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Items: 1 to 50 of 246

1.

Endoplasmic Reticulum Stress-Induced Upregulation of STARD1 Promotes Acetaminophen-Induced Acute Liver Failure.

Torres S, Baulies A, Insausti-Urkia N, Alarcón-Vila C, Fucho R, Solsona-Vilarrasa E, Núñez S, Robles D, Ribas V, Wakefield L, Grompe M, Lucena MI, Andrade RJ, Win S, Aung TA, Kaplowitz N, García-Ruiz C, Fernández-Checa JC.

Gastroenterology. 2019 Apr 25. pii: S0016-5085(19)36716-2. doi: 10.1053/j.gastro.2019.04.023. [Epub ahead of print]

2.

Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells.

Furuyama K, Chera S, van Gurp L, Oropeza D, Ghila L, Damond N, Vethe H, Paulo JA, Joosten AM, Berney T, Bosco D, Dorrell C, Grompe M, Ræder H, Roep BO, Thorel F, Herrera PL.

Nature. 2019 Mar;567(7746):43-48. doi: 10.1038/s41586-019-0942-8. Epub 2019 Feb 13.

PMID:
30760930
3.

Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture.

Peng WC, Logan CY, Fish M, Anbarchian T, Aguisanda F, Álvarez-Varela A, Wu P, Jin Y, Zhu J, Li B, Grompe M, Wang B, Nusse R.

Cell. 2018 Nov 29;175(6):1607-1619.e15. doi: 10.1016/j.cell.2018.11.012.

4.

Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease.

Moss J, Magenheim J, Neiman D, Zemmour H, Loyfer N, Korach A, Samet Y, Maoz M, Druid H, Arner P, Fu KY, Kiss E, Spalding KL, Landesberg G, Zick A, Grinshpun A, Shapiro AMJ, Grompe M, Wittenberg AD, Glaser B, Shemer R, Kaplan T, Dor Y.

Nat Commun. 2018 Nov 29;9(1):5068. doi: 10.1038/s41467-018-07466-6.

5.

Combination therapy with atorvastatin and celecoxib delays tumor formation in a Fanconi anemia mouse model.

Zhang QS, Deater M, Phan N, Marcogliese A, Major A, Guinan EC, Grompe M.

Pediatr Blood Cancer. 2019 Jan;66(1):e27460. doi: 10.1002/pbc.27460. Epub 2018 Sep 25.

PMID:
30255556
6.

Monitoring liver damage using hepatocyte-specific methylation markers in cell-free circulating DNA.

Lehmann-Werman R, Magenheim J, Moss J, Neiman D, Abraham O, Piyanzin S, Zemmour H, Fox I, Dor T, Grompe M, Landesberg G, Loza BL, Shaked A, Olthoff K, Glaser B, Shemer R, Dor Y.

JCI Insight. 2018 Jun 21;3(12). pii: 120687. doi: 10.1172/jci.insight.120687. eCollection 2018 Jun 21.

7.

Long-Term Correction of Diabetes in Mice by In Vivo Reprogramming of Pancreatic Ducts.

Wang Y, Dorrell C, Naugler WE, Heskett M, Spellman P, Li B, Galivo F, Haft A, Wakefield L, Grompe M.

Mol Ther. 2018 May 2;26(5):1327-1342. doi: 10.1016/j.ymthe.2018.02.014. Epub 2018 Feb 21.

8.

Effects of erythropoietin receptor activity on angiogenesis, tubular injury, and fibrosis in acute kidney injury: a "U-shaped" relationship.

Shi M, Flores B, Li P, Gillings N, McMillan KL, Ye J, Huang LJ, Sidhu SS, Zhong YP, Grompe MT, Streeter PR, Moe OW, Hu MC.

Am J Physiol Renal Physiol. 2018 Apr 1;314(4):F501-F516. doi: 10.1152/ajprenal.00306.2017. Epub 2017 Nov 29.

9.

Genome-wide genetic and epigenetic analyses of pancreatic acinar cell carcinomas reveal aberrations in genome stability.

Jäkel C, Bergmann F, Toth R, Assenov Y, van der Duin D, Strobel O, Hank T, Klöppel G, Dorrell C, Grompe M, Moss J, Dor Y, Schirmacher P, Plass C, Popanda O, Schmezer P.

