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Iron(ii) complexes with diazinyl-NHC ligands: impact of π-deficiency of the azine core on photophysical properties.

Darari M, Domenichini E, Francés-Monerris A, Cebrián C, Magra K, Beley M, Pastore M, Monari A, Assfeld X, Haacke S, Gros PC.

Dalton Trans. 2019 May 31. doi: 10.1039/c9dt01731c. [Epub ahead of print]


Insights into IgM-mediated complement activation based on in situ structures of IgM-C1-C4b.

Sharp TH, Boyle AL, Diebolder CA, Kros A, Koster AJ, Gros P.

Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11900-11905. doi: 10.1073/pnas.1901841116. Epub 2019 May 30.


WASABI: a dynamic iterative framework for gene regulatory network inference.

Bonnaffoux A, Herbach U, Richard A, Guillemin A, Gonin-Giraud S, Gros PA, Gandrillon O.

BMC Bioinformatics. 2019 May 2;20(1):220. doi: 10.1186/s12859-019-2798-1.


Impact of the fac/ mer Isomerism on the Excited-State Dynamics of Pyridyl-carbene Fe(II) Complexes.

Magra K, Domenichini E, Francés-Monerris A, Cebrián C, Beley M, Darari M, Pastore M, Monari A, Assfeld X, Haacke S, Gros PC.

Inorg Chem. 2019 Apr 15;58(8):5069-5081. doi: 10.1021/acs.inorgchem.9b00138. Epub 2019 Apr 5.


Influence of metal ions on glyphosate detection by FMOC-Cl.

Gros P, Ahmed AA, Kühn O, Leinweber P.

Environ Monit Assess. 2019 Mar 26;191(4):244. doi: 10.1007/s10661-019-7387-2.


Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.

Teyra J, Singer AU, Schmitges FW, Jaynes P, Kit Leng Lui S, Polyak MJ, Fodil N, Krieger JR, Tong J, Schwerdtfeger C, Brasher BB, Ceccarelli DFJ, Moffat J, Sicheri F, Moran MF, Gros P, Eichhorn PJA, Lenter M, Boehmelt G, Sidhu SS.

Structure. 2019 Apr 2;27(4):590-605.e5. doi: 10.1016/j.str.2019.01.002. Epub 2019 Jan 31.


Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells.

Fenderico N, van Scherpenzeel RC, Goldflam M, Proverbio D, Jordens I, Kralj T, Stryeck S, Bass TZ, Hermans G, Ullman C, Aastrup T, Gros P, Maurice MM.

Nat Commun. 2019 Jan 21;10(1):365. doi: 10.1038/s41467-018-08172-z.


Deep brain stimulation: potential for neuroprotection.

McKinnon C, Gros P, Lee DJ, Hamani C, Lozano AM, Kalia LV, Kalia SK.

Ann Clin Transl Neurol. 2018 Nov 8;6(1):174-185. doi: 10.1002/acn3.682. eCollection 2019 Jan. Review.


Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction.

Oosterheert W, van Bezouwen LS, Rodenburg RNP, Granneman J, Förster F, Mattevi A, Gros P.

Nat Commun. 2018 Oct 18;9(1):4337. doi: 10.1038/s41467-018-06817-7.


Analysis of C3 Gene Variants in Patients With Idiopathic Recurrent Spontaneous Pregnancy Loss.

Mohlin FC, Gros P, Mercier E, Gris JR, Blom AM.

Front Immunol. 2018 Aug 7;9:1813. doi: 10.3389/fimmu.2018.01813. eCollection 2018.


Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency.

Kong XF, Martinez-Barricarte R, Kennedy J, Mele F, Lazarov T, Deenick EK, Ma CS, Breton G, Lucero KB, Langlais D, Bousfiha A, Aytekin C, Markle J, Trouillet C, Jabot-Hanin F, Arlehamn CSL, Rao G, Picard C, Lasseau T, Latorre D, Hambleton S, Deswarte C, Itan Y, Abarca K, Moraes-Vasconcelos D, Ailal F, Ikinciogullari A, Dogu F, Benhsaien I, Sette A, Abel L, Boisson-Dupuis S, Schröder B, Nussenzweig MC, Liu K, Geissmann F, Tangye SG, Gros P, Sallusto F, Bustamante J, Casanova JL.

Nat Immunol. 2018 Sep;19(9):973-985. doi: 10.1038/s41590-018-0178-z. Epub 2018 Aug 20.


Synthesis and Computational Study of a Pyridylcarbene Fe(II) Complex: Unexpected Effects of fac/ mer Isomerism in Metal-to-Ligand Triplet Potential Energy Surfaces.

