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Does the FSHB c.-211G > T polymorphism impact Sertoli cell number and the spermatogenic potential in infertile patients?

Schubert M, Kaldewey S, Pérez Lanuza L, Krenz H, Dugas M, Berres S, Kliesch S, Wistuba J, Gromoll J.

Andrology. 2020 Feb 24. doi: 10.1111/andr.12777. [Epub ahead of print]


Response to: X-linked miR-506 family miRNAs promote FMRP expression in mouse spermatogonia.

Ramaiah M, Tan K, Plank TM, Song HW, Dumdie JN, Jones S, Shum EY, Sheridan SD, Peterson KJ, Gromoll J, Haggarty SJ, Cook-Andersen H, Wilkinson MF.

EMBO Rep. 2020 Jan 7;21(1):e49354. doi: 10.15252/embr.201949354. Epub 2019 Dec 6. No abstract available.


High-resolution analysis of germ cells from men with sex chromosomal aneuploidies reveals normal transcriptome but impaired imprinting.

Laurentino S, Heckmann L, Di Persio S, Li X, Meyer Zu Hörste G, Wistuba J, Cremers JF, Gromoll J, Kliesch S, Schlatt S, Neuhaus N.

Clin Epigenetics. 2019 Aug 28;11(1):127. doi: 10.1186/s13148-019-0720-3.


Ageing in men with normal spermatogenesis alters spermatogonial dynamics and nuclear morphology in Sertoli cells.

Pohl E, Höffken V, Schlatt S, Kliesch S, Gromoll J, Wistuba J.

Andrology. 2019 Nov;7(6):827-839. doi: 10.1111/andr.12665. Epub 2019 Jun 27.


Pharmacogenetics of FSH Action in the Male.

Schubert M, Pérez Lanuza L, Gromoll J.

Front Endocrinol (Lausanne). 2019 Feb 28;10:47. doi: 10.3389/fendo.2019.00047. eCollection 2019.


FSHB -211 G>T Polymorphism as Predictor for TESE Success in Patients With Unexplained Azoospermia.

Busch AS, Tüttelmann F, Cremers JF, Schubert M, Nordhoff V, Schüring AN, Zitzmann M, Gromoll J, Kliesch S.

J Clin Endocrinol Metab. 2019 Jun 1;104(6):2315-2324. doi: 10.1210/jc.2018-02249.


A microRNA cluster in the Fragile-X region expressed during spermatogenesis targets FMR1.

Ramaiah M, Tan K, Plank TM, Song HW, Dumdie JN, Jones S, Shum EY, Sheridan SD, Peterson KJ, Gromoll J, Haggarty SJ, Cook-Andersen H, Wilkinson MF.

EMBO Rep. 2019 Feb;20(2). pii: e46566. doi: 10.15252/embr.201846566. Epub 2018 Dec 20.


The impact of FSH receptor polymorphism on time-to-pregnancy: a cross-sectional single-centre study.

Zilaitiene B, Dirzauskas M, Verkauskiene R, Ostrauskas R, Gromoll J, Nieschlag E.

BMC Pregnancy Childbirth. 2018 Jun 28;18(1):272. doi: 10.1186/s12884-018-1910-2.


Is the FSHR 2039A>G variant associated with susceptibility to testicular germ cell cancer?

Bang AK, Busch AS, Almstrup K, Gromoll J, Kliesch S, Rajpert-De Meyts E, Skakkebaek NE, Juul A, Tüttelmann F, Jørgensen N.

Andrology. 2018 Jan;6(1):176-183. doi: 10.1111/andr.12440. Epub 2017 Nov 27.


The human RHOX gene cluster: target genes and functional analysis of gene variants in infertile men.

Borgmann J, Tüttelmann F, Dworniczak B, Röpke A, Song HW, Kliesch S, Wilkinson MF, Laurentino S, Gromoll J.

Hum Mol Genet. 2016 Nov 15;25(22):4898-4910. doi: 10.1093/hmg/ddw313.


Testosterone and androgen receptor gene polymorphism are associated with confidence and competitiveness in men.

Eisenegger C, Kumsta R, Naef M, Gromoll J, Heinrichs M.

Horm Behav. 2017 Jun;92:93-102. doi: 10.1016/j.yhbeh.2016.09.011. Epub 2016 Oct 1.


De novo methylation in male germ cells of the common marmoset monkey occurs during postnatal development and is maintained in vitro.

Langenstroth-Röwer D, Gromoll J, Wistuba J, Tröndle I, Laurentino S, Schlatt S, Neuhaus N.

