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Items: 1 to 50 of 170

1.

Bioconjugation of Supramolecular Metallacages to Integrin Ligands for Targeted Delivery of Cisplatin.

Han J, Räder AFB, Reichart F, Aikman B, Wenzel MN, Woods B, Weinmüller M, Ludwig BS, Stürup S, Groothuis GMM, Permentier HP, Bischoff R, Kessler H, Horvatovich P, Casini A.

Bioconjug Chem. 2018 Nov 21;29(11):3856-3865. doi: 10.1021/acs.bioconjchem.8b00682. Epub 2018 Nov 13.

PMID:
30380298
2.

Human and rat precision-cut intestinal slices as ex vivo models to study bile acid uptake by the apical sodium-dependent bile acid transporter.

Li M, Vokral I, Evers B, de Graaf IAM, de Jager MH, Groothuis GMM.

Eur J Pharm Sci. 2018 May 9;121:65-73. doi: 10.1016/j.ejps.2018.05.005. [Epub ahead of print] No abstract available.

PMID:
29751102
3.

Targeting Oxidative Stress for the Treatment of Liver Fibrosis.

Luangmonkong T, Suriguga S, Mutsaers HAM, Groothuis GMM, Olinga P, Boersema M.

Rev Physiol Biochem Pharmacol. 2018;175:71-102. doi: 10.1007/112_2018_10.

PMID:
29728869
4.

Corrigendum to 'Development of a mechanistic biokinetic model for hepatic bile acid handling to predict possible cholestatic effects of drugs' [European Journal of Pharmaceutical Sciences 115 (2018) 175-184].

Notenboom S, Weigand KM, Proost JH, van Lipzig MM, van de Steeg E, van den Broek PHH, Greupink R, Russel FGM, Groothuis GMM.

Eur J Pharm Sci. 2018 May 30;117:392-393. doi: 10.1016/j.ejps.2018.04.005. No abstract available.

PMID:
29650218
5.

Cleavable Crosslinkers as Tissue Fixation Reagents for Proteomic Analysis.

Ongay S, Langelaar-Makkinje M, Stoop MP, Liu N, Overkleeft H, Luider TM, Groothuis GMM, Bischoff R.

Chembiochem. 2018 Apr 4;19(7):736-743. doi: 10.1002/cbic.201700625. Epub 2018 Feb 16.

PMID:
29356267
6.

Development of a mechanistic biokinetic model for hepatic bile acid handling to predict possible cholestatic effects of drugs.

Notenboom S, Weigand KM, Proost JH, van Lipzig MMH, van de Steeg E, van den Broek PHH, Greupink R, Russel FGM, Groothuis GMM.

Eur J Pharm Sci. 2018 Mar 30;115:175-184. doi: 10.1016/j.ejps.2018.01.007. Epub 2018 Jan 5. Erratum in: Eur J Pharm Sci. 2018 May 30;117:392-393.

7.

Alterations in gene expression in vitamin D-deficiency: Down-regulation of liver Cyp7a1 and renal Oat3 in mice.

Quach HP, Noh K, Hoi SY, Bruinsma A, Groothuis GMM, Li AP, Chow ECY, Pang KS.

Biopharm Drug Dispos. 2018 Feb;39(2):99-115. doi: 10.1002/bdd.2118. Epub 2018 Jan 30.

PMID:
29243851
8.

On the toxicity and transport mechanisms of cisplatin in kidney tissues in comparison to a gold-based cytotoxic agent.

Spreckelmeyer S, Estrada-Ortiz N, Prins GGH, van der Zee M, Gammelgaard B, Stürup S, de Graaf IAM, Groothuis GMM, Casini A.

Metallomics. 2017 Dec 1;9(12):1786-1795. doi: 10.1039/c7mt00271h. Epub 2017 Nov 6.

PMID:
29104982
9.

Anticancer Gold N-Heterocyclic Carbene Complexes: A Comparative in vitro and ex vivo Study.

Estrada-Ortiz N, Guarra F, de Graaf IAM, Marchetti L, de Jager MH, Groothuis GMM, Gabbiani C, Casini A.

ChemMedChem. 2017 Sep 7;12(17):1429-1435. doi: 10.1002/cmdc.201700316. Epub 2017 Aug 29.

PMID:
28741878
10.

Rat precision-cut liver slices predict drug-induced cholestatic injury.

