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Items: 25

1.

Metabolism of strained rings: glutathione S-transferase catalyzed formation of a glutathione conjugated spiro-azetidine without prior bioactivation.

Li XQ, Gronberg G, Bangur EH, Hayes MA, Castagnoli N Jr, Weidolf L.

Drug Metab Dispos. 2019 Sep 6. pii: dmd.119.088658. doi: 10.1124/dmd.119.088658. [Epub ahead of print]

2.

Synthesis of 2 C-14 labeled cathepsin C inhibitors: The use of a cyanide to displace a Benzotriazole.

Kingston L, Bergare J, Lönn H, Ericsson C, Grönberg G, Chen S, Elmore CS.

J Labelled Comp Radiopharm. 2017 May 30;60(6):294-301. doi: 10.1002/jlcr.3502.

PMID:
28324911
3.

Synthesis of 1β-hydroxydeoxycholic acid in H-2 and unlabeled forms.

Hayes MA, Roberts I, Grönberg G, Lv K, Lin B, Bergare J, Elmore CS.

J Labelled Comp Radiopharm. 2017 Apr;60(4):221-229. doi: 10.1002/jlcr.3495. Epub 2017 Mar 20.

PMID:
28183147
4.

Phenotypic Screen for Cardiac Regeneration Identifies Molecules with Differential Activity in Human Epicardium-Derived Cells versus Cardiac Fibroblasts.

Paunovic AI, Drowley L, Nordqvist A, Ericson E, Mouchet E, Jonebring A, Grönberg G, Kvist AJ, Engkvist O, Brown MR, Gedda K, Goumans MJ, Wang QD, Plowright AT.

ACS Chem Biol. 2017 Jan 20;12(1):132-141. doi: 10.1021/acschembio.6b00683. Epub 2016 Nov 30.

PMID:
28103692
5.

CYP3A Specifically Catalyzes 1β-Hydroxylation of Deoxycholic Acid: Characterization and Enzymatic Synthesis of a Potential Novel Urinary Biomarker for CYP3A Activity.

Hayes MA, Li XQ, Grönberg G, Diczfalusy U, Andersson TB.

Drug Metab Dispos. 2016 Sep;44(9):1480-9. doi: 10.1124/dmd.116.070805. Epub 2016 Jul 11.

PMID:
27402728
6.

Macrocyclic Prodrugs of a Selective Nonpeptidic Direct Thrombin Inhibitor Display High Permeability, Efficient Bioconversion but Low Bioavailability.

Andersson V, Bergström F, Brånalt J, Grönberg G, Gustafsson D, Karlsson S, Polla M, Bergman J, Kihlberg J.

J Med Chem. 2016 Jul 28;59(14):6658-70. doi: 10.1021/acs.jmedchem.5b01871. Epub 2016 Jul 12.

PMID:
27347787
7.

Synthesis of [(3) H] and [(2) H6 ]AZD6642, an inhibitor of 5-lipoxygenase activating protein (FLAP).

Lindelöf Å, Ericsson C, Simonsson R, Nilsson G, Grönberg G, Elmore CS.

J Labelled Comp Radiopharm. 2016 Jul;59(9):340-5. doi: 10.1002/jlcr.3409. Epub 2016 Jun 14.

PMID:
27298225
8.

Discovery of a Novel Microsomal Epoxide Hydrolase-Catalyzed Hydration of a Spiro Oxetane.

Li XQ, Hayes MA, Grönberg G, Berggren K, Castagnoli N Jr, Weidolf L.

Drug Metab Dispos. 2016 Aug;44(8):1341-8. doi: 10.1124/dmd.116.071142. Epub 2016 Jun 2.

PMID:
27256986
9.

A P450 fusion library of heme domains from Rhodococcus jostii RHA1 and its evaluation for the biotransformation of drug molecules.

Kulig JK, Spandolf C, Hyde R, Ruzzini AC, Eltis LD, Grönberg G, Hayes MA, Grogan G.

Bioorg Med Chem. 2015 Sep 1;23(17):5603-9. doi: 10.1016/j.bmc.2015.07.025. Epub 2015 Jul 21.

PMID:
26234905
10.

Impact of stereospecific intramolecular hydrogen bonding on cell permeability and physicochemical properties.

Over B, McCarren P, Artursson P, Foley M, Giordanetto F, Grönberg G, Hilgendorf C, Lee MD 4th, Matsson P, Muncipinto G, Pellisson M, Perry MW, Svensson R, Duvall JR, Kihlberg J.

