Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 156

1.

RNA-sequencing reveals altered skeletal muscle contraction, E3 ligases, autophagy, apoptosis, and chaperone expression in patients with critical illness myopathy.

Llano-Diez M, Fury W, Okamoto H, Bai Y, Gromada J, Larsson L.

Skelet Muscle. 2019 Apr 16;9(1):9. doi: 10.1186/s13395-019-0194-1.

2.

Increased SLC38A4 Amino Acid Transporter Expression in Human Pancreatic α-Cells After Glucagon Receptor Inhibition.

Kim J, Dominguez Gutierrez G, Xin Y, Cavino K, Sung B, Sipos B, Kloeppel G, Gromada J, Okamoto H.

Endocrinology. 2019 May 1;160(5):979-988. doi: 10.1210/en.2019-00022.

PMID:
30938753
3.

The liver-alpha cell axis and type 2 diabetes.

Wewer Albrechtsen NJ, Pedersen J, Galsgaard KD, Winther-Sørensen M, Suppli MP, Janah L, Gromada J, Vilstrup H, Knop FK, Holst JJ.

Endocr Rev. 2019 Mar 28. pii: er.2018-00251. doi: 10.1210/er.2018-00251. [Epub ahead of print]

PMID:
30920583
4.

Hepatic Glucagon Signaling Regulates PCSK9 and Low-Density Lipoprotein Cholesterol.

Spolitu S, Okamoto H, Dai W, Zadroga JA, Wittchen ES, Gromada J, Ozcan L.

Circ Res. 2019 Jan 4;124(1):38-51. doi: 10.1161/CIRCRESAHA.118.313648.

PMID:
30582457
5.

Gene Signature of the Human Pancreatic ε Cell.

Dominguez Gutierrez G, Kim J, Lee AH, Tong J, Niu J, Gray SM, Wei Y, Ding Y, Ni M, Adler C, Murphy AJ, Gromada J, Xin Y.

Endocrinology. 2018 Dec 1;159(12):4023-4032. doi: 10.1210/en.2018-00833.

PMID:
30380031
6.

Characterization of glucose-stimulated insulin release protocols in african green monkeys (Chlorocebus aethiops).

Liddie S, Okamoto H, Gromada J, Lawrence M.

J Med Primatol. 2019 Feb;48(1):10-21. doi: 10.1111/jmp.12374. Epub 2018 Oct 25.

7.

The α-cell in diabetes mellitus.

Gromada J, Chabosseau P, Rutter GA.

Nat Rev Endocrinol. 2018 Dec;14(12):694-704. doi: 10.1038/s41574-018-0097-y. Review.

PMID:
30310153
8.

Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity.

Kleiner S, Gomez D, Megra B, Na E, Bhavsar R, Cavino K, Xin Y, Rojas J, Dominguez-Gutierrez G, Zambrowicz B, Carrat G, Chabosseau P, Hu M, Murphy AJ, Yancopoulos GD, Rutter GA, Gromada J.

Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):E7642-E7649. doi: 10.1073/pnas.1721418115. Epub 2018 Jul 23.

9.

Gene Signature of Proliferating Human Pancreatic α Cells.

Dominguez Gutierrez G, Xin Y, Okamoto H, Kim J, Lee AH, Ni M, Adler C, Yancopoulos GD, Murphy AJ, Gromada J.

Endocrinology. 2018 Sep 1;159(9):3177-3186. doi: 10.1210/en.2018-00469.

PMID:
30010845
10.

Pseudotime Ordering of Single Human β-Cells Reveals States of Insulin Production and Unfolded Protein Response.

Xin Y, Dominguez Gutierrez G, Okamoto H, Kim J, Lee AH, Adler C, Ni M, Yancopoulos GD, Murphy AJ, Gromada J.

Diabetes. 2018 Sep;67(9):1783-1794. doi: 10.2337/db18-0365. Epub 2018 Jun 27.

11.

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.

