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High prevalence of non-alcoholic fatty liver disease and metabolic risk factors in Guatemala: A population-based study.

Rivera-Andrade A, Kroker-Lobos MF, Lazo M, Freedman ND, Smith JW, Torres O, McGlynn KA, Groopman JD, Guallar E, Ramirez-Zea M.

Nutr Metab Cardiovasc Dis. 2018 Oct 31. pii: S0939-4753(18)30305-3. doi: 10.1016/j.numecd.2018.10.008. [Epub ahead of print]


Aflatoxin-guanine DNA Adducts and Oxidatively-induced DNA Damage in Aflatoxin-treated Mice in vivo as Measured by Liquid Chromatography-Tandem Mass Spectrometry with Isotope-dilution.

Coskun E, Jaruga P, Vartanian V, Erdem O, Egner PA, Groopman JD, Lloyd RS, Dizdaroglu M.

Chem Res Toxicol. 2018 Dec 11. doi: 10.1021/acs.chemrestox.8b00202. [Epub ahead of print]


Intrahepatic Cholangiocarcinoma: Continuing Challenges and Translational Advances.

Sirica AE, Gores GJ, Groopman JD, Selaru FM, Strazzabosco M, Wang XW, Zhu AX.

Hepatology. 2018 Sep 25. doi: 10.1002/hep.30289. [Epub ahead of print]


Aflatoxin exposure in children living in Mirpur, Dhaka: data from MAL-ED companion study.

Mahfuz M, Alam MA, Fahim SM, Gazi MA, Raihan MJ, Hossain M, Egner PA, Bessong PO, Petri WA, Groopman JD, Ahmed T.

J Expo Sci Environ Epidemiol. 2018 Sep 5. doi: 10.1038/s41370-018-0066-5. [Epub ahead of print]


Exposure to aflatoxin and fumonisin in children at risk for growth impairment in rural Tanzania.

Chen C, Mitchell NJ, Gratz J, Houpt ER, Gong Y, Egner PA, Groopman JD, Riley RT, Showker JL, Svensen E, Mduma ER, Patil CL, Wu F.

Environ Int. 2018 Jun;115:29-37. doi: 10.1016/j.envint.2018.03.001. Epub 2018 Mar 13.


Qidong hepatitis B virus infection cohort: a 25-year prospective study in high risk area of primary liver cancer.

Chen T, Qian G, Fan C, Sun Y, Wang J, Lu P, Xue X, Wu Y, Zhang Q, Jin Y, Wu Y, Gan Y, Lu J, Kensler TW, Groopman JD, Tu H.

Hepatoma Res. 2018;4. pii: 4. doi: 10.20517/2394-5079.2017.50. Epub 2018 Jan 26.


Aflatoxin and viral hepatitis exposures in Guatemala: Molecular biomarkers reveal a unique profile of risk factors in a region of high liver cancer incidence.

Smith JW, Kroker-Lobos MF, Lazo M, Rivera-Andrade A, Egner PA, Wedemeyer H, Torres O, Freedman ND, McGlynn KA, Guallar E, Groopman JD, Ramirez-Zea M.

PLoS One. 2017 Dec 13;12(12):e0189255. doi: 10.1371/journal.pone.0189255. eCollection 2017.


Unique pulmonary immunotoxicological effects of urban PM are not recapitulated solely by carbon black, diesel exhaust or coal fly ash.

Gour N, Sudini K, Khalil SM, Rule AM, Lees P, Gabrielson E, Groopman JD, Lajoie S, Singh A.

Environ Res. 2018 Feb;161:304-313. doi: 10.1016/j.envres.2017.10.041. Epub 2017 Nov 24.


Editor's Highlight: Pregnancy Alters Aflatoxin B1 Metabolism and Increases DNA Damage in Mouse Liver.

Sriwattanapong K, Slocum SL, Chawanthayatham S, Fedeles BI, Egner PA, Groopman JD, Satayavivad J, Croy RG, Essigmann JM.

Toxicol Sci. 2017 Nov 1;160(1):173-179. doi: 10.1093/toxsci/kfx171.


NEIL1 protects against aflatoxin-induced hepatocellular carcinoma in mice.