Francés-Monerris A, Magra K, Darari M, Cebrián C, Beley M, Domenichini E, Haacke S, Pastore M, Assfeld X, Gros PC, Monari A.

Inorg Chem. 2018 Aug 20;57(16):10431-10441. doi: 10.1021/acs.inorgchem.8b01695. Epub 2018 Jul 31.


Genetic analysis of cerebral malaria in the mouse model infected with Plasmodium berghei.

Torre S, Langlais D, Gros P.

Mamm Genome. 2018 Aug;29(7-8):488-506. doi: 10.1007/s00335-018-9752-9. Epub 2018 Jun 19. Review.


Giant worms chez moi! Hammerhead flatworms (Platyhelminthes, Geoplanidae, Bipalium spp., Diversibipalium spp.) in metropolitan France and overseas French territories.

Justine JL, Winsor L, Gey D, Gros P, Thévenot J.

PeerJ. 2018 May 22;6:e4672. doi: 10.7717/peerj.4672. eCollection 2018.


Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade.

Geuijen CAW, De Nardis C, Maussang D, Rovers E, Gallenne T, Hendriks LJA, Visser T, Nijhuis R, Logtenberg T, de Kruif J, Gros P, Throsby M.

Cancer Cell. 2018 May 14;33(5):922-936.e10. doi: 10.1016/j.ccell.2018.04.003.


Change in Cognition and Other Non-Motor Symptoms With Obstructive Sleep Apnea Treatment in Parkinson Disease.

Kaminska M, Mery VP, Lafontaine AL, Robinson A, Benedetti A, Gros P, Kimoff RJ.

J Clin Sleep Med. 2018 May 15;14(5):819-828. doi: 10.5664/jcsm.7114.


Rocaglates as dual-targeting agents for experimental cerebral malaria.

Langlais D, Cencic R, Moradin N, Kennedy JM, Ayi K, Brown LE, Crandall I, Tarry MJ, Schmeing M, Kain KC, Porco JA Jr, Pelletier J, Gros P.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2366-E2375. doi: 10.1073/pnas.1713000115. Epub 2018 Feb 20.


Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement.

Ugurlar D, Howes SC, de Kreuk BJ, Koning RI, de Jong RN, Beurskens FJ, Schuurman J, Koster AJ, Sharp TH, Parren PWHI, Gros P.

Science. 2018 Feb 16;359(6377):794-797. doi: 10.1126/science.aao4988.


Molecular level investigation of the role of peptide interactions in the glyphosate analytics.

Ahmed AA, Gros P, Kühn O, Leinweber P.

Chemosphere. 2018 Apr;196:129-134. doi: 10.1016/j.chemosphere.2017.12.162. Epub 2017 Dec 27.



Gros P, Videnovic A.

Curr Sleep Med Rep. 2017 Sep;3(3):222-234. doi: 10.1007/s40675-017-0079-y. Epub 2017 Jul 6.


Stochastic palmitoylation of accessible cysteines in membrane proteins revealed by native mass spectrometry.

Rodenburg RNP, Snijder J, van de Waterbeemd M, Schouten A, Granneman J, Heck AJR, Gros P.

Nat Commun. 2017 Nov 3;8(1):1280. doi: 10.1038/s41467-017-01461-z.


Identification and characterization of a novel chemically induced allele at the planar cell polarity gene Vangl2.

El-Hassan AR, Leung V, Kharfallah F, Guyot MC, Allache R, Gros P, Kibar Z.

Mamm Genome. 2018 Apr;29(3-4):229-244. doi: 10.1007/s00335-017-9721-8. Epub 2017 Oct 24.


CCDC88B is required for pathogenesis of inflammatory bowel disease.

Fodil N, Moradin N, Leung V, Olivier JF, Radovanovic I, Jeyakumar T, Flores Molina M, McFarquhar A, Cayrol R, Bozec D, Shoukry NH, Kubo M, Dimitrieva J, Louis E, Theatre E, Dahan S, Momozawa Y, Georges M, Yeretssian G, Gros P.

Nat Commun. 2017 Oct 13;8(1):932. doi: 10.1038/s41467-017-01381-y.


Controlling charge-transfer properties through a microwave-assisted mono- or bis-annulation of dialkynyl-N-(het)arylpyrroles.

Pierrat P, Hesse S, Cebrián C, Gros PC.

Org Biomol Chem. 2017 Oct 18;15(40):8568-8575. doi: 10.1039/c7ob02149f.


IRF-8 regulates expansion of myeloid-derived suppressor cells and Foxp3+ regulatory T cells and modulates Th2 immune responses to gastrointestinal nematode infection.