Gusarova V, O'Dushlaine C, Teslovich TM, Benotti PN, Mirshahi T, Gottesman O, Van Hout CV, Murray MF, Mahajan A, Nielsen JB, Fritsche L, Wulff AB, Gudbjartsson DF, Sjögren M, Emdin CA, Scott RA, Lee WJ, Small A, Kwee LC, Dwivedi OP, Prasad RB, Bruse S, Lopez AE, Penn J, Marcketta A, Leader JB, Still CD, Kirchner HL, Mirshahi UL, Wardeh AH, Hartle CM, Habegger L, Fetterolf SN, Tusie-Luna T, Morris AP, Holm H, Steinthorsdottir V, Sulem P, Thorsteinsdottir U, Rotter JI, Chuang LM, Damrauer S, Birtwell D, Brummett CM, Khera AV, Natarajan P, Orho-Melander M, Flannick J, Lotta LA, Willer CJ, Holmen OL, Ritchie MD, Ledbetter DH, Murphy AJ, Borecki IB, Reid JG, Overton JD, Hansson O, Groop L, Shah SH, Kraus WE, Rader DJ, Chen YI, Hveem K, Wareham NJ, Kathiresan S, Melander O, Stefansson K, Nordestgaard BG, Tybjærg-Hansen A, Abecasis GR, Altshuler D, Florez JC, Boehnke M, McCarthy MI, Yancopoulos GD, Carey DJ, Shuldiner AR, Baras A, Dewey FE, Gromada J.

Nat Commun. 2018 Jun 13;9(1):2252. doi: 10.1038/s41467-018-04611-z.

12.

Corrigendum to 'Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells' [Cellular Signalling 46 (2018) 120-128].

Rajasekaran SS, Kim J, Gaboardi GC, Gromada J, Shears SB, Dos Santos KT, Nolasco EL, de Souza Ferreira S, Illies C, Köhler M, Gu C, Ryu SH, Martins JO, Darè E, Barker CJ, Berggren PO.

Cell Signal. 2019 Jan;53:415. doi: 10.1016/j.cellsig.2018.05.004. Epub 2018 May 25. No abstract available.

13.

Preemptive Activation of the Integrated Stress Response Protects Mice From Diet-Induced Obesity and Insulin Resistance by Fibroblast Growth Factor 21 Induction.

Xu X, Krumm C, So JS, Bare CJ, Holman C, Gromada J, Cohen DE, Lee AH.

Hepatology. 2018 Dec;68(6):2167-2181. doi: 10.1002/hep.30060. Epub 2018 Nov 5.

PMID:
29698569
14.

A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease.

Abul-Husn NS, Cheng X, Li AH, Xin Y, Schurmann C, Stevis P, Liu Y, Kozlitina J, Stender S, Wood GC, Stepanchick AN, Still MD, McCarthy S, O'Dushlaine C, Packer JS, Balasubramanian S, Gosalia N, Esopi D, Kim SY, Mukherjee S, Lopez AE, Fuller ED, Penn J, Chu X, Luo JZ, Mirshahi UL, Carey DJ, Still CD, Feldman MD, Small A, Damrauer SM, Rader DJ, Zambrowicz B, Olson W, Murphy AJ, Borecki IB, Shuldiner AR, Reid JG, Overton JD, Yancopoulos GD, Hobbs HH, Cohen JC, Gottesman O, Teslovich TM, Baras A, Mirshahi T, Gromada J, Dewey FE.

N Engl J Med. 2018 Mar 22;378(12):1096-1106. doi: 10.1056/NEJMoa1712191.

15.

Glucagon contributes to liver zonation.

Cheng X, Kim SY, Okamoto H, Xin Y, Yancopoulos GD, Murphy AJ, Gromada J.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4111-E4119. doi: 10.1073/pnas.1721403115. Epub 2018 Mar 19.

16.

Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells.

Rajasekaran SS, Kim J, Gaboardi GC, Gromada J, Shears SB, Dos Santos KT, Nolasco EL, Ferreira SS, Illies C, Köhler M, Gu C, Ryu SH, Martins JO, Darè E, Barker CJ, Berggren PO.

Cell Signal. 2018 Jun;46:120-128. doi: 10.1016/j.cellsig.2018.03.001. Epub 2018 Mar 6. Erratum in: Cell Signal. 2019 Jan;53:415.

17.

Increased thermogenesis by a noncanonical pathway in ANGPTL3/8-deficient mice.

Banfi S, Gusarova V, Gromada J, Cohen JC, Hobbs HH.

Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1249-E1258. doi: 10.1073/pnas.1717420115. Epub 2018 Jan 22.

18.

Muscle-specific differences in expression and phosphorylation of the Janus kinase 2/Signal Transducer and Activator of Transcription 3 following long-term mechanical ventilation and immobilization in rats.

Salah H, Fury W, Gromada J, Bai Y, Tchkonia T, Kirkland JL, Larsson L.

Acta Physiol (Oxf). 2018 Mar;222(3). doi: 10.1111/apha.12980. Epub 2017 Oct 30.

PMID:
29032602
19.

