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Items: 1 to 50 of 110

1.

Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.

Harris PA, Faucher N, George N, Eidam PM, King BW, White GV, Anderson NA, Bandyopadhyay D, Beal AM, Beneton V, Berger SB, Campobasso N, Campos S, Capriotti CA, Cox JA, Daugan A, Donche F, Fouchet MH, Finger JN, Geddes B, Gough PJ, Grondin P, Hoffman BL, Hoffman SJ, Hutchinson SE, Jeong JU, Jigorel E, Lamoureux P, Leister LK, Lich JD, Mahajan MK, Meslamani J, Mosley JE, Nagilla R, Nassau PM, Ng SL, Ouellette MT, Pasikanti KK, Potvain F, Reilly MA, Rivera EJ, Sautet S, Schaeffer MC, Sehon CA, Sun H, Thorpe JH, Totoritis RD, Ward P, Wellaway N, Wisnoski DD, Woolven JM, Bertin J, Marquis RW.

J Med Chem. 2019 May 23;62(10):5096-5110. doi: 10.1021/acs.jmedchem.9b00318. Epub 2019 May 2.

PMID:
31013427
2.

A new AMPK activator, GSK773, corrects fatty acid oxidation and differentiation defect in CPT2-deficient myotubes.

Boufroura FZ, Le Bachelier C, Tomkiewicz-Raulet C, Schlemmer D, Benoist JF, Grondin P, Lamotte Y, Mirguet O, Mouillet-Richard S, Bastin J, Djouadi F.

Hum Mol Genet. 2018 Oct 1;27(19):3417-3433. doi: 10.1093/hmg/ddy254.

PMID:
30007356
3.

Drivers of postfire soil organic carbon accumulation in the boreal forest.

Andrieux B, Beguin J, Bergeron Y, Grondin P, Paré D.

Glob Chang Biol. 2018 Oct;24(10):4797-4815. doi: 10.1111/gcb.14365. Epub 2018 Jul 16.

PMID:
29963722
4.

Ultrasound-guided tendon fenestration versus open-release surgery for the treatment of chronic lateral epicondylosis of the elbow: protocol for a prospective, randomised, single blinded study.

Lungu E, Grondin P, Tétreault P, Desmeules F, Cloutier G, Choinière M, Bureau NJ.

BMJ Open. 2018 Jun 9;8(6):e021373. doi: 10.1136/bmjopen-2017-021373.

5.

Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2).

Woolford AJ, Day PJ, Bénéton V, Berdini V, Coyle JE, Dudit Y, Grondin P, Huet P, Lee LY, Manas ES, McMenamin RL, Murray CW, Page LW, Patel VK, Potvain F, Rich SJ, Sang Y, Somers DO, Trottet L, Wan Z, Zhang X.

J Med Chem. 2016 Dec 8;59(23):10738-10749. Epub 2016 Nov 18.

PMID:
27933945
6.

Thrombospondin-1 Mimetic Agonist Peptides Induce Selective Death in Tumor Cells: Design, Synthesis, and Structure-Activity Relationship Studies.

Denèfle T, Boullet H, Herbi L, Newton C, Martinez-Torres AC, Guez A, Pramil E, Quiney C, Pourcelot M, Levasseur MD, Lardé E, Moumné R, Ogi FX, Grondin P, Merle-Beral H, Lequin O, Susin SA, Karoyan P.

J Med Chem. 2016 Sep 22;59(18):8412-21. doi: 10.1021/acs.jmedchem.6b00781. Epub 2016 Sep 2.

PMID:
27526615
7.

Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening.

Woolford AJ, Pero JE, Aravapalli S, Berdini V, Coyle JE, Day PJ, Dodson AM, Grondin P, Holding FP, Lee LY, Li P, Manas ES, Marino J Jr, Martin AC, McCleland BW, McMenamin RL, Murray CW, Neipp CE, Page LW, Patel VK, Potvain F, Rich S, Rivero RA, Smith K, Somers DO, Trottet L, Velagaleti R, Williams G, Xie R.

