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Items: 1 to 50 of 158

1.

Repair of exogenous DNA double-strand breaks promotes chromosome synapsis in SPO11-mutant mouse meiocytes, and is altered in the absence of HORMAD1.

Carofiglio F, Sleddens-Linkels E, Wassenaar E, Inagaki A, van Cappellen WA, Grootegoed JA, Toth A, Baarends WM.

DNA Repair (Amst). 2018 Mar;63:25-38. doi: 10.1016/j.dnarep.2018.01.007. Epub 2018 Jan 31.

2.

Round Spermatid Injection Rescues Female Lethality of a Paternally Inherited Xist Deletion in Mouse.

Federici F, Magaraki A, Wassenaar E, van Veen-Buurman CJ, van de Werken C, Baart EB, Laven JS, Grootegoed JA, Gribnau J, Baarends WM.

PLoS Genet. 2016 Oct 7;12(10):e1006358. doi: 10.1371/journal.pgen.1006358. eCollection 2016 Oct.

3.

Xist and Tsix Transcription Dynamics Is Regulated by the X-to-Autosome Ratio and Semistable Transcriptional States.

Loos F, Maduro C, Loda A, Lehmann J, Kremers GJ, Ten Berge D, Grootegoed JA, Gribnau J.

Mol Cell Biol. 2016 Oct 13;36(21):2656-2667. doi: 10.1128/MCB.00183-16. Print 2016 Nov 1.

4.

Genomes of Ellobius species provide insight into the evolutionary dynamics of mammalian sex chromosomes.

Mulugeta E, Wassenaar E, Sleddens-Linkels E, van IJcken WF, Heard E, Grootegoed JA, Just W, Gribnau J, Baarends WM.

Genome Res. 2016 Sep;26(9):1202-10. doi: 10.1101/gr.201665.115. Epub 2016 Aug 10.

5.

Chromatin-Mediated Reversible Silencing of Sense-Antisense Gene Pairs in Embryonic Stem Cells Is Consolidated upon Differentiation.

Loos F, Loda A, van Wijk L, Grootegoed JA, Gribnau J.

Mol Cell Biol. 2015 Jul;35(14):2436-47. doi: 10.1128/MCB.00029-15. Epub 2015 May 11.

6.

Incomplete meiotic sex chromosome inactivation in the domestic dog.

Federici F, Mulugeta E, Schoenmakers S, Wassenaar E, Hoogerbrugge JW, van der Heijden GW, van Cappellen WA, Slotman JA, van IJcken WF, Laven JS, Grootegoed JA, Baarends WM.

BMC Genomics. 2015 Apr 12;16:291. doi: 10.1186/s12864-015-1501-9.

7.

Stable X chromosome reactivation in female human induced pluripotent stem cells.

Barakat TS, Ghazvini M, de Hoon B, Li T, Eussen B, Douben H, van der Linden R, van der Stap N, Boter M, Laven JS, Galjaard RJ, Grootegoed JA, de Klein A, Gribnau J.

Stem Cell Reports. 2015 Feb 10;4(2):199-208. doi: 10.1016/j.stemcr.2014.12.012. Epub 2015 Jan 29.

8.

The trans-activator RNF12 and cis-acting elements effectuate X chromosome inactivation independent of X-pairing.

Barakat TS, Loos F, van Staveren S, Myronova E, Ghazvini M, Grootegoed JA, Gribnau J.

Mol Cell. 2014 Mar 20;53(6):965-78. doi: 10.1016/j.molcel.2014.02.006. Epub 2014 Mar 6.

9.

SPO11-independent DNA repair foci and their role in meiotic silencing.

Carofiglio F, Inagaki A, de Vries S, Wassenaar E, Schoenmakers S, Vermeulen C, van Cappellen WA, Sleddens-Linkels E, Grootegoed JA, Te Riele HP, de Massy B, Baarends WM.

PLoS Genet. 2013 Jun;9(6):e1003538. doi: 10.1371/journal.pgen.1003538. Epub 2013 Jun 6.