Starokozhko V, Greupink R, van de Broek P, Soliman N, Ghimire S, de Graaf IAM, Groothuis GMM.

Arch Toxicol. 2017 Oct;91(10):3403-3413. doi: 10.1007/s00204-017-1960-7. Epub 2017 Apr 8.

11.

Bioconjugation strategies to couple supramolecular exo-functionalized palladium cages to peptides for biomedical applications.

Han J, Schmidt A, Zhang T, Permentier H, Groothuis GM, Bischoff R, Kühn FE, Horvatovich P, Casini A.

Chem Commun (Camb). 2017 Jan 24;53(8):1405-1408. doi: 10.1039/c6cc08937b.

PMID:
28079225
12.

Challenges on the road to a multicellular bioartificial liver.

Starokozhko V, Groothuis GMM.

J Tissue Eng Regen Med. 2018 Jan;12(1):e227-e236. doi: 10.1002/term.2385. Epub 2017 May 31. Review.

PMID:
27943623
13.

The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo.

Li M, de Graaf IA, van de Steeg E, de Jager MH, Groothuis GM.

Toxicol In Vitro. 2017 Apr;40:26-33. doi: 10.1016/j.tiv.2016.12.002. Epub 2016 Dec 7.

PMID:
27939799
14.

Erratum to: Maintenance of drug metabolism and transport functions in human precision-cut liver slices during prolonged incubation for 5 days.

Starokozhko V, Vatakuti S, Schievink B, Merema MT, Asplund A, Synnergren J, Aspegren A, Groothuis GMM.

Arch Toxicol. 2017 Jul;91(7):2711. doi: 10.1007/s00204-016-1895-4. No abstract available.

PMID:
27900403
15.

P-gp activity and inhibition in the different regions of human intestine ex vivo.

Li M, de Graaf IA, de Jager MH, Groothuis GM.

Biopharm Drug Dispos. 2017 Mar;38(2):127-138. doi: 10.1002/bdd.2047. Epub 2016 Nov 14.

PMID:
27757966
16.

Judging the value of 'liver-on-a-chip' devices for prediction of toxicity.

Starokozhko V, Groothuis GM.

Expert Opin Drug Metab Toxicol. 2017 Feb;13(2):125-128. doi: 10.1080/17425255.2017.1246537. Epub 2016 Oct 18. No abstract available.

PMID:
27724053
17.

Maintenance of drug metabolism and transport functions in human precision-cut liver slices during prolonged incubation for 5 days.

Starokozhko V, Vatakuti S, Schievink B, Merema MT, Asplund A, Synnergren J, Aspegren A, Groothuis GMM.

Arch Toxicol. 2017 May;91(5):2079-2092. doi: 10.1007/s00204-016-1865-x. Epub 2016 Oct 7. Erratum in: Arch Toxicol. 2017 Jul;91(7):2711.

18.

Validation of precision-cut liver slices to study drug-induced cholestasis: a transcriptomics approach.

Vatakuti S, Olinga P, Pennings JLA, Groothuis GMM.

Arch Toxicol. 2017 Mar;91(3):1401-1412. doi: 10.1007/s00204-016-1778-8. Epub 2016 Jun 25.

19.

Human precision-cut liver slices as a model to test antifibrotic drugs in the early onset of liver fibrosis.

Westra IM, Mutsaers HA, Luangmonkong T, Hadi M, Oosterhuis D, de Jong KP, Groothuis GM, Olinga P.

Toxicol In Vitro. 2016 Sep;35:77-85. doi: 10.1016/j.tiv.2016.05.012. Epub 2016 May 26.

PMID:
27235791
20.

Erratum to: Translational Modeling in Schizophrenia: Predicting Human Dopamine D₂ Receptor Occupancy.

Johnson M, Kozielska M, Pilla Reddy V, Vermeulen A, Barton HA, Grimwood S, de Greef R, Groothuis GM, Danhof M, Proost JH.

Pharm Res. 2016 May;33(5):1305-6. doi: 10.1007/s11095-016-1888-2. Epub 2016 Mar 10. No abstract available.

21.

The Consequence of Drug-Drug Interactions Influencing the Interplay between P-Glycoprotein and Cytochrome P450 3a: An Ex Vivo Study with Rat Precision-Cut Intestinal Slices.

Li M, de Graaf IA, Siissalo S, de Jager MH, van Dam A, Groothuis GM.