Nat Commun. 2017 Nov 6;8(1):1323. doi: 10.1038/s41467-017-01118-x.

10.

Bioengineered AAV Capsids with Combined High Human Liver Transduction In Vivo and Unique Humoral Seroreactivity.

Paulk NK, Pekrun K, Zhu E, Nygaard S, Li B, Xu J, Chu K, Leborgne C, Dane AP, Haft A, Zhang Y, Zhang F, Morton C, Valentine MB, Davidoff AM, Nathwani AC, Mingozzi F, Grompe M, Alexander IE, Lisowski L, Kay MA.

Mol Ther. 2018 Jan 3;26(1):289-303. doi: 10.1016/j.ymthe.2017.09.021. Epub 2017 Sep 25.

11.

Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors.

Cogger KF, Sinha A, Sarangi F, McGaugh EC, Saunders D, Dorrell C, Mejia-Guerrero S, Aghazadeh Y, Rourke JL, Screaton RA, Grompe M, Streeter PR, Powers AC, Brissova M, Kislinger T, Nostro MC.

Nat Commun. 2017 Aug 24;8(1):331. doi: 10.1038/s41467-017-00561-0.

12.

Reprogramming human gallbladder cells into insulin-producing β-like cells.

Galivo F, Benedetti E, Wang Y, Pelz C, Schug J, Kaestner KH, Grompe M.

PLoS One. 2017 Aug 16;12(8):e0181812. doi: 10.1371/journal.pone.0181812. eCollection 2017.

13.

Diagnosis and treatment of tyrosinemia type I: a US and Canadian consensus group review and recommendations.

Chinsky JM, Singh R, Ficicioglu C, van Karnebeek CDM, Grompe M, Mitchell G, Waisbren SE, Gucsavas-Calikoglu M, Wasserstein MP, Coakley K, Scott CR.

Genet Med. 2017 Dec;19(12). doi: 10.1038/gim.2017.101. Epub 2017 Aug 3. Review.

14.

Fah Knockout Animals as Models for Therapeutic Liver Repopulation.

Grompe M.

Adv Exp Med Biol. 2017;959:215-230. doi: 10.1007/978-3-319-55780-9_20. Review.

PMID:
28755199
15.

Adult Mouse Liver Contains Two Distinct Populations of Cholangiocytes.

Li B, Dorrell C, Canaday PS, Pelz C, Haft A, Finegold M, Grompe M.

Stem Cell Reports. 2017 Aug 8;9(2):478-489. doi: 10.1016/j.stemcr.2017.06.003. Epub 2017 Jul 6.

16.

A Drug Screen using Human iPSC-Derived Hepatocyte-like Cells Reveals Cardiac Glycosides as a Potential Treatment for Hypercholesterolemia.

Cayo MA, Mallanna SK, Di Furio F, Jing R, Tolliver LB, Bures M, Urick A, Noto FK, Pashos EE, Greseth MD, Czarnecki M, Traktman P, Yang W, Morrisey EE, Grompe M, Rader DJ, Duncan SA.

Cell Stem Cell. 2017 Apr 6;20(4):478-489.e5. doi: 10.1016/j.stem.2017.01.011.

17.

Chronic Phenotype Characterization of a Large-Animal Model of Hereditary Tyrosinemia Type 1.

Elgilani F, Mao SA, Glorioso JM, Yin M, Iankov ID, Singh A, Amiot B, Rinaldo P, Marler RJ, Ehman RL, Grompe M, Lillegard JB, Hickey RD, Nyberg SL.

Am J Pathol. 2017 Jan;187(1):33-41. doi: 10.1016/j.ajpath.2016.09.013. Epub 2016 Nov 14.

18.

Efficient generation of pancreatic β-like cells from the mouse gallbladder.

Wang Y, Galivo F, Pelz C, Haft A, Lee J, Kim SK, Grompe M.

Stem Cell Res. 2016 Nov;17(3):587-596. doi: 10.1016/j.scr.2016.10.009. Epub 2016 Oct 27.

19.

Successful Engraftment of Human Hepatocytes in uPA-SCID and FRG® KO Mice.

Foquet L, Wilson EM, Verhoye L, Grompe M, Leroux-Roels G, Bial J, Meuleman P.

