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Items: 16

1.

Cited4 is a sex-biased mediator of the antidiabetic glitazone response in adipocyte progenitors.

Bayindir-Buchhalter I, Wolff G, Lerch S, Sijmonsma T, Schuster M, Gronych J, Billeter AT, Babaei R, Krunic D, Ketscher L, Spielmann N, Hrabe de Angelis M, Ruas JL, Müller-Stich BP, Heikenwalder M, Lichter P, Herzig S, Vegiopoulos A.

EMBO Mol Med. 2018 Jul 4. pii: e8613. doi: 10.15252/emmm.201708613. [Epub ahead of print]

2.

Novel MYC-driven medulloblastoma models from multiple embryonic cerebellar cells.

Kawauchi D, Ogg RJ, Liu L, Shih DJH, Finkelstein D, Murphy BL, Rehg JE, Korshunov A, Calabrese C, Zindy F, Phoenix T, Kawaguchi Y, Gronych J, Gilbertson RJ, Lichter P, Gajjar A, Kool M, Northcott PA, Pfister SM, Roussel MF.

Oncogene. 2017 Sep 14;36(37):5231-5242. doi: 10.1038/onc.2017.110. Epub 2017 May 15.

3.

Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme.

Feng W, Kawauchi D, Körkel-Qu H, Deng H, Serger E, Sieber L, Lieberman JA, Jimeno-González S, Lambo S, Hanna BS, Harim Y, Jansen M, Neuerburg A, Friesen O, Zuckermann M, Rajendran V, Gronych J, Ayrault O, Korshunov A, Jones DT, Kool M, Northcott PA, Lichter P, Cortés-Ledesma F, Pfister SM, Liu HK.

Nat Commun. 2017 Mar 20;8:14758. doi: 10.1038/ncomms14758.

4.

Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing.

Selt F, Hohloch J, Hielscher T, Sahm F, Capper D, Korshunov A, Usta D, Brabetz S, Ridinger J, Ecker J, Oehme I, Gronych J, Marquardt V, Pauck D, Bächli H, Stiles CD, von Deimling A, Remke M, Schuhmann MU, Pfister SM, Brummer T, Jones DT, Witt O, Milde T.

Oncotarget. 2017 Feb 14;8(7):11460-11479. doi: 10.18632/oncotarget.14004.

5.

TALEN/CRISPR-mediated engineering of a promoterless anti-viral RNAi hairpin into an endogenous miRNA locus.

Senís E, Mockenhaupt S, Rupp D, Bauer T, Paramasivam N, Knapp B, Gronych J, Grosse S, Windisch MP, Schmidt F, Theis FJ, Eils R, Lichter P, Schlesner M, Bartenschlager R, Grimm D.

Nucleic Acids Res. 2017 Jan 9;45(1):e3. doi: 10.1093/nar/gkw805. Epub 2016 Sep 9.

6.

Applications of the CRISPR/Cas9 system in murine cancer modeling.

Zuckermann M, Kawauchi D, Gronych J.

Brief Funct Genomics. 2017 Jan;16(1):25-33. doi: 10.1093/bfgp/elw021. Epub 2016 Jun 5. Review.

PMID:
27273122
7.

"CRISPR" validation of recessive brain cancer genes in vivo.

Zuckermann M, Kawauchi D, Gronych J.

Oncotarget. 2015 Jul 20;6(20):17865-6. No abstract available.

8.

Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling.

Zuckermann M, Hovestadt V, Knobbe-Thomsen CB, Zapatka M, Northcott PA, Schramm K, Belic J, Jones DT, Tschida B, Moriarity B, Largaespada D, Roussel MF, Korshunov A, Reifenberger G, Pfister SM, Lichter P, Kawauchi D, Gronych J.

Nat Commun. 2015 Jun 11;6:7391. doi: 10.1038/ncomms8391.

9.

Targeting self-renewal in high-grade brain tumors leads to loss of brain tumor stem cells and prolonged survival.

Zhu Z, Khan MA, Weiler M, Blaes J, Jestaedt L, Geibert M, Zou P, Gronych J, Bernhardt O, Korshunov A, Bugner V, Lichter P, Radlwimmer B, Heiland S, Bendszus M, Wick W, Liu HK.

Cell Stem Cell. 2014 Aug 7;15(2):185-98. doi: 10.1016/j.stem.2014.04.007. Epub 2014 May 15.

10.