A first-in-human pharmacodynamic and pharmacokinetic study of a fully human anti-glucagon receptor monoclonal antibody in normal healthy volunteers.

Kostic A, King TA, Yang F, Chan KC, Yancopoulos GD, Gromada J, Harp JB.

Diabetes Obes Metab. 2018 Feb;20(2):283-291. doi: 10.1111/dom.13075. Epub 2017 Sep 14.

20.

ANGPTL3 Inhibition in Homozygous Familial Hypercholesterolemia.

Gaudet D, Gipe DA, Pordy R, Ahmad Z, Cuchel M, Shah PK, Chyu KY, Sasiela WJ, Chan KC, Brisson D, Khoury E, Banerjee P, Gusarova V, Gromada J, Stahl N, Yancopoulos GD, Hovingh GK.

N Engl J Med. 2017 Jul 20;377(3):296-297. doi: 10.1056/NEJMc1705994. No abstract available.

PMID:
28723334
21.

Inflammatory Ly6Chi monocytes and their conversion to M2 macrophages drive atherosclerosis regression.

Rahman K, Vengrenyuk Y, Ramsey SA, Vila NR, Girgis NM, Liu J, Gusarova V, Gromada J, Weinstock A, Moore KJ, Loke P, Fisher EA.

J Clin Invest. 2017 Aug 1;127(8):2904-2915. doi: 10.1172/JCI75005. Epub 2017 Jun 26.

22.

Inhibition of PCSK9 does not improve lipopolysaccharide-induced mortality in mice.

Berger JM, Loza Valdes A, Gromada J, Anderson N, Horton JD.

J Lipid Res. 2017 Aug;58(8):1661-1669. doi: 10.1194/jlr.M076844. Epub 2017 Jun 9.

23.

Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice.

Kim J, Okamoto H, Huang Z, Anguiano G, Chen S, Liu Q, Cavino K, Xin Y, Na E, Hamid R, Lee J, Zambrowicz B, Unger R, Murphy AJ, Xu Y, Yancopoulos GD, Li WH, Gromada J.

Cell Metab. 2017 Jun 6;25(6):1348-1361.e8. doi: 10.1016/j.cmet.2017.05.006.

24.

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease.

Dewey FE, Gusarova V, Dunbar RL, O'Dushlaine C, Schurmann C, Gottesman O, McCarthy S, Van Hout CV, Bruse S, Dansky HM, Leader JB, Murray MF, Ritchie MD, Kirchner HL, Habegger L, Lopez A, Penn J, Zhao A, Shao W, Stahl N, Murphy AJ, Hamon S, Bouzelmat A, Zhang R, Shumel B, Pordy R, Gipe D, Herman GA, Sheu WHH, Lee IT, Liang KW, Guo X, Rotter JI, Chen YI, Kraus WE, Shah SH, Damrauer S, Small A, Rader DJ, Wulff AB, Nordestgaard BG, Tybjærg-Hansen A, van den Hoek AM, Princen HMG, Ledbetter DH, Carey DJ, Overton JD, Reid JG, Sasiela WJ, Banerjee P, Shuldiner AR, Borecki IB, Teslovich TM, Yancopoulos GD, Mellis SJ, Gromada J, Baras A.

N Engl J Med. 2017 Jul 20;377(3):211-221. doi: 10.1056/NEJMoa1612790. Epub 2017 May 24.

25.

Activin A more prominently regulates muscle mass in primates than does GDF8.

Latres E, Mastaitis J, Fury W, Miloscio L, Trejos J, Pangilinan J, Okamoto H, Cavino K, Na E, Papatheodorou A, Willer T, Bai Y, Hae Kim J, Rafique A, Jaspers S, Stitt T, Murphy AJ, Yancopoulos GD, Gromada J.

Nat Commun. 2017 Apr 28;8:15153. doi: 10.1038/ncomms15153.

26.

ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance.

Haller JF, Mintah IJ, Shihanian LM, Stevis P, Buckler D, Alexa-Braun CA, Kleiner S, Banfi S, Cohen JC, Hobbs HH, Yancopoulos GD, Murphy AJ, Gusarova V, Gromada J.

J Lipid Res. 2017 Jun;58(6):1166-1173. doi: 10.1194/jlr.M075689. Epub 2017 Apr 15.

27.

Insulin and Glucagon: Partners for Life.

Holst JJ, Holland W, Gromada J, Lee Y, Unger RH, Yan H, Sloop KW, Kieffer TJ, Damond N, Herrera PL.