Vartanian V, Minko IG, Chawanthayatham S, Egner PA, Lin YC, Earley LF, Makar R, Eng JR, Camp MT, Li L, Stone MP, Lasarev MR, Groopman JD, Croy RG, Essigmann JM, McCullough AK, Lloyd RS.

Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):4207-4212. doi: 10.1073/pnas.1620932114. Epub 2017 Apr 3.


Profound changes in miRNA expression during cancer initiation by aflatoxin B1 and their abrogation by the chemopreventive triterpenoid CDDO-Im.

Livingstone MC, Johnson NM, Roebuck BD, Kensler TW, Groopman JD.

Mol Carcinog. 2017 Nov;56(11):2382-2390. doi: 10.1002/mc.22635. Epub 2017 Sep 2.


Aflatoxin exposure during the first 36 months of life was not associated with impaired growth in Nepalese children: An extension of the MAL-ED study.

Mitchell NJ, Hsu HH, Chandyo RK, Shrestha B, Bodhidatta L, Tu YK, Gong YY, Egner PA, Ulak M, Groopman JD, Wu F.

PLoS One. 2017 Feb 17;12(2):e0172124. doi: 10.1371/journal.pone.0172124. eCollection 2017.


The Plasma Proteome Is Associated with Anthropometric Status of Undernourished Nepalese School-Aged Children.

Lee SE, Stewart CP, Schulze KJ, Cole RN, Wu LS, Yager JD, Groopman JD, Khatry SK, Adhikari RK, Christian P, West KP Jr.

J Nutr. 2017 Mar;147(3):304-313. doi: 10.3945/jn.116.243014. Epub 2017 Feb 1.


Plasma Selenium Protein P Isoform 1 (SEPP1): A Predictor of Selenium Status in Nepalese Children Detected by Plasma Proteomics.

Schulze KJ, Cole RN, Chaerkady R, Wu LS, Nonyane BA, Lee SE, Yager JD, Groopman JD, Christian P, West KP Jr.

Int J Vitam Nutr Res. 2016 May 10:1-10. [Epub ahead of print]


Chronic aflatoxin exposure in children living in Bhaktapur, Nepal: Extension of the MAL-ED study.

Mitchell NJ, Riley RT, Egner PA, Groopman JD, Wu F.

J Expo Sci Environ Epidemiol. 2017 Jan;27(1):106-111. doi: 10.1038/jes.2015.87. Epub 2016 Jan 6.


A Plasma α-Tocopherome Can Be Identified from Proteins Associated with Vitamin E Status in School-Aged Children of Nepal.

West KP Jr, Cole RN, Shrestha S, Schulze KJ, Lee SE, Betz J, Nonyane BA, Wu LS, Yager JD, Groopman JD, Christian P.

J Nutr. 2015 Dec;145(12):2646-56. doi: 10.3945/jn.115.210682. Epub 2015 Oct 7.


Dietary aflatoxin-induced stunting in a novel rat model: evidence for toxin-induced liver injury and hepatic growth hormone resistance.

Knipstein B, Huang J, Barr E, Sossenheimer P, Dietzen D, Egner PA, Groopman JD, Rudnick DA.

Pediatr Res. 2015 Aug;78(2):120-7. doi: 10.1038/pr.2015.84. Epub 2015 May 4.


Serial Free Bisphenol A and Bisphenol A Glucuronide Concentrations in Neonates.

Nachman RM, Fox SD, Golden WC, Sibinga E, Groopman JD, Lees PS.

J Pediatr. 2015 Jul;167(1):64-9. doi: 10.1016/j.jpeds.2015.03.036. Epub 2015 Apr 25.


Molecular characteristics of Hepatitis B and chronic liver disease in a cohort of HB carriers from Bamako, Mali.

Traoré F, Gormally E, Villar S, Friesen MD, Groopman JD, Vernet G, Diallo S, Hainaut P, Maiga MY.

BMC Infect Dis. 2015 Apr 11;15:180. doi: 10.1186/s12879-015-0916-x.


Early Life Metabolism of Bisphenol A: A Systematic Review of the Literature.

Nachman RM, Hartle JC, Lees PS, Groopman JD.

Curr Environ Health Rep. 2014 Mar;1(1):90-100.


Translational cancer research: balancing prevention and treatment to combat cancer globally.

