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Items: 1 to 50 of 272

1.

The histone deacetylases HDAC1 and HDAC2 are required for the growth and survival of renal carcinoma cells.

Kiweler N, Brill B, Wirth M, Breuksch I, Laguna T, Dietrich C, Strand S, Schneider G, Groner B, Butter F, Heinzel T, Brenner W, Krämer OH.

Arch Toxicol. 2018 Jul;92(7):2227-2243. doi: 10.1007/s00204-018-2229-5. Epub 2018 May 29.

PMID:
29845424
2.

Jak Stat signaling and cancer: Opportunities, benefits and side effects of targeted inhibition.

Groner B, von Manstein V.

Mol Cell Endocrinol. 2017 Aug 15;451:1-14. doi: 10.1016/j.mce.2017.05.033. Epub 2017 May 30. Review.

PMID:
28576744
3.

O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies.

Freund P, Kerenyi MA, Hager M, Wagner T, Wingelhofer B, Pham HTT, Elabd M, Han X, Valent P, Gouilleux F, Sexl V, Krämer OH, Groner B, Moriggl R.

Leukemia. 2017 Oct;31(10):2132-2142. doi: 10.1038/leu.2017.4. Epub 2017 Jan 11.

4.
5.

Breast Cancer Patients Have Greatly Benefited from the Progress in Molecular Oncology.

Groner BL, Hynes NE.

PLoS Biol. 2016 Sep 29;14(9):e2000314. doi: 10.1371/journal.pbio.2000314. eCollection 2016 Sep.

6.

Paul Ehrlich (1854-1915) and His Contributions to the Foundation and Birth of Translational Medicine.

Valent P, Groner B, Schumacher U, Superti-Furga G, Busslinger M, Kralovics R, Zielinski C, Penninger JM, Kerjaschki D, Stingl G, Smolen JS, Valenta R, Lassmann H, Kovar H, Jäger U, Kornek G, Müller M, Sörgel F.

J Innate Immun. 2016;8(2):111-20. doi: 10.1159/000443526. Epub 2016 Feb 5.

7.

Improving Drug Penetrability with iRGD Leverages the Therapeutic Response to Sorafenib and Doxorubicin in Hepatocellular Carcinoma.

Schmithals C, Köberle V, Korkusuz H, Pleli T, Kakoschky B, Augusto EA, Ibrahim AA, Arencibia JM, Vafaizadeh V, Groner B, Korf HW, Kronenberger B, Zeuzem S, Vogl TJ, Waidmann O, Piiper A.

Cancer Res. 2015 Aug 1;75(15):3147-54. doi: 10.1158/0008-5472.CAN-15-0395.

8.

5-Lipoxygenase is a direct p53 target gene in humans.

Gilbert B, Ahmad K, Roos J, Lehmann C, Chiba T, Ulrich-Rückert S, Smeenk L, van Heeringen S, Maier TJ, Groner B, Steinhilber D.

Biochim Biophys Acta. 2015 Aug;1849(8):1003-16. doi: 10.1016/j.bbagrm.2015.06.004. Epub 2015 Jun 9.

PMID:
26070487
9.

Expression of the miR-302/367 cluster in glioblastoma cells suppresses tumorigenic gene expression patterns and abolishes transformation related phenotypes.

Yang CM, Chiba T, Brill B, Delis N, von Manstein V, Vafaizadeh V, Oellerich T, Groner B.

Int J Cancer. 2015 Nov 15;137(10):2296-309. doi: 10.1002/ijc.29606. Epub 2015 Jun 5.

10.

Stat5 Exerts Distinct, Vital Functions in the Cytoplasm and Nucleus of Bcr-Abl+ K562 and Jak2(V617F)+ HEL Leukemia Cells.

Weber A, Borghouts C, Brendel C, Moriggl R, Delis N, Brill B, Vafaizadeh V, Groner B.

Cancers (Basel). 2015 Mar 19;7(1):503-37. doi: 10.3390/cancers7010503.

11.

Adaptive Resistance to Immunotherapy Directed Against p53 Can be Overcome by Global Expression of Tumor-Antigens in Dendritic Cells.

Humar M, Azemar M, Maurer M, Groner B.

Front Oncol. 2014 Oct 6;4:270. doi: 10.3389/fonc.2014.00270. eCollection 2014.

12.

Endotoxin depletion of recombinant protein preparations through their preferential binding to histidine tags.