Endocrinology. 2017 Apr 1;158(4):696-701. doi: 10.1210/en.2016-1748. Review.

28.

Heterogeneity of the Pancreatic Beta Cell.

Gutierrez GD, Gromada J, Sussel L.

Front Genet. 2017 Mar 6;8:22. doi: 10.3389/fgene.2017.00022. eCollection 2017. Review.

29.

ANGPTL8 Blockade With a Monoclonal Antibody Promotes Triglyceride Clearance, Energy Expenditure, and Weight Loss in Mice.

Gusarova V, Banfi S, Alexa-Braun CA, Shihanian LM, Mintah IJ, Lee JS, Xin Y, Su Q, Kamat V, Cohen JC, Hobbs HH, Zambrowicz B, Yancopoulos GD, Murphy AJ, Gromada J.

Endocrinology. 2017 May 1;158(5):1252-1259. doi: 10.1210/en.2016-1894.

30.

Angptl4 does not control hyperglucagonemia or α-cell hyperplasia following glucagon receptor inhibition.

Okamoto H, Cavino K, Na E, Krumm E, Kim S, Stevis PE, Harp J, Murphy AJ, Yancopoulos GD, Gromada J.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2747-2752. doi: 10.1073/pnas.1620989114. Epub 2017 Jan 31.

31.

PC1/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons.

Wang L, Sui L, Panigrahi SK, Meece K, Xin Y, Kim J, Gromada J, Doege CA, Wardlaw SL, Egli D, Leibel RL.

Stem Cell Reports. 2017 Feb 14;8(2):264-277. doi: 10.1016/j.stemcr.2016.12.021. Epub 2017 Jan 26.

32.

Glucagon receptor inhibition normalizes blood glucose in severe insulin-resistant mice.

Okamoto H, Cavino K, Na E, Krumm E, Kim SY, Cheng X, Murphy AJ, Yancopoulos GD, Gromada J.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2753-2758. doi: 10.1073/pnas.1621069114. Epub 2017 Jan 23.

33.

Variants in ANGPTL4 and the Risk of Coronary Artery Disease.

Dewey FE, Gromada J, Shuldiner AR.

N Engl J Med. 2016 Dec 8;375(23):2305-2306. doi: 10.1056/NEJMc1607380. No abstract available.

PMID:
27959690
34.

RNA Sequencing of Single Human Islet Cells Reveals Type 2 Diabetes Genes.

Xin Y, Kim J, Okamoto H, Ni M, Wei Y, Adler C, Murphy AJ, Yancopoulos GD, Lin C, Gromada J.

Cell Metab. 2016 Oct 11;24(4):608-615. doi: 10.1016/j.cmet.2016.08.018. Epub 2016 Sep 22.

35.

Single-Cell RNAseq Reveals That Pancreatic β-Cells From Very Old Male Mice Have a Young Gene Signature.

Xin Y, Okamoto H, Kim J, Ni M, Adler C, Cavino K, Na E, Murphy AJ, Yancopoulos GD, Lin C, Gromada J.

Endocrinology. 2016 Sep;157(9):3431-8. doi: 10.1210/en.2016-1235. Epub 2016 Jul 28.

PMID:
27466694
36.

Glucagon orchestrates stress-induced hyperglycaemia.

Harp JB, Yancopoulos GD, Gromada J.

Diabetes Obes Metab. 2016 Jul;18(7):648-53. doi: 10.1111/dom.12668. Epub 2016 May 4. Review.

37.

Mechano-signalling pathways in an experimental intensive critical illness myopathy model.

Corpeno Kalamgi R, Salah H, Gastaldello S, Martinez-Redondo V, Ruas JL, Fury W, Bai Y, Gromada J, Sartori R, Guttridge DC, Sandri M, Larsson L.

J Physiol. 2016 Aug 1;594(15):4371-88. doi: 10.1113/JP271973. Epub 2016 Apr 24.

38.

Use of the Fluidigm C1 platform for RNA sequencing of single mouse pancreatic islet cells.

Xin Y, Kim J, Ni M, Wei Y, Okamoto H, Lee J, Adler C, Cavino K, Murphy AJ, Yancopoulos GD, Lin HC, Gromada J.

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3293-8. doi: 10.1073/pnas.1602306113. Epub 2016 Mar 7.

39.

Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease.

Dewey FE, Gusarova V, O'Dushlaine C, Gottesman O, Trejos J, Hunt C, Van Hout CV, Habegger L, Buckler D, Lai KM, Leader JB, Murray MF, Ritchie MD, Kirchner HL, Ledbetter DH, Penn J, Lopez A, Borecki IB, Overton JD, Reid JG, Carey DJ, Murphy AJ, Yancopoulos GD, Baras A, Gromada J, Shuldiner AR.

