Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 80


Improved efficacy against malignant brain tumors with EGFRwt/EGFRvIII targeting immunotoxin and checkpoint inhibitor combinations.

Chandramohan V, Bao X, Yu X, Parker S, McDowall C, Yu YR, Healy P, Desjardins A, Gunn MD, Gromeier M, Nair SK, Pastan IH, Bigner DD.

J Immunother Cancer. 2019 May 29;7(1):142. doi: 10.1186/s40425-019-0614-0.


Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors.

Yu X, Dobrikov M, Keir ST, Gromeier M, Pastan IH, Reisfeld R, Bigner DD, Chandramohan V.

PLoS One. 2019 Jan 9;14(1):e0210608. doi: 10.1371/journal.pone.0210608. eCollection 2019.


Ribosomal RACK1:Protein Kinase C βII Modulates Intramolecular Interactions between Unstructured Regions of Eukaryotic Initiation Factor 4G (eIF4G) That Control eIF4E and eIF3 Binding.

Dobrikov MI, Dobrikova EY, Gromeier M.

Mol Cell Biol. 2018 Sep 14;38(19). pii: e00306-18. doi: 10.1128/MCB.00306-18. Print 2018 Oct 1.


Ribosomal RACK1:Protein Kinase C βII Phosphorylates Eukaryotic Initiation Factor 4G1 at S1093 To Modulate Cap-Dependent and -Independent Translation Initiation.

Dobrikov MI, Dobrikova EY, Gromeier M.

Mol Cell Biol. 2018 Sep 14;38(19). pii: e00304-18. doi: 10.1128/MCB.00304-18. Print 2018 Oct 1.


Engineered Oncolytic Poliovirus PVSRIPO Subverts MDA5-Dependent Innate Immune Responses in Cancer Cells.

Walton RW, Brown MC, Sacco MT, Gromeier M.

J Virol. 2018 Sep 12;92(19). pii: e00879-18. doi: 10.1128/JVI.00879-18. Print 2018 Oct 1.


Recurrent Glioblastoma Treated with Recombinant Poliovirus.

Desjardins A, Gromeier M, Herndon JE 2nd, Beaubier N, Bolognesi DP, Friedman AH, Friedman HS, McSherry F, Muscat AM, Nair S, Peters KB, Randazzo D, Sampson JH, Vlahovic G, Harrison WT, McLendon RE, Ashley D, Bigner DD.

N Engl J Med. 2018 Jul 12;379(2):150-161. doi: 10.1056/NEJMoa1716435. Epub 2018 Jun 26.


Poliovirus Receptor (CD155) Expression in Pediatric Brain Tumors Mediates Oncolysis of Medulloblastoma and Pleomorphic Xanthoastrocytoma.

Thompson EM, Brown M, Dobrikova E, Ramaswamy V, Taylor MD, McLendon R, Sanks J, Chandramohan V, Bigner D, Gromeier M.

J Neuropathol Exp Neurol. 2018 Aug 1;77(8):696-702. doi: 10.1093/jnen/nly045.


Regulation of Hypoxia-Inducible Factor 1α during Hypoxia by DAP5-Induced Translation of PHD2.

Bryant JD, Brown MC, Dobrikov MI, Dobrikova EY, Gemberling SL, Zhang Q, Gromeier M.

Mol Cell Biol. 2018 May 15;38(11). pii: e00647-17. doi: 10.1128/MCB.00647-17. Print 2018 Jun 1.


Recombinant Poliovirus for Cancer Immunotherapy.

Gromeier M, Nair SK.

Annu Rev Med. 2018 Jan 29;69:289-299. doi: 10.1146/annurev-med-050715-104655. Review.


XIAP Regulation by MNK Links MAPK and NFκB Signaling to Determine an Aggressive Breast Cancer Phenotype.