Connect four with glioblastoma stem cell factors.

Gronych J, Pfister SM, Jones DT.

Cell. 2014 Apr 24;157(3):525-7. doi: 10.1016/j.cell.2014.04.001.

11.

Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas.

Bender S, Tang Y, Lindroth AM, Hovestadt V, Jones DT, Kool M, Zapatka M, Northcott PA, Sturm D, Wang W, Radlwimmer B, Højfeldt JW, Truffaux N, Castel D, Schubert S, Ryzhova M, Seker-Cin H, Gronych J, Johann PD, Stark S, Meyer J, Milde T, Schuhmann M, Ebinger M, Monoranu CM, Ponnuswami A, Chen S, Jones C, Witt O, Collins VP, von Deimling A, Jabado N, Puget S, Grill J, Helin K, Korshunov A, Lichter P, Monje M, Plass C, Cho YJ, Pfister SM.

Cancer Cell. 2013 Nov 11;24(5):660-72. doi: 10.1016/j.ccr.2013.10.006. Epub 2013 Oct 31.

12.

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.

Jones DT, Hutter B, Jäger N, Korshunov A, Kool M, Warnatz HJ, Zichner T, Lambert SR, Ryzhova M, Quang DA, Fontebasso AM, Stütz AM, Hutter S, Zuckermann M, Sturm D, Gronych J, Lasitschka B, Schmidt S, Seker-Cin H, Witt H, Sultan M, Ralser M, Northcott PA, Hovestadt V, Bender S, Pfaff E, Stark S, Faury D, Schwartzentruber J, Majewski J, Weber UD, Zapatka M, Raeder B, Schlesner M, Worth CL, Bartholomae CC, von Kalle C, Imbusch CD, Radomski S, Lawerenz C, van Sluis P, Koster J, Volckmann R, Versteeg R, Lehrach H, Monoranu C, Winkler B, Unterberg A, Herold-Mende C, Milde T, Kulozik AE, Ebinger M, Schuhmann MU, Cho YJ, Pomeroy SL, von Deimling A, Witt O, Taylor MD, Wolf S, Karajannis MA, Eberhart CG, Scheurlen W, Hasselblatt M, Ligon KL, Kieran MW, Korbel JO, Yaspo ML, Brors B, Felsberg J, Reifenberger G, Collins VP, Jabado N, Eils R, Lichter P, Pfister SM; International Cancer Genome Consortium PedBrain Tumor Project.

Nat Genet. 2013 Aug;45(8):927-32. doi: 10.1038/ng.2682. Epub 2013 Jun 30.

13.

Suppression of proinvasive RGS4 by mTOR inhibition optimizes glioma treatment.

Weiler M, Pfenning PN, Thiepold AL, Blaes J, Jestaedt L, Gronych J, Dittmann LM, Berger B, Jugold M, Kosch M, Combs SE, von Deimling A, Weller M, Bendszus M, Platten M, Wick W.

Oncogene. 2013 Feb 28;32(9):1099-109. doi: 10.1038/onc.2012.137. Epub 2012 May 7.

14.

MAPK pathway activation in pilocytic astrocytoma.

Jones DT, Gronych J, Lichter P, Witt O, Pfister SM.

Cell Mol Life Sci. 2012 Jun;69(11):1799-811. doi: 10.1007/s00018-011-0898-9. Epub 2011 Dec 13. Review.

15.

Downregulation of PRDX1 by promoter hypermethylation is frequent in 1p/19q-deleted oligodendroglial tumours and increases radio- and chemosensitivity of Hs683 glioma cells in vitro.

Dittmann LM, Danner A, Gronych J, Wolter M, Stühler K, Grzendowski M, Becker N, Bageritz J, Goidts V, Toedt G, Felsberg J, Sabel MC, Barbus S, Reifenberger G, Lichter P, Tews B.

Oncogene. 2012 Jul 19;31(29):3409-18. doi: 10.1038/onc.2011.513. Epub 2011 Dec 12.

PMID:
22158042
16.

An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice.

Gronych J, Korshunov A, Bageritz J, Milde T, Jugold M, Hambardzumyan D, Remke M, Hartmann C, Witt H, Jones DT, Witt O, Heiland S, Bendszus M, Holland EC, Pfister S, Lichter P.

J Clin Invest. 2011 Apr;121(4):1344-8. doi: 10.1172/JCI44656. Epub 2011 Mar 14.

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