Valanparambil RM, Tam M, Gros PP, Auger JP, Segura M, Gros P, Jardim A, Geary TG, Ozato K, Stevenson MM.

PLoS Pathog. 2017 Oct 2;13(10):e1006647. doi: 10.1371/journal.ppat.1006647. eCollection 2017 Oct.


New ruthenium compounds bearing semicarbazone 2-formylopyridine moiety: Playing with auxiliary ligands for tuning the mechanism of biological activity.

Łomzik M, Mazuryk O, Rutkowska-Zbik D, Stochel G, Gros PC, Brindell M.

J Inorg Biochem. 2017 Oct;175:80-91. doi: 10.1016/j.jinorgbio.2017.07.006. Epub 2017 Jul 14.


Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.

Xue X, Wu J, Ricklin D, Forneris F, Di Crescenzio P, Schmidt CQ, Granneman J, Sharp TH, Lambris JD, Gros P.

Nat Struct Mol Biol. 2017 Aug;24(8):643-651. doi: 10.1038/nsmb.3427. Epub 2017 Jul 3.


A new approach for generating bispecific antibodies based on a common light chain format and the stable architecture of human immunoglobulin G1.

De Nardis C, Hendriks LJA, Poirier E, Arvinte T, Gros P, Bakker ABH, de Kruif J.

J Biol Chem. 2017 Sep 1;292(35):14706-14717. doi: 10.1074/jbc.M117.793497. Epub 2017 Jun 27.


Sexual dimorphism in the alpine butterflies Boloria pales and Boloria napaea: differences in movement and foraging behavior (Lepidoptera: Nymphalidae).

Ehl S, Hostert K, Korsch J, Gros P, Schmitt T.

Insect Sci. 2018 Dec;25(6):1089-1101. doi: 10.1111/1744-7917.12494. Epub 2017 Aug 31.


The mouse Char10 locus regulates severity of pyruvate kinase deficiency and susceptibility to malaria.

Laroque A, Min-Oo G, Tam M, Ponka P, Stevenson MM, Gros P.

PLoS One. 2017 May 18;12(5):e0177818. doi: 10.1371/journal.pone.0177818. eCollection 2017.


Glyphosate binding in soil as revealed by sorption experiments and quantum-chemical modeling.

Gros P, Ahmed A, Kühn O, Leinweber P.

Sci Total Environ. 2017 May 15;586:527-535. doi: 10.1016/j.scitotenv.2017.02.007. Epub 2017 Feb 21.


Reduced cognitive function in patients with Parkinson disease and obstructive sleep apnea.

Mery VP, Gros P, Lafontaine AL, Robinson A, Benedetti A, Kimoff RJ, Kaminska M.

Neurology. 2017 Mar 21;88(12):1120-1128. doi: 10.1212/WNL.0000000000003738. Epub 2017 Feb 22.


A role for the histone H2A deubiquitinase MYSM1 in maintenance of CD8+ T cells.

Förster M, Boora RK, Petrov JC, Fodil N, Albanese I, Kim J, Gros P, Nijnik A.

Immunology. 2017 May;151(1):110-121. doi: 10.1111/imm.12710. Epub 2017 Feb 20.


Recombinant Expression of the Full-length Ectodomain of LDL Receptor-related Protein 1 (LRP1) Unravels pH-dependent Conformational Changes and the Stoichiometry of Binding with Receptor-associated Protein (RAP).

De Nardis C, Lössl P, van den Biggelaar M, Madoori PK, Leloup N, Mertens K, Heck AJ, Gros P.

J Biol Chem. 2017 Jan 20;292(3):912-924. doi: 10.1074/jbc.M116.758862. Epub 2016 Dec 12.


Genetics of Infectious and Inflammatory Diseases: Overlapping Discoveries from Association and Exome-Sequencing Studies.

Langlais D, Fodil N, Gros P.

Annu Rev Immunol. 2017 Apr 26;35:1-30. doi: 10.1146/annurev-immunol-051116-052442. Epub 2016 Dec 1. Review.


Erratum: USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation.

Torre S, Polyak MJ, Langlais D, Fodil N, Kennedy JM, Radovanovic I, Berghout J, Leiva-Torres GA, Krawczyk CM, Ilangumaran S, Mossman K, Liang C, Knobeloch KP, Healy LM, Antel J, Arbour N, Prat A, Majewski J, Lathrop M, Vidal SM, Gros P.

Nat Immunol. 2016 Nov 16;17(12):1479. doi: 10.1038/ni1216-1479c. No abstract available.


USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation.