Evans MK, Brown MC, Geradts J, Bao X, Robinson TJ, Jolly MK, Vermeulen PB, Palmer GM, Gromeier M, Levine H, Morse MA, Van Laere SJ, Devi GR.

Cancer Res. 2018 Apr 1;78(7):1726-1738. doi: 10.1158/0008-5472.CAN-17-1667. Epub 2018 Jan 19.


Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen-specific CTLs.

Brown MC, Holl EK, Boczkowski D, Dobrikova E, Mosaheb M, Chandramohan V, Bigner DD, Gromeier M, Nair SK.

Sci Transl Med. 2017 Sep 20;9(408). pii: eaan4220. doi: 10.1126/scitranslmed.aan4220.


Validation of an Immunohistochemistry Assay for Detection of CD155, the Poliovirus Receptor, in Malignant Gliomas.

Chandramohan V, Bryant JD, Piao H, Keir ST, Lipp ES, Lefaivre M, Perkinson K, Bigner DD, Gromeier M, McLendon RE.

Arch Pathol Lab Med. 2017 Dec;141(12):1697-1704. doi: 10.5858/arpa.2016-0580-OA. Epub 2017 Aug 22.


MNK inversely regulates TELO2 vs. DEPTOR to control mTORC1 signaling.

Brown MC, Gromeier M.

Mol Cell Oncol. 2017 Mar 17;4(3):e1306010. doi: 10.1080/23723556.2017.1306010. eCollection 2017.


Gender Differences in Motor Skills of the Overarm Throw.

Gromeier M, Koester D, Schack T.

Front Psychol. 2017 Feb 17;8:212. doi: 10.3389/fpsyg.2017.00212. eCollection 2017.


MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1.

Brown MC, Gromeier M.

Cell Rep. 2017 Feb 7;18(6):1444-1457. doi: 10.1016/j.celrep.2017.01.023.


Recombinant oncolytic poliovirus, PVSRIPO, has potent cytotoxic and innate inflammatory effects, mediating therapy in human breast and prostate cancer xenograft models.

Holl EK, Brown MC, Boczkowski D, McNamara MA, George DJ, Bigner DD, Gromeier M, Nair SK.

Oncotarget. 2016 Nov 29;7(48):79828-79841. doi: 10.18632/oncotarget.12975.


Cytotoxic and immunogenic mechanisms of recombinant oncolytic poliovirus.

Brown MC, Gromeier M.

Curr Opin Virol. 2015 Aug;13:81-5. doi: 10.1016/j.coviro.2015.05.007. Epub 2015 Jun 12. Review.


Induction of viral, 7-methyl-guanosine cap-independent translation and oncolysis by mitogen-activated protein kinase-interacting kinase-mediated effects on the serine/arginine-rich protein kinase.

Brown MC, Bryant JD, Dobrikova EY, Shveygert M, Bradrick SS, Chandramohan V, Bigner DD, Gromeier M.

J Virol. 2014 Nov;88(22):13135-48. doi: 10.1128/JVI.01883-14. Epub 2014 Sep 3.


Oncolytic polio virotherapy of cancer.

Brown MC, Dobrikova EY, Dobrikov MI, Walton RW, Gemberling SL, Nair SK, Desjardins A, Sampson JH, Friedman HS, Friedman AH, Tyler DS, Bigner DD, Gromeier M.

Cancer. 2014 Nov 1;120(21):3277-86. doi: 10.1002/cncr.28862. Epub 2014 Jun 17. Review.


Mitotic phosphorylation of eukaryotic initiation factor 4G1 (eIF4G1) at Ser1232 by Cdk1:cyclin B inhibits eIF4A helicase complex binding with RNA.

Dobrikov MI, Shveygert M, Brown MC, Gromeier M.

Mol Cell Biol. 2014 Feb;34(3):439-51. doi: 10.1128/MCB.01046-13. Epub 2013 Nov 18.


PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma.

