: Pharmacological Characterization of the Native Store-Operated Calcium Channels of Cortical Neurons from Embryonic Mouse Brain.

Chauvet S, Jarvis L, Chevallet M, Shrestha N, Groschner K, Bouron A.

Front Pharmacol. 2017 Mar 22;8:152. doi: 10.3389/fphar.2017.00152. eCollection 2017.

18.

Pharmacological Characterization of the Native Store-Operated Calcium Channels of Cortical Neurons from Embryonic Mouse Brain.

Chauvet S, Jarvis L, Chevallet M, Shrestha N, Groschner K, Bouron A.

Front Pharmacol. 2016 Dec 12;7:486. doi: 10.3389/fphar.2016.00486. eCollection 2016. Erratum in: Front Pharmacol. 2017 Mar 22;8:152.

19.

Live-cell imaging of ER-PM contact architecture by a novel TIRFM approach reveals extension of junctions in response to store-operated Ca2+-entry.

Poteser M, Leitinger G, Pritz E, Platzer D, Frischauf I, Romanin C, Groschner K.

Sci Rep. 2016 Oct 19;6:35656. doi: 10.1038/srep35656.

20.

Reprint of "Mechanisms of lipid regulation and lipid gating in TRPC channels".

Svobodova B, Groschner K.

Cell Calcium. 2016 Aug;60(2):133-41. doi: 10.1016/j.ceca.2016.06.010. Epub 2016 Jul 16. Review.

PMID:
27431463
21.

Optopharmacological control of TRPC channels by coumarin-caged lipids is associated with a phototoxic membrane effect.

Tiapko O, Bacsa B, de la Cruz GG, Glasnov T, Groschner K.

Sci China Life Sci. 2016 Aug;59(8):802-10. doi: 10.1007/s11427-016-5095-5. Epub 2016 Jul 19.

PMID:
27430887
22.

Mechanisms of lipid regulation and lipid gating in TRPC channels.

Svobodova B, Groschner K.

Cell Calcium. 2016 Jun;59(6):271-9. doi: 10.1016/j.ceca.2016.03.012. Epub 2016 Apr 16. Review.

23.

Functional impairment of endothelial cells by the antimycotic amphotericin B.

Pelzmann B, Di Giuro CM, Zorn-Pauly K, Rossmann C, Hallström S, Groschner K, Fameli N.

Biochem Biophys Res Commun. 2016 Mar 25;472(1):40-5. doi: 10.1016/j.bbrc.2016.02.054. Epub 2016 Feb 18.

PMID:
26902113
24.

Cholesterol modulates Orai1 channel function.

Derler I, Jardin I, Stathopulos PB, Muik M, Fahrner M, Zayats V, Pandey SK, Poteser M, Lackner B, Absolonova M, Schindl R, Groschner K, Ettrich R, Ikura M, Romanin C.

Sci Signal. 2016 Jan 26;9(412):ra10. doi: 10.1126/scisignal.aad7808.

25.

Piezo1 forms mechanosensitive ion channels in the human MCF-7 breast cancer cell line.

Li C, Rezania S, Kammerer S, Sokolowski A, Devaney T, Gorischek A, Jahn S, Hackl H, Groschner K, Windpassinger C, Malle E, Bauernhofer T, Schreibmayer W.

Sci Rep. 2015 Feb 10;5:8364. doi: 10.1038/srep08364.

26.

TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1.

Doleschal B, Primessnig U, Wölkart G, Wolf S, Schernthaner M, Lichtenegger M, Glasnov TN, Kappe CO, Mayer B, Antoons G, Heinzel F, Poteser M, Groschner K.

Cardiovasc Res. 2015 Apr 1;106(1):163-73. doi: 10.1093/cvr/cvv022. Epub 2015 Jan 28.

27.

Localization of VE-cadherin in plasmalemmal cholesterol rich microdomains and the effects of cholesterol depletion on VE-cadherin mediated cell-cell adhesion.

Baumgartner W, Weth A, Gutberlet J, Harms G, Groschner K.

Biochim Biophys Acta. 2014 Dec;1841(12):1725-32.

PMID:
25281911
28.

Urocortin 2 stimulates nitric oxide production in ventricular myocytes via Akt- and PKA-mediated phosphorylation of eNOS at serine 1177.

Walther S, Pluteanu F, Renz S, Nikonova Y, Maxwell JT, Yang LZ, Schmidt K, Edwards JN, Wakula P, Groschner K, Maier LS, Spiess J, Blatter LA, Pieske B, Kockskämper J.