Torre S, Polyak MJ, Langlais D, Fodil N, Kennedy JM, Radovanovic I, Berghout J, Leiva-Torres GA, Krawczyk CM, Ilangumaran S, Mossman K, Liang C, Knobeloch KP, Healy LM, Antel J, Arbour N, Prat A, Majewski J, Lathrop M, Vidal SM, Gros P.

Nat Immunol. 2017 Jan;18(1):54-63. doi: 10.1038/ni.3581. Epub 2016 Oct 10. Erratum in: Nat Immunol. 2016 Nov 16;17 (12 ):1479.


Complement component C3 - The "Swiss Army Knife" of innate immunity and host defense.

Ricklin D, Reis ES, Mastellos DC, Gros P, Lambris JD.

Immunol Rev. 2016 Nov;274(1):33-58. doi: 10.1111/imr.12500. Review.


Interfacial charge separation and photovoltaic efficiency in Fe(ii)-carbene sensitized solar cells.

Pastore M, Duchanois T, Liu L, Monari A, Assfeld X, Haacke S, Gros PC.

Phys Chem Chem Phys. 2016 Oct 12;18(40):28069-28081.


Imaging complement by phase-plate cryo-electron tomography from initiation to pore formation.

Sharp TH, Faas FGA, Koster AJ, Gros P.

J Struct Biol. 2017 Feb;197(2):155-162. doi: 10.1016/j.jsb.2016.09.008. Epub 2016 Sep 20.


Specialized or opportunistic-how does the high mountain endemic butterfly Erebia nivalis survive in its extreme habitats?

Ehl S, Dalstein V, Tull F, Gros P, Schmitt T.

Insect Sci. 2018 Feb;25(1):161-171. doi: 10.1111/1744-7917.12400. Epub 2016 Nov 11.


Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen.

Wang G, de Jong RN, van den Bremer ET, Beurskens FJ, Labrijn AF, Ugurlar D, Gros P, Schuurman J, Parren PW, Heck AJ.

Mol Cell. 2016 Jul 7;63(1):135-45. doi: 10.1016/j.molcel.2016.05.016. Epub 2016 Jun 16.


Cysteamine broadly improves the anti-plasmodial activity of artemisinins against murine blood stage and cerebral malaria.

Moradin N, Torre S, Gauthier S, Tam M, Hawari J, Vandercruyssen K, De Spiegeleer B, Fortin A, Stevenson MM, Gros P.

Malar J. 2016 May 6;15(1):260. doi: 10.1186/s12936-016-1317-3.


A new record excited state (3)MLCT lifetime for metalorganic iron(ii) complexes.

Liu L, Duchanois T, Etienne T, Monari A, Beley M, Assfeld X, Haacke S, Gros PC.

Phys Chem Chem Phys. 2016 May 14;18(18):12550-6. doi: 10.1039/c6cp01418f. Epub 2016 Apr 18.


Heterogeneous MAC Initiator and Pore Structures in a Lipid Bilayer by Phase-Plate Cryo-electron Tomography.

Sharp TH, Koster AJ, Gros P.

Cell Rep. 2016 Apr 5;15(1):1-8. doi: 10.1016/j.celrep.2016.03.002. Epub 2016 Mar 24.


Regulators of complement activity mediate inhibitory mechanisms through a common C3b-binding mode.

Forneris F, Wu J, Xue X, Ricklin D, Lin Z, Sfyroera G, Tzekou A, Volokhina E, Granneman JC, Hauhart R, Bertram P, Liszewski MK, Atkinson JP, Lambris JD, Gros P.

EMBO J. 2016 May 17;35(10):1133-49. doi: 10.15252/embj.201593673. Epub 2016 Mar 24.


The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation.

Langlais D, Barreiro LB, Gros P.

J Exp Med. 2016 Apr 4;213(4):585-603. doi: 10.1084/jem.20151764. Epub 2016 Mar 21.


Mapping hyper-susceptibility to colitis-associated colorectal cancer in FVB/NJ mice.

Van Der Kraak L, Langlais D, Jothy S, Beauchemin N, Gros P.

Mamm Genome. 2016 Jun;27(5-6):213-24. doi: 10.1007/s00335-016-9625-z. Epub 2016 Mar 15.


Primary Immunodeficiencies and Inflammatory Disease: A Growing Genetic Intersection.

Fodil N, Langlais D, Gros P.

Trends Immunol. 2016 Feb;37(2):126-140. doi: 10.1016/ Epub 2016 Jan 12. Review.


Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance.

Belle JI, Petrov JC, Langlais D, Robert F, Cencic R, Shen S, Pelletier J, Gros P, Nijnik A.

Cell Death Differ. 2016 May;23(5):759-75. doi: 10.1038/cdd.2015.140. Epub 2016 Jan 15.

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