Barton KL, Misuraca K, Cordero F, Dobrikova E, Min HD, Gromeier M, Kirsch DG, Becher OJ.

PLoS One. 2013 Oct 2;8(10):e77639. doi: 10.1371/journal.pone.0077639. eCollection 2013.


Dynamic regulation of the translation initiation helicase complex by mitogenic signal transduction to eukaryotic translation initiation factor 4G.

Dobrikov MI, Dobrikova EY, Gromeier M.

Mol Cell Biol. 2013 Mar;33(5):937-46. doi: 10.1128/MCB.01441-12. Epub 2012 Dec 21.


p38α mitogen-activated protein kinase depletion and repression of signal transduction to translation machinery by miR-124 and -128 in neurons.

Lawson SK, Dobrikova EY, Shveygert M, Gromeier M.

Mol Cell Biol. 2013 Jan;33(1):127-35. doi: 10.1128/MCB.00695-12. Epub 2012 Oct 29.


Attenuation of neurovirulence, biodistribution, and shedding of a poliovirus:rhinovirus chimera after intrathalamic inoculation in Macaca fascicularis.

Dobrikova EY, Goetz C, Walters RW, Lawson SK, Peggins JO, Muszynski K, Ruppel S, Poole K, Giardina SL, Vela EM, Estep JE, Gromeier M.

J Virol. 2012 Mar;86(5):2750-9. doi: 10.1128/JVI.06427-11. Epub 2011 Dec 14.


Oncolytic poliovirus against malignant glioma.

Goetz C, Dobrikova E, Shveygert M, Dobrikov M, Gromeier M.

Future Virol. 2011 Sep;6(9):1045-1058.


Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1.

Dobrikov M, Dobrikova E, Shveygert M, Gromeier M.

Mol Cell Biol. 2011 Jul;31(14):2947-59. doi: 10.1128/MCB.05589-11. Epub 2011 May 16.


Adaptation of an ICAM-1-tropic enterovirus to the mouse respiratory tract.

Wang ES, Dobrikova E, Goetz C, Dufresne AT, Gromeier M.

J Virol. 2011 Jun;85(11):5606-17. doi: 10.1128/JVI.01502-10. Epub 2011 Mar 30.


Regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction.

Shveygert M, Kaiser C, Bradrick SS, Gromeier M.

Mol Cell Biol. 2010 Nov;30(21):5160-7. doi: 10.1128/MCB.00448-10. Epub 2010 Sep 7.


Tissue type-specific expression of the dsRNA-binding protein 76 and genome-wide elucidation of its target mRNAs.

Neplioueva V, Dobrikova EY, Mukherjee N, Keene JD, Gromeier M.

PLoS One. 2010 Jul 23;5(7):e11710. doi: 10.1371/journal.pone.0011710.


MAPK signal-integrating kinase controls cap-independent translation and cell type-specific cytotoxicity of an oncolytic poliovirus.

Goetz C, Everson RG, Zhang LC, Gromeier M.

Mol Ther. 2010 Nov;18(11):1937-46. doi: 10.1038/mt.2010.145. Epub 2010 Jul 20.


Preparing an oncolytic poliovirus recombinant for clinical application against glioblastoma multiforme.

Goetz C, Gromeier M.

Cytokine Growth Factor Rev. 2010 Apr-Jun;21(2-3):197-203. doi: 10.1016/j.cytogfr.2010.02.005. Epub 2010 Mar 17. Review.


Poly(A)-binding protein modulates mRNA susceptibility to cap-dependent miRNA-mediated repression.

Walters RW, Bradrick SS, Gromeier M.

RNA. 2010 Jan;16(1):239-50. doi: 10.1261/rna.1795410. Epub 2009 Nov 24.


Herpes simplex virus proteins ICP27 and UL47 associate with polyadenylate-binding protein and control its subcellular distribution.

Dobrikova E, Shveygert M, Walters R, Gromeier M.