J Med Chem. 2016 Jun 9;59(11):5356-67. doi: 10.1021/acs.jmedchem.6b00212. Epub 2016 May 20.

PMID:
27167608
8.

Regional paleofire regimes affected by non-uniform climate, vegetation and human drivers.

Blarquez O, Ali AA, Girardin MP, Grondin P, Fréchette B, Bergeron Y, Hély C.

Sci Rep. 2015 Sep 2;5:13356. doi: 10.1038/srep13356.

9.

Ecological gradients driving the distribution of four Ericaceae in boreal Quebec, Canada.

Thiffault N, Grondin P, Noël J, Poirier V.

Ecol Evol. 2015 May;5(9):1837-53. doi: 10.1002/ece3.1476. Epub 2015 Apr 9.

10.

Discovery of Pyridones As Oral AMPK Direct Activators.

Mirguet O, Sautet S, Clément CA, Toum J, Donche F, Marques C, Rondet E, Pizzonero M, Beaufils B, Dudit Y, Huet P, Trottet L, Grondin P, Brusq JM, Boursier E, Saintillan Y, Nicodeme E.

ACS Med Chem Lett. 2013 May 17;4(7):632-6. doi: 10.1021/ml400157g. eCollection 2013 Jul 11.

11.

Comparison of soluble guanylate cyclase stimulators and activators in models of cardiovascular disease associated with oxidative stress.

Costell MH, Ancellin N, Bernard RE, Zhao S, Upson JJ, Morgan LA, Maniscalco K, Olzinski AR, Ballard VL, Herry K, Grondin P, Dodic N, Mirguet O, Bouillot A, Gellibert F, Coatney RW, Lepore JJ, Jucker BM, Jolivette LJ, Willette RN, Schnackenberg CG, Behm DJ.

Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012.

12.

Liquid-crystalline zinc(II) and iron(II) alkyltriazoles one-dimensional coordination polymers.

Grondin P, Siretanu D, Roubeau O, Achard MF, Clérac R.

Inorg Chem. 2012 May 7;51(9):5417-26. doi: 10.1021/ic300404r. Epub 2012 Apr 9.

PMID:
22486423
13.

Multifunctional gels from polymeric spin-crossover metallo-gelators.

Grondin P, Roubeau O, Castro M, Saadaoui H, Colin A, Clérac R.

Langmuir. 2010 Apr 6;26(7):5184-95. doi: 10.1021/la903653d.

PMID:
20099819
14.
15.

Shear-induced fractures and three-dimensional motions in an organogel.

Grondin P, Manneville S, Pozzo JL, Colin A.

Phys Rev E Stat Nonlin Soft Matter Phys. 2008 Jan;77(1 Pt 1):011401. Epub 2008 Jan 11.

PMID:
18351851
16.

Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade.

Sanders MJ, Grondin PO, Hegarty BD, Snowden MA, Carling D.

Biochem J. 2007 Apr 1;403(1):139-48.

17.

Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine.

Brusq JM, Ancellin N, Grondin P, Guillard R, Martin S, Saintillan Y, Issandou M.

J Lipid Res. 2006 Jun;47(6):1281-8. Epub 2006 Feb 28.

18.

Thixotropic organogels based on a simple N-hydroxyalkyl amide: rheological and aging properties.

Lescanne M, Grondin P, d'Aléo A, Fages F, Pozzo JL, Monval OM, Reinheimer P, Colin A.

Langmuir. 2004 Apr 13;20(8):3032-41.

PMID:
15875826
19.

Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver.

Foretz M, Ancellin N, Andreelli F, Saintillan Y, Grondin P, Kahn A, Thorens B, Vaulont S, Viollet B.

Diabetes. 2005 May;54(5):1331-9.

20.

The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues.

Daugan A, Grondin P, Ruault C, Le Monnier de Gouville AC, Coste H, Linget JM, Kirilovsky J, Hyafil F, Labaudinière R.

J Med Chem. 2003 Oct 9;46(21):4533-42.