Drug Metab Dispos. 2016 May;44(5):683-91. doi: 10.1124/dmd.115.068684. Epub 2016 Mar 1.

22.

Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices.

Vatakuti S, Pennings JL, Gore E, Olinga P, Groothuis GM.

Chem Res Toxicol. 2016 Mar 21;29(3):342-51. doi: 10.1021/acs.chemrestox.5b00491. Epub 2016 Mar 9.

PMID:
26881866
23.

Precision-cut intestinal slices: alternative model for drug transport, metabolism, and toxicology research.

Li M, de Graaf IA, Groothuis GM.

Expert Opin Drug Metab Toxicol. 2016;12(2):175-90. doi: 10.1517/17425255.2016.1125882. Epub 2016 Jan 9. Review.

PMID:
26750630
24.

Translational Modeling in Schizophrenia: Predicting Human Dopamine D2 Receptor Occupancy.

Johnson M, Kozielska M, Pilla Reddy V, Vermeulen A, Barton HA, Grimwood S, de Greef R, Groothuis GM, Danhof M, Proost JH.

Pharm Res. 2016 Apr;33(4):1003-17. doi: 10.1007/s11095-015-1846-4. Epub 2015 Dec 30. Erratum in: Pharm Res. 2016 May;33(5):1305-6.

PMID:
26718955
25.

Viability, function and morphological integrity of precision-cut liver slices during prolonged incubation: Effects of culture medium.

Starokozhko V, Abza GB, Maessen HC, Merema MT, Kuper F, Groothuis GM.

Toxicol In Vitro. 2015 Dec 25;30(1 Pt B):288-99. doi: 10.1016/j.tiv.2015.10.008. Epub 2015 Oct 26.

PMID:
26514934
26.

Rat precision-cut intestinal slices to study P-gp activity and the potency of its inhibitors ex vivo.

Li M, de Graaf IA, de Jager MH, Groothuis GM.

Toxicol In Vitro. 2015 Aug;29(5):1070-8. doi: 10.1016/j.tiv.2015.04.011. Epub 2015 Apr 25.

PMID:
25917215
27.

Acute toxicity of CCl4 but not of paracetamol induces a transcriptomic signature of fibrosis in precision-cut liver slices.

Vatakuti S, Schoonen WG, Elferink ML, Groothuis GM, Olinga P.

Toxicol In Vitro. 2015 Aug;29(5):1012-20. doi: 10.1016/j.tiv.2015.03.015. Epub 2015 Apr 6.

PMID:
25858767
28.

Influence of inflammation on voriconazole metabolism.

Encalada Ventura MA, Span LF, van den Heuvel ER, Groothuis GM, Alffenaar JW.

Antimicrob Agents Chemother. 2015 May;59(5):2942-3. doi: 10.1128/AAC.04789-14. Epub 2015 Mar 2.

29.

Improved synthesis of N-benzylaminoferrocene-based prodrugs and evaluation of their toxicity and antileukemic activity.

Daum S, Chekhun VF, Todor IN, Lukianova NY, Shvets YV, Sellner L, Putzker K, Lewis J, Zenz T, de Graaf IA, Groothuis GM, Casini A, Zozulia O, Hampel F, Mokhir A.

J Med Chem. 2015 Feb 26;58(4):2015-24. doi: 10.1021/jm5019548. Epub 2015 Feb 9.

PMID:
25633601
30.

Consequences of Mrp2 deficiency for diclofenac toxicity in the rat intestine ex vivo.

Niu X, de Graaf IA, van de Vegte D, Langelaar-Makkinje M, Sekine S, Groothuis GM.

Toxicol In Vitro. 2015 Feb;29(1):168-75.

PMID:
25450747
31.

Precision cut intestinal slices are an appropriate ex vivo model to study NSAID-induced intestinal toxicity in rats.

Niu X, de Graaf IA, van der Bij HA, Groothuis GM.

Toxicol In Vitro. 2014 Oct;28(7):1296-305. doi: 10.1016/j.tiv.2014.06.010. Epub 2014 Jul 8.

PMID:
25014874
32.

Dopamine D2 receptor occupancy as a predictor of catalepsy in rats: a pharmacokinetic-pharmacodynamic modeling approach.

Johnson M, Kozielska M, Pilla Reddy V, Vermeulen A, Barton HA, Grimwood S, de Greef R, Groothuis GM, Danhof M, Proost JH.