Mack L, Brill B, Delis N, Groner B.

Anal Biochem. 2014 Dec 1;466:83-8. doi: 10.1016/j.ab.2014.08.020. Epub 2014 Aug 27.

13.

Low PIAS3 expression in malignant mesothelioma is associated with increased STAT3 activation and poor patient survival.

Dabir S, Kluge A, Kresak A, Yang M, Fu P, Groner B, Wildey G, Dowlati A.

Clin Cancer Res. 2014 Oct 1;20(19):5124-32. doi: 10.1158/1078-0432.CCR-14-1233. Epub 2014 Aug 14.

14.

Resistance of Cancer Cells to Targeted Therapies Through the Activation of Compensating Signaling Loops.

von Manstein V, Yang CM, Richter D, Delis N, Vafaizadeh V, Groner B.

Curr Signal Transduct Ther. 2013 Dec;8(3):193-202.

15.

STAT3 induction of miR-146b forms a feedback loop to inhibit the NF-κB to IL-6 signaling axis and STAT3-driven cancer phenotypes.

Xiang M, Birkbak NJ, Vafaizadeh V, Walker SR, Yeh JE, Liu S, Kroll Y, Boldin M, Taganov K, Groner B, Richardson AL, Frank DA.

Sci Signal. 2014 Jan 28;7(310):ra11. doi: 10.1126/scisignal.2004497.

16.

Molecular and cellular endocrinology: special issue on cytokine signaling.

Groner B.

Mol Cell Endocrinol. 2014 Jan 25;382(1):551. No abstract available.

PMID:
24427791
17.

The inhibition of stat5 by a Peptide aptamer ligand specific for the DNA binding domain prevents target gene transactivation and the growth of breast and prostate tumor cells.

Weber A, Borghouts C, Brendel C, Moriggl R, Delis N, Brill B, Vafaizadeh V, Groner B.

Pharmaceuticals (Basel). 2013 Aug 20;6(8):960-87. doi: 10.3390/ph6080960.

18.

Cytokine regulation of mammary gland development and epithelial cell functions through discrete activities of Stat proteins.

Groner B, Vafaizadeh V.

Mol Cell Endocrinol. 2014 Jan 25;382(1):552-559. doi: 10.1016/j.mce.2013.08.019. Epub 2013 Sep 27. No abstract available.

PMID:
24076095
19.

Targeting survivin in cancer: novel drug development approaches.

Groner B, Weiss A.

BioDrugs. 2014 Feb;28(1):27-39. doi: 10.1007/s40259-013-0058-x. Review.

20.

Stem cells of the mammary epithelium and their role in breast cancer.

Vafaizadeh V, Groner B.

Eur J Radiol. 2012 Sep;81 Suppl 1:S174-6. doi: 10.1016/S0720-048X(12)70071-2. No abstract available.

PMID:
23083579
21.

STAT3 silencing inhibits glioma single cell infiltration and tumor growth.

Priester M, Copanaki E, Vafaizadeh V, Hensel S, Bernreuther C, Glatzel M, Seifert V, Groner B, Kögel D, Weissenberger J.

Neuro Oncol. 2013 Jul;15(7):840-52. doi: 10.1093/neuonc/not025. Epub 2013 Mar 13. Erratum in: Neuro Oncol. 2013 Oct;15(10):1452.

22.

Increasing the range of drug targets: interacting peptides provide leads for the development of oncoprotein inhibitors.

Groner B, Weber A, Mack L.

Bioengineered. 2012 Nov-Dec;3(6):320-5. doi: 10.4161/bioe.21272. Epub 2012 Jul 24. Review.

23.

Determinants of the extent and duration of STAT3 signaling.

Groner B.

JAKSTAT. 2012 Jul 1;1(3):211-5. doi: 10.4161/jkst.21469.

24.

Inhibition of Stat3 by peptide aptamer rS3-PA enhances growth suppressive effects of irinotecan on colorectal cancer cells.

Weber A, Borghouts C, Delis N, Mack L, Brill B, Bernard AC, Coqueret O, Groner B.

Horm Mol Biol Clin Investig. 2012 Jun;10(2):273-9. doi: 10.1515/hmbci-2012-0014.

PMID:
25436684
25.

Stat3 is activated in skin lesions by the local application of imiquimod, a ligand of TLR7, and inhibited by the recombinant peptide aptamer rS3-PA.

