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Items: 1 to 50 of 69

1.

Eicosanoid and Specialized Proresolving Mediator Regulation of Lymphoid Cells.

Wei J, Gronert K.

Trends Biochem Sci. 2019 Mar;44(3):214-225. doi: 10.1016/j.tibs.2018.10.007. Epub 2018 Nov 23. Review.

PMID:
30477730
2.

Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch.

Emrick JJ, Mathur A, Wei J, Gracheva EO, Gronert K, Rosenblum MD, Julius D.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12091-E12100. doi: 10.1073/pnas.1814132115. Epub 2018 Nov 21.

3.

Dietary DHA amplifies LXA4 circuits in tissues and lymph node PMN and is protective in immune-driven dry eye disease.

Gao Y, Su J, Zhang Y, Chan A, Sin JH, Wu D, Min K, Gronert K.

Mucosal Immunol. 2018 Nov;11(6):1674-1683. doi: 10.1038/s41385-018-0070-z. Epub 2018 Aug 13.

4.

Immunoregulatory role of 15-lipoxygenase in the pathogenesis of bacterial keratitis.

Carion TW, Greenwood M, Ebrahim AS, Jerome A, Suvas S, Gronert K, Berger EA.

FASEB J. 2018 Sep;32(9):5026-5038. doi: 10.1096/fj.201701502R. Epub 2018 Apr 13.

PMID:
29913556
5.

Lipid droplet formation in Mycobacterium tuberculosis infected macrophages requires IFN-γ/HIF-1α signaling and supports host defense.

Knight M, Braverman J, Asfaha K, Gronert K, Stanley S.

PLoS Pathog. 2018 Jan 25;14(1):e1006874. doi: 10.1371/journal.ppat.1006874. eCollection 2018 Jan.

6.

Maresin 1 Promotes Inflammatory Resolution, Neuroprotection, and Functional Neurological Recovery After Spinal Cord Injury.

Francos-Quijorna I, Santos-Nogueira E, Gronert K, Sullivan AB, Kopp MA, Brommer B, David S, Schwab JM, López-Vales R.

J Neurosci. 2017 Nov 29;37(48):11731-11743. doi: 10.1523/JNEUROSCI.1395-17.2017. Epub 2017 Nov 6.

7.

Astrocyte-derived lipoxins A4 and B4 promote neuroprotection from acute and chronic injury.

Livne-Bar I, Wei J, Liu HH, Alqawlaq S, Won GJ, Tuccitto A, Gronert K, Flanagan JG, Sivak JM.

J Clin Invest. 2017 Dec 1;127(12):4403-4414. doi: 10.1172/JCI77398. Epub 2017 Nov 6.

8.

Pseudomonas aeruginosa ExoU augments neutrophil transepithelial migration.

Pazos MA, Lanter BB, Yonker LM, Eaton AD, Pirzai W, Gronert K, Bonventre JV, Hurley BP.

PLoS Pathog. 2017 Aug 3;13(8):e1006548. doi: 10.1371/journal.ppat.1006548. eCollection 2017 Aug.

9.

NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8.

Rauch I, Deets KA, Ji DX, von Moltke J, Tenthorey JL, Lee AY, Philip NH, Ayres JS, Brodsky IE, Gronert K, Vance RE.

Immunity. 2017 Apr 18;46(4):649-659. doi: 10.1016/j.immuni.2017.03.016. Epub 2017 Apr 11.

10.

The role of pro-resolving lipid mediators in ocular diseases.

Wei J, Gronert K.

Mol Aspects Med. 2017 Dec;58:37-43. doi: 10.1016/j.mam.2017.03.006. Epub 2017 Apr 6. Review. No abstract available.

11.

Local TNFR1 Signaling Licenses Murine Neutrophils for Increased TLR-Dependent Cytokine and Eicosanoid Production.

Deguine J, Wei J, Barbalat R, Gronert K, Barton GM.

J Immunol. 2017 Apr 1;198(7):2865-2875. doi: 10.4049/jimmunol.1601465. Epub 2017 Feb 20.