10.

Evolution of testis-specific kinases TSSK1B and TSSK2 in primates.

Shang P, Hoogerbrugge J, Baarends WM, Grootegoed JA.

Andrology. 2013 Jan;1(1):160-8. doi: 10.1111/j.2047-2927.2012.00021.x. Epub 2012 Oct 23.

11.

Identification of quiescent, stem-like cells in the distal female reproductive tract.

Wang Y, Sacchetti A, van Dijk MR, van der Zee M, van der Horst PH, Joosten R, Burger CW, Grootegoed JA, Blok LJ, Fodde R.

PLoS One. 2012;7(7):e40691. doi: 10.1371/journal.pone.0040691. Epub 2012 Jul 24.

12.

The male germ cell gene regulator CTCFL is functionally different from CTCF and binds CTCF-like consensus sites in a nucleosome composition-dependent manner.

Sleutels F, Soochit W, Bartkuhn M, Heath H, Dienstbach S, Bergmaier P, Franke V, Rosa-Garrido M, van de Nobelen S, Caesar L, van der Reijden M, Bryne JC, van Ijcken W, Grootegoed JA, Delgado MD, Lenhard B, Renkawitz R, Grosveld F, Galjart N.

Epigenetics Chromatin. 2012 Jun 18;5(1):8. doi: 10.1186/1756-8935-5-8.

13.

RNF12 initiates X-chromosome inactivation by targeting REX1 for degradation.

Gontan C, Achame EM, Demmers J, Barakat TS, Rentmeester E, van IJcken W, Grootegoed JA, Gribnau J.

Nature. 2012 Apr 29;485(7398):386-90. doi: 10.1038/nature11070.

PMID:
22596162
14.

Origin and evolution of X chromosome inactivation.

Gribnau J, Grootegoed JA.

Curr Opin Cell Biol. 2012 Jun;24(3):397-404. doi: 10.1016/j.ceb.2012.02.004. Epub 2012 Mar 14. Review.

PMID:
22425180
15.

Human RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaks.

Inagaki A, Sleddens-Linkels E, van Cappellen WA, Hibbert RG, Sixma TK, Hoeijmakers JH, Grootegoed JA, Baarends WM.

PLoS One. 2011;6(8):e23155. doi: 10.1371/journal.pone.0023155. Epub 2011 Aug 17.

16.

Meiotic functions of RAD18.

Inagaki A, Sleddens-Linkels E, Wassenaar E, Ooms M, van Cappellen WA, Hoeijmakers JH, Seibler J, Vogt TF, Shin MK, Grootegoed JA, Baarends WM.

J Cell Sci. 2011 Aug 15;124(Pt 16):2837-50. doi: 10.1242/jcs.081968.

17.

Precise BAC targeting of genetically polymorphic mouse ES cells.

Barakat TS, Rentmeester E, Sleutels F, Grootegoed JA, Gribnau J.

Nucleic Acids Res. 2011 Oct;39(18):e121. doi: 10.1093/nar/gkr550. Epub 2011 Jul 7.

18.

Sex and gender issues in competitive sports: investigation of a historical case leads to a new viewpoint.

Ballantyne KN, Kayser M, Grootegoed JA.

Br J Sports Med. 2012 Jun;46(8):614-7. doi: 10.1136/bjsm.2010.082552. Epub 2011 May 3.

19.

RNF12 activates Xist and is essential for X chromosome inactivation.

Barakat TS, Gunhanlar N, Pardo CG, Achame EM, Ghazvini M, Boers R, Kenter A, Rentmeester E, Grootegoed JA, Gribnau J.

PLoS Genet. 2011 Jan 27;7(1):e1002001. doi: 10.1371/journal.pgen.1002001.

20.

Evaluating the relationship between spermatogenic silencing of the X chromosome and evolution of the Y chromosome in chimpanzee and human.

Mulugeta Achame E, Baarends WM, Gribnau J, Grootegoed JA.

PLoS One. 2010 Dec 14;5(12):e15598. doi: 10.1371/journal.pone.0015598.