Mack L, Brill B, Delis N, Borghouts C, Weber A, Groner B.

Horm Mol Biol Clin Investig. 2012 Jun;10(2):265-72. doi: 10.1515/hmbci-2012-0007.

PMID:
25436683
26.

Stat3 inhibition in neural lineage cells.

Chiba T, Mack L, Delis N, Brill B, Groner B.

Horm Mol Biol Clin Investig. 2012 Jun;10(2):255-63. doi: 10.1515/hmbci-2012-0005.

PMID:
25436682
27.

Expression of reprogramming factors in breast cancer cell lines and the regulation by activated Stat3.

Yang CM, Chiba T, Groner B.

Horm Mol Biol Clin Investig. 2012 Jun;10(2):241-8. doi: 10.1515/hmbci-2012-0003.

PMID:
25436680
28.

Transforming growth factor β signaling regulates the invasiveness of normal mammary epithelial cells and the metastasis formation of tumor cells.

Vafaizadeh V, Graab U, Darvishi T, Machado R, Groner B.

Horm Mol Biol Clin Investig. 2012 Jun;10(1):227-39. doi: 10.1515/hmbci-2012-0016.

PMID:
25436679
29.

The versatile regulation of cellular events by Jak-Stat signaling: from transcriptional control to microtubule dynamics and energy metabolism.

Groner B, Hennighausen L.

Horm Mol Biol Clin Investig. 2012 Jun;10(1):193-200. doi: 10.1515/hmbci-2012-0010. No abstract available.

PMID:
25436675
30.

Cytokine receptors and their Stat-mediated mechanisms of action.

Groner B, Hennighausen L.

Horm Mol Biol Clin Investig. 2012 Jun;10(1):191. doi: 10.1515/hmbci-2012-0017. No abstract available.

PMID:
25436674
31.

Survivin inhibition by an interacting recombinant peptide, derived from the human ferritin heavy chain, impedes tumor cell growth.

Weiss A, Brill B, Borghouts C, Delis N, Mack L, Groner B.

J Cancer Res Clin Oncol. 2012 Jul;138(7):1205-20. doi: 10.1007/s00432-012-1195-1. Epub 2012 Mar 18.

PMID:
22426960
32.

A membrane penetrating peptide aptamer inhibits STAT3 function and suppresses the growth of STAT3 addicted tumor cells.

Borghouts C, Delis N, Brill B, Weiss A, Mack L, Lucks P, Groner B.

JAKSTAT. 2012 Jan 1;1(1):44-54. doi: 10.4161/jkst.18947.

33.

Stat5 assumes distinct functions in mammary gland development and mammary tumor formation.

Vafaizadeh V, Klemmt PA, Groner B.

Front Biosci (Landmark Ed). 2012 Jan 1;17:1232-50.

PMID:
22201800
34.

c-Kit is required for growth and survival of the cells of origin of Brca1-mutation-associated breast cancer.

Regan JL, Kendrick H, Magnay FA, Vafaizadeh V, Groner B, Smalley MJ.

Oncogene. 2012 Feb 16;31(7):869-83. doi: 10.1038/onc.2011.289. Epub 2011 Jul 18.

PMID:
21765473
35.

The potential of amniotic fluid stem cells for cellular therapy and tissue engineering.

Klemmt PA, Vafaizadeh V, Groner B.

Expert Opin Biol Ther. 2011 Oct;11(10):1297-314. doi: 10.1517/14712598.2011.587800. Epub 2011 May 31. Review.

PMID:
21623704
36.

Tracking the activation of Stat5 through the expression of an inducible reporter gene in a transgenic mouse line.

Bednorz NL, Brill B, Klein A, Gäbel K, Groner B.

Endocrinology. 2011 May;152(5):1935-47. doi: 10.1210/en.2011-0053. Epub 2011 Mar 22.

PMID:
21427222
37.

The integration of a Stat3 specific peptide aptamer into the thioredoxin scaffold protein strongly enhances its inhibitory potency.

Schöneberger H, Weiss A, Brill B, Delis N, Borghouts C, Groner B.

Horm Mol Biol Clin Investig. 2011 Mar 1;5(1):1-9. doi: 10.1515/HMBCI.2011.013.

PMID:
25961238
38.

MicroRNA-dependent regulation of the microenvironment and the epithelial stromal cell interactions in the mouse mammary gland.