Methods Mol Biol. 2017;1506:117-130.

PMID:
27830549
20.

Metformin improves defective hematopoiesis and delays tumor formation in Fanconi anemia mice.

Zhang QS, Tang W, Deater M, Phan N, Marcogliese AN, Li H, Al-Dhalimy M, Major A, Olson S, Monnat RJ Jr, Grompe M.

Blood. 2016 Dec 15;128(24):2774-2784. Epub 2016 Oct 18.

21.

Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas.

Wang YJ, Golson ML, Schug J, Traum D, Liu C, Vivek K, Dorrell C, Naji A, Powers AC, Chang KM, Grompe M, Kaestner KH.

Cell Metab. 2016 Oct 11;24(4):616-626. doi: 10.1016/j.cmet.2016.09.007.

22.

Stem Cells and Regeneration in the Digestive System: Keystone Meeting.

Soffers JH, Hansen D, Sinagoga KL, Li B, Martin MG, Wells J, Grompe M, Li L.

Gastroenterology. 2016 Sep;151(3):e6-9. doi: 10.1053/j.gastro.2016.07.037. Epub 2016 Jul 29. No abstract available.

23.

Curative ex vivo liver-directed gene therapy in a pig model of hereditary tyrosinemia type 1.

Hickey RD, Mao SA, Glorioso J, Elgilani F, Amiot B, Chen H, Rinaldo P, Marler R, Jiang H, DeGrado TR, Suksanpaisan L, O'Connor MK, Freeman BL, Ibrahim SH, Peng KW, Harding CO, Ho CS, Grompe M, Ikeda Y, Lillegard JB, Russell SJ, Nyberg SL.

Sci Transl Med. 2016 Jul 27;8(349):349ra99. doi: 10.1126/scitranslmed.aaf3838.

24.

Human islets contain four distinct subtypes of β cells.

Dorrell C, Schug J, Canaday PS, Russ HA, Tarlow BD, Grompe MT, Horton T, Hebrok M, Streeter PR, Kaestner KH, Grompe M.

Nat Commun. 2016 Jul 11;7:11756. doi: 10.1038/ncomms11756.

25.

Silent Tyrosinemia Type I Without Elevated Tyrosine or Succinylacetone Associated with Liver Cirrhosis and Hepatocellular Carcinoma.

Blackburn PR, Hickey RD, Nace RA, Giama NH, Kraft DL, Bordner AJ, Chaiteerakij R, McCormick JB, Radulovic M, Graham RP, Torbenson MS, Tortorelli S, Scott CR, Lindor NM, Milliner DS, Oglesbee D, Al-Qabandi W, Grompe M, Gavrilov DK, El-Youssef M, Clark KJ, Atwal PS, Roberts LR, Klee EW, Ekker SC.

Hum Mutat. 2016 Oct;37(10):1097-105. doi: 10.1002/humu.23047. Epub 2016 Aug 8.

26.

A universal system to select gene-modified hepatocytes in vivo.

Nygaard S, Barzel A, Haft A, Major A, Finegold M, Kay MA, Grompe M.

Sci Transl Med. 2016 Jun 8;8(342):342ra79. doi: 10.1126/scitranslmed.aad8166.

27.

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function.

Arda HE, Li L, Tsai J, Torre EA, Rosli Y, Peiris H, Spitale RC, Dai C, Gu X, Qu K, Wang P, Wang J, Grompe M, Scharfmann R, Snyder MS, Bottino R, Powers AC, Chang HY, Kim SK.

Cell Metab. 2016 May 10;23(5):909-20. doi: 10.1016/j.cmet.2016.04.002. Epub 2016 Apr 28.

28.

TGF-β Inhibition Rescues Hematopoietic Stem Cell Defects and Bone Marrow Failure in Fanconi Anemia.

Zhang H, Kozono DE, O'Connor KW, Vidal-Cardenas S, Rousseau A, Hamilton A, Moreau L, Gaudiano EF, Greenberger J, Bagby G, Soulier J, Grompe M, Parmar K, D'Andrea AD.

Cell Stem Cell. 2016 May 5;18(5):668-81. doi: 10.1016/j.stem.2016.03.002. Epub 2016 Mar 24.

29.

Identification of tissue-specific cell death using methylation patterns of circulating DNA.