Am J Physiol Heart Circ Physiol. 2014 Sep 1;307(5):H689-700. doi: 10.1152/ajpheart.00694.2013. Epub 2014 Jul 11.

29.

Contribution of TRPC3 to store-operated calcium entry and inflammatory transductions in primary nociceptors.

Alkhani H, Ase AR, Grant R, O'Donnell D, Groschner K, Séguéla P.

Mol Pain. 2014 Jun 26;10:43. doi: 10.1186/1744-8069-10-43.

30.

TRPC3: a multifunctional signaling molecule.

Lichtenegger M, Groschner K.

Handb Exp Pharmacol. 2014;222:67-84. doi: 10.1007/978-3-642-54215-2_4. Review.

PMID:
24756703
31.

Enhanced Ca2+Entry and Tyrosine Phosphorylation Mediate Nanostructure-Induced Endothelial Proliferation.

Schernthaner M, Leitinger G, Wolinski H, Kohlwein SD, Reisinger B, Barb RA, Graier WF, Heitz J, Groschner K.

J Nanomater. 2013 Oct 6;2013. pii: 251063.

32.

15-deoxy-Δ¹²,¹⁴-PGJ₂ promotes inflammation and apoptosis in cardiomyocytes via the DP2/MAPK/TNFα axis.

Koyani CN, Windischhofer W, Rossmann C, Jin G, Kickmaier S, Heinzel FR, Groschner K, Alavian-Ghavanini A, Sattler W, Malle E.

Int J Cardiol. 2014 May 15;173(3):472-80. doi: 10.1016/j.ijcard.2014.03.086. Epub 2014 Mar 20.

33.

Inhibition of Orai1-mediated Ca(2+) entry is a key mechanism of the antiproliferative action of sirolimus in human arterial smooth muscle.

König S, Browne S, Doleschal B, Schernthaner M, Poteser M, Mächler H, Wittchow E, Braune M, Muik M, Romanin C, Groschner K.

Am J Physiol Heart Circ Physiol. 2013 Dec 1;305(11):H1646-57. doi: 10.1152/ajpheart.00365.2013. Epub 2013 Sep 20.

34.

The extended transmembrane Orai1 N-terminal (ETON) region combines binding interface and gate for Orai1 activation by STIM1.

Derler I, Plenk P, Fahrner M, Muik M, Jardin I, Schindl R, Gruber HJ, Groschner K, Romanin C.

J Biol Chem. 2013 Oct 4;288(40):29025-34. doi: 10.1074/jbc.M113.501510. Epub 2013 Aug 13.

35.

Bile acids induce arrhythmias in human atrial myocardium--implications for altered serum bile acid composition in patients with atrial fibrillation.

Rainer PP, Primessnig U, Harenkamp S, Doleschal B, Wallner M, Fauler G, Stojakovic T, Wachter R, Yates A, Groschner K, Trauner M, Pieske BM, von Lewinski D.

Heart. 2013 Nov;99(22):1685-92. doi: 10.1136/heartjnl-2013-304163. Epub 2013 Jul 26.

PMID:
23894089
36.

A novel homology model of TRPC3 reveals allosteric coupling between gate and selectivity filter.

Lichtenegger M, Stockner T, Poteser M, Schleifer H, Platzer D, Romanin C, Groschner K.

Cell Calcium. 2013 Sep;54(3):175-85. doi: 10.1016/j.ceca.2013.05.010. Epub 2013 Jun 22.

37.

A TRPC3 blocker, ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (Pyr3), prevents stent-induced arterial remodeling.

Koenig S, Schernthaner M, Maechler H, Kappe CO, Glasnov TN, Hoefler G, Braune M, Wittchow E, Groschner K.

J Pharmacol Exp Ther. 2013 Jan;344(1):33-40. doi: 10.1124/jpet.112.196832. Epub 2012 Sep 25.

PMID:
23010361
38.

Canonical transient receptor potential (TRPC) 1 acts as a negative regulator for vanilloid TRPV6-mediated Ca2+ influx.

Schindl R, Fritsch R, Jardin I, Frischauf I, Kahr H, Muik M, Riedl MC, Groschner K, Romanin C.

J Biol Chem. 2012 Oct 12;287(42):35612-20. doi: 10.1074/jbc.M112.400952. Epub 2012 Aug 29.

39.

Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways.