Ucar A, Vafaizadeh V, Chowdhury K, Groner B.

Cell Cycle. 2011 Feb 15;10(4):563-5. Epub 2011 Feb 15. No abstract available.

PMID:
21266838
39.

Unfavorable drug interactions in targeted breast cancer therapy.

Groner B, Hynes NE.

Cancer Cell. 2010 Nov 16;18(5):401-2. doi: 10.1016/j.ccr.2010.10.027. No abstract available.

40.

miR-212 and miR-132 are required for epithelial stromal interactions necessary for mouse mammary gland development.

Ucar A, Vafaizadeh V, Jarry H, Fiedler J, Klemmt PA, Thum T, Groner B, Chowdhury K.

Nat Genet. 2010 Dec;42(12):1101-8. doi: 10.1038/ng.709. Epub 2010 Nov 7.

PMID:
21057503
41.

Murine amniotic fluid stem cells contribute mesenchymal but not epithelial components to reconstituted mammary ducts.

Klemmt PA, Vafaizadeh V, Groner B.

Stem Cell Res Ther. 2010 Jul 7;1(3):20. doi: 10.1186/scrt20.

42.

The intracellular delivery of a recombinant peptide derived from the acidic domain of PIAS3 inhibits STAT3 transactivation and induces tumor cell death.

Borghouts C, Tittmann H, Delis N, Kirchenbauer M, Brill B, Groner B.

Mol Cancer Res. 2010 Apr;8(4):539-53. doi: 10.1158/1541-7786.MCR-09-0417. Epub 2010 Apr 6.

43.

Mammary epithelial reconstitution with gene-modified stem cells assigns roles to Stat5 in luminal alveolar cell fate decisions, differentiation, involution, and mammary tumor formation.

Vafaizadeh V, Klemmt P, Brendel C, Weber K, Doebele C, Britt K, Grez M, Fehse B, Desriviéres S, Groner B.

Stem Cells. 2010 May;28(5):928-38. doi: 10.1002/stem.407.

44.

Stem cells of the breast and cancer therapy.

Groner B, Vafaizadeh V, Brill B, Klemmt P.

Womens Health (Lond). 2010 Mar;6(2):205-19. doi: 10.2217/whe.10.5. Review.

PMID:
20187727
45.

Visualization of Stat3 and Stat5 transactivation activity with specific response element dependent reporter constructs integrated into lentiviral gene transfer vectors.

Gäbel K, Bednorz NL, Klemmt P, Vafaizadeh V, Borghouts C, Groner B.

Horm Mol Biol Clin Investig. 2010 Jan 1;1(3):127-37. doi: 10.1515/HMBCI.2010.017.

PMID:
25961188
46.

Mammary epithelial and breast cancer stem cells.

Groner B, Vafaizadeh V, Brill B, Klemmt P.

Eur J Cancer. 2009 Sep;45 Suppl 1:186-93. doi: 10.1016/S0959-8049(09)70032-2. No abstract available.

PMID:
19775617
47.

Heat shock protein-90-alpha, a prolactin-STAT5 target gene identified in breast cancer cells, is involved in apoptosis regulation.

Perotti C, Liu R, Parusel CT, Böcher N, Schultz J, Bork P, Pfitzner E, Groner B, Shemanko CS.

Breast Cancer Res. 2008;10(6):R94. doi: 10.1186/bcr2193. Epub 2008 Nov 13.

48.

DNA vaccination with a mutated p53 allele induces specific cytolytic T cells and protects against tumor cell growth and the formation of metastasis.

Humar M, Maurer M, Azemar M, Groner B.

J Cancer Res Clin Oncol. 2009 Apr;135(4):567-80. doi: 10.1007/s00432-008-0491-2. Epub 2008 Oct 10.

PMID:
18846387
49.

The function of Stat3 in tumor cells and their microenvironment.

Groner B, Lucks P, Borghouts C.

Semin Cell Dev Biol. 2008 Aug;19(4):341-50. doi: 10.1016/j.semcdb.2008.06.005. Epub 2008 Jun 24. Review.

PMID:
18621135
50.

A sparing procedure to clear the mouse mammary fat pad of epithelial components for transplantation analysis.

Brill B, Boecher N, Groner B, Shemanko CS.

Lab Anim. 2008 Jan;42(1):104-10. doi: 10.1258/la.2007.06003e.

PMID:
18348772

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