21.

The ubiquitin-conjugating enzyme HR6B is required for maintenance of X chromosome silencing in mouse spermatocytes and spermatids.

Mulugeta Achame E, Wassenaar E, Hoogerbrugge JW, Sleddens-Linkels E, Ooms M, Sun ZW, van IJcken WF, Grootegoed JA, Baarends WM.

BMC Genomics. 2010 Jun 10;11:367. doi: 10.1186/1471-2164-11-367.

22.

Meiotic silencing and fragmentation of the male germline restricted chromosome in zebra finch.

Schoenmakers S, Wassenaar E, Laven JS, Grootegoed JA, Baarends WM.

Chromosoma. 2010 Jun;119(3):311-24. doi: 10.1007/s00412-010-0258-9. Epub 2010 Feb 17.

23.

Functional transformation of the chromatoid body in mouse spermatids requires testis-specific serine/threonine kinases.

Shang P, Baarends WM, Hoogerbrugge J, Ooms MP, van Cappellen WA, de Jong AA, Dohle GR, van Eenennaam H, Gossen JA, Grootegoed JA.

J Cell Sci. 2010 Feb 1;123(Pt 3):331-9. doi: 10.1242/jcs.059949. Epub 2010 Jan 5.

24.

RNF12 is an X-Encoded dose-dependent activator of X chromosome inactivation.

Jonkers I, Barakat TS, Achame EM, Monkhorst K, Kenter A, Rentmeester E, Grosveld F, Grootegoed JA, Gribnau J.

Cell. 2009 Nov 25;139(5):999-1011. doi: 10.1016/j.cell.2009.10.034.

25.

Progesterone inhibition of Wnt/beta-catenin signaling in normal endometrium and endometrial cancer.

Wang Y, Hanifi-Moghaddam P, Hanekamp EE, Kloosterboer HJ, Franken P, Veldscholte J, van Doorn HC, Ewing PC, Kim JJ, Grootegoed JA, Burger CW, Fodde R, Blok LJ.

Clin Cancer Res. 2009 Sep 15;15(18):5784-93. doi: 10.1158/1078-0432.CCR-09-0814. Epub 2009 Sep 8.

26.

Female meiotic sex chromosome inactivation in chicken.

Schoenmakers S, Wassenaar E, Hoogerbrugge JW, Laven JS, Grootegoed JA, Baarends WM.

PLoS Genet. 2009 May;5(5):e1000466. doi: 10.1371/journal.pgen.1000466. Epub 2009 May 22.

27.

The probability to initiate X chromosome inactivation is determined by the X to autosomal ratio and X chromosome specific allelic properties.

Monkhorst K, de Hoon B, Jonkers I, Mulugeta Achame E, Monkhorst W, Hoogerbrugge J, Rentmeester E, Westerhoff HV, Grosveld F, Grootegoed JA, Gribnau J.

PLoS One. 2009;4(5):e5616. doi: 10.1371/journal.pone.0005616. Epub 2009 May 19.

28.

DNA dependent recruitment of DDX17 and other interacting proteins by the human androgen receptor.

Wong HY, Demmers JA, Bezstarosti K, Grootegoed JA, Brinkmann AO.

Biochim Biophys Acta. 2009 Feb;1794(2):193-8. doi: 10.1016/j.bbapap.2008.11.001. Epub 2008 Nov 14.

PMID:
19059367
29.

Dynamic localization of human RAD18 during the cell cycle and a functional connection with DNA double-strand break repair.

Inagaki A, van Cappellen WA, van der Laan R, Houtsmuller AB, Hoeijmakers JH, Grootegoed JA, Baarends WM.

DNA Repair (Amst). 2009 Feb 1;8(2):190-201. doi: 10.1016/j.dnarep.2008.10.008. Epub 2008 Dec 2.

PMID:
19013543
30.

A novel mutation F826L in the human androgen receptor in partial androgen insensitivity syndrome; increased NH2-/COOH-terminal domain interaction and TIF2 co-activation.