N Engl J Med. 2016 Mar 24;374(12):1123-33. doi: 10.1056/NEJMoa1510926. Epub 2016 Mar 2.

40.

Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice.

Latres E, Pangilinan J, Miloscio L, Bauerlein R, Na E, Potocky TB, Huang Y, Eckersdorff M, Rafique A, Mastaitis J, Lin C, Murphy AJ, Yancopoulos GD, Gromada J, Stitt T.

Skelet Muscle. 2015 Oct 9;5:34. doi: 10.1186/s13395-015-0060-8. eCollection 2015.

41.

Loss of SFRP4 Alters Body Size, Food Intake, and Energy Expenditure in Diet-Induced Obese Male Mice.

Mastaitis J, Eckersdorff M, Min S, Xin Y, Cavino K, Aglione J, Okamoto H, Na E, Stitt T, Dominguez MG, Schmahl JP, Lin C, Gale NW, Valenzuela DM, Murphy AJ, Yancopoulos GD, Gromada J.

Endocrinology. 2015 Dec;156(12):4502-10. doi: 10.1210/en.2015-1257. Epub 2015 Sep 25.

PMID:
26406932
42.

Hepatic ANGPTL3 regulates adipose tissue energy homeostasis.

Wang Y, McNutt MC, Banfi S, Levin MG, Holland WL, Gusarova V, Gromada J, Cohen JC, Hobbs HH.

Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11630-5. doi: 10.1073/pnas.1515374112. Epub 2015 Aug 24.

43.

Reply.

Smagris E, BasuRay S, Gromada J, Cohen JC, Hobbs HH.

Hepatology. 2016 Feb;63(2):677. doi: 10.1002/hep.27945. Epub 2015 Aug 21. No abstract available.

PMID:
26099489
44.

Glucagon Receptor Blockade With a Human Antibody Normalizes Blood Glucose in Diabetic Mice and Monkeys.

Okamoto H, Kim J, Aglione J, Lee J, Cavino K, Na E, Rafique A, Kim JH, Harp J, Valenzuela DM, Yancopoulos GD, Murphy AJ, Gromada J.

Endocrinology. 2015 Aug;156(8):2781-94. doi: 10.1210/en.2015-1011. Epub 2015 May 28.

PMID:
26020795
45.

ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys.

Gusarova V, Alexa CA, Wang Y, Rafique A, Kim JH, Buckler D, Mintah IJ, Shihanian LM, Cohen JC, Hobbs HH, Xin Y, Valenzuela DM, Murphy AJ, Yancopoulos GD, Gromada J.

J Lipid Res. 2015 Jul;56(7):1308-17. doi: 10.1194/jlr.M054890. Epub 2015 May 11.

46.

Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion.

Wang Y, Gusarova V, Banfi S, Gromada J, Cohen JC, Hobbs HH.

J Lipid Res. 2015 Jul;56(7):1296-307. doi: 10.1194/jlr.M054882. Epub 2015 May 7.

47.

GPR17 gene disruption does not alter food intake or glucose homeostasis in mice.

Mastaitis J, Min S, Elvert R, Kannt A, Xin Y, Ochoa F, Gale NW, Valenzuela DM, Murphy AJ, Yancopoulos GD, Gromada J.

Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1845-9. doi: 10.1073/pnas.1424968112. Epub 2015 Jan 26.

48.

ANGPTL8/betatrophin does not control pancreatic beta cell expansion.

Gusarova V, Alexa CA, Na E, Stevis PE, Xin Y, Bonner-Weir S, Cohen JC, Hobbs HH, Murphy AJ, Yancopoulos GD, Gromada J.

Cell. 2014 Oct 23;159(3):691-6. doi: 10.1016/j.cell.2014.09.027.

49.

Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis.

Smagris E, BasuRay S, Li J, Huang Y, Lai KM, Gromada J, Cohen JC, Hobbs HH.

Hepatology. 2015 Jan;61(1):108-18. doi: 10.1002/hep.27242. Epub 2014 Oct 1.

50.

Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis.

Wang Y, Quagliarini F, Gusarova V, Gromada J, Valenzuela DM, Cohen JC, Hobbs HH.

Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16109-14. doi: 10.1073/pnas.1315292110. Epub 2013 Sep 16.

Supplemental Content

Loading ...
Support Center