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Items: 41


Induced degradation of protein kinases by bifunctional small molecules: a next-generation strategy.

Groppe JC.

Expert Opin Drug Discov. 2019 Dec;14(12):1237-1253. doi: 10.1080/17460441.2019.1660641. Epub 2019 Sep 12. Review.


Hypoxia-selective allosteric destabilization of activin receptor-like kinases: A potential therapeutic avenue for prophylaxis of heterotopic ossification.

Lu G, Tandang-Silvas MR, Dawson AC, Dawson TJ, Groppe JC.

Bone. 2018 Jul;112:71-89. doi: 10.1016/j.bone.2018.03.027. Epub 2018 Apr 5.


Cellular Hypoxia Promotes Heterotopic Ossification by Amplifying BMP Signaling.

Wang H, Lindborg C, Lounev V, Kim JH, McCarrick-Walmsley R, Xu M, Mangiavini L, Groppe JC, Shore EM, Schipani E, Kaplan FS, Pignolo RJ.

J Bone Miner Res. 2016 Sep;31(9):1652-65. doi: 10.1002/jbmr.2848. Epub 2016 Apr 20.


Multi-system involvement in a severe variant of fibrodysplasia ossificans progressiva (ACVR1 c.772G>A; R258G): A report of two patients.

Kaplan FS, Kobori JA, Orellana C, Calvo I, Rosello M, Martinez F, Lopez B, Xu M, Pignolo RJ, Shore EM, Groppe JC.

Am J Med Genet A. 2015 Oct;167A(10):2265-71. doi: 10.1002/ajmg.a.37205. Epub 2015 Jun 11.


Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3.

Whitman M, Rosen V, Brivanlou AH, Groppe JC, Sebald W, Mueller T.

Nat Med. 2013 Jul;19(7):809-10. doi: 10.1038/nm.3080. No abstract available.


Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice.

Wang X, Wang S, Li C, Gao T, Liu Y, Rangiani A, Sun Y, Hao J, George A, Lu Y, Groppe J, Yuan B, Feng JQ, Qin C.

PLoS Genet. 2012;8(5):e1002708. doi: 10.1371/journal.pgen.1002708. Epub 2012 May 17.


Functional analysis of alleged NOGGIN mutation G92E disproves its pathogenic relevance.

Zimmer J, Doelken SC, Horn D, Groppe JC, Shore EM, Kaplan FS, Seemann P.

PLoS One. 2012;7(4):e35062. doi: 10.1371/journal.pone.0035062. Epub 2012 Apr 18.


Nucleotide polymorphisms in the canine Noggin gene and their distribution among dog (Canis lupus familiaris) breeds.

Ishii Y, Takizawa T, Iwasaki H, Fujita Y, Murakami M, Groppe JC, Tanaka K.

Biochem Genet. 2012 Feb;50(1-2):12-8. doi: 10.1007/s10528-011-9453-5. Epub 2011 Sep 1.


The TβR-I pre-helix extension is structurally ordered in the unbound form and its flanking prolines are essential for binding.

Zuniga JE, Ilangovan U, Mahlawat P, Hinck CS, Huang T, Groppe JC, McEwen DG, Hinck AP.

J Mol Biol. 2011 Sep 30;412(4):601-18. doi: 10.1016/j.jmb.2011.07.046. Epub 2011 Jul 29.


In vitro analyses of the dysregulated R206H ALK2 kinase-FKBP12 interaction associated with heterotopic ossification in FOP.

Groppe JC, Wu J, Shore EM, Kaplan FS.

Cells Tissues Organs. 2011;194(2-4):291-5. doi: 10.1159/000324230. Epub 2011 Apr 28.


Identification of a core domain within the proregion of bone morphogenetic proteins that interacts with the dimeric, mature domain.

Kuhfahl S, Hauburger A, Thieme T, Groppe J, Ihling C, Tomic S, Schutkowski M, Sinz A, Schwarz E.

Biochem Biophys Res Commun. 2011 May 6;408(2):300-5. doi: 10.1016/j.bbrc.2011.04.021. Epub 2011 Apr 9.