Lehmann-Werman R, Neiman D, Zemmour H, Moss J, Magenheim J, Vaknin-Dembinsky A, Rubertsson S, Nellgård B, Blennow K, Zetterberg H, Spalding K, Haller MJ, Wasserfall CH, Schatz DA, Greenbaum CJ, Dorrell C, Grompe M, Zick A, Hubert A, Maoz M, Fendrich V, Bartsch DK, Golan T, Ben Sasson SA, Zamir G, Razin A, Cedar H, Shapiro AM, Glaser B, Shemer R, Dor Y.

Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):E1826-34. doi: 10.1073/pnas.1519286113. Epub 2016 Mar 14.

30.

Stem cells versus plasticity in liver and pancreas regeneration.

Kopp JL, Grompe M, Sander M.

Nat Cell Biol. 2016 Mar;18(3):238-45. doi: 10.1038/ncb3309. Review.

PMID:
26911907
31.

Adeno-associated virus finds its disease.

Russell DW, Grompe M.

Nat Genet. 2015 Oct;47(10):1104-5. doi: 10.1038/ng.3407.

32.

Directed differentiation of cholangiocytes from human pluripotent stem cells.

Ogawa M, Ogawa S, Bear CE, Ahmadi S, Chin S, Li B, Grompe M, Keller G, Kamath BM, Ghanekar A.

Nat Biotechnol. 2015 Aug;33(8):853-61. doi: 10.1038/nbt.3294. Epub 2015 Jul 13.

PMID:
26167630
33.

Novel surface markers directed against adult human gallbladder.

Galivo FH, Dorrell C, Grompe MT, Zhong Y, Streeter PR, Grompe M.

Stem Cell Res. 2015 Jul;15(1):172-81. doi: 10.1016/j.scr.2015.06.004. Epub 2015 Jun 11.

34.

The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice.

Zhang QS, Deater M, Schubert K, Marquez-Loza L, Pelz C, Sinclair DA, Grompe M.

Stem Cell Res. 2015 Jul;15(1):130-40. doi: 10.1016/j.scr.2015.05.007. Epub 2015 May 22.

35.

Fibroblast Growth Factor Signaling Controls Liver Size in Mice With Humanized Livers.

Naugler WE, Tarlow BD, Fedorov LM, Taylor M, Pelz C, Li B, Darnell J, Grompe M.

Gastroenterology. 2015 Sep;149(3):728-40.e15. doi: 10.1053/j.gastro.2015.05.043. Epub 2015 May 29.

36.

Oxymetholone therapy of fanconi anemia suppresses osteopontin transcription and induces hematopoietic stem cell cycling.

Zhang QS, Benedetti E, Deater M, Schubert K, Major A, Pelz C, Impey S, Marquez-Loza L, Rathbun RK, Kato S, Bagby GC, Grompe M.

Stem Cell Reports. 2015 Jan 13;4(1):90-102. doi: 10.1016/j.stemcr.2014.10.014. Epub 2014 Nov 26.

37.

Bipotential adult liver progenitors are derived from chronically injured mature hepatocytes.

Tarlow BD, Pelz C, Naugler WE, Wakefield L, Wilson EM, Finegold MJ, Grompe M.

Cell Stem Cell. 2014 Nov 6;15(5):605-18. doi: 10.1016/j.stem.2014.09.008. Epub 2014 Oct 9.

38.

Extensive double humanization of both liver and hematopoiesis in FRGN mice.

Wilson EM, Bial J, Tarlow B, Bial G, Jensen B, Greiner DL, Brehm MA, Grompe M.

Stem Cell Res. 2014 Nov;13(3 Pt A):404-12. doi: 10.1016/j.scr.2014.08.006. Epub 2014 Sep 6.

39.

Liver stem cells, where art thou?

Grompe M.

Cell Stem Cell. 2014 Sep 4;15(3):257-258. doi: 10.1016/j.stem.2014.08.004.

40.

The organoid-initiating cells in mouse pancreas and liver are phenotypically and functionally similar.

Dorrell C, Tarlow B, Wang Y, Canaday PS, Haft A, Schug J, Streeter PR, Finegold MJ, Shenje LT, Kaestner KH, Grompe M.