Epigenetics. 2017 Jul 3;12(7):527-539. doi: 10.1080/15592294.2016.1248007. Epub 2016 Oct 27.


Interindividual Variation in DNA Methylation at a Putative POMC Metastable Epiallele Is Associated with Obesity.

Kühnen P, Handke D, Waterland RA, Hennig BJ, Silver M, Fulford AJ, Dominguez-Salas P, Moore SE, Prentice AM, Spranger J, Hinney A, Hebebrand J, Heppner FL, Walzer L, Grötzinger C, Gromoll J, Wiegand S, Grüters A, Krude H.

Cell Metab. 2016 Sep 13;24(3):502-509. doi: 10.1016/j.cmet.2016.08.001. Epub 2016 Aug 25.


The Klinefelter syndrome: current management and research challenges.

Nieschlag E, Ferlin A, Gravholt CH, Gromoll J, Köhler B, Lejeune H, Rogol AD, Wistuba J.

Andrology. 2016 May;4(3):545-9. doi: 10.1111/andr.12208. No abstract available.


An alternative interpretation of cellular 'selfish spermatogonial selection'-clusters in the human testis indicates the need for 3-D-analyses.

Pohl E, Gromoll J, Kliesch S, Wistuba J.

Andrology. 2016 Mar;4(2):213-7. doi: 10.1111/andr.12142. Epub 2016 Feb 19.


On the origin of sperm epigenetic heterogeneity.

Laurentino S, Borgmann J, Gromoll J.

Reproduction. 2016 May;151(5):R71-8. doi: 10.1530/REP-15-0436. Epub 2016 Feb 16. Review.


[Social freezing - the male perspective].

Gromoll J, Tüttelmann F, Kliesch S.

Urologe A. 2016 Jan;55(1):58-62. doi: 10.1007/s00120-015-3943-8. Review. German.


Differences in Signal Activation by LH and hCG are Mediated by the LH/CG Receptor's Extracellular Hinge Region.

Grzesik P, Kreuchwig A, Rutz C, Furkert J, Wiesner B, Schuelein R, Kleinau G, Gromoll J, Krause G.

Front Endocrinol (Lausanne). 2015 Sep 22;6:140. doi: 10.3389/fendo.2015.00140. eCollection 2015.


Non-viral generation of marmoset monkey iPS cells by a six-factor-in-one-vector approach.

Debowski K, Warthemann R, Lentes J, Salinas-Riester G, Dressel R, Langenstroth D, Gromoll J, Sasaki E, Behr R.

PLoS One. 2015 Mar 18;10(3):e0118424. doi: 10.1371/journal.pone.0118424. eCollection 2015.


Direct but no transgenerational effects of decitabine and vorinostat on male fertility.

Kläver R, Sánchez V, Damm OS, Redmann K, Lahrmann E, Sandhowe-Klaverkamp R, Rohde C, Wistuba J, Ehmcke J, Schlatt S, Gromoll J.

PLoS One. 2015 Feb 18;10(2):e0117839. doi: 10.1371/journal.pone.0117839. eCollection 2015.


Gene expression patterns in relation to the clinical phenotype in Klinefelter syndrome.

Zitzmann M, Bongers R, Werler S, Bogdanova N, Wistuba J, Kliesch S, Gromoll J, Tüttelmann F.

J Clin Endocrinol Metab. 2015 Mar;100(3):E518-23. doi: 10.1210/jc.2014-2780. Epub 2014 Dec 22.


Epigenetic germline mosaicism in infertile men.

Laurentino S, Beygo J, Nordhoff V, Kliesch S, Wistuba J, Borgmann J, Buiting K, Horsthemke B, Gromoll J.

Hum Mol Genet. 2015 Mar 1;24(5):1295-304. doi: 10.1093/hmg/ddu540. Epub 2014 Oct 21.


The FSHB -211G>T variant attenuates serum FSH levels in the supraphysiological gonadotropin setting of Klinefelter syndrome.

Busch AS, Tüttelmann F, Zitzmann M, Kliesch S, Gromoll J.

Eur J Hum Genet. 2015 May;23(5):700-3. doi: 10.1038/ejhg.2014.142. Epub 2014 Jul 23.


Separation of somatic and germ cells is required to establish primate spermatogonial cultures.

Langenstroth D, Kossack N, Westernströer B, Wistuba J, Behr R, Gromoll J, Schlatt S.