J Med Chem. 2014 Mar 27;57(6):2746-54. doi: 10.1021/jm500059t. Epub 2014 Feb 26.

11.

Novel metabolites of amodiaquine formed by CYP1A1 and CYP1B1: structure elucidation using electrochemistry, mass spectrometry, and NMR.

Johansson T, Jurva U, Grönberg G, Weidolf L, Masimirembwa C.

Drug Metab Dispos. 2009 Mar;37(3):571-9. doi: 10.1124/dmd.108.025171. Epub 2008 Dec 15.

PMID:
19074972
12.

Electrochemical oxidation of troglitazone: identification and characterization of the major reactive metabolite in liver microsomes.

Madsen KG, Grönberg G, Skonberg C, Jurva U, Hansen SH, Olsen J.

Chem Res Toxicol. 2008 Oct;21(10):2035-41. doi: 10.1021/tx8002214. Epub 2008 Sep 13.

PMID:
18788755
13.

Electrochemical generation of electrophilic drug metabolites: characterization of amodiaquine quinoneimine and cysteinyl conjugates by MS, IR, and NMR.

Jurva U, Holmén A, Grönberg G, Masimirembwa C, Weidolf L.

Chem Res Toxicol. 2008 Apr;21(4):928-35. doi: 10.1021/tx700400c. Epub 2008 Mar 25.

PMID:
18361508
15.
16.

Investigation of the structural heterogeneity in the carbohydrate portion of a mouse monoclonal immunoglobulin A antibody.

Lipniunas P, Grönberg G, Krotkiewski H, Angel AS, Nilsson B.

Arch Biochem Biophys. 1993 Jan;300(1):335-45.

PMID:
8424667
17.

Structural analysis of five new monosialylated oligosaccharides from human milk.

Grönberg G, Lipniunas P, Lundgren T, Lindh F, Nilsson B.

Arch Biochem Biophys. 1992 Aug 1;296(2):597-610.

PMID:
1632647
18.

Isolation of two novel sialyl-Lewis X-active oligosaccharides by high-performance liquid affinity chromatography using monoclonal antibody Onc-M26.

Wang WT, Lundgren T, Lindh F, Nilsson B, Grönberg G, Brown JP, Mentzer-Dibert H, Zopf D.

Arch Biochem Biophys. 1992 Feb 1;292(2):433-41.

PMID:
1346241
19.

Structural analysis of the N-linked oligosaccharides from murine glycophorin.

Angel AS, Grönberg G, Krotkiewski H, Lisowska E, Nilsson B.

Arch Biochem Biophys. 1991 Nov 15;291(1):76-88.

PMID:
1929437
20.

The carbohydrate structures of a mouse monoclonal IgG antibody OKT3.

Krotkiewski H, Grönberg G, Krotkiewska B, Nilsson B, Svensson S.

J Biol Chem. 1990 Nov 25;265(33):20195-201.

21.

Isolation and structural analysis of three new disialylated oligosaccharides from human milk.

Grönberg G, Lipniunas P, Lundgren T, Lindh F, Nilsson B.

Arch Biochem Biophys. 1990 May 1;278(2):297-311.

PMID:
2327786
22.

Isolation of monosialyated oligosaccharides from human milk and structural analysis of three new compounds.

Grönberg G, Lipniunas P, Lundgren T, Erlansson K, Lindh F, Nilsson B.

Carbohydr Res. 1989 Aug 15;191(2):261-78.

PMID:
2582462
23.

Structural and immunochemical analysis of three alpha-limit dextrin oligosaccharides.

Kumlien J, Grönberg G, Nilsson B, Månsson O, Zopf D, Lundblad A.

Arch Biochem Biophys. 1989 Mar;269(2):678-89.

PMID:
2919890
24.

Oligosaccharides from feces of preterm infants fed on breast milk.

Sabharwal H, Nilsson B, Grönberg G, Chester MA, Dakour J, Sjöblad S, Lundblad A.

Arch Biochem Biophys. 1988 Sep;265(2):390-406.

PMID:
3421714
25.

Oligosaccharides from faeces of a blood-group B, breast-fed infant.

Sabharwal H, Nilsson B, Chester MA, Lindh F, Grönberg G, Sjöblad S, Lundblad A.

Carbohydr Res. 1988 Jul 15;178:145-54.

PMID:
3191506

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