Wild CP, Bucher JR, de Jong BW, Dillner J, von Gertten C, Groopman JD, Herceg Z, Holmes E, Holmila R, Olsen JH, Ringborg U, Scalbert A, Shibata T, Smith MT, Ulrich C, Vineis P, McLaughlin J.

J Natl Cancer Inst. 2014 Dec 16;107(1):353. doi: 10.1093/jnci/dju353. Print 2015 Jan.


Sulforaphane, a cancer chemopreventive agent, induces pathways associated with membrane biosynthesis in response to tissue damage by aflatoxin B1.

Techapiesancharoenkij N, Fiala JL, Navasumrit P, Croy RG, Wogan GN, Groopman JD, Ruchirawat M, Essigmann JM.

Toxicol Appl Pharmacol. 2015 Jan 1;282(1):52-60. doi: 10.1016/j.taap.2014.11.004. Epub 2014 Nov 18.


Aflatoxin exposure during the first 1000 days of life in rural South Asia assessed by aflatoxin B₁-lysine albumin biomarkers.

Groopman JD, Egner PA, Schulze KJ, Wu LS, Merrill R, Mehra S, Shamim AA, Ali H, Shaikh S, Gernand A, Khatry SK, LeClerq SC, West KP Jr, Christian P.

Food Chem Toxicol. 2014 Dec;74:184-9. doi: 10.1016/j.fct.2014.09.016. Epub 2014 Oct 13.


Prenatal exposure of mice to the human liver carcinogen aflatoxin B1 reveals a critical window of susceptibility to genetic change.

Chawanthayatham S, Thiantanawat A, Egner PA, Groopman JD, Wogan GN, Croy RG, Essigmann JM.

Int J Cancer. 2015 Mar 15;136(6):1254-62. doi: 10.1002/ijc.29102. Epub 2014 Aug 7.


Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China.

Egner PA, Chen JG, Zarth AT, Ng DK, Wang JB, Kensler KH, Jacobson LP, Muñoz A, Johnson JL, Groopman JD, Fahey JW, Talalay P, Zhu J, Chen TY, Qian GS, Carmella SG, Hecht SS, Kensler TW.

Cancer Prev Res (Phila). 2014 Aug;7(8):813-823. doi: 10.1158/1940-6207.CAPR-14-0103. Epub 2014 Jun 9.


Novel natural mutations in the hepatitis B virus reverse transcriptase domain associated with hepatocellular carcinoma.

Wu Y, Gan Y, Gao F, Zhao Z, Jin Y, Zhu Y, Sun Z, Wu H, Chen T, Wang J, Sun Y, Fan C, Xiang Y, Qian G, Groopman JD, Gu J, Tu H.

PLoS One. 2014 May 1;9(5):e94864. doi: 10.1371/journal.pone.0094864. eCollection 2014.


Genetic or pharmacologic activation of Nrf2 signaling fails to protect against aflatoxin genotoxicity in hypersensitive GSTA3 knockout mice.

Kensler KH, Slocum SL, Chartoumpekis DV, Dolan PM, Johnson NM, Ilic Z, Crawford DR, Sell S, Groopman JD, Kensler TW, Egner PA.

Toxicol Sci. 2014 Jun;139(2):293-300. doi: 10.1093/toxsci/kfu056. Epub 2014 Mar 27.


Complete protection against aflatoxin B(1)-induced liver cancer with a triterpenoid: DNA adduct dosimetry, molecular signature, and genotoxicity threshold.

Johnson NM, Egner PA, Baxter VK, Sporn MB, Wible RS, Sutter TR, Groopman JD, Kensler TW, Roebuck BD.

Cancer Prev Res (Phila). 2014 Jul;7(7):658-65. doi: 10.1158/1940-6207.CAPR-13-0430. Epub 2014 Mar 24.


Public health impacts of foodborne mycotoxins.

Wu F, Groopman JD, Pestka JJ.

Annu Rev Food Sci Technol. 2014;5:351-72. doi: 10.1146/annurev-food-030713-092431. Epub 2014 Jan 9. Review.


Reduced aflatoxin exposure presages decline in liver cancer mortality in an endemic region of China.

Chen JG, Egner PA, Ng D, Jacobson LP, Muñoz A, Zhu YR, Qian GS, Wu F, Yuan JM, Groopman JD, Kensler TW.