Stem Cell Res. 2014 Sep;13(2):275-83. doi: 10.1016/j.scr.2014.07.006. Epub 2014 Jul 27.

41.

Fumarylacetoacetate hydrolase deficient pigs are a novel large animal model of metabolic liver disease.

Hickey RD, Mao SA, Glorioso J, Lillegard JB, Fisher JE, Amiot B, Rinaldo P, Harding CO, Marler R, Finegold MJ, Grompe M, Nyberg SL.

Stem Cell Res. 2014 Jul;13(1):144-53. doi: 10.1016/j.scr.2014.05.003. Epub 2014 May 14.

42.

Clonal tracing of Sox9+ liver progenitors in mouse oval cell injury.

Tarlow BD, Finegold MJ, Grompe M.

Hepatology. 2014 Jul;60(1):278-89. doi: 10.1002/hep.27084. Epub 2014 May 28.

43.

Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype.

Yin H, Xue W, Chen S, Bogorad RL, Benedetti E, Grompe M, Koteliansky V, Sharp PA, Jacks T, Anderson DG.

Nat Biotechnol. 2014 Jun;32(6):551-3. doi: 10.1038/nbt.2884. Epub 2014 Mar 30. Erratum in: Nat Biotechnol. 2014 Sep;32(9):952.

44.

Pharmacologic inhibition of L-tyrosine degradation ameliorates cerebral dopamine deficiency in murine phenylketonuria (PKU).

Harding CO, Winn SR, Gibson KM, Arning E, Bottiglieri T, Grompe M.

J Inherit Metab Dis. 2014 Sep;37(5):735-43. doi: 10.1007/s10545-013-9675-2. Epub 2014 Feb 3.

45.

Selection and evaluation of clinically relevant AAV variants in a xenograft liver model.

Lisowski L, Dane AP, Chu K, Zhang Y, Cunningham SC, Wilson EM, Nygaard S, Grompe M, Alexander IE, Kay MA.

Nature. 2014 Feb 20;506(7488):382-6. doi: 10.1038/nature12875. Epub 2013 Dec 25.

46.

Mice with chimeric livers are an improved model for human lipoprotein metabolism.

Ellis EC, Naugler WE, Parini P, Mörk LM, Jorns C, Zemack H, Sandblom AL, Björkhem I, Ericzon BG, Wilson EM, Strom SC, Grompe M.

PLoS One. 2013 Nov 4;8(11):e78550. doi: 10.1371/journal.pone.0078550. eCollection 2013. Erratum in: PLoS One. 2014;9(7):e103870. Nauglers, Scott [corrected to Naugler, Willscott Edward].

47.

Anthracyclines induce DNA damage response-mediated protection against severe sepsis.

Figueiredo N, Chora A, Raquel H, Pejanovic N, Pereira P, Hartleben B, Neves-Costa A, Moita C, Pedroso D, Pinto A, Marques S, Faridi H, Costa P, Gozzelino R, Zhao JL, Soares MP, Gama-Carvalho M, Martinez J, Zhang Q, Döring G, Grompe M, Simas JP, Huber TB, Baltimore D, Gupta V, Green DR, Ferreira JA, Moita LF.

Immunity. 2013 Nov 14;39(5):874-84. doi: 10.1016/j.immuni.2013.08.039. Epub 2013 Oct 31.

48.

Evaluation of resveratrol and N-acetylcysteine for cancer chemoprevention in a Fanconi anemia murine model.

Zhang QS, Marquez-Loza L, Sheehan AM, Watanabe-Smith K, Eaton L, Benedetti E, Major A, Schubert K, Deater M, Joseph E, Grompe M.

Pediatr Blood Cancer. 2014 Apr;61(4):740-2. doi: 10.1002/pbc.24780. Epub 2013 Sep 20.

49.

Mice with human livers.

Grompe M, Strom S.

Gastroenterology. 2013 Dec;145(6):1209-14. doi: 10.1053/j.gastro.2013.09.009. Epub 2013 Sep 13. Review.

PMID:
24042096
50.

Assessing the potential of induced liver regeneration.

Michalopoulos GK, Grompe M, Theise ND.

Nat Med. 2013 Sep;19(9):1096-7. doi: 10.1038/nm.3325. No abstract available.

PMID:
24013747

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