Pharm Res. 2014 Oct;31(10):2605-17. doi: 10.1007/s11095-014-1358-7. Epub 2014 May 3.

PMID:
24792824
33.

Diclofenac toxicity in human intestine ex vivo is not related to the formation of intestinal metabolites.

Niu X, de Graaf IA, Langelaar-Makkinje M, Horvatovich P, Groothuis GM.

Arch Toxicol. 2015 Jan;89(1):107-19. doi: 10.1007/s00204-014-1242-6. Epub 2014 Apr 26.

PMID:
24770551
34.

The effect of antifibrotic drugs in rat precision-cut fibrotic liver slices.

Westra IM, Oosterhuis D, Groothuis GM, Olinga P.

PLoS One. 2014 Apr 22;9(4):e95462. doi: 10.1371/journal.pone.0095462. eCollection 2014.

35.

Caffeine-based gold(I) N-heterocyclic carbenes as possible anticancer agents: synthesis and biological properties.

Bertrand B, Stefan L, Pirrotta M, Monchaud D, Bodio E, Richard P, Le Gendre P, Warmerdam E, de Jager MH, Groothuis GM, Picquet M, Casini A.

Inorg Chem. 2014 Feb 17;53(4):2296-303. doi: 10.1021/ic403011h. Epub 2014 Feb 5.

PMID:
24499428
36.

Precision-cut liver slices as a model for the early onset of liver fibrosis to test antifibrotic drugs.

Westra IM, Oosterhuis D, Groothuis GM, Olinga P.

Toxicol Appl Pharmacol. 2014 Jan 15;274(2):328-38. doi: 10.1016/j.taap.2013.11.017. Epub 2013 Dec 7.

PMID:
24321339
37.

Nutlin-3 preferentially sensitises wild-type p53-expressing cancer cells to DR5-selective TRAIL over rhTRAIL.

Meijer A, Kruyt FA, van der Zee AG, Hollema H, Le P, ten Hoor KA, Groothuis GM, Quax WJ, de Vries EG, de Jong S.

Br J Cancer. 2013 Nov 12;109(10):2685-95. doi: 10.1038/bjc.2013.636. Epub 2013 Oct 17.

38.

Population pharmacokinetic-pharmacodynamic modeling of haloperidol in patients with schizophrenia using positive and negative syndrome rating scale.

Pilla Reddy V, Kozielska M, Johnson M, Mafirakureva N, Vermeulen A, Liu J, de Greef R, Rujescu D, Groothuis GM, Danhof M, Proost JH.

J Clin Psychopharmacol. 2013 Dec;33(6):731-9. doi: 10.1097/JCP.0b013e3182a4ee2c.

PMID:
24113674
39.

Proteomic profiling in incubation medium of mouse, rat and human precision-cut liver slices for biomarker detection regarding acute drug-induced liver injury.

van Swelm RP, Hadi M, Laarakkers CM, Masereeuw R, Groothuis GM, Russel FG.

J Appl Toxicol. 2014 Sep;34(9):993-1001. doi: 10.1002/jat.2917. Epub 2013 Aug 30.

PMID:
24038040
40.

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

Godoy P, Hewitt NJ, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, Bode JG, Bolleyn J, Borner C, Böttger J, Braeuning A, Budinsky RA, Burkhardt B, Cameron NR, Camussi G, Cho CS, Choi YJ, Craig Rowlands J, Dahmen U, Damm G, Dirsch O, Donato MT, Dong J, Dooley S, Drasdo D, Eakins R, Ferreira KS, Fonsato V, Fraczek J, Gebhardt R, Gibson A, Glanemann M, Goldring CE, Gómez-Lechón MJ, Groothuis GM, Gustavsson L, Guyot C, Hallifax D, Hammad S, Hayward A, Häussinger D, Hellerbrand C, Hewitt P, Hoehme S, Holzhütter HG, Houston JB, Hrach J, Ito K, Jaeschke H, Keitel V, Kelm JM, Kevin Park B, Kordes C, Kullak-Ublick GA, LeCluyse EL, Lu P, Luebke-Wheeler J, Lutz A, Maltman DJ, Matz-Soja M, McMullen P, Merfort I, Messner S, Meyer C, Mwinyi J, Naisbitt DJ, Nussler AK, Olinga P, Pampaloni F, Pi J, Pluta L, Przyborski SA, Ramachandran A, Rogiers V, Rowe C, Schelcher C, Schmich K, Schwarz M, Singh B, Stelzer EH, Stieger B, Stöber R, Sugiyama Y, Tetta C, Thasler WE, Vanhaecke T, Vinken M, Weiss TS, Widera A, Woods CG, Xu JJ, Yarborough KM, Hengstler JG.