Cancer Prev Res (Phila). 2013 Oct;6(10):1038-45. doi: 10.1158/1940-6207.CAPR-13-0168. Epub 2013 Aug 20.


Reduced formation of depurinating estrogen-DNA adducts by sulforaphane or KEAP1 disruption in human mammary epithelial MCF-10A cells.

Yang L, Zahid M, Liao Y, Rogan EG, Cavalieri EL, Davidson NE, Yager JD, Visvanathan K, Groopman JD, Kensler TW.

Carcinogenesis. 2013 Nov;34(11):2587-92. doi: 10.1093/carcin/bgt246. Epub 2013 Jul 10.


Association between TP53 R249S mutation and polymorphisms in TP53 intron 1 in hepatocellular carcinoma.

Ortiz-Cuaran S, Cox D, Villar S, Friesen MD, Durand G, Chabrier A, Khuhaprema T, Sangrajrang S, Ognjanovic S, Groopman JD, Hainaut P, Le Calvez-Kelm F.

Genes Chromosomes Cancer. 2013 Oct;52(10):912-9. doi: 10.1002/gcc.22086. Epub 2013 Jul 8.


Urinary free bisphenol A and bisphenol A-glucuronide concentrations in newborns.

Nachman RM, Fox SD, Golden WC, Sibinga E, Veenstra TD, Groopman JD, Lees PS.

J Pediatr. 2013 Apr;162(4):870-2. doi: 10.1016/j.jpeds.2012.11.083. Epub 2013 Jan 11.


Statistical inference from multiple iTRAQ experiments without using common reference standards.

Herbrich SM, Cole RN, West KP Jr, Schulze K, Yager JD, Groopman JD, Christian P, Wu L, O'Meally RN, May DH, McIntosh MW, Ruczinski I.

J Proteome Res. 2013 Feb 1;12(2):594-604. doi: 10.1021/pr300624g. Epub 2013 Jan 16.


Association between HBX status, aflatoxin-induced R249S TP53 mutation and risk of hepatocellular carcinoma in a case-control study from Thailand.

Ortiz-Cuaran S, Villar S, Gouas D, Ferro G, Plymoth A, Khuhaprema T, Kalalak A, Sangrajrang S, Friesen MD, Groopman JD, Hainaut P.

Cancer Lett. 2013 Apr 30;331(1):46-51. doi: 10.1016/j.canlet.2012.11.012. Epub 2012 Nov 27.


Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane.

Kensler TW, Egner PA, Agyeman AS, Visvanathan K, Groopman JD, Chen JG, Chen TY, Fahey JW, Talalay P.

Top Curr Chem. 2013;329:163-77. doi: 10.1007/128_2012_339. Review.


Aflatoxin-induced TP53 R249S mutation in hepatocellular carcinoma in Thailand: association with tumors developing in the absence of liver cirrhosis.

Villar S, Ortiz-Cuaran S, Abedi-Ardekani B, Gouas D, Nogueira da Costa A, Plymoth A, Khuhaprema T, Kalalak A, Sangrajrang S, Friesen MD, Groopman JD, Hainaut P.

PLoS One. 2012;7(6):e37707. doi: 10.1371/journal.pone.0037707. Epub 2012 Jun 4.


A single neonatal exposure to aflatoxin b1 induces prolonged genetic damage in two loci of mouse liver.

Wattanawaraporn R, Woo LL, Belanger C, Chang SC, Adams JE, Trudel LJ, Bouhenguel JT, Egner PA, Groopman JD, Croy RG, Essigmann JM, Wogan GN.

Toxicol Sci. 2012 Aug;128(2):326-33. doi: 10.1093/toxsci/kfs151. Epub 2012 Apr 26.


Maternal serum proteome changes between the first and third trimester of pregnancy in rural southern Nepal.

Scholl PF, Cole RN, Ruczinski I, Gucek M, Diez R, Rennie A, Nathasingh C, Schulze K, Christian P, Yager JD, Groopman JD, West KP Jr.

Placenta. 2012 May;33(5):424-32. doi: 10.1016/j.placenta.2012.02.009. Epub 2012 Mar 3.


Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China.

Kensler TW, Ng D, Carmella SG, Chen M, Jacobson LP, Muñoz A, Egner PA, Chen JG, Qian GS, Chen TY, Fahey JW, Talalay P, Groopman JD, Yuan JM, Hecht SS.