Wong HY, Hoogerbrugge JW, Pang KL, van Leeuwen M, van Royen ME, Molier M, Berrevoets CA, Dooijes D, Dubbink HJ, van de Wijngaart DJ, Wolffenbuttel KP, Trapman J, Kleijer WJ, Drop SL, Grootegoed JA, Brinkmann AO.

Mol Cell Endocrinol. 2008 Sep 24;292(1-2):69-78. doi: 10.1016/j.mce.2008.06.016. Epub 2008 Jul 5.

PMID:
18656523
31.

Xist RNA is confined to the nuclear territory of the silenced X chromosome throughout the cell cycle.

Jonkers I, Monkhorst K, Rentmeester E, Grootegoed JA, Grosveld F, Gribnau J.

Mol Cell Biol. 2008 Sep;28(18):5583-94. doi: 10.1128/MCB.02269-07. Epub 2008 Jul 14.

32.

Increased frequency of asynapsis and associated meiotic silencing of heterologous chromatin in the presence of irradiation-induced extra DNA double strand breaks.

Schoenmakers S, Wassenaar E, van Cappellen WA, Derijck AA, de Boer P, Laven JS, Grootegoed JA, Baarends WM.

Dev Biol. 2008 May 1;317(1):270-81. doi: 10.1016/j.ydbio.2008.02.027. Epub 2008 Mar 4.

33.

Increased phosphorylation and dimethylation of XY body histones in the Hr6b-knockout mouse is associated with derepression of the X chromosome.

Baarends WM, Wassenaar E, Hoogerbrugge JW, Schoenmakers S, Sun ZW, Grootegoed JA.

J Cell Sci. 2007 Jun 1;120(Pt 11):1841-51. Epub 2007 May 8.

34.

Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis.

Wesoly J, Agarwal S, Sigurdsson S, Bussen W, Van Komen S, Qin J, van Steeg H, van Benthem J, Wassenaar E, Baarends WM, Ghazvini M, Tafel AA, Heath H, Galjart N, Essers J, Grootegoed JA, Arnheim N, Bezzubova O, Buerstedde JM, Sung P, Kanaar R.

Mol Cell Biol. 2006 Feb;26(3):976-89.

35.

The microtubule plus-end-tracking protein CLIP-170 associates with the spermatid manchette and is essential for spermatogenesis.

Akhmanova A, Mausset-Bonnefont AL, van Cappellen W, Keijzer N, Hoogenraad CC, Stepanova T, Drabek K, van der Wees J, Mommaas M, Onderwater J, van der Meulen H, Tanenbaum ME, Medema RH, Hoogerbrugge J, Vreeburg J, Uringa EJ, Grootegoed JA, Grosveld F, Galjart N.

Genes Dev. 2005 Oct 15;19(20):2501-15.

36.

Hedgehog signaling in mouse ovary: Indian hedgehog and desert hedgehog from granulosa cells induce target gene expression in developing theca cells.

Wijgerde M, Ooms M, Hoogerbrugge JW, Grootegoed JA.

Endocrinology. 2005 Aug;146(8):3558-66. Epub 2005 May 5.

PMID:
15878962
37.

Progesterone-induced inhibition of growth and differential regulation of gene expression in PRA- and/or PRB-expressing endometrial cancer cell lines.

Smid-Koopman E, Kuhne LC, Hanekamp EE, Gielen SC, De Ruiter PE, Grootegoed JA, Helmerhorst TJ, Burger CW, Brinkmann AO, Huikeshoven FJ, Blok LJ.

J Soc Gynecol Investig. 2005 May;12(4):285-92.

PMID:
15866122
38.

Differences in invasive capacity of endometrial cancer cell lines expressing different progesterone receptor isotypes: possible involvement of cadherins.

Hanekamp EE, Gielen SC, De Ruiter PE, Chadha-Ajwani S, Huikeshoven FJ, Burger CW, Grootegoed JA, Blok LJ.

J Soc Gynecol Investig. 2005 May;12(4):278-84.