PMID:
14521415
21.

The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 1: 5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione analogues.

Daugan A, Grondin P, Ruault C, Le Monnier de Gouville AC, Coste H, Kirilovsky J, Hyafil F, Labaudinière R.

J Med Chem. 2003 Oct 9;46(21):4525-32.

PMID:
14521414
22.
23.

Effect of a cGMP-specific phosphodiesterase inhibitor on retinal function.

Estrade M, Grondin P, Cluzel J, Bonhomme B, Doly M.

Eur J Pharmacol. 1998 Jul 10;352(2-3):157-63.

PMID:
9716350
24.

Appearance of low signal intensity lines in MRI of silicone breast implants.

Stroman PW, Rolland C, Dufour M, Grondin P, Guidoin RG.

Biomaterials. 1996 May;17(10):983-8.

PMID:
8736732
25.

Characterization of a novel potent and specific inhibitor of type V phosphodiesterase.

Coste H, Grondin P.

Biochem Pharmacol. 1995 Nov 9;50(10):1577-85.

PMID:
7503759
26.

Adrenoleukodystrophy: magnetic resonance follow-up after Lorenzo's oil therapy.

Duchesne N, Dufour M, Bouchard G, Grondin P, Lemieux B.

Can Assoc Radiol J. 1995 Oct;46(5):386-91.

PMID:
7552831
27.

Magnetic resonance study of virgin and explanted silicone breast prostheses. Can proton relaxation times be used to monitor their biostability?

Dorne L, Stroman P, Rolland C, Auger M, Alikacem N, Bronskill M, Grondin P, King MW, Guidoin R.

ASAIO J. 1994 Jul-Sep;40(3):M625-31.

PMID:
8555590
28.

Magnetic resonance imaging in moyamoya disease.

Trottier F, Dufour M, Grondin P, Bouchard G, Dionne G.

Can Assoc Radiol J. 1994 Apr;45(2):137-9.

PMID:
8149270
29.

Radiographic features of cauda equina syndrome complicating ankylosing spondylitis.

Normand JP, Dufour M, Lang JY, Grondin P, Bouchard G.

Can Assoc Radiol J. 1994 Feb;45(1):58-61.

PMID:
8118718
30.

Involvement of platelet glycoprotein IIb-IIIa (alpha IIb-beta 3 integrin) in thrombin-induced synthesis of phosphatidylinositol 3',4'-bisphosphate.

Sultan C, Plantavid M, Bachelot C, Grondin P, Breton M, Mauco G, Lévy-Toledano S, Caen JP, Chap H.

J Biol Chem. 1991 Dec 15;266(35):23554-7.

31.

Interaction of pp60c-src, phospholipase C, inositol-lipid, and diacyglycerol kinases with the cytoskeletons of thrombin-stimulated platelets.

Grondin P, Plantavid M, Sultan C, Breton M, Mauco G, Chap H.

J Biol Chem. 1991 Aug 25;266(24):15705-9.

32.

The novel inositol lipid phosphatidylinositol 3,4-bisphosphate is produced by human blood platelets upon thrombin stimulation.

Sultan C, Breton M, Mauco G, Grondin P, Plantavid M, Chap H.

Biochem J. 1990 Aug 1;269(3):831-4.

33.

Purification and characterization of a novel phospholipid transfer protein from filamentous fungi.

Grondin P, Vergnolle C, Chavant L, Kader JC.

Int J Biochem. 1990;22(1):93-8.

PMID:
2328823
34.

Aseptic necrosis of the cricoid: a complication of tracheal intubation.

Charlin B, Dehon A, Bergeron D, Mongeau CJ, Grondin P.

J Otolaryngol. 1987 Dec;16(6):377-81.

PMID:
3694746
35.

Cancer of the kidney invading the vena cava and heart. Results after 11 years of treatment.

Vaislic CD, Puel P, Grondin P, Vargas A, Thevenet A, Fontan F, Deville C, Leguerrier A, Touchot B, Piwnica A, et al.