Arch Toxicol. 2013 Aug;87(8):1315-530. doi: 10.1007/s00204-013-1078-5. Epub 2013 Aug 23. Review.

41.

Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices.

Oenema TA, Maarsingh H, Smit M, Groothuis GM, Meurs H, Gosens R.

PLoS One. 2013 Jun 26;8(6):e65580. doi: 10.1371/journal.pone.0065580. Print 2013.

42.

Nanoparticle formulation of a poorly soluble cannabinoid receptor 1 antagonist improves absorption by rat and human intestine.

Siissalo S, de Waard H, de Jager MH, Hayeshi R, Frijlink HW, Hinrichs WL, Dinter-Heidorn H, van Dam A, Proost JH, Groothuis GM, de Graaf IA.

Drug Metab Dispos. 2013 Aug;41(8):1557-65. doi: 10.1124/dmd.112.049585. Epub 2013 Jun 3.

43.

Human precision-cut liver slices as an ex vivo model to study idiosyncratic drug-induced liver injury.

Hadi M, Westra IM, Starokozhko V, Dragovic S, Merema MT, Groothuis GM.

Chem Res Toxicol. 2013 May 20;26(5):710-20. doi: 10.1021/tx300519p. Epub 2013 Apr 19.

PMID:
23565644
44.

Pharmacokinetic-pharmacodynamic modelling of antipsychotic drugs in patients with schizophrenia: part II: the use of subscales of the PANSS score.

Pilla Reddy V, Kozielska M, Suleiman AA, Johnson M, Vermeulen A, Liu J, de Greef R, Groothuis GM, Danhof M, Proost JH.

Schizophr Res. 2013 May;146(1-3):153-61. doi: 10.1016/j.schres.2013.02.010. Epub 2013 Mar 6.

45.

Pharmacokinetic-pharmacodynamic modeling of antipsychotic drugs in patients with schizophrenia Part I: the use of PANSS total score and clinical utility.

Pilla Reddy V, Kozielska M, Suleiman AA, Johnson M, Vermeulen A, Liu J, de Greef R, Groothuis GM, Danhof M, Proost JH.

Schizophr Res. 2013 May;146(1-3):144-52. doi: 10.1016/j.schres.2013.02.011. Epub 2013 Mar 6.

46.

Bilitranslocase is involved in the uptake of bromosulfophthalein in rat and human liver.

Terdoslavich M, de Graaf IA, Proost JH, Cocolo A, Passamonti S, Groothuis GM.

Drug Metab Lett. 2012 Sep 1;6(3):165-73.

PMID:
23470127
47.

Sensitivity of individual items of the Positive and Negative Syndrome Scale (PANSS) and items subgroups to differentiate between placebo and drug treatment in schizophrenia.

Kozielska M, Pilla Reddy V, Johnson M, de Ridder F, Vermeulen A, Liu J, Groothuis GM, Danhof M, Proost JH.

Schizophr Res. 2013 May;146(1-3):53-8. doi: 10.1016/j.schres.2013.01.022. Epub 2013 Feb 20.

PMID:
23434198
48.

Analysis of gene expression changes to elucidate the mechanism of chilling injury in precision-cut liver slices.

Guan N, Blomsma SA, Fahy GM, Groothuis GM, de Graaf IA.

Toxicol In Vitro. 2013 Mar;27(2):890-9. doi: 10.1016/j.tiv.2012.10.009. Epub 2012 Oct 27.

PMID:
23111282
49.

Evaluation of the intestinal toxicity and transport of xenobiotics utilizing precision-cut slices.

Niu X, de Graaf IA, Groothuis GM.

Xenobiotica. 2013 Jan;43(1):73-83. doi: 10.3109/00498254.2012.729870. Epub 2012 Oct 30. Review.

PMID:
23106567
50.

Cryopreservation of precision-cut tissue slices.

Fahy GM, Guan N, de Graaf IA, Tan Y, Griffin L, Groothuis GM.

Xenobiotica. 2013 Jan;43(1):113-32. doi: 10.3109/00498254.2012.728300. Epub 2012 Oct 30. Review.

PMID:
23106534

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