12.

Pathway Markers for Pro-resolving Lipid Mediators in Maternal and Umbilical Cord Blood: A Secondary Analysis of the Mothers, Omega-3, and Mental Health Study.

Mozurkewich EL, Greenwood M, Clinton C, Berman D, Romero V, Djuric Z, Qualls C, Gronert K.

Front Pharmacol. 2016 Sep 7;7:274. doi: 10.3389/fphar.2016.00274. eCollection 2016.

13.

ω-3 Tear Film Lipids Correlate With Clinical Measures of Dry Eye.

Walter SD, Gronert K, McClellan AL, Levitt RC, Sarantopoulos KD, Galor A.

Invest Ophthalmol Vis Sci. 2016 May 1;57(6):2472-8. doi: 10.1167/iovs.16-19131.

14.

Female-Specific Downregulation of Tissue Polymorphonuclear Neutrophils Drives Impaired Regulatory T Cell and Amplified Effector T Cell Responses in Autoimmune Dry Eye Disease.

Gao Y, Min K, Zhang Y, Su J, Greenwood M, Gronert K.

J Immunol. 2015 Oct 1;195(7):3086-99. doi: 10.4049/jimmunol.1500610. Epub 2015 Aug 31.

15.

Distinct cellular sources of hepoxilin A3 and leukotriene B4 are used to coordinate bacterial-induced neutrophil transepithelial migration.

Pazos MA, Pirzai W, Yonker LM, Morisseau C, Gronert K, Hurley BP.

J Immunol. 2015 Feb 1;194(3):1304-15. doi: 10.4049/jimmunol.1402489. Epub 2014 Dec 29.

16.

Intravenous fish oil lipid emulsion promotes a shift toward anti-inflammatory proresolving lipid mediators.

Kalish BT, Le HD, Fitzgerald JM, Wang S, Seamon K, Gura KM, Gronert K, Puder M.

Am J Physiol Gastrointest Liver Physiol. 2013 Dec;305(11):G818-28. doi: 10.1152/ajpgi.00106.2013. Epub 2013 Oct 3.

17.

Systemic disease during Streptococcus pneumoniae acute lung infection requires 12-lipoxygenase-dependent inflammation.

Bhowmick R, Maung N, Hurley BP, Ghanem EB, Gronert K, McCormick BA, Leong JM.

J Immunol. 2013 Nov 15;191(10):5115-23. doi: 10.4049/jimmunol.1300522. Epub 2013 Oct 2.

18.

Proresolution lipid mediators in multiple sclerosis - differential, disease severity-dependent synthesis - a clinical pilot trial.

Prüss H, Rosche B, Sullivan AB, Brommer B, Wengert O, Gronert K, Schwab JM.

PLoS One. 2013;8(2):e55859. doi: 10.1371/journal.pone.0055859. Epub 2013 Feb 8.

19.

Hepoxilin A(3) facilitates neutrophilic breach of lipoxygenase-expressing airway epithelial barriers.

Tamang DL, Pirzai W, Priebe GP, Traficante DC, Pier GB, Falck JR, Morisseau C, Hammock BD, McCormick BA, Gronert K, Hurley BP.

J Immunol. 2012 Nov 15;189(10):4960-9. doi: 10.4049/jimmunol.1201922. Epub 2012 Oct 8.

20.

Rapid induction of inflammatory lipid mediators by the inflammasome in vivo.

von Moltke J, Trinidad NJ, Moayeri M, Kintzer AF, Wang SB, van Rooijen N, Brown CR, Krantz BA, Leppla SH, Gronert K, Vance RE.

Nature. 2012 Oct 4;490(7418):107-11. doi: 10.1038/nature11351. Epub 2012 Aug 19.

21.

Estrogen negatively regulates epithelial wound healing and protective lipid mediator circuits in the cornea.

Wang SB, Hu KM, Seamon KJ, Mani V, Chen Y, Gronert K.

FASEB J. 2012 Apr;26(4):1506-16. doi: 10.1096/fj.11-198036. Epub 2011 Dec 20.