Hum Reprod. 2014 Sep;29(9):2018-31. doi: 10.1093/humrep/deu157. Epub 2014 Jun 24.


Bringing epigenetics into the diagnostics of the andrology laboratory: challenges and perspectives.

Kläver R, Gromoll J.

Asian J Androl. 2014 Sep-Oct;16(5):669-74. doi: 10.4103/1008-682X.125412.


MicroRNA miR-513a-3p acts as a co-regulator of luteinizing hormone/chorionic gonadotropin receptor gene expression in human granulosa cells.

Troppmann B, Kossack N, Nordhoff V, Schüring AN, Gromoll J.

Mol Cell Endocrinol. 2014 Jun 5;390(1-2):65-72. doi: 10.1016/j.mce.2014.04.003. Epub 2014 Apr 18.


Intratesticular testosterone is increased in men with Klinefelter syndrome and may not be released into the bloodstream owing to altered testicular vascularization– a preliminary report.

Tuttelmann F, Damm OS, Luetjens CM, Baldi M, Zitzmann M, Kliesch S, Nieschlag E, Gromoll J, Wistuba J, Simoni M.

Andrology. 2014 Mar;2(2):275-81.


Differences between lutropin-mediated and choriogonadotropin-mediated receptor activation.

Grzesik P, Teichmann A, Furkert J, Rutz C, Wiesner B, Kleinau G, Schülein R, Gromoll J, Krause G.

FEBS J. 2014 Mar;281(5):1479-92. doi: 10.1111/febs.12718. Epub 2014 Feb 10.


Germ cell loss is associated with fading Lin28a expression in a mouse model for Klinefelter's syndrome.

Werler S, Demond H, Damm OS, Ehmcke J, Middendorff R, Gromoll J, Wistuba J.

Reproduction. 2014 Jan 25;147(3):253-64. doi: 10.1530/REP-13-0608. Print 2014 Mar.


The origin of the RB1 imprint.

Kanber D, Buiting K, Roos C, Gromoll J, Kaya S, Horsthemke B, Lohmann D.

PLoS One. 2013 Nov 25;8(11):e81502. doi: 10.1371/journal.pone.0081502. eCollection 2013.


A combined approach facilitates the reliable detection of human spermatogonia in vitro.

Kossack N, Terwort N, Wistuba J, Ehmcke J, Schlatt S, Schöler H, Kliesch S, Gromoll J.

Hum Reprod. 2013 Nov;28(11):3012-25. doi: 10.1093/humrep/det336. Epub 2013 Sep 3.


Broad DNA methylation changes of spermatogenesis, inflammation and immune response-related genes in a subgroup of sperm samples for assisted reproduction.

Schütte B, El Hajj N, Kuhtz J, Nanda I, Gromoll J, Hahn T, Dittrich M, Schorsch M, Müller T, Haaf T.

Andrology. 2013 Nov;1(6):822-9. doi: 10.1111/j.2047-2927.2013.00122.x. Epub 2013 Aug 28.


DNA methylation in spermatozoa as a prospective marker in andrology.

Kläver R, Tüttelmann F, Bleiziffer A, Haaf T, Kliesch S, Gromoll J.

Andrology. 2013 Sep;1(5):731-40. doi: 10.1111/j.2047-2927.2013.00118.x.


Epigenetic regulation of the RHOX homeobox gene cluster and its association with human male infertility.

Richardson ME, Bleiziffer A, Tüttelmann F, Gromoll J, Wilkinson MF.

Hum Mol Genet. 2014 Jan 1;23(1):12-23. doi: 10.1093/hmg/ddt392. Epub 2013 Aug 13.


Structural and functional plasticity of the luteinizing hormone/choriogonadotrophin receptor.

Troppmann B, Kleinau G, Krause G, Gromoll J.

Hum Reprod Update. 2013 Sep-Oct;19(5):583-602. doi: 10.1093/humupd/dmt023. Epub 2013 May 17. Review.


The relation between sex hormone levels, the androgen receptor CAGn-polymorphism and depression and mortality in older men in a community study.

Schneider G, Zitzmann M, Gromoll J, Ladwig KH, Berger K.

Psychoneuroendocrinology. 2013 Oct;38(10):2083-90. doi: 10.1016/j.psyneuen.2013.03.016. Epub 2013 Apr 17.


The RHOX homeobox gene cluster is selectively expressed in human oocytes and male germ cells.

Song HW, Anderson RA, Bayne RA, Gromoll J, Shimasaki S, Chang RJ, Parast MM, Laurent LC, de Rooij DG, Hsieh TC, Wilkinson MF.