Mutations in GDF5 reveal a key residue mediating BMP inhibition by NOGGIN.

Seemann P, Brehm A, König J, Reissner C, Stricker S, Kuss P, Haupt J, Renninger S, Nickel J, Sebald W, Groppe JC, Plöger F, Pohl J, Schmidt-von Kegler M, Walther M, Gassner I, Rusu C, Janecke AR, Dathe K, Mundlos S.

PLoS Genet. 2009 Nov;5(11):e1000747. doi: 10.1371/journal.pgen.1000747. Epub 2009 Nov 26.


Intricacies of BMP receptor assembly.

Nickel J, Sebald W, Groppe JC, Mueller TD.

Cytokine Growth Factor Rev. 2009 Oct-Dec;20(5-6):367-77. doi: 10.1016/j.cytogfr.2009.10.022. Review.


Pathogenic mechanisms of tooth agenesis linked to paired domain mutations in human PAX9.

Wang Y, Groppe JC, Wu J, Ogawa T, Mues G, D'Souza RN, Kapadia H.

Hum Mol Genet. 2009 Aug 1;18(15):2863-74. doi: 10.1093/hmg/ddp221. Epub 2009 May 9.


Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1.

Kaplan FS, Xu M, Seemann P, Connor JM, Glaser DL, Carroll L, Delai P, Fastnacht-Urban E, Forman SJ, Gillessen-Kaesbach G, Hoover-Fong J, Köster B, Pauli RM, Reardon W, Zaidi SA, Zasloff M, Morhart R, Mundlos S, Groppe J, Shore EM.

Hum Mutat. 2009 Mar;30(3):379-90. doi: 10.1002/humu.20868.


Response to "Mutations of the NOGGIN and of the activin A type I receptor genes in fibrodysplasia ossificans progressiva (FOP)" by Lucotte et al.

Kaplan FS, Xu M, Feldman G, Brown M, Cho TJ, Choi IH, Connor JM, Delai PL, Economides AN, Glaser DL, Groppe J, Katagiri T, Le Merrer M, Morhart R, Ravazzolo R, Rogers JG, Smith R, Triffitt JT, Urtizberea JA, Zasloff M, Shore EM.

Genet Couns. 2008;19(3):357-9; author reply 361-3. No abstract available.


Skeletal metamorphosis in fibrodysplasia ossificans progressiva (FOP).

Kaplan FS, Shen Q, Lounev V, Seemann P, Groppe J, Katagiri T, Pignolo RJ, Shore EM.

J Bone Miner Metab. 2008;26(6):521-30. doi: 10.1007/s00774-008-0879-8. Epub 2008 Nov 1. Review.


Fibrodysplasia ossificans progressiva.

Kaplan FS, Le Merrer M, Glaser DL, Pignolo RJ, Goldsby RE, Kitterman JA, Groppe J, Shore EM.

Best Pract Res Clin Rheumatol. 2008 Mar;22(1):191-205. doi: 10.1016/j.berh.2007.11.007. Review.


Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding.

Groppe J, Hinck CS, Samavarchi-Tehrani P, Zubieta C, Schuermann JP, Taylor AB, Schwarz PM, Wrana JL, Hinck AP.

Mol Cell. 2008 Feb 1;29(2):157-68. doi: 10.1016/j.molcel.2007.11.039.


Morphogen receptor genes and metamorphogenes: skeleton keys to metamorphosis.

Kaplan FS, Groppe J, Pignolo RJ, Shore EM.

Ann N Y Acad Sci. 2007 Nov;1116:113-33. Epub 2007 Sep 13. Review.


Functional modeling of the ACVR1 (R206H) mutation in FOP.

Groppe JC, Shore EM, Kaplan FS.

Clin Orthop Relat Res. 2007 Sep;462:87-92.


Assembly of TbetaRI:TbetaRII:TGFbeta ternary complex in vitro with receptor extracellular domains is cooperative and isoform-dependent.

Zúñiga JE, Groppe JC, Cui Y, Hinck CS, Contreras-Shannon V, Pakhomova ON, Yang J, Tang Y, Mendoza V, López-Casillas F, Sun L, Hinck AP.