22.

Gender differences in re-epithelialisation time in fungal corneal ulcers.

Krishnan T, Prajna NV, Gronert K, Oldenburg CE, Ray KJ, Keenan JD, Lietman TM, Acharya NR.

Br J Ophthalmol. 2012 Jan;96(1):137-8. doi: 10.1136/bjophthalmol-2011-300441. Epub 2011 Oct 6. No abstract available.

23.

5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of ω-3 polyunsaturated fatty acids.

Sapieha P, Stahl A, Chen J, Seaward MR, Willett KL, Krah NM, Dennison RJ, Connor KM, Aderman CM, Liclican E, Carughi A, Perelman D, Kanaoka Y, Sangiovanni JP, Gronert K, Smith LE.

Sci Transl Med. 2011 Feb 9;3(69):69ra12. doi: 10.1126/scitranslmed.3001571.

24.

Selective eicosanoid-generating capacity of cytoplasmic phospholipase A2 in Pseudomonas aeruginosa-infected epithelial cells.

Hurley BP, Pirzai W, Mumy KL, Gronert K, McCormick BA.

Am J Physiol Lung Cell Mol Physiol. 2011 Feb;300(2):L286-94. doi: 10.1152/ajplung.00147.2010. Epub 2010 Nov 19.

25.

Resolution, the grail for healthy ocular inflammation.

Gronert K.

Exp Eye Res. 2010 Oct;91(4):478-85. doi: 10.1016/j.exer.2010.07.004. Epub 2010 Jul 14. Review.

26.

Selective activation of the prostaglandin E2 circuit in chronic injury-induced pathologic angiogenesis.

Liclican EL, Nguyen V, Sullivan AB, Gronert K.

Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6311-20. doi: 10.1167/iovs.10-5455. Epub 2010 Jul 7.

27.

Molecular circuits of resolution in the eye.

Liclican EL, Gronert K.

ScientificWorldJournal. 2010 Jun 1;10:1029-47. doi: 10.1100/tsw.2010.99. Review.

28.

Endogenous LXA4 circuits are determinants of pathological angiogenesis in response to chronic injury.

Leedom AJ, Sullivan AB, Dong B, Lau D, Gronert K.

Am J Pathol. 2010 Jan;176(1):74-84. doi: 10.2353/ajpath.2010.090678. Epub 2009 Dec 11.

30.

Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: a role for resolvins and protectins.

González-Périz A, Horrillo R, Ferré N, Gronert K, Dong B, Morán-Salvador E, Titos E, Martínez-Clemente M, López-Parra M, Arroyo V, Clària J.

FASEB J. 2009 Jun;23(6):1946-57. doi: 10.1096/fj.08-125674. Epub 2009 Feb 11.

31.

Neuroprotectin D1 inhibits retinal ganglion cell death following axotomy.

Qin Q, Patil KA, Gronert K, Sharma SC.

Prostaglandins Leukot Essent Fatty Acids. 2008 Dec;79(6):201-7. doi: 10.1016/j.plefa.2008.09.022. Epub 2008 Nov 18.

PMID:
19019647
32.

Multidrug resistance-associated transporter 2 regulates mucosal inflammation by facilitating the synthesis of hepoxilin A3.

Pazos M, Siccardi D, Mumy KL, Bien JD, Louie S, Shi HN, Gronert K, Mrsny RJ, McCormick BA.

J Immunol. 2008 Dec 1;181(11):8044-52.

33.

Distinct isoforms of phospholipase A2 mediate the ability of Salmonella enterica serotype typhimurium and Shigella flexneri to induce the transepithelial migration of neutrophils.

Mumy KL, Bien JD, Pazos MA, Gronert K, Hurley BP, McCormick BA.

Infect Immun. 2008 Aug;76(8):3614-27. doi: 10.1128/IAI.00407-08. Epub 2008 May 27.

34.

Lipid autacoids in inflammation and injury responses: a matter of privilege.

Gronert K.

Mol Interv. 2008 Feb;8(1):28-35. doi: 10.1124/mi.8.1.7. Review.