Hum Reprod. 2013 Jun;28(6):1635-46. doi: 10.1093/humrep/det043. Epub 2013 Mar 12.


Comprehensive sequence analysis of the NR5A1 gene encoding steroidogenic factor 1 in a large group of infertile males.

Röpke A, Tewes AC, Gromoll J, Kliesch S, Wieacker P, Tüttelmann F.

Eur J Hum Genet. 2013 Sep;21(9):1012-5. doi: 10.1038/ejhg.2012.290. Epub 2013 Jan 9.


Aberrant transcription of the LHCGR gene caused by a mutation in exon 6A leads to Leydig cell hypoplasia type II.

Kossack N, Troppmann B, Richter-Unruh A, Kleinau G, Gromoll J.

Mol Cell Endocrinol. 2013 Feb 5;366(1):59-67. doi: 10.1016/j.mce.2012.11.018. Epub 2012 Dec 8.


Effects of the FSH-β-subunit promoter polymorphism -211G->T on the hypothalamic-pituitary-ovarian axis in normally cycling women indicate a gender-specific regulation of gonadotropin secretion.

Schüring AN, Busch AS, Bogdanova N, Gromoll J, Tüttelmann F.

J Clin Endocrinol Metab. 2013 Jan;98(1):E82-6. doi: 10.1210/jc.2012-2780. Epub 2012 Nov 1.


Combined effects of the variants FSHB -211G>T and FSHR 2039A>G on male reproductive parameters.

Tüttelmann F, Laan M, Grigorova M, Punab M, Sõber S, Gromoll J.

J Clin Endocrinol Metab. 2012 Oct;97(10):3639-47. doi: 10.1210/jc.2012-1761. Epub 2012 Jul 12.


Comparative marker analysis after isolation and culture of testicular cells from the immature marmoset.

Albert S, Wistuba J, Eildermann K, Ehmcke J, Schlatt S, Gromoll J, Kossack N.

Cells Tissues Organs. 2012;196(6):543-54. doi: 10.1159/000339010. Epub 2012 Jun 27.


Routine cryopreservation of spermatozoa is safe--evidence from the DNA methylation pattern of nine spermatozoa genes.

Kläver R, Bleiziffer A, Redmann K, Mallidis C, Kliesch S, Gromoll J.

J Assist Reprod Genet. 2012 Sep;29(9):943-50. doi: 10.1007/s10815-012-9813-z. Epub 2012 Jun 13.


The pluripotency factor LIN28 in monkey and human testes: a marker for spermatogonial stem cells?

Aeckerle N, Eildermann K, Drummer C, Ehmcke J, Schweyer S, Lerchl A, Bergmann M, Kliesch S, Gromoll J, Schlatt S, Behr R.

Mol Hum Reprod. 2012 Oct;18(10):477-88. Epub 2012 Jun 11.


Developmental expression of the pluripotency factor sal-like protein 4 in the monkey, human and mouse testis: restriction to premeiotic germ cells.

Eildermann K, Aeckerle N, Debowski K, Godmann M, Christiansen H, Heistermann M, Schweyer S, Bergmann M, Kliesch S, Gromoll J, Ehmcke J, Schlatt S, Behr R.

Cells Tissues Organs. 2012;196(3):206-20. doi: 10.1159/000335031. Epub 2012 May 8.


Misleading and reliable markers to differentiate between primate testis-derived multipotent stromal cells and spermatogonia in culture.

Eildermann K, Gromoll J, Behr R.

Hum Reprod. 2012 Jun;27(6):1754-67. doi: 10.1093/humrep/des091. Epub 2012 Mar 22.


Role of the CAG repeat polymorphism of the androgen receptor gene in polycystic ovary syndrome (PCOS).

Schüring AN, Welp A, Gromoll J, Zitzmann M, Sonntag B, Nieschlag E, Greb RR, Kiesel L.

Exp Clin Endocrinol Diabetes. 2012 Feb;120(2):73-9. doi: 10.1055/s-0031-1291343. Epub 2011 Nov 8.


Evaluation of CAG repeat length of androgen receptor expressing cells in human testes showing different pictures of spermatogenic impairment.

Fietz D, Geyer J, Kliesch S, Gromoll J, Bergmann M.

Histochem Cell Biol. 2011 Dec;136(6):689-97. doi: 10.1007/s00418-011-0871-6. Epub 2011 Oct 25.


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