J Mol Biol. 2005 Dec 16;354(5):1052-68. Epub 2005 Oct 27.


Structure and dynamics of the homodimeric dynein light chain km23.

Ilangovan U, Ding W, Zhong Y, Wilson CL, Groppe JC, Trbovich JT, Zúñiga J, Demeler B, Tang Q, Gao G, Mulder KM, Hinck AP.

J Mol Biol. 2005 Sep 16;352(2):338-54.


Structural basis of BMP signaling inhibition by Noggin, a novel twelve-membered cystine knot protein.

Groppe J, Greenwald J, Wiater E, Rodriguez-Leon J, Economides AN, Kwiatkowski W, Baban K, Affolter M, Vale WW, Izpisua Belmonte JC, Choe S.

J Bone Joint Surg Am. 2003;85-A Suppl 3:52-8.


The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly.

Greenwald J, Groppe J, Gray P, Wiater E, Kwiatkowski W, Vale W, Choe S.

Mol Cell. 2003 Mar;11(3):605-17.


Structural basis of BMP signalling inhibition by the cystine knot protein Noggin.

Groppe J, Greenwald J, Wiater E, Rodriguez-Leon J, Economides AN, Kwiatkowski W, Affolter M, Vale WW, Izpisua Belmonte JC, Choe S.

Nature. 2002 Dec 12;420(6916):636-42.


The Fe-only nitrogenase from Rhodobacter capsulatus: identification of the cofactor, an unusual, high-nuclearity iron-sulfur cluster, by Fe K-edge EXAFS and 57Fe Mössbauer spectroscopy.

Krahn E, Weiss R, Kröckel M, Groppe J, Henkel G, Cramer P, Trautwein X, Schneider K, Müller A.

J Biol Inorg Chem. 2002 Jan;7(1-2):37-45. Epub 2001 Jul 4.


Expression, purification, and characterization of a soluble form of the first extracellular domain of the human type 1 corticotropin releasing factor receptor.

Perrin MH, Fischer WH, Kunitake KS, Craig AG, Koerber SC, Cervini LA, Rivier JE, Groppe JC, Greenwald J, Møller Nielsen S, Vale WW.

J Biol Chem. 2001 Aug 24;276(34):31528-34. Epub 2001 Jun 25.


Expression of the blistered/DSRF gene is controlled by different morphogens during Drosophila trachea and wing development.

Nussbaumer U, Halder G, Groppe J, Affolter M, Montagne J.

Mech Dev. 2000 Aug;96(1):27-36.


Biochemical and biophysical characterization of refolded Drosophila DPP, a homolog of bone morphogenetic proteins 2 and 4.

Groppe J, Rumpel K, Economides AN, Stahl N, Sebald W, Affolter M.

J Biol Chem. 1998 Oct 30;273(44):29052-65.


The Drosophila Serum Response Factor gene is required for the formation of intervein tissue of the wing and is allelic to blistered.

Montagne J, Groppe J, Guillemin K, Krasnow MA, Gehring WJ, Affolter M.

Development. 1996 Sep;122(9):2589-97.


The pruned gene encodes the Drosophila serum response factor and regulates cytoplasmic outgrowth during terminal branching of the tracheal system.

Guillemin K, Groppe J, Ducker K, Treisman R, Hafen E, Affolter M, Krasnow MA.

Development. 1996 May;122(5):1353-62.


The Drosophila SRF homolog is expressed in a subset of tracheal cells and maps within a genomic region required for tracheal development.

Affolter M, Montagne J, Walldorf U, Groppe J, Kloter U, LaRosa M, Gehring WJ.

Development. 1994 Apr;120(4):743-53.


Recent advances in atomic force microscopy of DNA.

Hansma HG, Sinsheimer RL, Groppe J, Bruice TC, Elings V, Gurley G, Bezanilla M, Mastrangelo IA, Hough PV, Hansma PK.

Scanning. 1993 Sep-Oct;15(5):296-9.


Molluscan chymotrypsin-like protease: structure, localization, and substrate specificity.

Groppe JC, Morse DE.

Arch Biochem Biophys. 1993 Aug 15;305(1):159-69.


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