J Thorac Cardiovasc Surg. 1986 Apr;91(4):604-9.

PMID:
3959581
36.

Partial ileal bypass in type II familial hypercholesterolemia. Eleven-year experience at the Montreal Heart institute.

Vaislic CD, Grondin PR, Bourassa MG, Campeau L.

Am Surg. 1984 Mar;50(3):165-8.

PMID:
6367576
37.

[Familial auriculo-ventricular heart block?].

Grondin P, Nguyen HV, Malcolm I.

Can Med Assoc J. 1983 May 15;128(10):1144. French. No abstract available.

38.

[10-12 years' clinical results in 300 initial patients undergoing aortocoronary bypass at the Montreal Cardiology Institute].

Vaislic CD, Grondin PR, Bourassa MG, Campeau L.

Union Med Can. 1983 Mar;112(3):229-34. French. No abstract available.

PMID:
6602410
39.

Technical hint to correct loose anastomoses.

Grondin PR, Vaislic CD, Vargas A.

J Thorac Cardiovasc Surg. 1982 Jun;83(6):939-40. No abstract available.

PMID:
7045538
40.

How valuable is perioperative flow measurement in aortocoronary bypass grafts?

Grondin PR.

Ann Thorac Surg. 1981 May;31(5):398-9. No abstract available.

PMID:
6971628
41.

[Valve replacement: past, present and future].

Grondin P.

Union Med Can. 1979 Oct;108(10):1145-56. French. No abstract available.

PMID:
392866
42.

[Sub-dural hematoma, complication of anti-coagulants for valvular mechanical protheses. Role of heterografts (author's transl)].

Barra JA, Kretz JG, Grondin P.

Ann Cardiol Angeiol (Paris). 1979 May-Jun;28(3):163-5. French. No abstract available.

PMID:
507720
43.

A simple device for achieving pulsatile flow during cardiopulmonary bypass.

Desjardins J, Maillé JG, Lussier J, Grondin P.

Ann Thorac Surg. 1979 Feb;27(2):178-80. No abstract available.

PMID:
453977
44.

Natural history of saccular aneurysms of the left ventricle.

Grondin P, Kretz JG, Bical O, Donzeau-Gouge P, Petitclerc R, Campeau L.

J Thorac Cardiovasc Surg. 1979 Jan;77(1):57-64.

PMID:
758565
45.

Surgical correction of chronic postembolic obstructions of the pulmonary arteries.

Cabrol C, Cabrol A, Acar J, Gandjbakhch I, Guiraudon G, Laughlin L, Mattei MF, Godeau P, Grondin P.

J Thorac Cardiovasc Surg. 1978 Nov;76(5):620-8.

PMID:
703366
46.

Combined valve replacement or valvulotomy and bypass graft surgery.

Grondin P, Donzeau-Gouge P, Bical O, Kretz JG.

Cleve Clin Q. 1978 Spring;45(1):123-4. No abstract available.

PMID:
306299
47.

Successful course after supraarterial myotomy for myocardial bridging and milking effect of the left anterior descending artery.

Grondin P, Bourassa MG, Noble J, Petitclerc R, Dydra I.

Ann Thorac Surg. 1977 Nov;24(5):422-9.

PMID:
921375
48.

Primary arteritis in Takayasu's disease: a case studied by selective coronary arteriography.

Pasternac A, Lesperance J, Grondin P, Cantin M.

AJR Am J Roentgenol. 1977 Mar;128(3):488-90. No abstract available.

PMID:
14517
49.

Royal College Lecture, 1976. Preoperative left ventricular ejection fraction and survival after coronary artery surgery.

Grondin P, Donzaeau-Gouge GP, Bical O, Lesperance J.

Can J Surg. 1976 Nov;19(6):487-93.

PMID:
1086704
50.

[Long-term development of pure operated mitral insufficiency].

Bical O, Donzeau-Gouge GP, Grondin P, Lepage G.

Union Med Can. 1976 Jul;105(7):1083-88. French. No abstract available.

PMID:
960286

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