J Virol. 2010 Jan;84(1):270-9. doi: 10.1128/JVI.01740-09.


Identification of gemin5 as a novel 7-methylguanosine cap-binding protein.

Bradrick SS, Gromeier M.

PLoS One. 2009 Sep 14;4(9):e7030. doi: 10.1371/journal.pone.0007030.


Evaluation of IRES-mediated, cell-type-specific cytotoxicity of poliovirus using a colorimetric cell proliferation assay.

Yang X, Chen E, Jiang H, Muszynski K, Harris RD, Giardina SL, Gromeier M, Mitra G, Soman G.

J Virol Methods. 2009 Jan;155(1):44-54. doi: 10.1016/j.jviromet.2008.09.020. Epub 2008 Nov 8.


Recombinant oncolytic poliovirus eliminates glioma in vivo without genetic adaptation to a pathogenic phenotype.

Dobrikova EY, Broadt T, Poiley-Nelson J, Yang X, Soman G, Giardina S, Harris R, Gromeier M.

Mol Ther. 2008 Nov;16(11):1865-72. doi: 10.1038/mt.2008.184. Epub 2008 Sep 2.


Activation of cap-independent translation by variant eukaryotic initiation factor 4G in vivo.

Kaiser C, Dobrikova EY, Bradrick SS, Shveygert M, Herbert JT, Gromeier M.

RNA. 2008 Oct;14(10):2170-82. doi: 10.1261/rna.1171808. Epub 2008 Aug 28.


Immunotherapy against angiogenesis-associated targets: evidence and implications for the treatment of malignant glioma.

Everson RG, Graner MW, Gromeier M, Vredenburgh JJ, Desjardins A, Reardon DA, Friedman HS, Friedman AH, Bigner DD, Sampson JH.

Expert Rev Anticancer Ther. 2008 May;8(5):717-32. doi: 10.1586/14737140.8.5.717. Review.


Molecular strategies for the treatment of malignant glioma--genes, viruses, and vaccines.

Selznick LA, Shamji MF, Fecci P, Gromeier M, Friedman AH, Sampson J.

Neurosurg Rev. 2008 Apr;31(2):141-55; discussion 155. doi: 10.1007/s10143-008-0121-0. Epub 2008 Feb 8. Review.


Growth phenotypes and biosafety profiles in poliovirus-receptor transgenic mice of recombinant oncolytic polio/human rhinoviruses.

Cello J, Toyoda H, Dejesus N, Dobrikova EY, Gromeier M, Wimmer E.

J Med Virol. 2008 Feb;80(2):352-9.


Poly(A)-binding protein is differentially required for translation mediated by viral internal ribosome entry sites.

Bradrick SS, Dobrikova EY, Kaiser C, Shveygert M, Gromeier M.

RNA. 2007 Sep;13(9):1582-93. Epub 2007 Jul 25.


Genetic adaptation to untranslated region-mediated enterovirus growth deficits by mutations in the nonstructural proteins 3AB and 3CD.

Florez de Sessions P, Dobrikova E, Gromeier M.

J Virol. 2007 Aug;81(16):8396-405. Epub 2007 May 30.


Viruses in the treatment of malignant glioma.

Everson RG, Gromeier M, Sampson JH.

Expert Rev Neurother. 2007 Apr;7(4):321-4. Review. No abstract available.


Attenuation of herpes simplex virus neurovirulence with picornavirus cis-acting genetic elements.

Campbell SA, Mulvey M, Mohr I, Gromeier M.

J Virol. 2007 Jan;81(2):791-9. Epub 2006 Nov 1.


The hepatitis C virus 3'-untranslated region or a poly(A) tract promote efficient translation subsequent to the initiation phase.

Bradrick SS, Walters RW, Gromeier M.

Nucleic Acids Res. 2006 Mar 1;34(4):1293-303. Print 2006.

Supplemental Content

Loading ...
Support Center