PMID:
18332482
35.

Interdependence of lipoxin A4 and heme-oxygenase in counter-regulating inflammation during corneal wound healing.

Biteman B, Hassan IR, Walker E, Leedom AJ, Dunn M, Seta F, Laniado-Schwartzman M, Gronert K.

FASEB J. 2007 Jul;21(9):2257-66. Epub 2007 Mar 23.

PMID:
17384141
36.

Heme oxygenase-2 is a critical determinant for execution of an acute inflammatory and reparative response.

Seta F, Bellner L, Rezzani R, Regan RF, Dunn MW, Abraham NG, Gronert K, Laniado-Schwartzman M.

Am J Pathol. 2006 Nov;169(5):1612-23.

37.

Docosahexaenoic acid (DHA) blunts liver injury by conversion to protective lipid mediators: protectin D1 and 17S-hydroxy-DHA.

González-Périz A, Planagumà A, Gronert K, Miquel R, López-Parra M, Titos E, Horrillo R, Ferré N, Deulofeu R, Arroyo V, Rodés J, Clària J.

FASEB J. 2006 Dec;20(14):2537-9. Epub 2006 Oct 20.

PMID:
17056761
38.

Lipoxins in the eye and their role in wound healing.

Gronert K.

Prostaglandins Leukot Essent Fatty Acids. 2005 Sep-Oct;73(3-4):221-9. Review.

PMID:
15979295
39.

A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense.

Gronert K, Maheshwari N, Khan N, Hassan IR, Dunn M, Laniado Schwartzman M.

J Biol Chem. 2005 Apr 15;280(15):15267-78. Epub 2005 Feb 11.

40.

Lipoxins and novel 15-epi-lipoxin analogs display potent anti-inflammatory actions after oral administration.

Bannenberg G, Moussignac RL, Gronert K, Devchand PR, Schmidt BA, Guilford WJ, Bauman JG, Subramanyam B, Perez HD, Parkinson JF, Serhan CN.

Br J Pharmacol. 2004 Sep;143(1):43-52. Epub 2004 Aug 9.

41.

The opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase.

Vance RE, Hong S, Gronert K, Serhan CN, Mekalanos JJ.

Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2135-9. Epub 2004 Feb 6.

42.

A molecular defect in intracellular lipid signaling in human neutrophils in localized aggressive periodontal tissue damage.

Gronert K, Kantarci A, Levy BD, Clish CB, Odparlik S, Hasturk H, Badwey JA, Colgan SP, Van Dyke TE, Serhan CN.

J Immunol. 2004 Feb 1;172(3):1856-61.

43.

Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression.

Marcheselli VL, Hong S, Lukiw WJ, Tian XH, Gronert K, Musto A, Hardy M, Gimenez JM, Chiang N, Serhan CN, Bazan NG.

J Biol Chem. 2003 Oct 31;278(44):43807-17. Epub 2003 Aug 15. Erratum in: J Biol Chem. 2003 Dec 19;278(51):51974.

44.

Human ALX receptor regulates neutrophil recruitment in transgenic mice: roles in inflammation and host defense.

Devchand PR, Arita M, Hong S, Bannenberg G, Moussignac RL, Gronert K, Serhan CN.

FASEB J. 2003 Apr;17(6):652-9. Erratum in: FASEB J. 2003 Jun;17(9):4.

PMID:
12665478
45.

Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation.

Hong S, Gronert K, Devchand PR, Moussignac RL, Serhan CN.

J Biol Chem. 2003 Apr 25;278(17):14677-87. Epub 2003 Feb 17.

46.

Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals.

Serhan CN, Hong S, Gronert K, Colgan SP, Devchand PR, Mirick G, Moussignac RL.

J Exp Med. 2002 Oct 21;196(8):1025-37.

47.

Lipid mediator class switching during acute inflammation: signals in resolution.

Levy BD, Clish CB, Schmidt B, Gronert K, Serhan CN.

Nat Immunol. 2001 Jul;2(7):612-9.

PMID:
11429545
48.

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