PMID:
15866121
39.

Expression profiling of androgen-dependent and -independent LNCaP cells: EGF versus androgen signalling.

Oosterhoff JK, Grootegoed JA, Blok LJ.

Endocr Relat Cancer. 2005 Mar;12(1):135-48.

PMID:
15788645
40.

Expression and possible functions of DNA lesion bypass proteins in spermatogenesis.

Laan R, Baarends WM, Wassenaar E, Roest HP, Hoeijmakers JH, Grootegoed JA.

Int J Androl. 2005 Feb;28(1):1-15. Review.

PMID:
15679615
41.

Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis.

Baarends WM, Wassenaar E, van der Laan R, Hoogerbrugge J, Sleddens-Linkels E, Hoeijmakers JH, de Boer P, Grootegoed JA.

Mol Cell Biol. 2005 Feb;25(3):1041-53.

42.

Progesterone receptor A and B expression and progestagen treatment in growth and spread of endometrial cancer cells in nude mice.

Hanekamp EE, Kühne LM, Grootegoed JA, Burger CW, Blok LJ.

Endocr Relat Cancer. 2004 Dec;11(4):831-41.

PMID:
15613456
43.

Basic helix-loop-helix transcription factor Tcfl5 interacts with the Calmegin gene promoter in mouse spermatogenesis.

Siep M, Sleddens-Linkels E, Mulders S, van Eenennaam H, Wassenaar E, Van Cappellen WA, Hoogerbrugge J, Grootegoed JA, Baarends WM.

Nucleic Acids Res. 2004 Dec 7;32(21):6425-36. Print 2004.

44.

Functional analysis of a novel androgen receptor mutation, Q902K, in an individual with partial androgen insensitivity.

Umar A, Berrevoets CA, Van NM, van Leeuwen M, Verbiest M, Kleijer WJ, Dooijes D, Grootegoed JA, Drop SL, Brinkmann AO.

J Clin Endocrinol Metab. 2005 Jan;90(1):507-15. Epub 2004 Oct 14.

PMID:
15486055
45.

EGF signalling in prostate cancer cell lines is inhibited by a high expression level of the endocytosis protein REPS2.

Oosterhoff JK, Kühne LC, Grootegoed JA, Blok LJ.

Int J Cancer. 2005 Feb 10;113(4):561-7.

46.

Ubiquitin ligase Rad18Sc localizes to the XY body and to other chromosomal regions that are unpaired and transcriptionally silenced during male meiotic prophase.

van der Laan R, Uringa EJ, Wassenaar E, Hoogerbrugge JW, Sleddens E, Odijk H, Roest HP, de Boer P, Hoeijmakers JH, Grootegoed JA, Baarends WM.

J Cell Sci. 2004 Oct 1;117(Pt 21):5023-33. Epub 2004 Sep 21.

47.

Phosphorylation of androgen receptor isoforms.

Wong HY, Burghoorn JA, Van Leeuwen M, De Ruiter PE, Schippers E, Blok LJ, Li KW, Dekker HL, De Jong L, Trapman J, Grootegoed JA, Brinkmann AO.

Biochem J. 2004 Oct 15;383(Pt 2):267-76.

48.

Identification of REPS2 as a putative modulator of NF-kappaB activity in prostate cancer cells.

Penninkhof F, Grootegoed JA, Blok LJ.

Oncogene. 2004 Jul 22;23(33):5607-15.

PMID:
15184881
49.

The ubiquitin-conjugating DNA repair enzyme HR6A is a maternal factor essential for early embryonic development in mice.

Roest HP, Baarends WM, de Wit J, van Klaveren JW, Wassenaar E, Hoogerbrugge JW, van Cappellen WA, Hoeijmakers JH, Grootegoed JA.

Mol Cell Biol. 2004 Jun;24(12):5485-95.

50.

Chromatin dynamics in the male meiotic prophase.

Baarends WM, Grootegoed JA.

Cytogenet Genome Res. 2003;103(3-4):225-34. Review.

PMID:
15051943

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