Schleifer H, Doleschal B, Lichtenegger M, Oppenrieder R, Derler I, Frischauf I, Glasnov TN, Kappe CO, Romanin C, Groschner K.

Br J Pharmacol. 2012 Dec;167(8):1712-22. doi: 10.1111/j.1476-5381.2012.02126.x.

40.

Studying Subunit Interaction and Complex Assembly of TRP Channels.

Poteser M, Groschner K.

In: Zhu MX, editor. TRP Channels. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 4.

41.

Nanopatterned polymer substrates promote endothelial proliferation by initiation of β-catenin transcriptional signaling.

Schernthaner M, Reisinger B, Wolinski H, Kohlwein SD, Trantina-Yates A, Fahrner M, Romanin C, Itani H, Stifter D, Leitinger G, Groschner K, Heitz J.

Acta Biomater. 2012 Aug;8(8):2953-62. doi: 10.1016/j.actbio.2012.04.018. Epub 2012 Apr 20.

PMID:
22522133
42.

Sunitinib causes dose-dependent negative functional effects on myocardium and cardiomyocytes.

Rainer PP, Doleschal B, Kirk JA, Sivakumaran V, Saad Z, Groschner K, Maechler H, Hoefler G, Bauernhofer T, Samonigg H, Hutterer G, Kass DA, Pieske B, von Lewinski D, Pichler M.

BJU Int. 2012 Nov;110(10):1455-62. doi: 10.1111/j.1464-410X.2012.11134.x. Epub 2012 Apr 17.

43.

A cardiac pathway of cyclic GMP-independent signaling of guanylyl cyclase A, the receptor for atrial natriuretic peptide.

Klaiber M, Dankworth B, Kruse M, Hartmann M, Nikolaev VO, Yang RB, Völker K, Gassner B, Oberwinkler H, Feil R, Freichel M, Groschner K, Skryabin BV, Frantz S, Birnbaumer L, Pongs O, Kuhn M.

Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18500-5. doi: 10.1073/pnas.1103300108. Epub 2011 Oct 25.

44.

Molecular determinants within N terminus of Orai3 protein that control channel activation and gating.

Bergsmann J, Derler I, Muik M, Frischauf I, Fahrner M, Pollheimer P, Schwarzinger C, Gruber HJ, Groschner K, Romanin C.

J Biol Chem. 2011 Sep 9;286(36):31565-75. doi: 10.1074/jbc.M111.227546. Epub 2011 Jul 1.

45.

PKC-dependent coupling of calcium permeation through transient receptor potential canonical 3 (TRPC3) to calcineurin signaling in HL-1 myocytes.

Poteser M, Schleifer H, Lichtenegger M, Schernthaner M, Stockner T, Kappe CO, Glasnov TN, Romanin C, Groschner K.

Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10556-61. doi: 10.1073/pnas.1106183108. Epub 2011 Jun 8. Erratum in: Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13876-8.

46.

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation.

Muik M, Fahrner M, Schindl R, Stathopulos P, Frischauf I, Derler I, Plenk P, Lackner B, Groschner K, Ikura M, Romanin C.

EMBO J. 2011 May 4;30(9):1678-89. doi: 10.1038/emboj.2011.79. Epub 2011 Mar 22.

47.

Cooperativeness of Orai cytosolic domains tunes subtype-specific gating.

Frischauf I, Schindl R, Bergsmann J, Derler I, Fahrner M, Muik M, Fritsch R, Lackner B, Groschner K, Romanin C.

J Biol Chem. 2011 Mar 11;286(10):8577-84. doi: 10.1074/jbc.M110.187179. Epub 2011 Jan 10.

48.

Protein–Protein Interactions in TRPC Channel Complexes.

Eder P, Schindl R, Romanin C, Groschner K.

In: Liedtke WB, Heller S, editors. TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades. Boca Raton (FL): CRC Press/Taylor & Francis; 2007. Chapter 24.

49.

Polymodal TRPC signaling: Emerging role in phenotype switching and tissue remodeling.

Groschner K.

Commun Integr Biol. 2010 Sep;3(5):393-5. doi: 10.4161/cib.3.5.12131.

50.

Age-dependent associations of smoking and drinking with non-high-density lipoprotein cholesterol.

Wakabayashi I, Groschner K.

Metabolism. 2010 Jul;59(7):1074-81. doi: 10.1016/j.metabol.2009.11.004. Epub 2009 Dec 31.

PMID:
20045152

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