Carcinogenesis. 2012 Jan;33(1):101-7. doi: 10.1093/carcin/bgr229. Epub 2011 Nov 1. Erratum in: Carcinogenesis. 2012 Mar;33(3):722.


Seasonal variation in TP53 R249S-mutated serum DNA with aflatoxin exposure and hepatitis B virus infection.

Villar S, Le Roux-Goglin E, Gouas DA, Plymoth A, Ferro G, Boniol M, Lereau M, Bah E, Hall AJ, Wild CP, Mendy M, Norder H, van der Sande M, Whittle H, Friesen MD, Groopman JD, Hainaut P.

Environ Health Perspect. 2011 Nov;119(11):1635-40. doi: 10.1289/ehp.1103539. Epub 2011 Jul 18.


Present and future directions of translational research on aflatoxin and hepatocellular carcinoma. A review.

Wogan GN, Kensler TW, Groopman JD.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2012;29(2):249-57. doi: 10.1080/19440049.2011.563370. Epub 2011 Jun 1. Review.


Aflatoxin B1-DNA adduct formation and mutagenicity in livers of neonatal male and female B6C3F1 mice.

Woo LL, Egner PA, Belanger CL, Wattanawaraporn R, Trudel LJ, Croy RG, Groopman JD, Essigmann JM, Wogan GN, Bouhenguel JT.

Toxicol Sci. 2011 Jul;122(1):38-44. doi: 10.1093/toxsci/kfr087. Epub 2011 Apr 19. Erratum in: Toxicol Sci. 2012 Jan;125(1):326. Bouhenguel, Jason T [added].


Predictive power of hepatitis B 1762T/1764A mutations in plasma for hepatocellular carcinoma risk in Qidong, China.

Muñoz A, Chen JG, Egner PA, Marshall ML, Johnson JL, Schneider MF, Lu JH, Zhu YR, Wang JB, Chen TY, Kensler TW, Groopman JD.

Carcinogenesis. 2011 Jun;32(6):860-5. doi: 10.1093/carcin/bgr055. Epub 2011 Apr 7.


Interaction of mutant hepatitis B X protein with p53 tumor suppressor protein affects both transcription and cell survival.

Iyer S, Groopman JD.

Mol Carcinog. 2011 Dec;50(12):972-80. doi: 10.1002/mc.20767. Epub 2011 Mar 22.


Bioavailability of Sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China.

Egner PA, Chen JG, Wang JB, Wu Y, Sun Y, Lu JH, Zhu J, Zhang YH, Chen YS, Friesen MD, Jacobson LP, Muñoz A, Ng D, Qian GS, Zhu YR, Chen TY, Botting NP, Zhang Q, Fahey JW, Talalay P, Groopman JD, Kensler TW.

Cancer Prev Res (Phila). 2011 Mar;4(3):384-95. doi: 10.1158/1940-6207.CAPR-10-0296.


Sulforaphane-mediated reduction of aflatoxin B₁-N⁷-guanine in rat liver DNA: impacts of strain and sex.

Fiala JL, Egner PA, Wiriyachan N, Ruchirawat M, Kensler KH, Wogan GN, Groopman JD, Croy RG, Essigmann JM.

Toxicol Sci. 2011 May;121(1):57-62. doi: 10.1093/toxsci/kfr026. Epub 2011 Jan 28.


Physical/chemical/immunologic analytical methods.

Wang JS, Groopman JD.

IARC Sci Publ. 2011;(163):43-61. Review.


Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology.

Kensler TW, Roebuck BD, Wogan GN, Groopman JD.

Toxicol Sci. 2011 Mar;120 Suppl 1:S28-48. doi: 10.1093/toxsci/kfq283. Epub 2010 Sep 29. Review.


Temporal acquisition of sequential mutations in the enhancer II and basal core promoter of HBV in individuals at high risk for hepatocellular carcinoma.

Bai X, Zhu Y, Jin Y, Guo X, Qian G, Chen T, Zhang J, Wang J, Groopman JD, Gu J, Tu H.

Carcinogenesis. 2011 Jan;32(1):63-8. doi: 10.1093/carcin/bgq195. Epub 2010 Sep 28.

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